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Hyesook Yoon et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 40(7), 1483-1500 (2020-01-09)
Myelin loss limits neurological recovery and myelin regeneration and is critical for restoration of function. We recently discovered that global knock-out of the thrombin receptor, also known as Protease Activated Receptor 1 (PAR1), accelerates myelin development. Here we demonstrate that
Coy P McNew et al.
Chemosphere, 168, 65-79 (2016-10-25)
Despite the prevalence of nonspherical colloidal particles, the role of particle shape in the transport of colloids is largely understudied. This study investigates the attachment of colloidal particles onto environmentally relevant surfaces while varying particle shape and ionic strength. Using
Lauren Anllo et al.
Developmental biology, 446(1), 102-118 (2018-12-17)
Adult stem cells are often found in specialized niches, where the constituent cells direct self-renewal of their stem cell pool. The niche is therefore crucial for both normal homeostasis and tissue regeneration. In many mammalian tissues, niche cells have classically
Theodoros Rampias et al.
EMBO reports, 20(3) (2019-01-23)
Genome-wide studies in tumor cells have indicated that chromatin-modifying proteins are commonly mutated in human cancers. The lysine-specific methyltransferase 2C (KMT2C/MLL3) is a putative tumor suppressor in several epithelia and in myeloid cells. Here, we show that downregulation of KMT2C
Adema Ribic et al.
Cell reports, 26(2), 381-393 (2019-01-10)
Cortical plasticity peaks early in life and tapers in adulthood, as exemplified in the primary visual cortex (V1), wherein brief loss of vision in one eye reduces cortical responses to inputs from that eye during the critical period but not
Giulia Zanetti et al.
PLoS pathogens, 13(8), e1006567-e1006567 (2017-08-12)
Botulinum neurotoxin serotype C (BoNT/C) is a neuroparalytic toxin associated with outbreaks of animal botulism, particularly in birds, and is the only BoNT known to cleave two different SNARE proteins, SNAP-25 and syntaxin. BoNT/C was shown to be a good
Yehuda Salzberg et al.
PLoS genetics, 13(1), e1006579-e1006579 (2017-01-24)
Neurons receive excitatory or sensory inputs through their dendrites, which often branch extensively to form unique neuron-specific structures. How neurons regulate the formation of their particular arbor is only partially understood. In genetic screens using the multidendritic arbor of PVD
Y Kubo
The Journal of physiology, 442, 743-759 (1991-10-01)
1. Electrophysiological and immunohistochemical properties during the early stages of muscle differentiation were studied in two myoblastic cell lines, mouse C2C12 and rat L6, and compared to those in myogenic clonal cells derived from the mouse mesodermal stem cell line
Carmen Diaz-Ruiz et al.
The journals of gerontology. Series A, Biological sciences and medical sciences, 75(3), 416-424 (2018-11-10)
Sirtuin 3 (SIRT3) and angiotensin play a major role in aging-related disorders. Both modulate oxidative stress and neurodegeneration. We investigated the interaction between SIRT3 and angiotensin II (AngII) in the dopaminergic system. Both in vivo and in vitro, treatment with
Charles S Ferranti et al.
The Journal of cell biology, 219(4) (2020-04-25)
Diverse stresses, including reactive oxygen species (ROS), ionizing radiation, and chemotherapies, activate acid sphingomyelinase (ASMase) and generate the second messenger ceramide at plasma membranes, triggering apoptosis in specific cells, such as hematopoietic cells and endothelium. Ceramide elevation drives local bilayer
Jie Zhang et al.
Experimental physiology, 102(1), 48-69 (2016-10-13)
What is the central question of this study? Does improved metabolic health and insulin sensitivity following a weight-loss and fitness intervention in sedentary, obese women alter exercise-associated fuel metabolism and incomplete mitochondrial fatty acid oxidation (FAO), as tracked by blood
Erik Ellwardt et al.
European journal of pharmacology, 871, 172923-172923 (2020-01-22)
The humanized anti-CD52 antibody alemtuzumab is successfully used in the treatment of multiple sclerosis (MS) and is thought to exert most of its therapeutic action by depletion and repopulation of mainly B and T lymphocytes. Although neuroprotective effects of alemtuzumab
Michael S Fleming et al.
eLife, 4, e06828-e06828 (2015-04-04)
RET can be activated in cis or trans by its co-receptors and ligands in vitro, but the physiological roles of trans signaling are unclear. Rapidly adapting (RA) mechanoreceptors in dorsal root ganglia (DRGs) express Ret and the co-receptor Gfrα2 and
Toshiaki Shigeoka et al.
Cell reports, 29(11), 3605-3619 (2019-12-12)
Ribosome assembly occurs mainly in the nucleolus, yet recent studies have revealed robust enrichment and translation of mRNAs encoding many ribosomal proteins (RPs) in axons, far away from neuronal cell bodies. Here, we report a physical and functional interaction between
Ingmar Schoen et al.
Journal of neurophysiology, 100(1), 346-357 (2008-05-09)
Reliable extracellular stimulation of neuronal activity is the prerequisite for electrical interfacing of cultured networks and brain slices, as well as for neural implants. Safe stimulation must be achieved without damage to the cells. With respect to a future application
Xiaona Feng et al.
Communications biology, 3(1), 716-716 (2020-11-29)
Transient receptor potential vanilloid 4 (TRPV4) is a non-selective calcium-permeable cation channel that is widely expressed and activated in various neurons and glial cells in the nervous system. Schwann cells (SCs) are primary glia cells that wrap around axons to
Yu-Jie Lai et al.
Journal of molecular neuroscience : MN, 61(3), 436-448 (2017-02-06)
Estrogen exerts multiple actions in the brain and is an important neuroprotective factor in a number of neuronal disorders. However, the underlying mechanism remains unknown. Studies demonstrate that ubiquitin-conjugating enzyme 9 (ubc9) has an integral role in synaptic plasticity and
Amanda Phuong Tran et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 38(23), 5399-5414 (2018-05-16)
Severed axon tips reform growth cones following spinal cord injury that fail to regenerate, in part, because they become embedded within an inhibitory extracellular matrix. Chondroitin sulfate proteoglycans (CSPGs) are the major axon inhibitory matrix component that is increased within
Yosuke Tashiro et al.
Journal of bacteriology, 190(11), 3969-3978 (2008-04-09)
Pseudomonas aeruginosa is an opportunistic bacterial pathogen that is one of the most refractory to therapy when it forms biofilms in the airways of cystic fibrosis patients. To date, studies regarding the production of an immunogenic and protective antigen to
Juan A Parga et al.
Free radical biology & medicine, 129, 394-406 (2018-10-14)
Nuclear factor-E2-related factor 2 (NRF2) is a transcription factor that activates the antioxidant cellular defense in response to oxidative stress, leading to neuroprotective effects in Parkinson's disease (PD) models. We have previously shown that Angiotensin II (AngII) induces an increase
Nimrod Elazar et al.
Neuron, 101(2), 224-231 (2018-12-16)
The initiation of axoglial contact is considered a prerequisite for myelination, yet the role cell adhesion molecules (CAMs) play in mediating such interactions remains unclear. To examine the function of axoglial CAMs, we tested whether enhanced CAM-mediated adhesion between OLs
Nickolai Vysokov et al.
Scientific reports, 9(1), 12915-12915 (2019-09-11)
Voltage gated sodium channels are key players in aberrant pain signaling and sensitization of nociceptors after peripheral nerve injury. The extent to which sodium channel activity after injury contributes to synaptic transmission at the first pain synapse however remains unclear.
M Bulla et al.
The Journal of physiology, 597(2), 561-582 (2018-11-02)
Gain-of-function mutations in the highly selective Ca2+ channel ORAI1 cause tubular aggregate myopathy (TAM) characterized by muscular pain, weakness and cramping. TAM-associated mutations in ORAI1 first and third transmembrane domain facilitate channel opening by STIM1, causing constitutive Ca2+ influx and
I Kaverina et al.
The Journal of cell biology, 142(1), 181-190 (1998-07-14)
By co-injecting fluorescent tubulin and vinculin into fish fibroblasts we have revealed a "cross talk" between microtubules and early sites of substrate contact. This mutuality was first indicated by the targeting of vinculin-rich foci by microtubules during their growth towards
Adrienne Tin et al.
Nature genetics, 51(10), 1459-1474 (2019-10-04)
Elevated serum urate levels cause gout and correlate with cardiometabolic diseases via poorly understood mechanisms. We performed a trans-ancestry genome-wide association study of serum urate in 457,690 individuals, identifying 183 loci (147 previously unknown) that improve the prediction of gout
Guangyun Wang et al.
Cell death & disease, 11(6), 428-428 (2020-06-10)
Previous findings have shown that non-muscle myosin heavy-chain IIA (NMMHC IIA) is involved in autophagy induction triggered by starvation in D. melanogaster; however, its functional contribution to neuronal autophagy remains unclear. The aim of this study is to explore the
Huihui Sun et al.
Biology of reproduction, 100(3), 649-659 (2018-10-09)
Endometriosis is a common multifactorial gynecological disorder defined as the proliferation of endometrial tissue outside of the uterine cavity. Neuroangiogenesis (co-recruitment of nerves and blood vessels) is believed to play an integral part in the establishment and growth of endometriotic
Roberta Cagnetta et al.
Neuron, 99(1), 29-46 (2018-07-17)
Axonal protein synthesis and degradation are rapidly regulated by extrinsic signals during neural wiring, but the full landscape of proteomic changes remains unknown due to limitations in axon sampling and sensitivity. By combining pulsed stable isotope labeling of amino acids
Ewelina Betleja et al.
eLife, 7 (2018-05-10)
The two centrioles of the centrosome in quiescent cells are inherently asymmetric structures that differ in age, morphology and function. How these asymmetric properties are established and maintained during quiescence remains unknown. Here, we show that a daughter centriole-associated ciliopathy
Yi-Chun Kuo et al.
Scientific reports, 8(1), 10477-10477 (2018-07-12)
FARP1 is a multi-domain protein that is involved in regulating neuronal development through interacting with cell surface proteins such as class A Plexins and SynCAM 1. The N-terminal FERM domain in FARP1 is known to both promote membrane localization and
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