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Cyclin T1 and CDK9 T-loop phosphorylation are downregulated during establishment of HIV-1 latency in primary resting memory CD4+ T cells.
Budhiraja, S; Famiglietti, M; Bosque, A; Planelles, V; Rice, AP
Journal of virology null
Matthew J Keuss et al.
The EMBO journal, 38(6) (2019-02-26)
NEDD8 is a ubiquitin-like protein that activates cullin-RING E3 ubiquitin ligases (CRLs). Here, we identify a novel role for NEDD8 in regulating the activity of poly(ADP-ribose) polymerase 1 (PARP-1) in response to oxidative stress. We show that treatment of cells
Dong Zhou et al.
Journal of the American Society of Nephrology : JASN, 28(8), 2322-2336 (2017-03-25)
Cell-cell communication via Wnt ligands is necessary in regulating embryonic development and has been implicated in CKD. Because Wnt ligands are ubiquitously expressed, the exact cellular source of the Wnts involved in CKD remains undefined. To address this issue, we
Bo Pan et al.
Scientific reports, 6, 30040-30040 (2016-07-21)
Aripiprazole is a D2-like receptor (D2R) partial agonist with a favourable clinical profile. Previous investigations indicated that acute and short-term administration of aripiprazole had effects on PKA activity, GSK3β-dependent pathways, GABAA receptors, NMDA receptor and CREB1 in the brain. Since
Pelagia Foka et al.
Virulence, 7(6), 679-690 (2016-04-09)
Mechanisms that favor Hepatitis C virus (HCV) persistence over clearance are unclear, but involve defective innate immunity. Chronic infection is characterized by hepatic iron overload, hyperferraemia and hyperferittinaemia. Hepcidin modulates iron egress via ferroportin and its storage in ferritin. Chronic
Motahareh Solina Safari et al.
Frontiers in synaptic neuroscience, 13, 640495-640495 (2021-02-23)
Alterations in the processes that control α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) expression, assembly and trafficking are closely linked to psychiatric and neurodegenerative disorders. We have recently shown that the serine/threonine kinase Protein kinase N1 (PKN1) is a developmentally active regulator of
Mikael Johansson et al.
Neuro-oncology, 15(9), 1200-1211 (2013-06-01)
Deregulated growth factor signaling is a major driving force in the initiation and progression of glioblastoma. The tumor suppressor and stem cell marker Lrig1 is a negative regulator of the epidermal growth factor receptor (EGFR) family. Here, we addressed the
Laetitia Mouly et al.
Cell death & disease, 9(9), 931-931 (2018-09-14)
RHO GTPases regulate essential functions such as the organization of the actin cytoskeleton. The classic members cycle between an active GTP-bound and an inactive GDP-bound conformation whereas atypical members are predominantly GTP-bound. Besides their well-established role, the classic RHO GTPases
Jeanne E McKeon et al.
Cellular and molecular life sciences : CMLS, 72(9), 1811-1824 (2014-11-19)
Ubiquitin C-terminal hydrolase L1 (UCH-L1) is a key neuronal deubiquitinating enzyme which is mutated in Parkinson disease (PD) and in childhood-onset neurodegenerative disorder with optic atrophy. Furthermore, reduced UCH-L1 protein levels are associated with a number of neurodegenerative diseases, whereas
Amino Acid Uptake and Metabolism of Legionella pneumophila Hosted by Acanthamoeba castellanii.
Schunder, E; Gillmaier, N; Kutzner, E; Eisenreich, W; Herrmann, V; Lautner, M; Heuner, K
The Journal of Biological Chemistry null
Shamol Saha et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 29(29), 9210-9218 (2009-07-25)
Mutations in leucine-rich repeat kinase 2 (LRRK2) cause autosomal-dominant familial Parkinson's disease. We generated lines of Caenorhabditis elegans expressing neuronally directed human LRRK2. Expressing human LRRK2 increased nematode survival in response to rotenone or paraquat, which are agents that cause
Victor Z Chong et al.
Schizophrenia research, 100(1-3), 270-280 (2008-02-05)
Neuregulin-1 (NRG1) and its receptor, ErbB4, have been implicated in schizophrenia at both gene and transcript levels. The present investigation compared NRG1 and ErbB4 protein levels in prefrontal cortical (PFC) cytoplasmic and nuclear fractions among normal, schizophrenic, bipolar and major
Michael D Onken et al.
Science signaling, 11(546) (2018-09-06)
Constitutively active G protein α subunits cause cancer, cholera, Sturge-Weber syndrome, and other disorders. Therapeutic intervention by targeted inhibition of constitutively active Gα subunits in these disorders has yet to be achieved. We found that constitutively active Gαq in uveal
Robert H Oakley et al.
The Journal of biological chemistry, 292(14), 5825-5844 (2017-02-23)
Glucocorticoids are primary stress hormones that regulate many physiological processes, and synthetic derivatives of these molecules are widely used in the clinic. The molecular factors that govern tissue specificity of glucocorticoids, however, are poorly understood. The actions of glucocorticoids are
Xiankui Li et al.
Scientific reports, 7(1), 5872-5872 (2017-07-21)
The present study investigated the effects of exogenous thymosin β4 (TB4) on carbon tetrachloride (CCl4)-induced acute liver injury and fibrosis in rodent animals. Results showed that both in mice and rats CCl4 rendered significant increases in serum alanine aminotransferase and
Rohit B Sharma et al.
The Journal of clinical investigation, 125(10), 3831-3846 (2015-09-22)
Although stem cell populations mediate regeneration of rapid turnover tissues, such as skin, blood, and gut, a stem cell reservoir has not been identified for some slower turnover tissues, such as the pancreatic islet. Despite lacking identifiable stem cells, murine
Decreased p44/42 mitogen-activated protein kinase phosphorylation in gender- or hormone-related but not during age-related adrenal gland growth in mice.
Bielohuby, M; Sawitzky, M; Johnsen, I; Wittenburg, D; Beuschlein, F; Wolf, E; Hoeflich, A
Endocrinology null
D Kesley Robertson et al.
PLoS pathogens, 5(11), e1000664-e1000664 (2009-11-26)
Chlamydiae are obligate intracellular pathogens that must coordinate the acquisition of host cell-derived biosynthetic constituents essential for bacterial survival. Purified chlamydiae contain several lipids that are typically found in eukaryotes, implying the translocation of host cell lipids to the chlamydial
Genome and infection characteristics of human parechovirus type 1: the interplay between viral infection and type I interferon antiviral system.
Chang, JT; Yang, CS; Chen, YS; Chen, BC; Chiang, AJ; Chang, YH; Tsai, WL; Lin, YS; Chao et al.
Testing null
Experience-dependent brain plasticity after stroke: effect of ibuprofen and poststroke delay.
Jan A Jablonka,Malgorzata Kossut,Otto W Witte,Monika Liguz-Lecznar
The European Journal of Neuroscience null
Anita Toscani et al.
Molecules (Basel, Switzerland), 26(16) (2021-08-28)
Current therapy against herpes simplex viruses (HSV) relies on the use of a few nucleoside antivirals such as acyclovir, famciclovir and valacyclovir. However, the current drugs are ineffective against latent and drug-resistant HSV infections. A series of amidinourea compounds, designed
Mallory E Harden et al.
Virology, 507, 192-198 (2017-04-28)
Many tumors, including cervical carcinoma, show dysregulated expression of the microRNA processing machinery, specifically DROSHA and DICER. Some cervical cancers exhibit chromosome 5p amplifications and DROSHA is the most significantly upregulated transcript and is observed in all tumors with 5p
Antonis Papoutsidakis et al.
International journal of oncology, 57(3), 791-803 (2020-07-25)
Chondrosarcoma is a malignant bone tumor characterized by the production of a modified cartilage‑type extracellular matrix (ECM). In the present study, the expression levels of the small leucine‑rich proteoglycans (SLRPs), decorin, biglycan and lumican, were examined in the HTB94 human
Jui-Hua Lu et al.
Cancers, 12(11) (2020-11-05)
Traditional Chinese medicines Antler's extract (A) and Ganoderma lucidum (G) and Antrodia Camphorata (A) have been known to individually contain a plethora of bioactive factors including triterpenoids, polysaccharides etc., exerting various curative impacts such as anti-inflammatory, anti-oxidative, anti-atherosclerotic and anti-viral
Hanna Berger et al.
Journal of cell science, 130(11), 1890-1903 (2017-04-20)
Protein tyrosine kinase 7 (PTK7) is an evolutionarily conserved transmembrane receptor with important roles in embryonic development and disease. Originally identified as a gene upregulated in colon cancer, it was later shown to regulate planar cell polarity (PCP) and directional
Suman Chaudhary et al.
Prion, 15(1), 126-137 (2021-07-06)
Accumulation of redox-active iron in human sporadic Creutzfeldt-Jakob disease (sCJD) brain tissue and scrapie-infected mouse brains has been demonstrated previously. Here, we explored whether upregulation of local hepcidin secreted within the brain is the underlying cause of iron accumulation and
Junichi Yamamoto et al.
Nature communications, 5, 4263-4263 (2014-06-28)
The elongation factors DSIF and NELF are responsible for promoter-proximal RNA polymerase II (Pol II) pausing. NELF is also involved in 3' processing of replication-dependent histone genes, which produce non-polyadenylated mRNAs. Here we show that DSIF and NELF contribute to
Sang Ah Yi et al.
Molecules (Basel, Switzerland), 26(18) (2021-09-29)
Extensive epigenetic remodeling occurs during the cell fate determination of stem cells. Previously, we discovered that eudesmin regulates lineage commitment of mesenchymal stem cells through the inhibition of signaling molecules. However, the epigenetic modulations upon eudesmin treatment in genomewide level
Victor S Van Laar et al.
Neurobiology of disease, 91, 247-261 (2016-03-24)
Mitochondrial dysfunction has been implicated in Parkinson's disease (PD) neuropathology. Mic60, also known as mitofilin, is a protein of the inner mitochondrial membrane and a key component of the mitochondrial contact site and cristae junction organizing system (MICOS). Mic60 is
Eun Sung Kim et al.
PloS one, 10(5), e0128078-e0128078 (2015-05-30)
Human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) secrete various beneficial molecules, which have anti-apoptotic activity and cell proliferation. However, the effect of hUCB-MSCs in melanogenesis is largely unclear. In this study, we show that conditioned media (CM) derived from
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