Merck
Search Within
Applied Filters:
Keyword:'phr1330'
Showing 1-30 of 570 results for "

phr1330

" within Papers
Sort by Relevance
Ilaria Naldi et al.
PloS one, 9(5), e98101-e98101 (2014-05-24)
Epigenetic events are critical contributors to the pathogenesis of cancer, and targeting epigenetic mechanisms represents a novel strategy in anticancer therapy. Classic demethylating agents, such as 5-Aza-2'-deoxycytidine (Decitabine), hold the potential for reprograming somatic cancer cells demonstrating high therapeutic efficacy
Chuanshan Zhang et al.
Parasitology research, 113(10), 3745-3757 (2014-07-21)
Smad family proteins are essential cellular mediators of the transforming growth factor-β superfamily. In the present study, we identified two members of the Smad proteins, Smad8 and Smad4 homologues (termed as EgSmadE and EgSmadD, respectively), from Echinococcus granulosus, the causative
Jize Zhang et al.
PloS one, 10(4), e0123596-e0123596 (2015-04-23)
With the development of the poultry industry, ammonia, as a main contaminant in the air, is causing increasing problems with broiler health. To date, most studies of ammonia toxicity have focused on the nervous system and the gastrointestinal tract in
Cara L Sherwood et al.
American journal of physiology. Cell physiology, 307(8), C718-C726 (2014-08-22)
The airway epithelium provides a barrier that separates inhaled air and its various particulates from the underlying tissues. It provides key physiological functions in both sensing the environment and initiating appropriate innate immune defenses to protect the lung. Protease-activated receptor-2
Yee-Ki Lee et al.
Pflugers Archiv : European journal of physiology, 466(9), 1831-1844 (2013-12-12)
Friedreich ataxia (FRDA), a recessive neurodegenerative disorder commonly associated with hypertrophic cardiomyopathy, is due to GAA repeat expansions within the first intron of the frataxin (FXN) gene encoding the mitochondrial protein involved in iron-sulfur cluster biosynthesis. The triplet codon repeats
Ana Gracanin et al.
PloS one, 9(6), e98698-e98698 (2014-06-03)
Pet dogs very frequently develop spontaneous mammary tumors and have been suggested as a good model organism for breast cancer research. In order to obtain an insight into underlying signaling mechanisms during canine mammary tumorigenesis, in this study we assessed
Antonia Hildebrand et al.
Molecular vision, 20, 1749-1757 (2015-01-06)
Corneal transplantation is the most frequent and successful form of tissue transplantation in adults (<10% rejection). In young children, any corneal opacity should be corrected as early as possible to prevent lifelong visual impairment. However, the corneal graft rejection rate
Toshihiro Sato et al.
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 17(4), 475-484 (2015-01-13)
Organic anion-transporting polypeptide (OATP) 1B1 and OATP1B3 contribute to hepatic uptake of numerous drugs. Thus, reduced OATP1B1 and OATP1B3 activity in chronic kidney disease (CKD) may have a major impact on the hepatic clearance of drugs. The effect of drug-uremic
Vijesh Kumar et al.
Journal of chromatography. A, 1368, 155-162 (2014-12-03)
Aggregates of monoclonal antibody (mAb) therapeutics, due to their perceived impact on immunogenicity, are recognized as a critical quality attribute by the regulatory authorities as well as the industry. Hence, removal of aggregates is a key objective of bioprocessing. At
Elenaz Naderkhani et al.
Journal of pharmaceutical sciences, 103(2), 661-668 (2014-01-08)
The antiviral drug acyclovir (ACV) suffers from poor solubility both in lipophilic and hydrophilic environment, leading to low and highly variable bioavailability. To overcome these limitations, this study aimed at designing mucoadhesive ACV-containing liposomes to improve its permeability. Liposomes were
Marco Pistolozzi et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 968, 69-78 (2014-01-30)
A series of novel tocainide analogues were characterized for their HSA and RSA binding, by using high-performance liquid affinity chromatography (HPLAC) and circular dichroism (CD). In this HPLAC study, HSA and RSA were covalently immobilized to the silica matrix of
Toru Taguchi et al.
Pain, 156(3), 415-427 (2015-01-20)
Chronic widespread pain is a serious medical problem, yet the mechanisms of nociception and pain are poorly understood. Using a reserpine-induced pain model originally reported as a putative animal model for fibromyalgia, this study was undertaken to examine the following:
Ronald P M Gonçalves et al.
Shock (Augusta, Ga.), 42(5), 415-423 (2014-07-09)
The aim of the present study was to investigate the existence of gender-related differences in the profile of changes that occur in cardiac functionality during endotoxic shock. For this, both male and female Wistar rats received a single injection of
Ann T Hanna-Mitchell et al.
The Journal of endocrinology, 222(1), 113-121 (2014-05-16)
Corticotropin-releasing factor (CRF) plays a central role in the orchestration of behavioral and neuroendocrine responses to stress. The family of CRF-related peptides (CRF and paralogs: urocortin (Ucn)-I, -II, and -III) and associated receptors (CRFR1 and CRFR2) are also expressed in
Sabine May et al.
Pharmaceutical research, 31(11), 3211-3224 (2014-05-24)
The aim of this study was to investigate influencing factors on the dissolution test for powders for pulmonary delivery with USP apparatus 2 (paddle apparatus). We investigated the influence of dose collection method, membrane holder type and the presence of
Elżbieta Sikora et al.
Colloids and surfaces. B, Biointerfaces, 126, 541-545 (2015-01-27)
The skin permeation of forskolin, a diterpene isolated from Coleus forsholii, was studied using oil in water (O/W) emulsions as delivery formulations and also an oil solution for comparative purposes. Two forskolin-loaded emulsions of water/Brij 72:Symperonic A7/Miglyol 812:Isohexadecane, at 0.075
Silke Beermann et al.
PloS one, 9(9), e107481-e107481 (2014-09-23)
Histamine (HA) is recognized by its target cells via four G-protein-coupled receptors, referred to as histamine H1-receptor (H1R), H2R, H3R, and H4R. Both H1R and H4R exert pro-inflammatory functions. However, their signal transduction pathways have never been analyzed in a
Casper Skovgaard et al.
Journal of applied physiology (Bethesda, Md. : 1985), 117(10), 1097-1109 (2014-09-06)
The purpose of this study was to examine whether speed endurance training (SET, repeated 30-s sprints) and heavy resistance training (HRT, 80-90% of 1 repetition maximum) performed in succession are compatible and lead to performance improvements in moderately trained endurance
Cuilian Tao et al.
Dalton transactions (Cambridge, England : 2003), 43(41), 15482-15490 (2014-09-06)
Magnetic mesoporous silica (MMS) nanoparticles with controllable magnetization have been synthesized by encapsulating Fe3O4 nanoparticles in a mesoporous silica matrix. The structure, magnetic heating capacity and drug delivery ability of MMS nanoparticles were evaluated. The results showed that MMS nanoparticles
Aude Couturier et al.
Molecular vision, 20, 908-920 (2014-06-27)
To evaluate whether anti-vascular endothelial growth factor (VEGF) neutralizing antibodies injected in the vitreous of rat eyes influence retinal microglia and macrophage activation. To dissociate the effect of anti-VEGF on microglia and macrophages subsequent to its antiangiogenic effect, we chose
Reiko Yamagishi et al.
Molecular vision, 20, 1796-1805 (2015-01-17)
Astaxanthin is a type of carotenoid known to have strong antioxidant effects. The purpose of this study was to investigate whether astaxanthin confers a neuroprotective effect against glutamate stress, oxidative stress, and hypoxia-induced apoptotic or necrotic cell death in primary
Alana M Hahn et al.
The Journal of pharmacology and experimental therapeutics, 351(3), 605-615 (2014-10-09)
Prostatic inflammation is of considerable importance to urologic research because of its association with benign prostatic hyperplasia and prostate cancer. However, the mechanisms by which inflammation leads to proliferation and growth remain obscure. Here, we show that insulin-like growth factors
Zelene Edith Vázquez-Zamorano et al.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 27(4), 683-693 (2014-06-19)
Streptococcus pneumoniae is a gram positive encapsulated bacterium responsible of septicaemia and upper respiratory infections in children. This pathogen requires iron to survive in the host, which it can obtain of haemoglobin (Hb) or haem. Only two Hb-binding membrane proteins
Zeljka Car et al.
Chemical biology & drug design, 84(4), 393-401 (2014-03-29)
Structural alterations of the aglycon portions of α-mannosides influence their inhibitory potency toward type 1-fimbriated Escherichia coli. The aim of our work was to prepare and explore inhibitory properties of novel mannosylated N-aryl-substituted 3-hydroxypyridine-4-ones because they possess needed structural characteristics
Alban Bujard et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 63, 36-44 (2014-07-11)
The parallel artificial membrane permeability assay (PAMPA) is a high-throughput screening (HTS) method that is widely used to predict in vivo passive permeability through biological barriers, such as the skin, the blood brain barrier (BBB) and the gastrointestinal tract (GIT).
D H Currie et al.
Applied and environmental microbiology, 80(16), 5001-5011 (2014-06-08)
Thermoanaerobacterium saccharolyticum, a Gram-positive thermophilic anaerobic bacterium, grows robustly on insoluble hemicellulose, which requires a specialized suite of secreted and transmembrane proteins. We report here the characterization of proteins secreted by this organism. Cultures were grown on hemicellulose, glucose, xylose
Naozumi Ohnishi et al.
Chemical & pharmaceutical bulletin, 62(6), 538-544 (2014-06-03)
A novel in vitro release test methodology for a liposome formulation was developed using a column-switching high-performance liquid chromatography (HPLC) system. Doxorubicin (DXR) liposome formulations were used as a model. A DXR liposome formulation was dispersed into a release medium
Claire O Malécot et al.
Journal of cardiovascular electrophysiology, 26(3), 311-319 (2014-10-28)
Ectopic activity arising from pulmonary veins (PV) plays a prominent role in the onset of atrial fibrillation in humans. Rat PV cardiac muscle cells have a lower resting membrane potential (RMP) than the left atria (LA) and presents in the
Hamid Reza Moazami et al.
Analytica chimica acta, 841, 24-32 (2014-08-12)
In order to understand the limitations of electromebrane extraction procedure better, a simple equivalent circuit has been proposed for a supported liquid membrane consisting of a resistor and a low leakage capacitor in series. To verify the equivalent circuit, it
Edwin L de Vrij et al.
PloS one, 9(4), e93218-e93218 (2014-04-12)
Hibernation is an energy-conserving behavior in winter characterized by two phases: torpor and arousal. During torpor, markedly reduced metabolic activity results in inactivity and decreased body temperature. Arousal periods intersperse the torpor bouts and feature increased metabolism and euthermic body
Page 1 of 19
Page 1 of 19