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phr1215
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Johannes Woitzik et al.
Stroke, 45(4), 1183-1185 (2014-03-20)
We investigated to what extent excitotoxicity and metabolic changes in the peri-infarct region of patients with malignant hemispheric stroke are associated with delayed infarct progression. In 18 patients with malignant hemispheric stroke, 2 microdialysis probes were implanted within the peri-infarct
Edward D Buckingham
Facial plastic surgery clinics of North America, 21(2), 271-284 (2013-06-05)
Facial volume loss is an important component of facial aging and tends to present at an earlier age than other aspects of aging. Several surgical and nonsurgical products and techniques are available to replace volume loss associated with aging. One
Liliana Moreira et al.
Experimental cell research, 319(12), 1784-1795 (2013-05-15)
In this study we characterized (3)H-2-deoxy-d-glucose ((3)H -DG) uptake by the estrogen receptor (ER)-positive MCF7 and the ER-negative MDA-MB-231 human breast cancer cell lines and investigated the effect of quercetin (QUE) and epigallocatechin gallate (EGCG) upon (3)H-DG uptake, glucose metabolism
William Hubbard et al.
The Journal of surgical research, 193(1), 355-360 (2014-08-03)
From 2001-2011, >80% of potentially survivable United States battlefield deaths were due to severe hemorrhage. We subjected male rats to acute severe blood loss, administered a single dose of 17α-ethynylestradiol-3-sulfate (EE-3-SO4) without resuscitative fluids, and measured survival and also mean
Zhengfei Yang et al.
The American journal of emergency medicine, 32(1), 50-54 (2013-11-12)
The latest guidelines both increased the requirements of chest compression rate and depth during cardiopulmonary resuscitation (CPR), which may make it more difficult for the rescuer to provide high-quality chest compression. In this study, we investigated the quality of chest
Perplexity of a fungus in the sinus.
Radhika Dasararaju et al.
The American journal of medicine, 127(1), e1-e2 (2013-11-26)
Weimin Zhu et al.
Artificial cells, nanomedicine, and biotechnology, 42(5), 331-335 (2013-08-21)
By in situ polymerization of poly-L-lactic acid (PLLA) and nano-hydroxyapatite (Nano-HA), and finding the best proportion of composite, so as to get ideal interface fixation material. According to a certain ratio (the mass fraction of Nano-HA, respectively, is 0%, 10%
María C Merino et al.
PLoS neglected tropical diseases, 8(7), e2997-e2997 (2014-07-25)
Protein S-palmitoylation, a hydrophobic post-translational modification, is performed by protein acyltransferases that have a common DHHC Cys-rich domain (DHHC proteins), and provides a regulatory switch for protein membrane association. In this work, we analyzed the presence of DHHC proteins in
Yasuhiro Nakagami et al.
British journal of pharmacology, 172(5), 1237-1249 (2014-11-05)
Nuclear factor erythroid 2-related factor 2 (Nrf2) is a redox-sensitive transcription factor that binds to antioxidant response elements located in the promoter region of genes encoding many antioxidant enzymes and phase II detoxifying enzymes. Activation of the Nrf2 pathway seems
Sarang Dilip Pophaly et al.
Microbial cell factories, 11, 114-114 (2012-08-28)
Lactic acid bacteria (LAB) have taken centre stage in perspectives of modern fermented food industry and probiotic based therapeutics. These bacteria encounter various stress conditions during industrial processing or in the gastrointestinal environment. Such conditions are overcome by complex molecular
Priyanka Saxena et al.
Indian journal of experimental biology, 52(8), 793-798 (2014-08-22)
With an aim to devise a prophylactic and/or therapeutic approach for preventing internalization of radiothallium (201Tl), and more importantly by implication, its chemical analogue radiocesium (137Cs) during any nuclear emergency, different ex vivo and in vivo animal models were created
Andrea Felser et al.
Toxicology, 324, 136-146 (2014-08-12)
Benzbromarone is an uricosuric structurally related to amiodarone and a known mitochondrial toxicant. The aim of the current study was to improve our understanding in the molecular mechanisms of benzbromarone-associated hepatic mitochondrial toxicity. In HepG2 cells and primary human hepatocytes
Christopher M Furcht et al.
Journal of cell science, 127(Pt 16), 3555-3567 (2014-06-22)
Information from multiple signaling axes is integrated in the determination of cellular phenotypes. Here, we demonstrate this aspect of cellular decision making in glioblastoma multiforme (GBM) cells by investigating the multivariate signaling regulatory functions of the protein tyrosine phosphatase SHP2
[A man in his 70s found confused on his training ride].
Magnus Salomonsen et al.
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 133(23-24), 2483-2487 (2013-12-12)
Dongwook Choi et al.
The FEBS journal, 281(24), 5447-5462 (2014-10-07)
DJ-1 family proteins have recently been characterized as novel glyoxalases, although their cofactor-free catalytic mechanisms are not fully understood. Here, we obtained crystals of Arabidopsis thaliana DJ-1d (atDJ-1d) and Homo sapiens DJ-1 (hDJ-1) covalently bound to glyoxylate, an analog of
James Steele et al.
Current opinion in biotechnology, 24(2), 135-141 (2013-01-03)
It has been known since the 1960s that lactic acid bacteria are essential for the development of cheese flavor. In the ensuing 50 years significant research has been directed at understanding the microbiology, genetics and biochemistry of this process. This
Temmei Ito et al.
Biomedical materials (Bristol, England), 10(1), 015025-015025 (2015-03-03)
In order to obtain a hydroxyapatite (HAp)-poly(ethylene glycol) (PEG) composite, tetra amine-terminated PEG was crosslinked using disuccinimidyl tartrate to obtain a PEG hydrogel. Using two kinds of chelators with different stability constants for Ca ion (N-(2-hydroxyethyl) ethylenediamine-N,N',N'-triacetic acid (EDTA-OH, 8.14)
Laura Dato et al.
Microbial cell factories, 13, 147-147 (2014-11-02)
The great interest in the production of highly pure lactic acid enantiomers comes from the application of polylactic acid (PLA) for the production of biodegradable plastics. Yeasts can be considered as alternative cell factories to lactic acid bacteria for lactic
Quan Zhou et al.
Journal of cellular and molecular medicine, 19(3), 521-534 (2014-10-30)
Spermatogonial stem cells (SSCs) are undifferentiated cells that are required to maintain spermatogenesis throughout the reproductive life of mammals. Although SSC transplantation and culture provide a powerful tool to identify the mechanisms regulating SSC function, the precise signalling mechanisms governing
Lactic acidosis.
Rinaldo Bellomo et al.
The New England journal of medicine, 372(11), 1076-1076 (2015-03-12)
Shaoying Li et al.
The Journal of antibiotics, 68(2), 81-87 (2014-09-11)
The quinolone resistance of 19 lactic acid bacterial strains belonging to the genera Enterococcus and Lactobacillus isolated from the natural fermented koumiss and yoghurt were investigated. The objective of this study was to determine the quinolone resistance levels and to
Nhung Dang et al.
Journal of pharmaceutical sciences, 103(7), 2107-2115 (2014-05-29)
Nevirapine (NVP) was loaded in polycaprolactone (PCL) matrices to produce vaginal inserts with the aim of preventing HIV transmission. NVP dispersions in PCL were prepared, at 10% (w/w) theoretical loading, measured with respect to the PCL content of the matrices
Zhiyuan Lan et al.
Journal of biomedical nanotechnology, 10(7), 1194-1204 (2014-05-09)
Bioabsorbable drug-eluting stents (BDES) offer multiple advantages over a permanent bare metal stent (BMS) for coronary artery disease (CAD). However, current BDES remains two major issues: inferior radial strength and biocompatibility. PowerStent Absorb BDES, fabricated by co-formulating amorphous calcium phosphate
Chi-huan Chang et al.
International journal of systematic and evolutionary microbiology, 65(Pt 1), 101-106 (2014-10-05)
A Gram-reaction-positive, catalase-negative, facultatively anaerobic, rod-shaped lactic acid bacterium, designated strain S215(T), was isolated from fermented soybean meal. The organism produced d-lactic acid from glucose without gas formation. 16S rRNA gene sequencing results showed that strain S215(T) had 98.74-99.60 % sequence
Per A Tesch et al.
Aviation, space, and environmental medicine, 84(5), 516-521 (2013-05-30)
Astronauts are required to perform both resistance and aerobic exercise while in orbit. This study assessed the aerobic energy yield and related physiological measurements using a nongravity dependent flywheel device designed for both resistance and aerobic exercise (RAD) in space.
Per Aspenberg
Acta orthopaedica, 85(6), 687-690 (2014-10-29)
Due to the known drawbacks of metal implants, new biomaterials for internal fracture fixation are attracting increasing interest, among them poly(lactic-co-glucolic) acids (PLGAs) and the recently developed silk-tenoin derived materials (STDMs). In accordance with the new philosophy of bio-derived biomaterials
Yuxuan Wu et al.
Cell research, 25(1), 67-79 (2014-12-06)
Spermatogonial stem cells (SSCs) can produce numerous male gametes after transplantation into recipient testes, presenting a valuable approach for gene therapy and continuous production of gene-modified animals. However, successful genetic manipulation of SSCs has been limited, partially due to complexity
Leonardo Lorente et al.
PloS one, 10(3), e0121739-e0121739 (2015-03-31)
There have been found apoptotic changes in brain tissue samples from animals and humans after a traumatic brain injury (TBI). The protein cytokeratin 18 (CK-18), present in epithelial cells, is cleaved by the action of caspases during apoptosis, and the
Lactic acidosis.
Ibidumo Igah et al.
The New England journal of medicine, 372(11), 1077-1077 (2015-03-12)
Dietmar Wallner et al.
International journal of sports physiology and performance, 9(4), 661-666 (2013-11-16)
To analyze the acute physiological response to aerobic short-interval training (AESIT) at various high-intensity running speeds. A minor anaerobic glycolytic energy supply was aimed to mimic the characteristics of slow continuous runs. Eight trained male runners (maximal oxygen uptake [VO(2max)]
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