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Stefany Moreno-Gamez et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(22), E2874-E2883 (2015-06-04)
Infections with rapidly evolving pathogens are often treated using combinations of drugs with different mechanisms of action. One of the major goal of combination therapy is to reduce the risk of drug resistance emerging during a patient's treatment. Although this
Stephanie A Matthes et al.
BMC pulmonary medicine, 15, 140-140 (2015-11-08)
Idiopathic pulmonary fibrosis (IPF) is an interstitial fibrotic lung disease of unknown origin and without effective therapy characterized by deposition of extracellular matrix by activated fibroblasts in the lung. Fibroblast activation in IPF is associated with Wnt/β-catenin signaling, but little
Lars Regestein et al.
Bioresource technology, 196, 153-159 (2015-08-04)
The butanol yield of the classic fermentative acetone-butanol-ethanol (ABE) process has been enhanced in the past decades through the development of better strains and advanced process design. Nevertheless, by-product formation and the incomplete conversion of intermediates still decrease the butanol
Ruixue Sun et al.
Biochimica et biophysica acta, 1847(2), 248-261 (2014-12-03)
Minor antennae of photosystem (PS) II, located between the PSII core complex and the major antenna (LHCII), are important components for the structural and functional integrity of PSII supercomplexes. In order to study the functional significance of minor antennae in
Nicola Parisi et al.
International journal of pharmaceutics, 493(1-2), 404-411 (2015-08-04)
Hexamidine diisethionate (HEX D) has been used in the personal care industry and in a number of over-the-counter (OTC) drug products as an antimicrobial agent since the 1950's. Recently, the compound has also been investigated for its beneficial effects on
L M Berger et al.
Journal of dairy science, 98(8), 5688-5698 (2015-06-22)
The aim of the present study was to investigate the ruminal degradation of the flavonol quercetin and to determine its potential antimicrobial effects on ruminal fermentation in cows. Ruminal degradation of quercetin (0 or 100μmol/L, respectively) as well as its
Samy A F Morad et al.
Biochimica et biophysica acta, 1851(7), 919-928 (2015-03-15)
The triphenylethylene antiestrogen, tamoxifen, can be an effective inhibitor of sphingolipid metabolism. This off-target activity makes tamoxifen an interesting ancillary for boosting the apoptosis-inducing properties of ceramide, a sphingolipid with valuable tumor censoring activity. Here we show for the first
Christoph Stähli et al.
Journal of controlled release : official journal of the Controlled Release Society, 200, 222-232 (2015-01-13)
Copper ions represent a promising angiogenic agent but are associated with cytotoxicity at elevated concentrations. Phosphate-based glasses (PGs) exhibit adjustable dissolution properties and allow for controlled ion release. This study examined the formation of capillary-like networks by SVEC4-10 endothelial cells
Journal of Materials Science Letters, 12, 1221-1221 (1993)
Kamila Myszka et al.
Journal of bioscience and bioengineering, 113(5), 631-633 (2012-02-04)
A selective isolation procedure of clostridial strains from natural samples able to convert glycerol to 1,3-propanediol (1,3-PD) and organic acids was investigated. The modified PY medium of high concentration of NaHCO(3) was shown to be highly selective for Clostridium bifermentans.
Rajat S Barua et al.
Frontiers in immunology, 6, 572-572 (2015-12-01)
Emerging evidence suggests that infection and persistent inflammation are key players in the pathogenesis of atherosclerotic cardiovascular disease (CVD). Although it is well established that cigarette smoke (CS) promotes atherosclerotic CVD, very little is known about the potential impact of
Ragini Singh et al.
Antimicrobial agents and chemotherapy, 59(9), 5664-5674 (2015-07-08)
There are currently 18 drug classes for the treatment of tuberculosis, including those in the development pipeline. An in silico simulation enabled combing the innumerably large search space to derive multidrug combinations. Through the use of ordinary differential equations (ODE)
Rola Abboud et al.
The Journal of membrane biology, 248(4), 811-824 (2015-04-26)
The interaction of progesterone (PG), 17-hydroxyprogesterone (17-OHPG), 21-hydroxyprogesterone (21-OHPG), medroxyprogesterone (MP), medroxyprogesterone acetate (MPA), and dydrogesterone (DYG), with zwitterionic dipalmitoyl phosphatidylcholine (DPPC) multilamellar liposome, was investigated as a function of drug concentration using Fourier transform infrared spectroscopy and differential scanning
Effect of different calcination temperatures and post annealing on the properties of 1, 3 propanediol based Sol-Gel (Na0. 5K0. 5) NbO3 (NKN) thin films
Wiegand S, et al.
Journal of alloys and compounds, 548, 38-45 (2013)
Yanna Huang et al.
Bioresource technology, 128, 505-512 (2012-12-04)
Fed-batch cultures of Klebsiella pneumoniae expressing Escherichia coli aldH were performed under microaerobic conditions to investigate the effects on metabolites production. Increasing the aeration rate enhanced cell growth and 3-hydroxypropionic acid (3-HP) production, but reduced 1,3-propanediol (1,3-PDO) formation. The recombinant
Saskia G A van der Drift et al.
Veterinary journal (London, England : 1997), 204(2), 144-149 (2015-04-07)
This study investigated the metabolic effects of glucocorticoids when administered to propylene glycol-treated cows with clinical ketosis. Clinical ketosis was defined by depressed feed intake and milk production, and a maximal score for acetoacetate in urine. All cows received 250 mL
Duc-Viet Nguyen et al.
Molecular pharmaceutics, 12(2), 444-452 (2014-12-17)
Controlled release plays an essential role in formulating topical and transdermal drug delivery systems. In this study, we correlated the skin permeation of Sesamin, a lipophilic drug, with the rheological properties of two different organogel carriers, i.e., low molecular weight
Frédéric J Veyrier et al.
PLoS genetics, 11(7), e1005338-e1005338 (2015-07-15)
Respiratory infectious diseases are the third cause of worldwide death. The nasopharynx is the portal of entry and the ecological niche of many microorganisms, of which some are pathogenic to humans, such as Neisseria meningitidis and Moraxella catarrhalis. These microbes
Sophie Payne et al.
Developmental biology, 405(1), 82-95 (2015-06-24)
CHARGE syndrome is caused by spontaneous loss-of-function mutations to the ATP-dependant chromatin remodeller chromodomain-helicase-DNA-binding protein 7 (CHD7). It is characterised by a distinct pattern of congenital anomalies, including cardiovascular malformations. Disruption to the neural crest lineage has previously been emphasised
Megan P O'Brien et al.
Cartilage, 6(3), 174-184 (2015-07-16)
Evaluation of early compositional changes in healing articular cartilage is critical for understanding tissue repair and for therapeutic decision-making. Fourier transform infrared imaging spectroscopy (FT-IRIS) can be used to assess the molecular composition of harvested repair tissue. Furthermore, use of
Ruchun Wu et al.
Sheng wu gong cheng xue bao = Chinese journal of biotechnology, 27(3), 493-501 (2011-06-10)
1,3-propanediol is an important raw material in chemical industry. Microbial conversion of glycerol or glucose into 1,3-propanediol has been given much attention due to its renewable resource, mild reaction conditions, and other advantages. It is a challenge to efficiently separate
Graham D Cole et al.
JACC. Heart failure, 2(5), 545-548 (2014-10-11)
Prescription and adherence to medical therapy for heart failure are disappointing despite convincing randomized controlled trial (RCT) evidence for angiotensin-converting enzyme inhibition, beta-blockade, and aldosterone antagonism. In this study, we report an imbalanced approach amongst clinicians, who describe focusing during
Saumya Sarkar et al.
Indian journal of pharmacology, 47(5), 491-495 (2015-11-26)
This study compared the effectiveness of prophylactic administration of topical flurbiprofen 0.03% and nepafenac 0.1% in maintaining mydriasis during small incision cataract surgery (SICS). This study was a prospective, randomized, double-blind comparative study in adult cataract patients given topical flurbiprofen
Satoshi Ohno et al.
Journal of bioscience and bioengineering, 115(2), 221-228 (2012-10-09)
For efficient production of industrially useful metabolites by microorganisms, it is important to design metabolic networks suitable for production. For this purpose, constraint-based metabolic flux simulation is a powerful tool to predict the effect of reaction knockouts on target productivity.
Daria Szymanowska-Powałowska et al.
Applied microbiology and biotechnology, 99(7), 3179-3189 (2014-12-20)
Knowledge of tolerance of bacteria to toxic stress is important, especially for processes targeted at high final titers of product. Information on environmental limits and stress responses may help during selection of strains or design and control of processes. The
Ruijuan Gao et al.
Basic & clinical pharmacology & toxicology, 117(2), 105-116 (2015-01-24)
Gelatinases play important roles in tumour invasion and metastasis and are thus considered promising targets for cancer therapy. In this study, a new single-chain variable fragment (scFv)-based fusion protein Fv-LDP, composed of the anti-gelatinases scFv and lidamycin apoprotein (LDP), was
E Celińska
Biotechnology advances, 28(4), 519-530 (2010-04-07)
The history of 1,3-propanediol (1,3-PD) conversion from being a specialty chemical to being a bulk chemical illustrates that the concerted effort of different metabolic engineering approaches brings the most successful results. In order to metabolically tailor the 1,3-PD production pathway
Ming-Jun Tsai et al.
PloS one, 10(7), e0131026-e0131026 (2015-07-15)
Excessive production of radical oxygen species in skin is a contributor to a variety of skin pathologies. Naringenin is a potent antioxidant. The purpose of the present study was to develop elastic liposomes for naringenin topical application. Naringenin-loaded elastic liposomes
Laurent Imbert et al.
Journal of analytical toxicology, 38(9), 676-680 (2014-09-05)
A liquid chromatography coupled with electrospray tandem mass spectrometry method was developed for the analysis of ethylene glycol, diethylene glycol, triethylene glycol, 1,4-butanediol, 1,2-butanediol, 2,3-butanediol, 1,2-propanediol and 1,3-propanediol, in serum after a Schotten-Baumann derivatization by benzoyl chloride. Usual validation parameters
Susi Anheuser et al.
Journal of lipid research, 56(9), 1747-1761 (2015-07-16)
Ganglioside GM2 is the major lysosomal storage compound of Tay-Sachs disease. It also accumulates in Niemann-Pick disease types A and B with primary storage of SM and with cholesterol in type C. Reconstitution of GM2 catabolism with β-hexosaminidase A and
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