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P3347

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V Gebhardt et al.
Acta anaesthesiologica Scandinavica, 57(2), 249-256 (2012-12-04)
Hyperbaric prilocaine 20 mg/ml may be preferable for perianal outpatient surgery. The aim of this prospective, single-centre, randomised, single-blinded, controlled clinical trial was to determine the optimal dosage of hyperbaric prilocaine 20 mg/ml for a spinal anaesthesia (SPA) in patients...
Chantal Berna et al.
Revue medicale suisse, 9(392), 1360-1360 (2013-07-26)
Diagnostic or therapeutic procedures can lead to breakthrough pain. Thanks to a wise choice of analgesic medication started in due time, this type of pain can be avoided or decreased. The therapeutic options of this preventive approach are presented according...
Young-Eun Moon et al.
Archives of physical medicine and rehabilitation, 94(5), 919-924 (2012-12-25)
To compare the effects of a vapocoolant spray and an eutectic mixture of local anesthetics (EMLA) cream in reducing pain during needle electromyography examination. Randomized controlled trial. Physical medicine and rehabilitation department of a university hospital. Adults who underwent needle...
S Schreiber et al.
European journal of pediatrics, 172(2), 265-268 (2012-10-25)
Venipuncture and intravenous cannulation are the most common painful procedures performed on children. The most widely used topical anesthetic is eutectic mixture of local anesthetics (EMLA). EMLA use is associated with a transient cutaneous vasoconstriction which can make it difficult...
Oded Shamriz et al.
The Israel Medical Association journal : IMAJ, 16(4), 250-254 (2014-05-20)
With growing awareness of the importance of pain control in all procedures, the use of lidocaine-prilocaine cream (EMLA) for all ages is increasing. Lidocaine-prilocaine cream has been implicated as a cause of methemoglobinemia. Diagnostic clues may be oxygen-resistant cyanosis and...
M Anthony Pogrel
Journal of the California Dental Association, 40(10), 795-797 (2013-01-16)
Permanent nerve involvement has been reported following inferior alveolar nerve blocks. This study provides an update on cases reported to one unit in the preceding six years. Lidocaine was associated with 25 percent of cases, articaine with 33 percent of...
Ying Zhang et al.
International journal of pharmaceutics, 439(1-2), 187-192 (2012-10-02)
The objective of this study was to identify an adjuvant for anesthetics coated on microneedles to provide rapid onset and prolonged analgesic action with minimal skin tissue reaction. Aqueous lidocaine or prilocaine formulations with or without clonidine or the related...
R Seidel et al.
Der Anaesthesist, 62(3), 183-188 (2013-03-16)
The design of this study is related to an important current issue: should local anesthetics be intentionally injected into peripheral nerves? Answering this question is not possible without better knowledge regarding classical methods of nerve localization (e.g. cause of paresthesias...
A Chan et al.
Journal of dental research, 91(7 Suppl), 79S-84S (2012-09-21)
This double-blind, randomized, clinical trial investigated the effectiveness and underlying mechanism of neural inhibition of pulsed Nd:YAG laser induction of pulpal analgesia compared with 5% EMLA anesthetic cream. Forty-four paired premolars from 44 orthodontic patients requiring bilateral premolar extraction from...
Svetlana Stockmann et al.
Clinical laboratory, 59(1-2), 127-132 (2013-03-20)
Prilocaine, a local anesthetic of the amide type, is frequently applied in substantial doses during tumescent liposuction. Although it cannot be excluded that the subcutaneously infiltrated narcotic may enter the circulation and trigger adverse systemic reactions, prilocaine plasma levels have...
Gareth Rooke et al.
The New Zealand medical journal, 127(1407), 75-79 (2014-12-23)
This case report describes a rare side effect during a Bier's block. During local anaesthetic injection, the patient suffered a sudden onset painful petechial rash localised to the upper limb, distal to the tourniquet, without systemic effect. After deflation of...
C Schmitt et al.
Annales de dermatologie et de venereologie, 139(12), 824-827 (2012-12-15)
Emla(®) cream, a mixture of two local anaesthetics (prilocaine 2.5%, lidocaine 2.5%) has a good benefit-risk profile. However, methaemoglobinaemia can occur, especially when the cream is applied in excessive amounts or over long periods. The authors report a case of...
Aykut Saritas et al.
JPMA. The Journal of the Pakistan Medical Association, 64(4), 433-436 (2014-05-29)
To determine whether the addition of 8 mg dexamethasone to axillary brachial plexus block would prolong the duration of sensory and motor block in patients undergoing hand and forearm surgery. The prospective, randomised, double-blinded study was conducted at the Eskisehir...
Michelle Briggs et al.
The Cochrane database of systematic reviews, 11, CD001177-CD001177 (2012-11-16)
Venous leg ulcers affect up to 1% of people at some time in their lives and are often painful. The main treatments are compression bandages and dressings. Topical treatments to reduce pain during and between dressing changes are sometimes used....
Devendra Gupta et al.
Anesthesia and analgesia, 116(3), 568-571 (2013-02-13)
Topical capsaicin and eutectic mixture of local anesthetics (EMLA) have been found to be equally effective in minimizing the pain of venipuncture. After the injection of capsaicin, both tertiary amine local anesthetics and their quaternary ammonium derivatives can elicit a...
Rebeca M Plank et al.
Journal of pediatric urology, 9(1), e86-e90 (2012-10-30)
We report two cases of newborns who developed marked local edema after application of a eutectic mixture of local anesthetic (EMLA) topical anesthetic cream for neonatal male circumcision (NMC). Although local edema and erythema are known potential side effects of...
Improving the local anesthesia experience for our patients.
Gregori M Kurtzman
Dentistry today, 33(4), 120-120 (2014-05-06)
Ege C Serefoglu et al.
Asian journal of andrology, 14(6), 822-829 (2012-10-16)
There are ongoing debates about the definition, classification and prevalence of premature ejaculation (PE). The first evidence-based definition of PE was limited to heterosexual men with lifelong PE who engage in vaginal intercourse. Unfortunately, many patients with the complaint of...
Baldomero Arnau et al.
Acta obstetricia et gynecologica Scandinavica, 92(8), 978-981 (2013-06-07)
We investigated the efficacy of 5% lidocaine 25 mg-prilocaine 25 mg/g cream (EMLA(®) ) applied to the uterine cervix for reducing pain during diagnostic or operative hysteroscopy, using a visual analogue scale (VAS) for pain in a prospective randomized, non-blinded...
Matthew A Petoe et al.
Journal of neurophysiology, 109(4), 1091-1096 (2012-12-12)
Temporary deafferentation of the upper limb, with ischemic or anesthetic nerve block, has rapid effects on sensorimotor cortex. Cutaneous anesthesia of the forearm has recently been found to improve sensory and motor function of the paretic hand in chronic stroke...
Marco Bragagni et al.
International journal of pharmaceutics, 441(1-2), 468-475 (2012-11-21)
The use of injectable local anaesthetics for the treatment of severe postoperative pain is limited by the short duration of the painkilling effect. Pre-formulation studies were carried out for the development of an injectable microparticle formulation for controlled release of...
Austin Larson et al.
Pediatric emergency care, 29(3), 377-379 (2013-03-07)
Topical anesthetics are commonly used in many health care settings and for many clinical conditions. However, there are a number of potential adverse effects associated with their use. Their widespread administration can convey a false sense of security and failure...
K Anup et al.
Minerva urologica e nefrologica = The Italian journal of urology and nephrology, 65(1), 77-82 (2013-03-30)
The aim of this paper was to optimize pain control during transrectal ultrasound (TRUS) guided prostate biopsy, the efficacy and safety of three different analgesic techniques were compared. Two hundred and forty patients were prospectively randomized into 3 groups before...
Susan Parekh et al.
The Cochrane database of systematic reviews, 12(12), CD009742-CD009742 (2014-12-24)
Whilst carrying out dental procedures under general anaesthesia (GA), practitioners routinely give local anaesthetics (LA) intraoperatively to children. Local anaesthetics are used to help manage postoperative pain and reduce bleeding and the physiological response to procedures. Studies of effectiveness of...
Hasan Karanlik et al.
International journal of clinical oncology, 20(6), 1057-1062 (2015-04-26)
Our aim was to evaluate whether it is safe to use a totally implantable venous access device (TIVAD) on the day of implantation. We investigated data from 1315 cancer patients divided into two groups according to the time interval between...
Brett J Wong
American journal of physiology. Regulatory, integrative and comparative physiology, 304(8), R651-R656 (2013-02-15)
We tested the hypothesis that inhibition of cutaneous sensory nerves would attenuate reflex cutaneous vasodilation in response to an increase in core temperature. Nine subjects were equipped with four microdialysis fibers on the forearm. Two sites were treated with topical...
P K Gupta et al.
British journal of anaesthesia, 110(5), 831-836 (2013-02-09)
Our aim was to estimate the ED95 of prilocaine 1% w/v for femoral nerve block. This two-stage dose-finding sequential clinical trial followed an adaptive design based on the continual reassessment method (CRM). Adult patients undergoing Vastus medialis muscle biopsy under...
Nezih Sertoz et al.
Foot & ankle international, 34(1), 85-90 (2013-02-07)
The objective of the present study was to explore the effects of deficiencies in glucose regulation on the onset, regression, and block performance times in a group of patients with diabetes-related foot problems. Forty-eight patients with American Society of Anesthetists...
A Carbone et al.
Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia, 148(5), 465-469 (2013-09-06)
The aim of our study is to value the vasoconstrictor effect of two most utilized topical anesthetics, the first one containing a mixture 2.5% lidocaine and 2.5% prilocaine and the second one containing 4% liposomal lidocaine, in the treatment of...
Stephanie C J Keating et al.
PloS one, 7(9), e44437-e44437 (2012-09-13)
Ear tattooing is a routine procedure performed on laboratory, commercial and companion rabbits for the purpose of identification. Although this procedure is potentially painful, it is usually performed without the provision of analgesia, so compromising animal welfare. Furthermore, current means...
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