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Romina F Vázquez et al.
Colloids and surfaces. B, Biointerfaces, 158, 76-83 (2017-07-07)
Uropathogenic strains of Escherichia coli produce virulence factors, such as the protein toxin alpha-hemolysin (HlyA), that enable the bacteria to colonize the host and establish an infection. HlyA is synthetized as a protoxin (ProHlyA) that is transformed into the active...
Wenjia Zhang et al.
Langmuir : the ACS journal of surfaces and colloids, 35(22), 7231-7241 (2019-05-24)
Interactions of nonionic poly(ethylene oxide)- b-poly(propylene oxide) (PEO-PPO) block copolymers, known as Pluronics or poloxamers, with cell membranes have been widely studied for a host of biomedical applications. Herein, we report how cholesterol within phosphatidylcholine (POPC) lipid bilayer liposomes and...
Helena L E Coker et al.
Biophysical journal, 116(6), 1085-1094 (2019-03-09)
Diffusion in cell membranes is not just simple two-dimensional Brownian motion but typically depends on the timescale of the observation. The physical origins of this anomalous subdiffusion are unresolved, and model systems capable of quantitative and reproducible control of membrane...
Patrick Walsh et al.
The Journal of biological chemistry, 289(15), 10419-10430 (2014-02-21)
The formation of fibrillar aggregates has long been associated with neurodegenerative disorders such as Alzheimer and Parkinson diseases. Although fibrils are still considered important to the pathology of these disorders, it is now widely understood that smaller amyloid oligomers are...
Ziqing Wang et al.
Developmental cell, 43(2), 186-197 (2017-10-17)
Little is known about the cellular events promoting metastasis. We show that knockout of phospholipase D2 (PLD2), which generates the signaling lipid phosphatidic acid (PA), inhibits lung metastases in the mammary tumor virus (MMTV)-Neu transgenic mouse breast cancer model. PLD2...
Siddharth Deshpande et al.
Nature communications, 10(1), 1800-1800 (2019-04-19)
Liquid-liquid phase separation (LLPS), especially coacervation, plays a crucial role in cell biology, as it forms numerous membraneless organelles in cells. Coacervates play an indispensable role in regulating intracellular biochemistry, and their dysfunction is associated with several diseases. Understanding of...
Alina A Pashkovskaya et al.
Biophysical journal, 114(9), 2142-2151 (2018-05-10)
Long-chain free fatty acids (FFAs) play an important role in several physiological and pathological processes such as lipid fusion, adjustments of membrane permeability and fluidity, and the regulation of enzyme and protein activities. FFA-facilitated membrane proton transport (flip-flop) and FFA-dependent...
Jaehyoun Lee et al.
Biochemistry, 56(7), 977-985 (2017-01-28)
Nucleosomes impose physical barriers to DNA-templated processes, playing important roles in eukaryotic gene regulation. DNA is packaged into nucleosomes by histone proteins mainly through strong electrostatic interactions that can be modulated by various post-translational histone modifications. Investigating the dynamics of...
Grzegorz Chwastek et al.
Chembiochem : a European journal of chemical biology, 21(6), 836-844 (2019-10-01)
To unravel the underlying principles of membrane adaptation in small systems like bacterial cells, robust approaches to characterize membrane fluidity are needed. Currently available relevant methods require advanced instrumentation and are not suitable for high-throughput settings needed to elucidate the...
Masanao Kinoshita et al.
Biochimica et biophysica acta, 1838(5), 1372-1381 (2014-01-29)
Recently, DHSM, a minor constituent in naturally occurring SMs, was indicated to form a raft-like ordered phase more effectively than a naturally occurring form of SM because DHSM has greater potential to induce the intermolecular hydrogen bond. In order to...
Renee J Tran et al.
The journal of physical chemistry. B, 123(22), 4673-4687 (2019-05-16)
An extensive investigation into the initial association of HIV-1 Gag with lipid membranes was conducted with second harmonic generation. The roles of the lipid phase, phospholipid 1,2-dioleoyl- sn-glycero-3-phospho-(1-myo-inositol-4,5-bisphosphate) [PI(4,5)P2], the presence of the myristoyl group on Gag, the C-terminus of...
Evaluation of the effects of aldehydes on association colloid properties and oxidative stability in bulk oils.
Jo, et al.
Food Chemistry, 338, 127778-127778 (2020)
Michael C Owen et al.
The journal of physical chemistry. B (2019-08-10)
The great physiological relevance of glycolipids is being increasingly recognized, and glycolipid interactions have been shown to be central to cell-cell recognition, neuronal plasticity, protein-ligand recognition, and other important processes. However, detailed molecular-level understanding of these processes remains to be...
M A Bodescu et al.
Soft matter, 13(38), 6845-6851 (2017-08-23)
Melittin is a model system for the action of antimicrobial peptides which are potential candidates for novel antibiotics. We investigated the membrane lysis effect of melittin on phase-separated supported lipid bilayers (DOPC-DPPC) by atomic force microscopy. AFM images show that...
Amanda Musgrove et al.
Langmuir : the ACS journal of surfaces and colloids, 29(10), 3347-3360 (2013-02-19)
The potential-controlled incorporation of DOPC liposomes (100 nm diameter) into an adsorbed octadecanol layer on Au(111) was studied using electrochemical and in situ fluorescence microscopy. The adsorbed layer of octadecanol included a small amount of a lipophilic fluorophore-octadecanol modified with...
Tjeerd Pols et al.
The FEBS journal, 288(1), 293-309 (2020-04-20)
In cells, the breakdown of arginine to ornithine and ammonium ion plus carbon dioxide is coupled to the generation of metabolic energy in the form of ATP. The arginine breakdown pathway is minimally composed of arginine deiminase, ornithine transcarbamoylase, carbamate...
Patrizia M Spoerri et al.
Structure (London, England : 1993), 26(6), 829-838 (2018-05-08)
The protease-activated receptor 1 (PAR1), a G protein-coupled receptor (GPCR) involved in hemostasis, thrombosis, and inflammation, is activated by thrombin or other coagulation proteases. This activation is inhibited by the irreversible antagonist vorapaxar used for anti-platelet therapy. Despite detailed structural...
Naofumi Shimokawa et al.
Physical chemistry chemical physics : PCCP, 19(20), 13252-13263 (2017-05-12)
We investigated the phase behavior of lipid membranes containing fatty acids (FAs) by microscopy and differential scanning calorimetry. We used palmitic acid (saturated FA), oleic acid (cis-isomer of unsaturated FA), elaidic acid (trans-isomer of unsaturated FA), and phytanic acid (branched...
A phospholipid-based formulation for the treatment of airway inflammation in chronic respiratory diseases.
Komalla, et al.
European Journal of Pharmaceutics and Biopharmaceutics, 157, 47-58 (2020)
Tatyana I Rokitskaya et al.
FEBS letters, 588(9), 1590-1595 (2014-03-13)
In contrast to expectations that unsaturated fatty acids contribute to oxidative stress by providing a source of lipid peroxides, we demonstrated the protective effect of double bonds in lipids on oxidative damage to membrane proteins. Photodynamic inactivation of gramicidin channels...
Yuanfeng He et al.
Journal of controlled release : official journal of the Controlled Release Society, 264, 76-88 (2017-08-27)
Bone is the most common organ affected by metastatic breast cancer. Targeting cancers within the bone remains a great challenge due to the inefficient delivery of therapeutic to bone. In this study, a polyethylene glycol (PEG) coated nanoparticles (NPs) made...
Wade F Zeno et al.
Nature communications, 9(1), 4152-4152 (2018-10-10)
The ability of proteins to sense membrane curvature is essential to cellular function. All known sensing mechanisms rely on protein domains with specific structural features such as wedge-like amphipathic helices and crescent-shaped BAR domains. Yet many proteins that contain these domains...
Xin Wang et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 23(27), 6586-6595 (2017-02-22)
Herein, we report a facile strategy to prepare supported lipid-bilayer-coated polyacrylic acid/calcium phosphate nanoparticles (designated as PAA/CaP@SLB NPs) as a new dual pH-responsive drug-delivery platform for cancer chemotherapy. The synthesized PAA/CaP NPs exhibited both a high payload of doxorubicin (DOX)...
Philipp M G Löffler et al.
Scientific reports, 9(1), 13856-13856 (2019-09-27)
The ability to manipulate and fuse nano-compartmentalized volumes addresses a demand for spatiotemporal control in the field of synthetic biology, for example in the bottom-up construction of (bio)chemical nanoreactors and for the interrogation of enzymatic reactions in confined space. Herein...
Magda Przybyło et al.
Biochimica et biophysica acta, 1859(8), 1301-1309 (2017-05-04)
Organotin compounds, being biologically active, affect a variety of cellular functions due to their ability to accumulate in and penetrate biological membranes. These compounds influence the distribution of electrostatic charges, alter organization, disrupt molecular dynamics and change mechanical properties of...
Keishi Suga et al.
European biophysics journal : EBJ, 45(1), 55-62 (2015-09-20)
The hammerhead ribozyme (HHR) is one of smallest catalytic RNAs, composed of a catalytic core and three stems; it undergoes self-cleavage in the presence of divalent magnesium ions (Mg(2+)) or other cations. It is hypothesized that the function and metabolism...
Francesca Saitta et al.
Colloids and surfaces. B, Biointerfaces, 176, 167-175 (2019-01-07)
A stepwise micro-DSC study of Small, Large and Giant Unilamellar Vesicles prepared as pure and mixed systems of DMPC, DPPC, DSPC and DOPC was performed, achieving the preparation of final model membranes whose phospholipid compositions represent the 75% in terms...
Marcus Buggert et al.
PLoS pathogens, 14(4), e1006973-e1006973 (2018-04-14)
CD4+ T cells subsets have a wide range of important helper and regulatory functions in the immune system. Several studies have specifically suggested that circulating effector CD4+ T cells may play a direct role in control of HIV replication through...
Arnau Biosca et al.
Pharmaceutics, 11(7) (2019-07-19)
Combination therapies, where two drugs acting through different mechanisms are administered simultaneously, are one of the most efficient approaches currently used to treat malaria infections. However, the different pharmacokinetic profiles often exhibited by the combined drugs tend to decrease treatment...
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