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Markus Alexander Doll et al.
Genetics, 213(1), 173-194 (2019-07-13)
MicroRNAs (miRNAs) associate with argonaute (AGO) proteins to post-transcriptionally modulate the expression of genes involved in various cellular processes. Herein, we show that loss of the Caenorhabditis elegans AGO gene alg-2 results in rapid and significantly increased germ cell apoptosis
Javier Milara et al.
Respiratory research, 19(1), 226-226 (2018-11-22)
Lung inflammation in COPD is poorly controlled by inhaled corticosteroids (ICS). Strategies to improve ICS efficacy or the search of biomarkers who may select those patients candidates to receive ICS in COPD are needed. Recent data indicate that MUC1 cytoplasmic
Hadas Bar-Joseph et al.
Reproductive biomedicine online, 41(2), 335-342 (2020-06-14)
Does recombinant pigment epithelium derived factor (PEDF) have potential in treating uterine fibroids? In-vitro models that used human leiomyoma and Eker rat uterine leiomyoma (ELT-3) cell lines. The ELT-3 cell line was used to examine cellular targets after adding recombinant
R Seger et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 9(9), 726-735 (1995-06-01)
The transmission of extracellular signals into their intracellular targets is mediated by a network of interacting proteins that regulate a large number of cellular processes. Cumulative efforts from many laboratories over the past decade have allowed the elucidation of one
J Han et al.
Science (New York, N.Y.), 265(5173), 808-811 (1994-08-05)
Mammalian cells respond to endotoxic lipopolysaccharide (LPS) by activation of protein kinase cascades that lead to new gene expression. A protein kinase, p38, that was tyrosine phosphorylated in response to LPS, was cloned. The p38 enzyme and the product of
Miki Tokuoka et al.
Development (Cambridge, England), 145(11) (2018-05-17)
The transcriptional repressor Snail is required for proper differentiation of the tail muscle of ascidian tadpole larvae. Two muscle lineages (B5.1 and B6.4) contribute to the anterior tail muscle cells, and are consecutively separated from a transcriptionally quiescent germ cell
Ryan D Bickel et al.
EvoDevo, 4(1), 10-10 (2013-04-05)
In most species of aphid, female nymphs develop into either sexual or asexual adults depending on the length of the photoperiod to which their mothers were exposed. The progeny of these sexual and asexual females, in turn, develop in dramatically
Vincent Stepanik et al.
Current biology : CB, 30(16), 3141-3153 (2020-07-04)
Most fibroblast growth factors (FGFs) function as receptor ligands through their conserved FGF domain, but sequences outside this domain vary and are not well studied. This core domain of 120 amino acids (aa) is flanked in all FGFs by highly
Monophosphothreonyl extracellular signal-regulated kinases 1 and 2 (ERK1/2) are formed endogenously in intact cardiac myocytes and are enzymically active.
Sugden PH, et al.
Cellular Signalling, 23(2), 468-477 (2011)
Alberto Stolfi et al.
Development (Cambridge, England), 138(24), 5429-5439 (2011-11-24)
The motor ganglion (MG) controls the rhythmic swimming behavior of the Ciona intestinalis tadpole. Despite its cellular simplicity (five pairs of neurons), the MG exhibits conservation of transcription factor expression with the spinal cord of vertebrates. Evidence is presented that
Ramon Martinez et al.
The Journal of pharmacology and experimental therapeutics, 376(1), 84-97 (2020-10-29)
Constitutively active extracellular signal-regulated kinase (ERK) 1/2 signaling promotes cancer cell proliferation and survival. We previously described a class of compounds containing a 1,1-dioxido-2,5-dihydrothiophen-3-yl 4-benzenesulfonate scaffold that targeted ERK2 substrate docking sites and selectively inhibited ERK1/2-dependent functions, including activator protein-1-mediated
Roy Kalfon et al.
PloS one, 14(2), e0213081-e0213081 (2019-03-01)
c-Jun dimerization protein (JDP2) and Activating Transcription Factor 3 (ATF3) are closely related basic leucine zipper proteins. Transgenic mice with cardiac expression of either JDP2 or ATF3 showed maladaptive remodeling and cardiac dysfunction. Surprisingly, JDP2 knockout (KO) did not protect
Han Bao et al.
Oncology letters, 14(3), 2831-2837 (2017-09-21)
Long non-coding RNAs (lncRNAs) serve an important role in numerous human diseases, including cancer. Abnormal expression of lncRNAs has been associated with a number of tumor types; however, the underlying mechanisms through which lncRNA functions have yet to be elucidated.
Yiyun Zhou et al.
Development (Cambridge, England), 146(2) (2019-01-12)
Pleiotropic signaling pathways must somehow engender specific cellular responses. In the Drosophila mesoderm, Ras pathway signaling specifies muscle founder cells from among the broader population of myoblasts. For somatic muscles, this is an inductive process mediated by the ETS-domain downstream
The mitogen-activated protein kinase signal transduction pathway.
R J Davis
The Journal of biological chemistry, 268(20), 14553-14556 (1993-07-15)
ERK1 and ERK2 map kinases: specific roles or functional redundancy?
Pouyssegur J and Lenormand P
Frontiers in Cell and Developmental Biology, 4, 53-53 (2016)
Sven Reischauer et al.
PLoS genetics, 5(11), e1000720-e1000720 (2009-11-17)
Changes in tissue homeostasis, acquisition of invasive cell characteristics, and tumor formation can often be linked to the loss of epithelial cell polarity. In carcinogenesis, the grade of neoplasia correlates with impaired cell polarity. In Drosophila, lethal giant larvae (lgl)
Jose Raul Gonzalez-Garcia et al.
Journal of cell science, 127(Pt 12), 2749-2760 (2014-04-18)
Egg activation at fertilization in mammals is initiated by prolonged Ca(2+) oscillations that trigger the completion of meiosis and formation of pronuclei. A fall in mitogen-activated protein kinase (MAPK) activity is essential for pronuclear formation, but the precise timing and
Linda S Steelman et al.
Aging, 3(3), 192-222 (2011-03-23)
Dysregulated signaling through the Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways is often the result of genetic alterations in critical components in these pathways or upstream activators. Unrestricted cellular proliferation and decreased sensitivity to apoptotic-inducing agents are typically associated with activation of these
Douglas A Chapnick et al.
Molecular biology of the cell, 25(10), 1586-1593 (2014-03-14)
During wound healing and cancer metastasis, cells are frequently observed to migrate in collective groups. This mode of migration relies on the cooperative guidance of leader and follower cells throughout the collective group. The upstream determinants and molecular mechanisms behind
22q11. 2 distal deletion: a recurrent genomic disorder distinct from DiGeorge syndrome and velocardiofacial syndrome.
Ben-Shachar S, et al.
American Journal of Human Genetics, 82(1), 214-221 (2008)
Brad Davidson et al.
Genes & development, 20(19), 2728-2738 (2006-10-04)
Comprehensive gene networks in Ciona intestinalis embryos provide a foundation for characterizing complex developmental processes, such as the initial phases of chordate heart development. The basic helix-loop-helix regulatory gene Ci-Mesp is required for activation of cardiac transcription factors. Evidence is
Tal Hasin et al.
Basic research in cardiology, 106(2), 175-187 (2010-12-31)
The atria respond to various pathological stimuli including pressure and volume overload with remodeling and dilatation. Dilatation of the left atrium is associated with atrial fibrillation. The mechanisms involved in chamber-specific hypertrophy are largely unknown. Angiotensin II is hypothesized to
Bafetinib inhibits functional responses of human eosinophils in vitro.
Milara J, et al.
European Journal of Pharmacology, 715(1-3), 172-180 (2013)
A M Maillard et al.
Molecular psychiatry, 20(1), 140-147 (2014-11-26)
Anatomical structures and mechanisms linking genes to neuropsychiatric disorders are not deciphered. Reciprocal copy number variants at the 16p11.2 BP4-BP5 locus offer a unique opportunity to study the intermediate phenotypes in carriers at high risk for autism spectrum disorder (ASD)
François Sipieter et al.
iScience, 24(9), 103074-103074 (2021-09-28)
ERK1/2 involvement in cell death remains unclear, although many studies have demonstrated the importance of ERK1/2 dynamics in determining cellular responses. To untangle how ERK1/2 contributes to two cell death programs, we investigated ERK1/2 signaling dynamics during hFasL-induced apoptosis and
Gail Doughton et al.
PloS one, 9(4), e95434-e95434 (2014-04-23)
The primitive endoderm arises from the inner cell mass during mammalian pre-implantation development. It faces the blastocoel cavity and later gives rise to the extraembryonic parietal and visceral endoderm. Here, we investigate a key step in primitive endoderm development, the
Weiyang Shi et al.
Development (Cambridge, England), 135(5), 931-940 (2008-02-01)
Mesodermal tissues arise from diverse cell lineages and molecular strategies in the Ciona embryo. For example, the notochord and mesenchyme are induced by FGF/MAPK signaling, whereas the tail muscles are specified autonomously by the localized determinant, Macho-1. A unique mesoderm
Javier Milara et al.
Pulmonary pharmacology & therapeutics, 28(2), 138-148 (2014-02-15)
Epithelial to mesenchymal transition (EMT) is under discussion as a potential mechanism of small airway remodelling in COPD. In bronchial epithelium of COPD and smokers markers of EMT were described. In vitro, EMT may be reproduced by exposing well-differentiated human bronchial
Monica Guidi et al.
BMC molecular biology, 11, 95-95 (2010-12-15)
Neurotrophins and their receptors are key molecules in the regulation of neuronal differentiation and survival. They mediate the survival of neurons during development and adulthood and are implicated in synaptic plasticity. The human neurotrophin-3 receptor gene NTRK3 yields two major
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