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Alexandro Hoyer et al.
Naunyn-Schmiedeberg's archives of pharmacology, 387(12), 1221-1229 (2014-10-14)
Evidence as to how ACE inhibitors attenuate ischemia-reperfusion injury (IR) after cardioplegic arrest remains scarce. Twenty-four rabbit hearts were perfused on a Langendorff apparatus. Control hearts (n = 6) were arrested with pure histidine-tryptophan-ketoglutarate (HTK)-Bretschneider. Treatment groups received added to
Salvatore Fabbiano et al.
Molecular and cellular biology, 34(24), 4404-4419 (2014-10-08)
Vascular smooth muscle cells (vSMCs) are key in the regulation of blood pressure and the engagement of vascular pathologies, such as hypertension, arterial remodeling, and neointima formation. The role of the Rac1 GTPase in these cells remains poorly characterized. To
Ines Nevelsteen et al.
Journal of vascular research, 50(6), 486-497 (2013-11-07)
Insulin resistance, dyslipidemia and hypertension are independent mediators of endothelial dysfunction. It is incompletely defined whether dyslipidemia and hypertension in addition to diabetes mellitus type II (DMII), as seen in the metabolic syndrome (MS), worsen diabetes-induced endothelial dysfunction. Furthermore, it
Kim R Bridle et al.
Liver international : official journal of the International Association for the Study of the Liver, 35(4), 1451-1463 (2014-02-13)
Mammalian target of rapamycin and angiotensin-converting enzyme inhibition has been shown to have antifibrotic activity in models of liver fibrosis. The aim of our study was to determine the efficacy of rapamycin, everolimus, irbesartan and captopril, alone and in combination
Jenifer M Brown et al.
Hypertension (Dallas, Tex. : 1979), 63(2), 273-280 (2013-11-06)
Observational studies in primary hyperaldosteronism suggest a positive relationship between aldosterone and parathyroid hormone (PTH); however, interventions to better characterize the physiological relationship between the renin-angiotensin-aldosterone system (RAAS) and PTH are needed. We evaluated the effect of individual RAAS components
P Castro-Moreno et al.
Autonomic & autacoid pharmacology, 32(3 Pt 4), 61-69 (2012-09-22)
We investigated captopril effects, an ACE inhibitor, on hypertension development, on Ang II and Ang-(1-7) plasma concentrations, on Ang II-induced contraction in isolated kidneys, and on kidney AT1R from spontaneously hypertensive (SHR) rats. Five weeks-old SHR and Wistar Kyoto (WKY)
Pei-Pei Lin et al.
International journal of molecular medicine, 30(6), 1365-1375 (2012-10-16)
Cardiovascular hypertrophy is a common feature of hypertension and an important risk factor for heart damage. The regression of cardiovascular hypertrophy is currently considered an important therapeutic target in reducing the omplications of hypertension. The aim of this study was
John E Moulder et al.
International journal of radiation biology, 90(9), 762-768 (2014-07-06)
We tested five different angiotensin converting enzyme inhibitors (ACEI) as mitigators of experimental radiation nephropathy at drug doses calibrated to the plasma renin activity (PRA). This was done to determine whether all ACEI had the same efficacy as mitigators of
M Tondeur
Revue medicale de Bruxelles, 20(4), A352-A355 (1999-10-19)
The present work briefly describes the radionuclide renal functional tests available for the work up of adult hypertensive patients. The use and specific indications of the different techniques and radiopharmaceuticals are reviewed and summarized. A special attention is given to
Ritesh M Pabari et al.
Clinical therapeutics, 34(11), 2221-2229 (2012-11-15)
Administration of medications to pediatric patients is challenging because many drugs are not commercially available in appropriate dosage formulations and/or strengths. Consequently, these drugs are prepared extemporaneously as oral liquid (OL) formulations using marketed tablets or capsules. In many cases
Zhen-Gui Huang et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 38(3), 381-385 (2013-05-15)
To explore the effect of puerarin combined with felodipine on the mRNA and protein expression of apelin and APJ in renal tissue of renovascular hypertensive rat. Sixty-two Sprague-Dawley rats were used, of which 8 rats were randomly chosen as sham-operation
[Assessment of natriuretic peptides levels in the study of efficacy of perindopril and captopril in myocardial infarction with systolic dysfunction].
Iu A Vasiuk
Terapevticheskii arkhiv, 77(10), 89-93 (2005-12-03)
R I Ogilvie et al.
The Canadian journal of cardiology, 14(8), 1025-1033 (1998-09-17)
Twenty-four splenectomized dogs were subjected to rapid right ventricular pacing (RRVP) at 250 beats/min for five weeks. During the final three weeks, four groups six dogs were untreated or treated with captopril alone, with the angiotensin II type 1 (AT1)
Captopril prevention project--what shall we do about captopril and the risk of stroke?
A Fournier et al.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 15(1), 2-5 (1999-12-23)
Sanya Roysommuti et al.
Advances in experimental medicine and biology, 776, 67-80 (2013-02-09)
Perinatal taurine depletion followed by high sugar intake (postweaning) alters the renin-angiotensin system (RAS) and glucose regulation in adult female rats. This study tests the hypothesis that in adult female rats, RAS and estrogen contribute to insulin resistance resulting from
A O Nur et al.
International journal of pharmaceutics, 194(2), 139-146 (2000-02-29)
The development of oral sustained or controlled release dosage form of captopril has been an interested topic of research for a long period of time. Difficulties encountered with such topic based on the fact that the drug is freely water
Faïza Zidane et al.
Biochemistry, 52(48), 8722-8731 (2013-10-31)
Somatic angiotensin I-converting enzyme (ACE) possesses two catalytic domains and plays a major role in the regulation of blood pressure, thus representing a therapeutic target for the treatment of hypertension. We present a comprehensive surface plasmon resonance (SPR) study of
Ferrante S Gragasin et al.
Anesthesia and analgesia, 116(4), 775-783 (2013-02-23)
Both propofol use and advanced age are predictors of intraoperative hypotension. We previously demonstrated that propofol enhances vasodilation in mesenteric arteries from aged rats, partly due to increased nitric oxide (NO) bioavailability. Patients chronically treated with angiotensin-converting enzyme (ACE) inhibitors
Wenna Zhao et al.
Journal of ethnopharmacology, 145(1), 187-192 (2012-11-13)
ETHNOPHARMACOLOGICA RELEVANCE: Picrasma quassiodes (D. Don) Benn. (PQB) is a widely used herbal medicine used for gastroenteritis, snakebite, infection and hypertension in China. The aim of the study was to investigate the possible antihypertensive mechanisms on spontaneously hypertensive rats (SHR)
Yonghua Sun et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 105, 171-175 (2013-01-10)
Captopril exhibit electrogenerated chemiluminescence (ECL) in NaNO(3) solution when constant current is exerted. Based on this observation, a direct ECL method coupled with high-performance liquid chromatography (HPLC) separation is developed for determination of captopril in human serum. Factors affected the
Javed Mahmood et al.
International journal of radiation oncology, biology, physics, 89(4), 722-728 (2014-05-29)
To investigate the outcome of suppression of the renin angiotensin system using captopril combined with an antioxidant (Eukarion [EUK]-207) for mitigation of radiation-induced lung damage in rats. The thoracic cavity of female Sprague-Dawley rats was irradiated with a single dose
The use of captopril in rheumatoid arthritis: combining treatment targets!
Calin D Popa et al.
The Canadian journal of cardiology, 29(5), 639-639 (2013-04-02)
Antonio C M Camargo et al.
Toxicon : official journal of the International Society on Toxinology, 59(4), 516-523 (2011-08-13)
The identification of novel endogenous and exogenous molecules acting in the complex mechanism of regulating the vascular tonus has always been of great interest. The discovery of bradykinin (1949) and the bradykinin-potentiating peptides (1965) had a pivotal influence in the
G P Kapungu et al.
The journal of physical chemistry. A, 117(13), 2704-2717 (2013-02-16)
By nature of their nucleophilicity, all thiol-based drugs are oxidatively metabolized in the physiological environment. The key to understanding the physiological role of a hypertension drug, (2S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]pyrrolidine-2-carboxylic acid, medically known as captopril is through studying its oxidation pathway: its reactive
Basel A Abdel-Wahab et al.
Chemico-biological interactions, 216, 43-52 (2014-04-09)
Clozapine (CLZ) is the most effective therapeutic alternative in the treatment of resistant schizophrenia. However, the cardiotoxicity of CLZ, particularly in young patients, has raised concerns about its safety. Captopril is a well-known angiotensin-converting enzyme inhibitor with antioxidant properties effective
Sylwia Magiera et al.
Journal of AOAC International, 97(6), 1526-1537 (2015-01-30)
A rapid and sensitive ultra-HPLC/MSIMS (UHPLC/MSIMS) assay method for the simultaneous determination in human urine of 22 drugs belonging to different pharmaceutical groups was developed. The drugs were extracted from urine samples and then separated on a Zorbax Rapid Resolution
Carlo Lombardi et al.
Giornale italiano di cardiologia (2006), 13(10 Suppl 2), 55S-58S (2012-10-26)
Several large-scale trials have demonstrated improved survival with the administration of ACE-inhibitors to patients with a recent myocardial infarction. Many ACE-inhibitors with different pharmacological properties have been shown to be safe and effective. More recently the data provided by the
M Pêco
Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology, 19 Suppl 2, II35-II41 (2001-04-17)
The first application of angiotensin converting enzyme (ACE) inhibitors it was the treatment of arterial hypertension. Latter news application appears such as: heart failure, myocardial infarct, nephropathy and diabetic proteinuria. Captopril, the first oral ACE inhibitor was used, since 1986
Amy C Arnold et al.
Hypertension (Dallas, Tex. : 1979), 61(3), 701-706 (2012-12-26)
At least half of primary autonomic failure patients exhibit supine hypertension, despite profound impairments in sympathetic activity. Although the mechanisms underlying this hypertension are unknown, plasma renin activity is often undetectable, suggesting renin-angiotensin (Ang) pathways are not involved. However, because
Kyung Hee Chang et al.
Nature communications, 6, 5914-5914 (2015-01-13)
Patients with organ failure of vascular origin have increased circulating haematopoietic stem cells and progenitors (HSC/P). Plasma levels of angiotensin II (Ang-II), are commonly increased in vasculopathies. Hyperangiotensinemia results in activation of a very distinct Ang-II receptor set, Rho family
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