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Mehrdad Arjomandi et al.
PloS one, 6(10), e25678-e25678 (2011-10-28)
Osteopontin (OPN) is a member of the small integrin-binding ligand N-linked glycoprotein (SIBLING) family and a cytokine with diverse biologic roles. OPN undergoes extensive post-translational modifications, including polymerization and proteolytic fragmentation, which alters its biologic activity. Recent studies suggest that
Margaret O'Brien et al.
Reproductive biology and endocrinology : RB&E, 6, 1-1 (2008-01-15)
RHOGTPases play a significant role in modulating myometrial contractility in uterine smooth muscle. They are regulated by at least three families of proteins, RHO guanine nucleotide exchange factors (RHOGEFs), RHOGTPase-activating proteins (RHOGAPs) and RHO guanine nucleotide inhibitors (RHOGDIs). RHOGEFs activate
Daniel C Zielinski et al.
Nature communications, 6, 7101-7101 (2015-06-10)
Drug side effects cause a significant clinical and economic burden. However, mechanisms of drug action underlying side effect pathogenesis remain largely unknown. Here, we integrate pharmacogenomic and clinical data with a human metabolic network and find that non-pharmacokinetic metabolic pathways
Natalia Felitsyn et al.
Journal of neurochemistry, 106(5), 2068-2079 (2008-07-31)
Delta-aminolevulinic acid (delta-ALA) is a heme precursor implicated in neurological complications associated with porphyria and tyrosinemia type I. Delta-ALA is also elevated in the urine of animals and patients treated with the investigational drug dichloroacetate (DCA). We postulated that delta-ALA
Atsushi Kambe et al.
Cancer prevention research (Philadelphia, Pa.), 2(12), 1088-1099 (2009-11-26)
EP4 expression in human glioblastoma cells correlates with growth on soft agar. The cyclooxygenase inhibitor sulindac sulfide first altered specificity protein-1 (Sp-1) and early growth response gene-1 expression, then increased the expression of nonsteroidal anti-inflammatory drug-activated gene 1 and activating
Karine Loulier et al.
PLoS biology, 7(8), e1000176-e1000176 (2009-08-19)
During embryogenesis, the neural stem cells (NSC) of the developing cerebral cortex are located in the ventricular zone (VZ) lining the cerebral ventricles. They exhibit apical and basal processes that contact the ventricular surface and the pial basement membrane, respectively.
Mi Kyung Park et al.
The Korean journal of parasitology, 49(3), 235-243 (2011-11-11)
In order to get a better understanding of the role of protease-activated receptor 2 (PAR2) in type 2 helper T (Th2) cell responses against Trichinella spiralis infection, we analyzed Th2 responses in T. spiralis-infected PAR2 knockout (KO) mice. The levels
Polysorbates 20 and 80 used in the formulation of protein biotherapeutics: structure and degradation pathways.
Kerwin BA
Journal of Pharmaceutical Sciences, 97(8), 2924-2935 (2008)
Sara Faccidomo et al.
Psychopharmacology, 204(1), 135-147 (2009-01-07)
Extracellular signal-regulated protein kinase (ERK(1/2)) is a member of the mitogen-activated protein kinase (MAPK) signaling pathway and a key molecular target for ethanol (EtOH) and other drugs of abuse. The aim of the study was to assess the role of
Renee M McFee et al.
Biology of reproduction, 81(5), 966-977 (2009-07-17)
We hypothesized that vascular endothelial growth factor A (VEGFA) angiogenic isoforms and their receptors, FLT1 and KDR, regulate follicular progression in the perinatal rat ovary. Each VEGFA angiogenic isoform has unique functions (based on its exons) that affect diffusibility, cell
Jonathan S Duke-Cohan et al.
Vaccine, 27(8), 1154-1165 (2009-01-17)
The renewed interest in strategies to combat infectious agents with epidemic potential has led to a re-examination of vaccination protocols against smallpox. To help define which antigens elicit a human antibody response, we have targeted proteins known or predicted to
Shekar Srinivas et al.
Immunology, 125(4), 492-502 (2008-06-13)
Interferon (IFN)-lambda1 [interleukin (IL)-29] is a member of the interferon lambda family (also known as type III interferons), whose members are distantly related to both the type I interferons and members of the IL-10 family. While IFN-lambda1 has significant antiviral
Bret J Pearson et al.
Developmental dynamics : an official publication of the American Association of Anatomists, 238(2), 443-450 (2009-01-24)
Whole-mount in situ hybridization (WISH) is a powerful tool for visualizing gene expression patterns in specific cell and tissue types. Each model organism presents its own unique set of challenges for achieving robust and reproducible staining with cellular resolution. Here
Richard Milner et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 28(4), 812-823 (2007-11-22)
During focal cerebral ischemia, the detachment of astrocytes from the microvascular basal lamina is not completely explained by known integrin receptor expression changes. Here, the impact of experimental ischemia (oxygen-glucose deprivation (OGD)) on dystroglycan expression by murine endothelial cells and
X L Jin et al.
Biology of reproduction, 80(2), 286-294 (2008-10-17)
A universal response to cellular stress is the expression of transformation-related protein 53 (TRP53). This transcription factor reduces cell proliferation and/or survival and is classed as a tumour suppressor protein. Several stresses (including culture) cause increased TRP53 expression in blastocysts
Peng Wei et al.
Molecular and cellular neurosciences, 41(2), 258-273 (2009-04-07)
Cbln1, a glycoprotein secreted from granule cells and GluRdelta2 in the postsynaptic densities of Purkinje cells are components of an incompletely understood pathway essential for integrity and plasticity of parallel fiber-Purkinje cell synapses. We show that Cbln1 undergoes anterograde transport
P Lewis White et al.
Journal of clinical microbiology, 49(6), 2169-2174 (2011-04-01)
Diagnosis of invasive aspergillosis remains a significant problem. PCR testing may aid diagnosis but is not yet included in disease-defining criteria due to a lack of standardization of assays and methodologies. This study investigated the analytical performance and the clinical
Guangyuan Li et al.
Molecular vision, 17, 3156-3165 (2011-12-16)
The receptor for advanced glycation end products (RAGE) has been implicated in the pathogenesis of numerous complications of diabetes. We assessed the effect of a novel RAGE fusion protein inhibitor on retinal histopathology and nerve function, and on retinal inflammation
Peter Pastuszko et al.
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 35(4), 577-581 (2009-02-17)
To determine the effect of recovery with mild hypothermia after cardiopulmonary bypass (CPB) and deep hypothermic circulatory arrest (DHCA) on the activity of selected key proteins involved in initiation (Bax, Caspase-3) or inhibition of apoptotic injury (Bcl-2, increased ratio Bcl-2/Bax)
Peter T Beernink et al.
Infection and immunity, 76(9), 4232-4240 (2008-07-02)
No broadly protective vaccine is available for the prevention of group B meningococcal disease. One promising candidate is factor H-binding protein (fHbp), which is present in all strains but often sparsely expressed. We prepared seven murine immunoglobulin G monoclonal antibodies
Yutaka Nakanishi et al.
BMC cancer, 11, 3-3 (2011-01-06)
Runt-related transcription factor 3 (RUNX3) is known as a tumor suppressor gene for gastric cancer and other cancers, this gene may be involved in the development of hepatocellular carcinoma (HCC). RUNX3 expression was analyzed by immunoblot and immunohistochemistry in HCC
Victoria Rydengård et al.
PLoS pathogens, 4(8), e1000116-e1000116 (2008-09-18)
Fungi, such as Candida spp., are commonly found on the skin and at mucosal surfaces. Yet, they rarely cause invasive infections in immunocompetent individuals, an observation reflecting the ability of our innate immune system to control potentially invasive microbes found
Lili Lu et al.
Antioxidants & redox signaling, 11(4), 715-724 (2008-10-01)
Oxidative damage contributes to cone cell death in retinitis pigmentosa and death of rods, cones, and retinal pigmented epithelial (RPE) cells in age-related macular degeneration. In this study, we explored the strategy of overexpressing components of the endogenous antioxidant defense
Joseph G Dubouzet et al.
Plant biotechnology journal, 9(4), 466-485 (2010-10-20)
Approximately 20,000 of the rice-FOX Arabidopsis transgenic lines, which overexpress 13,000 rice full-length cDNAs at random in Arabidopsis, were screened for bacterial disease resistance by dip inoculation with Pseudomonas syringae pv. tomato DC3000 (Pst DC3000). The identities of the overexpressed
Helena Zientek-Targosz et al.
Molecular cancer, 7, 51-51 (2008-06-07)
Widely accepted somatic mutation theory of carcinogenesis states that mutations in oncogenes and tumor suppressor genes in genomes of somatic cells is the cause of neoplastic transformation. Identifying frequent mutations in cancer cells suggests the involvement of mutant genes in
Takayuki Nakayama et al.
International journal of hematology, 87(4), 363-370 (2008-03-29)
von Willebrand factor (VWF) performs its hemostatic functions through binding to various proteins. The A1 domain of VWF contains binding sites of not only physiologically important ligands, but also exogenous modulators that induce VWF-platelet aggregation. Sulfatides, 3-sulfated galactosyl ceramides, that
Verena Kallhoff-Munoz et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 28(44), 11421-11431 (2008-10-31)
Cell cycle markers have been shown to be upregulated and proposed to lead to apoptosis of postmitotic neurons in Alzheimer's disease (AD). Presenilin (PS) plays a critical role in AD pathogenesis, and loss-of-function studies in mice established a potent effect
Patrick P McCue et al.
Journal of agricultural and food chemistry, 56(22), 11011-11017 (2008-11-04)
St. John's wort (SJW; Hypericum perforatum L.) is commonly known for its antidepressant properties and was traditionally used to promote wound healing, but its molecular mechanism of action is not known. Here, chemical-genetic profiling in yeast was used to predict
Justin A Boddey et al.
Traffic (Copenhagen, Denmark), 10(3), 285-299 (2008-12-06)
The intracellular survival of Plasmodium falciparum within human erythrocytes is dependent on export of parasite proteins that remodel the host cell. Most exported proteins require a conserved motif (RxLxE/Q/D), termed the Plasmodium export element (PEXEL) or vacuolar targeting sequence (VTS)
Anna V Miller et al.
Molecular and cellular biology, 28(12), 4142-4151 (2008-04-23)
Transforming growth factor beta (TGFbeta) plays a dual role in oncogenesis, acting as both a tumor suppressor and a tumor promoter. These disparate processes of suppression and promotion are mediated primarily by Smad and non-Smad signaling, respectively. A central issue
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