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PHR1005

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Clinical question: are non-steroidal anti-inflammatories superior to acetaminophen for sprains/strains?
Heather Wheeler et al.
The Journal of the Oklahoma State Medical Association, 107(3), 109-110 (2014-05-08)
Harley T Syyong et al.
American journal of respiratory cell and molecular biology, 52(3), 304-314 (2014-07-24)
A characteristic feature of asthma is exaggerated airway narrowing, termed airway hyper-responsiveness (AHR) due to contraction of airway smooth muscle (ASM). Although smooth muscle (SM)-specific asthma susceptibility genes have been identified, it is not known whether asthmatic ASM is phenotypically
Huan Yang et al.
The Journal of experimental medicine, 212(1), 5-14 (2015-01-07)
Innate immune receptors for pathogen- and damage-associated molecular patterns (PAMPs and DAMPs) orchestrate inflammatory responses to infection and injury. Secreted by activated immune cells or passively released by damaged cells, HMGB1 is subjected to redox modification that distinctly influences its
[Effectiveness of analgesic combinations in the self-medication].
Eve C A Morgenstern et al.
MMW Fortschritte der Medizin, 155(9), 49-51 (2013-08-21)
Mahmoud Mohammadi et al.
Indian pediatrics, 40(12), 1183-1186 (2004-01-15)
The present study was done to explore the relationship between the cerebrospinal fluid (CSF) glucose concentration, body temperature, seizure duration, and acetaminophen administration. Retrospective record review of 117 consecutive febrile convulsive infants aging 3 to 18 months admitted to Bahrami
Treatment of paracetamol overdose.
Benjamin Kessler et al.
Lancet (London, England), 383(9926), 1382-1382 (2014-04-25)
Mona Darwish et al.
Clinical therapeutics, 37(2), 390-401 (2014-12-30)
A hydrocodone extended-release (ER) formulation was developed to provide sustained pain relief with twice-daily dosing. Developed using the CIMA abuse-deterrence technology platform (CIMA Labs Inc, Brooklyn Park, Minnesota), this formulation also provides resistance against rapid release of hydrocodone when tablets
Véronique Gilard et al.
Journal of pharmaceutical and biomedical analysis, 102, 476-493 (2014-12-03)
One hundred and fifty dietary supplements (DS) marketed to increase sexual performance were analyzed. All these formulations were claimed to contain only natural compounds, plant extracts and/or vitamins. (1)H NMR spectroscopy was used for detecting the presence of adulterants and
Sharad Mangal et al.
International journal of pharmaceutics, 479(2), 338-348 (2015-01-13)
In this study, polyvinylpyrrolidone (PVP) was spray dried with l-leucine (PVP-Leu) to create a prototype multifunctional interactive excipient. The physico-chemical and bulk properties such as particle size, surface composition, surface energy and bulk cohesion of PVP-Leu was measured and compared
Nabil A Khan et al.
Journal of opioid management, 9(3), 225-230 (2013-06-19)
Addiction to painkillers or other substances in pediatric and adolescent cases of noncancer chronic pain is an understudied phenomenon, even amidst documented increases in rates of prescription opioid use and misuse. Case studies can inform the training of clinicians in
Julia Dinger et al.
Toxicology letters, 230(1), 28-35 (2014-08-12)
Drugs of abuse are not tested for cytochrome P450 (CYP) inhibition potential before distribution. Therefore, a cocktail assay should be developed for testing the inhibition potential for all relevant CYPs. The following CYP test substrates and selective inhibitors were incubated
Syusuke Sano et al.
International journal of pharmaceutics, 468(1-2), 234-242 (2014-04-09)
The impact of different active pharmaceutical ingredients (APIs) loading on the properties of orally disintegrating tablets (ODTs) prepared according to our previously reported microwave (MW) treatment process was evaluated using famotidine (FAM), acetaminophen (AAP), and ibuprofen (IBU). None of the
Yutaka Kimura et al.
Toxicology in vitro : an international journal published in association with BIBRA, 28(5), 759-768 (2014-03-08)
We established a luciferase reporter assay system, the Multi-ImmunoTox Assay (MITA), to evaluate the effects on key predictivein vitro components of the human immune system. The system is composed of 3 stable reporter cell lines transfected with 3 luciferase genes
Luz María Martínez et al.
International journal of pharmaceutics, 477(1-2), 294-305 (2014-12-03)
There is a special interest in having pharmaceutical active ingredients in the amorphous state due to their increased solubility and therefore, higher bioavailability. Nevertheless, not all of them present stable amorphous phases. In particular, paracetamol is an active ingredient widely
FDA asks physicians to stop prescribing high-dose acetaminophen products.
Mike Mitka
JAMA, 311(6), 563-563 (2014-02-13)
Katarina Rubin et al.
Drug metabolism and disposition: the biological fate of chemicals, 43(1), 119-125 (2014-11-06)
The suppression of hepatic cytochrome P450 (P450) expression during inflammatory and infectious diseases and the relief of this suppression by successful disease treatment have been previously demonstrated to impact drug disposition. To address this clinically relevant phenomenon preclinically, the effect
Kyung-Ha Ryu et al.
Experimental cell research, 326(1), 143-154 (2014-06-24)
Acute liver failure, the fatal deterioration of liver function, is the most common indication for emergency liver transplantation, and drug-induced liver injury and viral hepatitis are frequent in young adults. Stem cell therapy has come into the limelight as a
Lihai Zhang et al.
The Journal of pharmacology and experimental therapeutics, 346(2), 259-269 (2013-06-14)
Our previous research showed that enolates formed from 1,3-dicarbonyl compounds, such as 2-acetylcyclopentanone (2-ACP), could provide protection in cell culture models from electrophile- or oxidative stress-induced toxicity. In the present study, we evaluated the protective abilities of 2-ACP in a
PKCs: pernicious kinase culprits in acetaminophen pathogenesis.
Cynthia Ju et al.
Hepatology (Baltimore, Md.), 59(4), 1229-1231 (2014-03-29)
Peggy Gandia et al.
Journal of clinical pharmacology, 43(11), 1235-1243 (2003-10-11)
This study evaluated the effect of simulated weightlessness on gastric emptying, using acetaminophen as a probe and -6 degrees head-down bed rest to simulate zero gravity. Eighteen volunteers were given 1 g of acetaminophen orally before the bed rest and
Fixed drug eruption: a selective reaction to amoxicillin.
Amel Chaabane et al.
Therapie, 68(3), 183-185 (2013-07-28)
Zeyan Liew et al.
JAMA pediatrics, 168(4), 313-320 (2014-02-26)
Acetaminophen (paracetamol) is the most commonly used medication for pain and fever during pregnancy in many countries. Research data suggest that acetaminophen is a hormone disruptor, and abnormal hormonal exposures in pregnancy may influence fetal brain development. To evaluate whether
Kalynne Harris et al.
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 40(8), 906-911 (2014-07-16)
Little is known about postoperative opioid prescribing patterns among dermatologic surgeons. To better understand postoperative opioid prescribing patterns among dermatologic surgeons in the United States. Two-part analysis consisting of a retrospective chart review of 233 dermatologic surgery patients at a
Eda Ozcelik et al.
Pharmacognosy magazine, 10(Suppl 2), S217-S224 (2014-07-06)
Liver diseases have become a major problem of the worldwide. More than 50% of all cases of liver failure can be attributed to drugs. Among these, acetaminophen is the most common cause. The aim of this study was to investigate
F Franceschi et al.
European review for medical and pharmacological sciences, 17(16), 2129-2135 (2013-07-31)
Pain is the most common reason people see doctors in developed Countries and a very common cause of access in Emergency Department (ED). The combination acetaminophen/codeine represents the standard medication in the second step of the WHO analgesic scale and
When is research clinical advice? Interpreting an exploratory study of paracetamol overdose.
Geoffrey K Isbister et al.
Clinical toxicology (Philadelphia, Pa.), 51(10), 1242-1242 (2013-11-14)
Dany Spaggiari et al.
Analytical and bioanalytical chemistry, 406(20), 4875-4887 (2014-06-05)
The cocktail approach is an advantageous strategy used to monitor the activities of several cytochromes P450 (CYPs) in a single test to increase the throughput of in vitro phenotyping studies. In this study, a cocktail mixture was developed with eight
The ability of a retrospective review of electronic health records to fully capture the frequency of supratherapeutic dosing of acetaminophen--reply.
Li Zhou et al.
JAMA internal medicine, 173(11), 1036-1036 (2013-06-12)
Genetics of drug-induced hepatotoxicity toxicity in Gilbert's syndrome.
Ali Raza et al.
The American journal of gastroenterology, 108(12), 1936-1937 (2013-12-05)
Hans-Christoph Diener et al.
The journal of headache and pain, 15, 76-76 (2014-11-20)
Most patients with episodic tension-type headache treat headache episodes with over-the-counter medication. Combination analgesics containing caffeine may be more effective and as well tolerated as monotherapy. The aim of this study was to evaluate the efficacy of the combination of
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