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Z Zhang et al.
Biomaterials, 16(5), 369-380 (1995-03-01)
Chemical, physical and structural analyses of polymers from explanted vascular prostheses are frequently jeopardized because of incomplete removal of the encroaching host tissue. In this study, microporous polyurethane arterial prostheses implanted as a canine thoraco-abdominal bypass were explanted after 1
Mette D Mosgaard et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 94, 493-500 (2015-07-15)
To develop a high-throughput in vitro intestinal lipolysis (HTP) model, without any means of pH-stat-titration, to enable a fast evaluation of lipid-based drug delivery systems (LbDDS). The HTP model was compared to the traditionally used dynamic in vitro lipolysis (DIVL)
Kimmo Halt et al.
Methods in molecular biology (Clifton, N.J.), 886, 23-30 (2012-05-29)
The organ culture setup of embryonic kidney has served as a model of nephrogenesis for several decades. In vitro culture of the mouse metanephric mesenchyme enables easy manipulation and analysis of the tissue and provides information of cellular interactions, morphogenesis
Mireille Andriamihaja et al.
Amino acids, 44(2), 563-572 (2012-09-12)
Utilisation of microbial enzymes may represent an alternative strategy to the use of conventional pancreatin obtained from pig pancreas for the treatment of severe pancreatic insufficiency. In this study, we focused on the capacity of two microbial preparations for their
Mariza Faria et al.
Journal of medicinal food, 11(3), 560-567 (2008-09-20)
Angiotensin-converting enzyme (ACE) inhibitory activity and antihypertensive activity of bovine and porcine collagen hydrolysates in spontaneously hypertensive rats (SHR) were investigated. The hydrolyzed collagens were subjected to ultrafiltration using membranes with cutoffs of 30-50 kDa (permeate P1), 5-8 kDa (permeate
Lindsay Smith et al.
Molecular pharmaceutics, 15(7), 2570-2583 (2018-05-16)
Nanoenabled lipid-based drug delivery systems offer a platform to overcome challenges encountered with current failed leads in the treatment of parasitic and infectious diseases. When prepared with FDA or EMA approved excipients, they can be readily translated without the need
C M Seiler et al.
Alimentary pharmacology & therapeutics, 37(7), 691-702 (2013-02-07)
Pancreatic exocrine insufficiency (PEI) often occurs following pancreatic surgery. To demonstrate the superior efficacy of pancreatin 25 000 minimicrospheres (Creon 25000 MMS; 9-15 capsules/day) over placebo in treating PEI after pancreatic resection. A 1-week, double-blind, randomised, placebo-controlled, parallel-group, multicentre study with
Zacharias Papanikolaou et al.
Journal of food science, 77(5), M298-M306 (2012-11-21)
Isolates (47) of lactobacilli from 5 different productions of Melichloro cheese were examined for potential use as adjunct cultures. The sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) of whole-cell proteins classified 29 isolates as L. paraplantarum and 18 as L. paracasei
Sun-Jong You et al.
Journal of food science, 76(6), C801-C807 (2012-03-16)
Egg is a well-known rich source of bioactive peptides. In this study, egg protein (egg white and egg yolk proteins) hydrolysates were produced with gastrointestinal enzymes (pepsin and pancreatin) or nongastrointestinal enzymes (thermolysin and alcalase), and fractionated by ultrafiltration and
Nina Pietrzyk et al.
Molecules (Basel, Switzerland), 26(13) (2021-07-20)
In the present study, an in vitro digestion method has been used to assay the influence of the physiological conditions in the mouth, stomach, and intestine on the stability and activity in different cell models of the main phenolic compounds
L V Vinokurova et al.
Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology, (7)(7), 59-63 (2012-03-01)
In order to identify features of the course pancreatic diabetes and discussion of the principles of conservative therapy were examined 66 patients with CP in age of 30 to 65 years (55 men, 11 women). Among them in 22 cases
Erik R Waara et al.
Advanced healthcare materials, 9(11), e2000057-e2000057 (2020-05-01)
Engineered mesoporous silica particles (MSP) are thermally and chemically stable porous materials composed of pure silica and have attracted attention for their potential biomedical applications. Oral intake of engineered MSP is shown to reduce body weight and adipose tissue in
Shunwen Hu et al.
International journal of pharmaceutics, 441(1-2), 693-700 (2012-10-24)
The objective of this study was to investigate the integrtity and stability of oral liposomes containing glycocholate (SGC-Lip) in simulated gastrointestinal (GI) media and ex vivo GI media from rats in comparison with conventional liposomes (CH-Lip) composed of soybean phosphatidylcholine
Alessandra Amoroso et al.
Food chemistry, 140(4), 654-659 (2013-05-23)
α-Dicarbonyl compounds (α-DCs), such as glyoxal, methylglyoxal and 2,3-butanedione, are highly reactive substances occurring in thermally treated and fermented foods, that may react with amino and sulphydryl groups of side chains of proteins to form Maillard reaction end products, inducing
Ruixin Zhu et al.
European journal of nutrition, 59(6), 2345-2355 (2019-09-26)
To compare the glycaemic response of whole grain oat kernels and pearled oats cooked under normal pressure or higher pressure and examine whether replacing half of the rice in a given meal with either of the two oat grains could
Chia-Rui Shen et al.
Molecules (Basel, Switzerland), 18(3), 2978-2987 (2013-03-06)
The versatile oligosaccharide biopolymers, chitin and chitosan, are typically produced using enzymatic processes. However, these processes are usually costly because chitinases and chitosanases are available in limited quantities. Fortunately, a number of commercial enzymes can hydrolyze chitin and chitosan to
Konstantinos Korompokis et al.
Food & function, 10(8), 4674-4684 (2019-07-12)
Wheat grain roller milling disrupts starch containing endosperm cell walls and extracts white flour. Many wheat based food processes involve simultaneous use of heat and water which then cause starch to gelatinize and enhance its digestibility. In this study, the
J Bannow et al.
International journal of pharmaceutics, 575, 118960-118960 (2019-12-18)
In this study, the influence of the polymeric precipitation inhibitor (PPI) PVP/VA 64 (polyvinylpyrrolidone-co-vinyl acetate) on the physical stability and in vitro performance of supersaturated self-nanoemulsifying drug delivery systems (super-SNEDDS) containing the model drug simvastatin (SIM) was investigated. A heating-cooling
Patrícia Anacleto et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 145, 111717-111717 (2020-09-06)
Human exposure to mercury (Hg) and methylmercury (MeHg) through the ingestion of seafood raises human health-related concerns. In contrast, green tea has health benefits and its consumption potentially reduces bioaccessibility of dietary Hg. The present study aimed to assess the
Jaroslaw Czubinski et al.
Food chemistry, 143, 418-426 (2013-09-24)
This study describes in vitro digestion of lupin seed globulins by pancreatin, trypsin and chymotrypsin. Lupin seed globulins turned out to be almost totally susceptible to chymotrypsin digestion. When panceratin or trypsin were used for digestion of lupin seed globulins
Cunxi Wang et al.
Regulatory toxicology and pharmacology : RTP, 71(2), 164-173 (2014-12-30)
DroughtGard maize was developed through constitutive expression of cold shock protein B (CSPB) from Bacillus subtilis to improve performance of maize (Zea mays) under water-limited conditions. B. subtilis commonly occurs in fermented foods and CSPB has a history of safe
Gema Pereira-Caro et al.
International journal of food sciences and nutrition, 63(6), 703-707 (2012-01-25)
The digestive stability of two natural antioxidant compounds present in virgin olive oil, hydroxytyrosol (HTy) and hydroxytyrosyl acetate (HTy-Ac) and a new series of hydroxytyrosyl ethers (methyl, ethyl and butyl hydroxytyrosyl ethers) was evaluated by a simulated digestion procedure. High
Konstantinos Korompokis et al.
Foods (Basel, Switzerland), 10(2) (2021-02-06)
The fine molecular structure of starch governs its functionality and digestibility, and enzymatic approaches can be utilized to tailor its properties. The aim of this study was to investigate the in situ modification of starch by amylomaltase (AMM) from Thermus
Xiao-Qiang Zou et al.
Journal of agricultural and food chemistry, 60(37), 9415-9423 (2012-08-28)
Human milk fat substitutes (HMFSs) were prepared by a two-step process, namely, Lipozyme RM IM-catalyzed acidolysis of interesterified high-melting palm stearin with fatty acids from rapeseed oil and blending of the enzymatic product with the selected oils on the basis
Jin-Feng Yao et al.
Amino acids, 43(4), 1557-1566 (2012-02-14)
Long-acting luteinizing hormone-releasing hormone (LHRH) antagonists designed to be protease resistant consisted of a series of novel decapeptides structurally similar to LHRH. The aim of this study was to evaluate the in vitro metabolic stability of the LHRH decapeptides using
D K Needham et al.
Journal of biomedical materials research, 16(5), 659-668 (1982-09-01)
A method is presented that can be utilized for the removal of formalin-fixed tissues from arterial grafts without affecting fiber material properties. Such a method could prove highly useful for studying the changes in the structure and properties of graft
Aaron L Wallace et al.
Vaccine, 38(47), 7490-7497 (2020-10-13)
Mucosal surfaces of the gastrointestinal tract play an important role in immune homeostasis and defense and may be compromised by enteric disorders or infection. Therapeutic intervention using monoclonal antibody (mAb) offers the potential for treatment with minimal off-target effects as
Hyun Jung Kim et al.
Journal of agricultural and food chemistry, 60(20), 5237-5242 (2012-05-09)
The in vitro starch digestion rate and estimated glycemic index (GI) of oat flours and oat starches from typical and high β-glucan oat lines were evaluated along with the impact of heating on starch digestion. Flour from oat lines ('Jim'
Miriam Mahler et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 18(35), 11046-11062 (2012-07-26)
An efficient synthesis of (S)- or (R)-3-(benzyloxy-methyl)-cyclopent-3-enol was developed by appling an enzyme-catalyzed kinetic-resolution approach. This procedure allowed the syntheses of the enantiomeric building blocks (S)- and (R)-cyclopentenol with high optical purity (>98 % ee). In contrast to previous approaches
Igor Guzar et al.
Journal of food science, 77(11), C1192-C1196 (2012-10-13)
A series of experiments were conducted to highlight the mechanism of inhibition of hydrolysis and differences in hydrolysis among starches from different sources in the presence of green or black tea extract. The first experiment showed that black tea extract
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