Showing 1-30 of 1871 results for "


Fanette Lasoudris et al.
European journal of immunology, 41(6), 1629-1638 (2011-04-07)
The L-phenylalanine oxidase IL4I1 inhibits T-cell proliferation in vitro through H(2) O(2) production, and is highly expressed in tumor-associated macrophages. IL4I1 is also detected by immunohistochemistry in neoplastic cells from several B-cell lymphomas and some non-lymphoid tumors. To evaluate IL4I1's...
Narjes Nasiri-Ansari et al.
International journal of molecular sciences, 22(2) (2021-01-21)
SGLT-2 inhibitors (SGLT-2i) have been studied as potential treatments against NAFLD, showing varying beneficial effects. The molecular mechanisms mediating these effects have not been fully clarified. Herein, we investigated the impact of empagliflozin on NAFLD, focusing particularly on ER stress...
Samer Kayali et al.
PloS one, 7(10), e46799-e46799 (2012-10-12)
Clonal erythroleukemia developing in susceptible mice infected by Friend virus complex are associated with highly recurrent proviral insertions at one of three loci called Spi-1, Fli-1 or Fli-3, leading to deregulated expression of oncogenic Spi-1 or Fli-1 transcription factors or...
Zaw Myo Hein et al.
Journal of neuroimmunology, 344, 577232-577232 (2020-04-21)
Neuron-Glial2 (NG2) expressing cells are described as the oligodendrocyte precursor cells in the brain. This study aimed to investigate the possible involvement of NG2 cells under the methamphetamine (METH)-induced neurotoxicity and neuroprotective capacity of melatonin. The results showed that the...
Meimei Zheng et al.
Frontiers in cell and developmental biology, 9, 623738-623738 (2021-03-26)
Spermatogenesis requires a large number of proteins to be properly expressed at certain stages, during which post-transcriptional regulation plays an important role. RNA-binding proteins (RBPs) are key players in post-transcriptional regulation, but only a few RBPs have been recognized and...
Nate Weymouth et al.
Developmental biology, 363(1), 1-14 (2011-11-30)
Smooth muscle α-actin (Acta2) is one of six highly conserved mammalian actin isoforms that appear to exhibit functional redundancy. Nonetheless, we have postulated a specific functional role for the smooth muscle specific isoform. Here, we show that Acta2 deficient mice...
Yanshu Wang et al.
Proceedings of the National Academy of Sciences of the United States of America, 115(50), E11827-E11836 (2018-11-28)
β-Catenin signaling controls the development and maintenance of the blood-brain barrier (BBB) and the blood-retina barrier (BRB), but the division of labor and degree of redundancy between the two principal ligand-receptor systems-the Norrin and Wnt7a/Wnt7b systems-are incompletely defined. Here, we...
Huizi Keiko Li et al.
Journal of radiation research, 57(5), 572-575 (2016-06-01)
PU-H71, a heat shock protein 90 (Hsp90) inhibitor, has yielded therapeutic efficacy in many preclinical models and is currently in clinical trials. Carbon-ion radiotherapy (CIRT) has provided successful tumor control; however, there is still room for improvement, particularly in terms...
Wei-Guang Li et al.
Nature communications, 7, 13770-13770 (2016-12-08)
Acid-sensing ion channel 1a (ASIC1a) has been shown to play important roles in synaptic plasticity, learning and memory. Here we identify a crucial role for ASIC1a in long-term depression (LTD) at mouse insular synapses. Genetic ablation and pharmacological inhibition of...
Hao-Jan Lin et al.
Evidence-based complementary and alternative medicine : eCAM, 2014, 916531-916531 (2014-06-03)
The purpose of this study was to investigate the effect of an immunomodulatory protein (Ling Zhi-8, LZ-8) on wound healing in rat liver tissues after monopolar electrosurgery. Animals were sacrificed for evaluations at 0, 3, 7, and 28 days postoperatively....
Simon Kaja et al.
Molecular neurobiology, 52(1), 545-554 (2014-09-11)
Mutations in presenilin (PS) proteins cause familial Alzheimer's disease. We herein tested the hypothesis that the expression levels of PS proteins are differentially affected during healthy aging, in the absence of pathological mutations. We used a preclinical model for aging...
Martina Meßner et al.
Scientific reports, 11(1), 11185-11185 (2021-05-29)
The human mitochondrial ClpXP protease complex (HsClpXP) has recently attracted major attention as a target for novel anti-cancer therapies. Despite its important role in disease progression, the cellular role of HsClpXP is poorly characterized and only few small molecule inhibitors...
Sophia Havaki et al.
Cancer cell international, 7, 16-16 (2007-10-04)
Integrins are transmembrane adhesion receptors that provide the physical link between the actin cytoskeleton and the extracellular matrix. It has been well established that integrins play a major role in various cancer stages, such as tumor growth, progression, invasion and...
Bo Pan et al.
Journal of psychopharmacology (Oxford, England), 32(11), 1252-1263 (2018-08-24)
Antipsychotics are developed to treat mental disorders in adults; however, the prescription (mostly "off-label") of antipsychotics for children/adolescents has been constantly increasing over years. The influences of antipsychotics on juveniles requires investigation to validate their clinic use. Antipsychotics mainly exert...
Individual Src-family tyrosine kinases direct the degradation or protection of the clock protein Timeless via differential ubiquitylation.
O'Reilly, LP; Zhang, X; Smithgall, TE
Cellular Signalling null
Barbara Rosati et al.
The Journal of physiology, 589(Pt 13), 3275-3288 (2011-04-28)
Mechanisms that contribute to maintaining expression of functional ion channels at relatively constant levels following perturbations of channel biosynthesis are likely to contribute significantly to the stability of electrophysiological systems in some pathological conditions. In order to examine the robustness...
G A Doyle et al.
Neuroscience, 277, 403-416 (2014-07-25)
Compared to DBA/2J (D2), C57BL/6J (B6) inbred mice exhibit strong morphine preference when tested using a two-bottle choice drinking paradigm. A morphine preference quantitative trait locus (QTL), Mop2, was originally mapped to proximal chromosome (Chr) 10 using a B6xD2 F2...
p53 regulates a non-apoptotic death induced by ROS.
Montero, J; Dutta, C; van Bodegom, D; Weinstock, D; Letai, A
Cell Death and Differentiation null
?-Catenin at adherens junctions: mechanism and biologic implications in hepatocellular cancer after ?-catenin knockdown.
Wickline, ED; Du, Y; Stolz, DB; Kahn, M; Monga, SP
Neoplasia null
Angeliki Chalkiadaki et al.
PLoS genetics, 10(7), e1004490-e1004490 (2014-07-18)
SIRT1 is a metabolic sensor and regulator in various mammalian tissues and functions to counteract metabolic and age-related diseases. Here we generated and analyzed mice that express SIRT1 at high levels specifically in skeletal muscle. We show that SIRT1 transgenic...
Jiayin Li et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 40(2), 297-310 (2019-11-21)
Pancreatitis-associated proteins (PAPs) display multiple functions in visceral diseases. Previous studies showed that the expression level of PAP-I was low in the DRG of naive rats but was de novo expressed after peripheral nerve injury. However, its role in neuropathic...
Hitomi Hasegawa et al.
PloS one, 9(12), e116048-e116048 (2014-12-30)
Activating transcription factor 2 (ATF2) and its homolog ATF7 are phosphorylated at Thr-69/Thr-71 and at Thr-51/Thr-53, respectively, by stress-activated MAPKs regulating their transcriptional functions in G1 and S phases. However, little is known about the role of ATF2 and ATF7...
Kyungtae Kim et al.
Nutrients, 12(2) (2020-02-13)
Ginsenoside Rg3, one of the major components in Panax ginseng, has been reported to possess several therapeutic effects including anti-obesity properties. However, its effect on the browning of mature white adipocytes as well as the underlying mechanism remains poorly understood....
S Faraj et al.
Oncoimmunology, 7(1), e1373232-e1373232 (2018-01-04)
Despite recent advances in high-risk neuroblastoma therapy, the prognosis for patients remains poor. In addition, many patients suffer from complications related to available therapies that are highly detrimental to their quality of life. New treatment modalities are, thus, urgently needed...
Kenneth L Pitter et al.
PloS one, 6(1), e14545-e14545 (2011-01-27)
Platelet derived growth factor receptor (PDGFR) activity is deregulated in human GBM due to amplification and rearrangement of the PDGFR-alpha gene locus or overexpression of the PDGF ligand, resulting in the activation of downstream kinases such as phosphatidylinositol 3-kinase (PI3K)...
Rui Yan et al.
Journal of innate immunity, 9(6), 546-560 (2017-06-29)
Sepsis is a severe systemic inflammatory response to infection. Endothelial activation and dysfunction play a critical role in the pathophysiology of sepsis and represent an important therapeutic target to reduce sepsis mortality. Interferon regulatory factor 1 (IRF-1) was recently identified...
Antwi-Boasiako Oteng et al.
Molecular nutrition & food research, 63(19), e1900385-e1900385 (2019-07-22)
The mechanisms underlying the deleterious effects of trans fatty acids on plasma cholesterol and non-alcoholic fatty liver disease (NAFLD) are unclear. Here, the aim is to investigate the molecular mechanisms of action of industrial trans fatty acids. Hepa1-6 hepatoma cells...
Ming-Shian Tsai et al.
Experimental & molecular medicine, 50(1), e426-e426 (2018-01-13)
This study investigated the regulatory role of nerve growth factor (NGF) in sirtuin 1 (SIRT1) expression in cholestatic livers. We evaluated the expression of NGF and its cognate receptors in human livers with hepatolithiasis and the effects of NGF therapy...
Ji Hyun Shin et al.
Biological & pharmaceutical bulletin, 35(7), 1069-1075 (2012-07-14)
Autophagy is associated with cell survival and cell death. Autophagy is implicated in the pathophysiology of various human diseases. In order to identify autophagy regulatory molecules, we screened a chemical drug library in SH-SY5Y cells and selected Sertindole as a...