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PHR1243
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Showing 1-30 of 170 results for "PHR1243" within Papers
D S Zhang et al.
British journal of cancer, 112(2), 266-270 (2014-12-05)
Gastric cancer is one of the leading causes of cancer-related death worldwide. There were debates on the value of the second-line and beyond chemotherapy by the time we designed this trial. So we designed this phase II trial to assess
Quinn Ostrom et al.
Epilepsia, 54 Suppl 9, 25-29 (2013-12-18)
Gene markers or biomarkers can be used for diagnostic or prognostic purposes for all different types of complex disease, including brain tumors. Prognostic markers can be useful to explain differences not only in overall survival but also in response to
Michaela Vorlíčková et al.
Methods (San Diego, Calif.), 57(1), 64-75 (2012-03-28)
Circular dichroism (CD) is remarkably sensitive to the conformational states of nucleic acids; therefore, CD spectroscopy has been used to study most features of DNA and RNA structures. Quadruplexes are among the significant noncanonical nucleic acids architectures that have received
Chun-Liang Tung et al.
Experimental cell research, 322(2), 345-354 (2014-02-18)
Elevated heat shock protein 90 (Hsp90) expression has been linked to poor prognosis in patients with non-small cell lung cancer (NSCLC). The multitargeted antifolate pemetrexed has demonstrated certain clinical activities against NSCLC. However, the efficacy of the combination of pemtrexed
Kristoffer Derwinger et al.
Anticancer research, 33(6), 2447-2451 (2013-06-12)
The enzyme thymidine phosphorylase (TYMP) has tumor-promoting functions and its expression is often elevated in tumors. TYMP gene expression in tumorous and mucosal tissues was assessed using real-time polymerase chain reaction, in a study of patients with rectal cancer where
Rapid and simple determination of adenine and guanine in DNA extract by micellar electrokinetic chromatography with indirect laser-induced fluorescence detection
Wang W, et al.
Talanta, 74(4), 1050-1055 (2008)
Matthew S Chang et al.
Transplantation, 95(7), 960-965 (2013-04-03)
Lamivudine (LAM) has been shown to prevent de novo hepatitis B virus (HBV) infection in recipients of hepatitis B core antibody (HBcAb)-positive liver transplants (LT) but primarily in small studies with limited follow-up. We conducted a retrospective cohort study of
Moriya Iwaizumi et al.
Mutation research, 747-748, 19-27 (2013-05-07)
Human DNA mismatch repair (MMR) recognizes and binds 5-fluorouracil (5FU) incorporated into DNA and triggers a MMR-dependent cell death. Absence of MMR in a patient's colorectal tumor abrogates 5FU's beneficial effects on survival. Changes in the tumor microenvironment like low
Huiying Song et al.
Journal of chromatography. A, 1369, 83-91 (2014-12-03)
An intrinsic performance comparison is made of the reduction in analysis time that can be obtained when switching from HPLC to UHPLC column formats in HILIC and reversed-phase conditions. A detailed overview of the packing characteristics of both stationary phase
Gunnar Boysen et al.
Mutation research, 678(2), 76-94 (2009-05-26)
DNA alkylation or adduct formation occurs at nucleophilic sites in DNA, mainly the N7-position of guanine. Ever since identification of the first N7-guanine adduct, several hundred studies on DNA adducts have been reported. Major issues addressed include the relationships between
Laura S Nyskohus et al.
Mutation research, 758(1-2), 80-86 (2013-10-22)
Azoxymethane (AOM) is an alkylating agent that generates mutagenic and carcinogenic O(6)-methylguanine (O(6)meG) adducts in DNA. O(6)meG has been detected in human colonic DNA; hence, understanding the innate cellular events occurring in response to the formation of O(6)meG is important
Tsung-Hui Hu et al.
Transplantation, 97 Suppl 8, S53-S59 (2014-05-23)
Antiviral prophylaxis with hepatitis B immunoglobulin (HBIg) plus lamivudine reduces the risk of hepatitis B virus (HBV) recurrence after HBV-related liver transplant (LT). However, HBIg is expensive, and lamivudine therapy is limited by drug resistance. This study assessed a pilot
J C Wang et al.
European review for medical and pharmacological sciences, 17(9), 1162-1166 (2013-05-22)
Either combination treatment or monotherapy using agents with a high genetic barrier are recommended for the retreatment of chronic hepatitis B (CHB) patients. In search of reasonable treatment, we compared the efficacy and safety of lamivudine (LAM) plus adefovir (ADV)
Yuqi Liu et al.
BMC medical genetics, 15, 84-84 (2014-07-25)
Hypertension is a very common cardiovascular disease influenced by multiple genetic and environmental factors. More recently, there are some studies showed that mutations in mitochondrial DNA have been involved in its pathogenesis. In this study we did further investigations on
Wuxiang Mao et al.
Nucleic acids research, 43(1), e3-e3 (2014-10-31)
Structural features of nucleic acids have become an integral part of current biomedical research. Highly selective and readily performed methods with little toxicity that target guanosines in non-duplex nucleic acids are needed, which led us to search for an effective
Toshihiko Ojima et al.
Gan to kagaku ryoho. Cancer & chemotherapy, 40(12), 2463-2465 (2014-01-08)
A 57-year-old man presented with abdominal discomfort. A computed tomography (CT) scan revealed a tumor, with a maximum diameter of approximately 5 cm, in the transverse mesocolon near the splenic flexure as well as a small nodular shadow suggestive of
Sara J Ireland et al.
JAMA neurology, 71(11), 1421-1428 (2014-09-30)
This study describes what is, to our knowledge, the previously unknown effect of glatiramer acetate therapy on B cells in patients with relapsing-remitting multiple sclerosis (MS). To determine whether glatiramer acetate therapy normalizes dysregulated B-cell proliferation and cytokine production in
Y Yang et al.
Journal of dental research, 92(6), 500-506 (2013-04-30)
Hypodontia, a tooth developmental disease, can affect chewing and pronunciation. Mutations in the ectodysplasin-A (EDA) gene can lead to both X-linked hypohidrotic ectodermal dysplasia (XLHED) and non-syndromic hypodontia (NSH). However, the mechanism by which these 2 related but different disorders
T Spiro et al.
Forum (Genoa, Italy), 10(3), 274-285 (2000-09-29)
The chloroethylating nitrosoureas (lomustine, fotemustine, cystemustine (BCNU) and methylating agents temozolomide (TMZ), dacarbazine (DTIC), procarbazine) have documented activity in metastatic malignant melanoma with single agent response rates of 15-25%. Chloroethylating agents form chloroethyl adducts at the O6 position of guanine
Melania Minoia et al.
Molecular and cellular biology, 34(19), 3570-3578 (2014-07-16)
The C289G mutation of the parkin E3-ubiquitin protein ligase (PARK2) is associated with autosomal recessive juvenile onset Parkinson's disease and was found to be associated with protein aggregation. Members of the human small heat shock proteins (HSPBs) have been implicated
Marc-Frédérick Blanchet et al.
Nucleic acids research, 42(17), 11261-11271 (2014-09-10)
Anti-infection drugs target vital functions of infectious agents, including their ribosome and other essential non-coding RNAs. One of the reasons infectious agents become resistant to drugs is due to mutations that eliminate drug-binding affinity while maintaining vital elements. Identifying these
Yukihisa Hatakeyama et al.
Cancer letters, 343(1), 74-79 (2013-10-22)
The purpose is to examine the synergistic effect of pemetrexed (PEM) and amrubicin (AMR) on the proliferation of lung cancer cell lines. In vitro, dose-dependent synergistic effects of concurrent PEM and AMRol, which is an active metabolite of AMR were
James Fung et al.
The American journal of gastroenterology, 108(6), 942-948 (2013-05-01)
The long-term outcomes of oral antiviral therapy without hepatitis B immune globulin (HBIG) in prevention of reinfection with hepatitis B after liver transplantation are not known. We aimed to determine the long-term outcomes from a large population of chronic hepatitis
Minehiko Inomata et al.
Gan to kagaku ryoho. Cancer & chemotherapy, 41(7), 849-852 (2014-08-19)
The efficacy of docetaxel, vinorelbine, or gemcitabine monotherapy in previously untreated elderly patients with non-small cell lung cancer has been reported.Pemetrexed monotherapy has shown clinically equivalent efficacy to docetaxel, a standard therapeutic option, in patients with previously treated non-small cell
T Nikopensius et al.
Journal of dental research, 92(6), 507-511 (2013-04-23)
Mutations in the ectodysplasin-A (EDA) gene have been generally associated with X-linked hypohidrotic ectodermal dysplasia (XLHED). Recently, missense mutations in EDA have been reported to cause familial non-syndromic tooth agenesis. In this study, we report a novel EDA mutation in
Clinical response to crizotinib retreatment after acquisition of drug resistance.
Hiromichi Matsuoka et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 31(19), e322-e323 (2013-05-30)
Samuel C Suarez et al.
Mutation research, 745-746, 46-54 (2013-03-19)
DNA polymerase η (pol η) plays a critical role in suppressing mutations caused by the bypass of cis-syn cyclobutane pyrimidine dimers (CPD) that escape repair. There is evidence this is also the case for the oxidative lesion 7,8-dihydro-8-oxo-guanine (8-oxoG). Both
Formation of ring-opened and rearranged products of guanine: mechanisms and biological significance.
N R Jena et al.
Free radical biology & medicine, 53(1), 81-94 (2012-05-16)
DNA damage by endogenous and exogenous agents is a serious concern, as the damaged products can affect genome integrity severely. Damage to DNA may arise from various factors such as DNA base modifications, strand break, inter- and intrastrand crosslinks, and
Carmela Protano et al.
The Science of the total environment, 500-501, 44-51 (2014-09-14)
The aims of the present study were to establish the background levels of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodGuo), 8-oxo-7,8-dihydroguanosine (8-oxoGuo), 8-oxo-7,8-dihydroguanine (8-oxoGua) among a group of healthy Italian children, and to evaluate the contribution of some potential interfering/confounding factors to the urinary (u)
Mechanisms of formation, genotoxicity, and mutation of guanine oxidation products.
William L Neeley et al.
Chemical research in toxicology, 19(4), 491-505 (2006-04-13)
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