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PHR1320

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M Corzo-Martínez et al.
Pharmaceutical research, 32(3), 1055-1071 (2014-10-02)
The aim of this work was to develop a milk-based powder formulation appropriate for pediatric delivery of ritonavir (RIT). Ultra-high pressure homogenization (UHPH) at 0.1, 300 and 500 MPa was used to process a dispersion of pasteurized skim milk (SM)...
Knut Fredrik Seip et al.
Journal of chromatography. A, 1347, 1-7 (2014-05-06)
Electromembrane extraction (EME) was performed on samples containing substantial amounts of NaCl to investigate how the presence of salts affected the recovery, repeatability, and membrane current in the extraction system. A group of 17 non-polar basic drugs with various physical...
Andrea Speltini et al.
Journal of chromatography. A, 1379, 9-15 (2015-01-07)
This work presents a novel analytical method based on graphene for the determination of five widely used fluoroquinolones (FQs) in aqueous matrices. The procedure entails solid-phase extraction (SPE) on graphene-derivatized silica (200mg), followed by liquid chromatography with fluorescence detection. Monolayer...
Kwang Jin Lee et al.
Journal of analytical methods in chemistry, 2014, 150509-150509 (2014-11-12)
The Acer tegmentosum (3 kg) was extracted using hot water, and the freeze-dried extract powder was partitioned successively using dichloromethane (DCM), ethyl acetate (EA), butyl alcohol (n-BuOH), and water. From the EA extract fraction (1.24 g), five phenolic compounds were isolated by...
Carina S D Wink et al.
Analytical and bioanalytical chemistry, 407(6), 1545-1557 (2015-01-13)
Lefetamine (N,N-dimethyl-1,2-diphenylethylamine, L-SPA) was marketed as an opioid analgesic in Japan and Italy. After being widely abused, it became a controlled substance. It seems to be a pharmaceutical lead for designer drugs because N-ethyl-1,2-diphenylethylamine (NEDPA) and N-iso-propyl-1,2-diphenylethylamine (NPDPA) were confiscated...
Oskar Karlsson et al.
Archives of toxicology, 89(3), 423-436 (2014-05-07)
The environmental neurotoxin β-N-methylamino-L-alanine (BMAA) has been implicated in the etiology of neurodegenerative disease, and recent studies indicate that BMAA can be misincorporated into proteins. BMAA is a developmental neurotoxicant that can induce long-term learning and memory deficits, as well...
Md Mujahid et al.
Journal of proteome research, 14(2), 711-727 (2014-11-13)
Aromatic amines are widely distributed in the environment and are major environmental pollutants. Although degradation of aromatic amines is well studied in bacteria, physiological adaptations and stress response to these toxic compounds is not yet fully understood. In the present...
Andreas Bimpilas et al.
Food chemistry, 178, 164-171 (2015-02-24)
Changes in the principal phenolic compounds and metal content during the vinification process and storage under modified atmosphere (50% N2, 50% CO2) of Merlot and Syrah wines, from grapes cultivated in Greece, have been investigated. Comparing the variation of metals...
Tõiv Haljasorg et al.
Journal of agricultural and food chemistry, 62(23), 5259-5268 (2014-05-23)
A wide range of anthropogenic pollutants that possess serious environmental and health risks are known. One type of these harmful substances that have become a focus of interest during the past decade are perfluoroalkyl acids (PFAAs), which are extensively used...
Valentina Trotta et al.
Drug development and industrial pharmacy, 40(9), 1233-1239 (2013-07-11)
Essential requirements for the efficacy of sunscreen agents are optimal UV absorption, high photostability and resistance against water removal. Aim of this study was to investigate the effect of encapsulation in lipid microparticles (LMs) on the overall performance of the...
Alice Pedrali et al.
Journal of pharmaceutical and biomedical analysis, 107, 125-130 (2015-01-16)
N-Acetylglucosamine is an ingredient in pharmaceuticals, nutritional supplements and in cosmetics. N-Acetylglucosamine in cosmetics is expected to improve skin hydration, reparation, and to contribute as anti-wrinkle agent. This study reports on the validation and application of an HPLC method based...
Duc-Viet Nguyen et al.
Molecular pharmaceutics, 12(2), 444-452 (2014-12-17)
Controlled release plays an essential role in formulating topical and transdermal drug delivery systems. In this study, we correlated the skin permeation of Sesamin, a lipophilic drug, with the rheological properties of two different organogel carriers, i.e., low molecular weight...
H Abdallah et al.
Journal of chromatography. A, 1355, 61-72 (2014-06-25)
A new high performance liquid chromatography-high resolution mass spectrometry (HPLC-HRMS) method was developed for a simultaneous multi-residue analysis of 22 sulfonamides (SAs) and their metabolites in edible animal (pig, beef, sheep and chicken) tissues. Sample preparation was optimized on the...
Seyedsina Moeinzadeh et al.
Tissue engineering. Part A, 21(1-2), 134-146 (2014-07-23)
An attractive approach to reduce the undesired side effects of bone morphogenetic proteins (BMPs) in regenerative medicine is to use osteoinductive peptide sequences derived from BMPs. Although the structure and function of BMPs have been studied extensively, there is limited...
Tomáš Řezanka et al.
Phytochemistry, 110, 37-45 (2015-01-08)
This study describes the identification of regioisomers and enantiomers of triacylglycerols of C20 polyunsaturated fatty acids (PUFAs) in the alga Trachydiscus minutus cultivated at different temperatures using reversed- and chiral-phase liquid chromatography-mass spectrometry. The use of the two different phases...
Xiaoqiang Chen et al.
Environmental science and pollution research international, 22(4), 2788-2799 (2014-09-12)
Although bisphenol A (BPA), a representative endocrine-disrupting compound, has been detected frequently in landfill leachate, effective technologies for BPA removal from landfill leachates are limited. We used high silica Y-type zeolite (HSZ-385) for the selective adsorption of BPA from landfill...
Heidi S Schultz et al.
Journal of immunology (Baltimore, Md. : 1950), 194(7), 3169-3179 (2015-03-01)
Osteoclast-associated receptor (OSCAR) is widely expressed on human myeloid cells. Collagen types (Col)I, II, and III have been described as OSCAR ligands, and ColII peptides can induce costimulatory signaling in receptor activator for NF-κB-dependent osteoclastogenesis. In this study, we isolated...
Richard H Lindberg et al.
Water research, 58, 221-229 (2014-04-29)
The concentrations and behaviour of 105 different active pharmaceutical ingredients (APIs) in the aqueous phase of sewage water within a municipal sewer collection system have been investigated. Sewage water samples were gathered from seven pump stations (one of which was...
Liming Wu et al.
Food chemistry, 173, 1111-1118 (2014-12-04)
Nucleotides, nucleosides and nucleobases play a greater role in the physiological activity of organisms which are highly present in royal jelly (RJ). The objective of the present study is to develop a HPLC method to simultaneous determine nucleotides, nucleosides and...
K Kishii et al.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 20(5), 424-430 (2013-10-16)
The clinical relevance of Acinetobacter species, other than A. baumannii, as human pathogens has not been sufficiently assessed owing to the insufficiency of simple phenotypic clinical diagnostic laboratory tests. Infections caused by these organisms have different impacts on clinical outcome...
Shannon L Haughney et al.
Nanoscale, 6(22), 13770-13778 (2014-10-07)
Acute respiratory infections represent a significant portion of global morbidity and mortality annually. There is a critical need for efficacious vaccines against respiratory pathogens. To vaccinate against respiratory disease, pulmonary delivery is an attractive route because it mimics the route...
Yong Fan et al.
Journal of pharmaceutical and biomedical analysis, 95, 213-219 (2014-04-02)
Sample extraction is the first challenge in analysis of herbal medicines (HMs). Numerous methods have been developed to improve extraction efficiency, use less solvent and short time. In this work, a tissue-smashing based ultra-rapid extraction (TSURE) method has been proposed...
Wenjing Guo et al.
Antonie van Leeuwenhoek, 107(4), 1017-1027 (2015-01-30)
Carotenoids are a naturally occurring and widely distributed group of pigments that provide protection against photooxidation and inactivate free radicals due to their highly conjugated double-bond systems. Phytoene dehydrogenation is the first rate-limiting step in the carotenoid biosynthetic pathway. Phytoene...
Yogini Jaiswal et al.
European journal of mass spectrometry (Chichester, England), 20(5), 383-393 (2015-02-25)
Curcuma longa L. is recognized for its therapeutic and culinary uses both in Ayurveda and traditional Chinese medicine and is considered to be a boon to mankind. It has been extensively studied for its benefits and still continues to be...
Kabo Masisi et al.
Journal of agricultural and food chemistry, 63(10), 2715-2724 (2015-02-24)
The antioxidant potential of carotenoids from aleurone, germ, and endosperm fractions of barley, corn, and wheat has been evaluated. HPLC analysis confirmed the presence of lutein and zeaxanthin carotenoids (nd-15139 μg/kg) in extracts of cereal grain fractions. The antioxidant properties...
Scott Boitano et al.
PloS one, 9(6), e99140-e99140 (2014-06-14)
Protease-activated receptor-2 (PAR2) is a G-Protein Coupled Receptor (GPCR) activated by proteolytic cleavage to expose an attached, tethered ligand (SLIGRL). We evaluated the ability for lipid-tethered-peptidomimetics to activate PAR2 with in vitro physiological and Ca2+ signaling assays to determine minimal...
Wenpei Fan et al.
Biomaterials, 35(32), 8992-9002 (2014-08-12)
To achieve the accurate diagnosis and efficient in situ therapy of malignant tumors is encouraging but still remains a big challenge. The integration of upconversion nanoparticles and mesoporous silica that can combine the diagnostic/therapeutic functions within a single platform, may...
Wanyuan Gui et al.
Chemphyschem : a European journal of chemical physics and physical chemistry, 16(3), 607-613 (2014-12-11)
A pH-controlled delivery system based on mesoporous silica nanoparticles (MSNs) was constructed for dual-cargo selective release. To achieve a better controlled-release effect, a modified sol-gel method was employed to obtain MSNs with tunable particle and pore sizes. The systems selectively...
Benjamin J Pages et al.
Dalton transactions (Cambridge, England : 2003), 43(41), 15566-15575 (2014-09-10)
Eight platinum(II) complexes with anticancer potential have been synthesised and characterised. These complexes are of the type [Pt(I(L))(A(L))](2+), where I(L) is either dipyrido[3,2-f:2',3'-h]quinoxaline (dpq) or 2,3-dimethyl-dpq (23Me2dpq) and A(L) is one of the R,R or S,S isomers of either 1,2-diaminocyclohexane...
Yuliya K Nikitina et al.
Journal of chromatography. A, 1363, 71-78 (2014-09-04)
The adsorption of two typical hydro-organic mobile phases, with methanol and acetonitrile as the organic component, on an antibiotic based chiral stationary phase (CSP) Nautilus-E was studied by the minor perturbation method. In both cases, the excess adsorption of water...
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