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Patrick Scheiermann et al.
Scientific reports, 5, 8521-8521 (2015-02-18)
Overdosing of the analgesic acetaminophen (APAP, paracetamol) is a major cause of acute liver injury. Whereas toxicity is initiated by hepatocyte necrosis, course of disease is regulated by mechanisms of innate immunity having the potential to serve in complex manner
Marcello Locatelli et al.
Journal of chromatography. A, 1388, 79-86 (2015-02-24)
This paper reports the validation of a quantitative high performance liquid chromatography-photodiode array (HPLC-PDA) method for the simultaneous analysis, in mouse plasma, of eperisone hydrochloride and paracetamol by protein precipitation using zinc sulphate-methanol-acetonitrile. The analytes were resolved on a Gemini
Shengdong Wang et al.
Liver international : official journal of the International Association for the Study of the Liver, 34(7), 1068-1073 (2013-10-15)
Acetaminophen (APAP) is widely used as an antipyretic agent which is safe at therapeutic doses. However, overdose of APAP induces fatal and non-fatal hepatic necroses. The chemical reactive metabolites of APAP initiate toxicity and inflammatory response within the liver and
Luz María Martínez et al.
International journal of pharmaceutics, 477(1-2), 294-305 (2014-12-03)
There is a special interest in having pharmaceutical active ingredients in the amorphous state due to their increased solubility and therefore, higher bioavailability. Nevertheless, not all of them present stable amorphous phases. In particular, paracetamol is an active ingredient widely
Syusuke Sano et al.
International journal of pharmaceutics, 468(1-2), 234-242 (2014-04-09)
The impact of different active pharmaceutical ingredients (APIs) loading on the properties of orally disintegrating tablets (ODTs) prepared according to our previously reported microwave (MW) treatment process was evaluated using famotidine (FAM), acetaminophen (AAP), and ibuprofen (IBU). None of the
Yutaka Kimura et al.
Toxicology in vitro : an international journal published in association with BIBRA, 28(5), 759-768 (2014-03-08)
We established a luciferase reporter assay system, the Multi-ImmunoTox Assay (MITA), to evaluate the effects on key predictivein vitro components of the human immune system. The system is composed of 3 stable reporter cell lines transfected with 3 luciferase genes
Mona Darwish et al.
Clinical therapeutics, 37(2), 390-401 (2014-12-30)
A hydrocodone extended-release (ER) formulation was developed to provide sustained pain relief with twice-daily dosing. Developed using the CIMA abuse-deterrence technology platform (CIMA Labs Inc, Brooklyn Park, Minnesota), this formulation also provides resistance against rapid release of hydrocodone when tablets
Sharad Mangal et al.
International journal of pharmaceutics, 479(2), 338-348 (2015-01-13)
In this study, polyvinylpyrrolidone (PVP) was spray dried with l-leucine (PVP-Leu) to create a prototype multifunctional interactive excipient. The physico-chemical and bulk properties such as particle size, surface composition, surface energy and bulk cohesion of PVP-Leu was measured and compared
Véronique Gilard et al.
Journal of pharmaceutical and biomedical analysis, 102, 476-493 (2014-12-03)
One hundred and fifty dietary supplements (DS) marketed to increase sexual performance were analyzed. All these formulations were claimed to contain only natural compounds, plant extracts and/or vitamins. (1)H NMR spectroscopy was used for detecting the presence of adulterants and
Clinical question: are non-steroidal anti-inflammatories superior to acetaminophen for sprains/strains?
Heather Wheeler et al.
The Journal of the Oklahoma State Medical Association, 107(3), 109-110 (2014-05-08)
Nabil A Khan et al.
Journal of opioid management, 9(3), 225-230 (2013-06-19)
Addiction to painkillers or other substances in pediatric and adolescent cases of noncancer chronic pain is an understudied phenomenon, even amidst documented increases in rates of prescription opioid use and misuse. Case studies can inform the training of clinicians in
Antonio Martinez-Gimeno et al.
Expert review of respiratory medicine, 7(2), 113-122 (2013-04-04)
During the last few decades, a huge epidemiological effort has been made all over the world in order to cast some light on the origin of asthma (or 'wheezing disorders' as a general term) and its recent increase in prevalence.
Julia Dinger et al.
Toxicology letters, 230(1), 28-35 (2014-08-12)
Drugs of abuse are not tested for cytochrome P450 (CYP) inhibition potential before distribution. Therefore, a cocktail assay should be developed for testing the inhibition potential for all relevant CYPs. The following CYP test substrates and selective inhibitors were incubated
Kalynne Harris et al.
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 40(8), 906-911 (2014-07-16)
Little is known about postoperative opioid prescribing patterns among dermatologic surgeons. To better understand postoperative opioid prescribing patterns among dermatologic surgeons in the United States. Two-part analysis consisting of a retrospective chart review of 233 dermatologic surgery patients at a
Fixed drug eruption: a selective reaction to amoxicillin.
Amel Chaabane et al.
Therapie, 68(3), 183-185 (2013-07-28)
Peggy Gandia et al.
Journal of clinical pharmacology, 43(11), 1235-1243 (2003-10-11)
This study evaluated the effect of simulated weightlessness on gastric emptying, using acetaminophen as a probe and -6 degrees head-down bed rest to simulate zero gravity. Eighteen volunteers were given 1 g of acetaminophen orally before the bed rest and
Kyung-Ha Ryu et al.
Experimental cell research, 326(1), 143-154 (2014-06-24)
Acute liver failure, the fatal deterioration of liver function, is the most common indication for emergency liver transplantation, and drug-induced liver injury and viral hepatitis are frequent in young adults. Stem cell therapy has come into the limelight as a
Zeyan Liew et al.
JAMA pediatrics, 168(4), 313-320 (2014-02-26)
Acetaminophen (paracetamol) is the most commonly used medication for pain and fever during pregnancy in many countries. Research data suggest that acetaminophen is a hormone disruptor, and abnormal hormonal exposures in pregnancy may influence fetal brain development. To evaluate whether
Lihai Zhang et al.
The Journal of pharmacology and experimental therapeutics, 346(2), 259-269 (2013-06-14)
Our previous research showed that enolates formed from 1,3-dicarbonyl compounds, such as 2-acetylcyclopentanone (2-ACP), could provide protection in cell culture models from electrophile- or oxidative stress-induced toxicity. In the present study, we evaluated the protective abilities of 2-ACP in a
PKCs: pernicious kinase culprits in acetaminophen pathogenesis.
Cynthia Ju et al.
Hepatology (Baltimore, Md.), 59(4), 1229-1231 (2014-03-29)
Yoko Nishimura et al.
Journal of applied toxicology : JAT, 35(2), 173-180 (2014-08-06)
Cardiotoxicity is one of the major safety concerns in drug development. Therefore, detecting and monitoring cardiotoxicity throughout preclinical and clinical studies is important for pharmaceutical companies. The present study was conducted in order to explore a plasma miRNA biomarker for
F Franceschi et al.
European review for medical and pharmacological sciences, 17(16), 2129-2135 (2013-07-31)
Pain is the most common reason people see doctors in developed Countries and a very common cause of access in Emergency Department (ED). The combination acetaminophen/codeine represents the standard medication in the second step of the WHO analgesic scale and
Huan Yang et al.
The Journal of experimental medicine, 212(1), 5-14 (2015-01-07)
Innate immune receptors for pathogen- and damage-associated molecular patterns (PAMPs and DAMPs) orchestrate inflammatory responses to infection and injury. Secreted by activated immune cells or passively released by damaged cells, HMGB1 is subjected to redox modification that distinctly influences its
Treatment of paracetamol overdose.
Benjamin Kessler et al.
Lancet (London, England), 383(9926), 1382-1382 (2014-04-25)
Eda Ozcelik et al.
Pharmacognosy magazine, 10(Suppl 2), S217-S224 (2014-07-06)
Liver diseases have become a major problem of the worldwide. More than 50% of all cases of liver failure can be attributed to drugs. Among these, acetaminophen is the most common cause. The aim of this study was to investigate
Mahmoud Mohammadi et al.
Indian pediatrics, 40(12), 1183-1186 (2004-01-15)
The present study was done to explore the relationship between the cerebrospinal fluid (CSF) glucose concentration, body temperature, seizure duration, and acetaminophen administration. Retrospective record review of 117 consecutive febrile convulsive infants aging 3 to 18 months admitted to Bahrami
FDA asks physicians to stop prescribing high-dose acetaminophen products.
Mike Mitka
JAMA, 311(6), 563-563 (2014-02-13)
Sebastiano Mercadante et al.
Critical reviews in oncology/hematology, 87(2), 140-145 (2013-02-12)
The aim of this review was to assess the value of NSAIDs and paracetamol in patients with cancer pain to update a previous review performed ten years ago on this topic. The approach was analytic and based on clinical considerations
Takako Ohkura et al.
Drug metabolism and pharmacokinetics, 29(5), 373-378 (2014-04-04)
We investigated the utility of three-dimensional (3D) spheroid cultures of human hepatocytes in discovering drug metabolites. Metabolites of acetaminophen, diclofenac, lamotrigine, midazolam, propranolol and salbutamol were analyzed by liquid chromatography-tandem mass spectrometry (LC/MS/MS) to measure enzyme activities in this system
Yiming Jiang et al.
Toxicological sciences : an official journal of the Society of Toxicology, 143(1), 107-115 (2014-10-17)
Acetaminophen (APAP) overdose is the most frequent cause of drug-induced acute liver failure. Schisandra sphenanthera is a traditional hepato-protective Chinese medicine and Schisandrol B (SolB) is one of its major active constituents. In this study, the protective effect of SolB
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