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Qian Gao et al.
Biochemical and biophysical research communications, 453(1), 37-42 (2014-09-24)
Beta-B2-crystallin (CRYBB2), encoded by Crybb2 gene, is a major protein in the mammalian eye lens that plays an important role in maintaining the transparency of the ocular lens. However, CRYBB2 also plays important roles in many extra-lenticular tissues and organs...
Yee-Ming Chan et al.
The Journal of clinical endocrinology and metabolism, 99(12), E2762-E2771 (2014-09-17)
Idiopathic hypogonadotropic hypogonadism (IHH) results from defective synthesis, secretion, or action of GnRH. Kisspeptin is a potent stimulus for GnRH secretion. We probed the functional capacity of the GnRH neuronal network in patients with IHH. Eleven subjects with congenital IHH...
Sébastien Fournier et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 308(7), R659-R667 (2015-02-06)
Human and animal studies on sleep-disordered breathing and respiratory regulation show that the effects of sex hormones are heterogeneous. Because neonatal stress results in sex-specific disruption of the respiratory control in adult rats, we postulate that it might affect respiratory...
Indu Upadhyaya et al.
Applied and environmental microbiology, 81(9), 2985-2994 (2015-02-25)
Salmonella enterica serovar Enteritidis is a major foodborne pathogen in the United States, causing gastroenteritis in humans, primarily through consumption of contaminated eggs. Chickens are the reservoir host of S. Enteritidis. In layer hens, S. Enteritidis colonizes the intestine and...
Zeranol and 17 beta-estradiol: a critical review of the toxicological properties when used as anabolic agents.
R Truhaut et al.
Regulatory toxicology and pharmacology : RTP, 5(3), 276-283 (1985-09-01)
Matthew M Roforth et al.
PloS one, 9(4), e95987-e95987 (2014-04-30)
The effects of 17-β-estradiol in osteoblasts are primarily mediated by the nuclear transcription factors, estrogen receptor (ER)α and ERβ. ERs function through three general modes of action: DNA-binding dependent through estrogen response elements (EREs; designated nuclear ERE signaling); nuclear signaling...
Hye Yeon Choi et al.
PloS one, 9(6), e99421-e99421 (2014-06-13)
Placenta, as a reservoir of nutrients, has been widely used in medical and cosmetic materials. Here, we focused on the antioxidant properties of placental extract and attempted to isolate and identify the main antioxidant factors. Porcine placental extracts were prepared...
Thomas R Gawriluk et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(40), E4194-E4203 (2014-09-24)
Autophagy is an important cellular process that serves as a companion pathway to the ubiquitin-proteasome system to degrade long-lived proteins and organelles to maintain cell homeostasis. Although initially characterized in yeast, autophagy is being realized as an important regulator of...
Meiyan Sun et al.
Endocrinology, 155(8), 2787-2796 (2014-05-16)
Calcium-dependent chloride conductances have been described in chicken and human granulosa cells (GCs) and may be involved in steroidogenesis. However, the molecular identities of corresponding chloride channels remain unknown. The purpose of this study was to explore the expression and...
Philipp Y Maximov et al.
Journal of medicinal chemistry, 57(11), 4569-4583 (2014-05-09)
Tamoxifen has biologically active metabolites: 4-hydroxytamoxifen (4OHT) and endoxifen. The E-isomers are not stable in solution as Z-isomerization occurs. We have synthesized fixed ring (FR) analogues of 4OHT and endoxifen as well as FR E and Z isomers with methoxy...
Ayse Gul Kebapcilar et al.
Archives of gynecology and obstetrics, 290(6), 1255-1263 (2014-07-16)
Previous studies suggest that serum IGF-1 is higher in women with polycystic ovary syndrome (PCOS). The ophthalmologic effects of IGF-1 excess have not yet been investigated in women with PCOS. The aim of the current study is to compare the...
Gülşah Aynaoğlu Yıldız et al.
European journal of obstetrics, gynecology, and reproductive biology, 182, 66-70 (2014-09-23)
To determine the effects of addition of different dosages of gonadotrophin releasing hormone agonist (GnRH-a) to routine luteal phase support (LPS) on implantation and pregnancy rates. Three hundred infertile couples who were treated by intracytoplasmic sperm injection and embryo transfer...
Enrique Fuentes-Mattei et al.
Journal of the National Cancer Institute, 106(7), doi:10-doi:10 (2014-06-25)
Obesity increases the risk of cancer death among postmenopausal women with estrogen receptor-positive (ER+) breast cancer, but the direct evidence for the mechanisms is lacking. The purpose of this study is to demonstrate direct evidence for the mechanisms mediating this...
J M Gámez et al.
Environmental toxicology and pharmacology, 39(1), 9-15 (2014-12-02)
The research work studies the effect of providing a low dose of bisphenol A (BPA), on the reproductive axis of prepubertal female rats. Wistar mated rats were treated with either 0.1% ethanol or BPA in their drinking water until their...
Astrid M Pedersen et al.
International journal of oncology, 45(5), 2167-2175 (2014-09-02)
Tamoxifen‑resistant breast cancer is a major clinical problem and new treatment strategies are highly warranted. In this study, the multitargeting kinase inhibitors sorafenib and nilotinib were investigated as potential new treatment options for tamoxifen‑resistant breast cancer. The two compounds inhibited...
Kasey A Reynolds et al.
Human reproduction (Oxford, England), 28(11), 2981-2989 (2013-07-28)
Does a luteal estradiol (LE) stimulation protocol improve outcomes in poor responders to IVF? LE priming is associated with decreased cycle cancellation and increased chance of clinical pregnancy in poor responders Poor responders to IVF are one of the most...
Andrea S Fung et al.
BMC cancer, 15, 112-112 (2015-04-18)
The growth of solid tumors and their regrowth after treatment is dependent upon functional tumor vasculature. Some chemotherapeutic agents have shown anti-angiogenic properties but there are limited studies of the effect of chemotherapy on tumor vasculature. Here we investigate the...
Aniruddha Das et al.
Archives of sexual behavior, 43(7), 1403-1415 (2014-03-07)
Using nationally representative data from the 2005-2006 U.S. National Social Life, Health, and Aging Project, this study queried relationship, sexual, and sex hormone patterns among married evangelical women and men aged 57-85, relative to those in other religions. Results suggested...
Estrogens and myocardial chymase: new insights into pathological hypertrophy and remodeling.
Jorge E Jalil et al.
Hypertension (Dallas, Tex. : 1979), 65(2), 271-272 (2014-11-19)
Lee P Shulman
The journal of family planning and reproductive health care, 39(3), 211-216 (2013-05-28)
Initial oral contraceptive regimens were characterised by high doses of ethinylestradiol (EE) and a progestogen in a 21-day regimen that either included seven additional hormone-free tablets or simply the 21 days of combination hormonal tablets. These regimens were developed to ensure...
Hey-Yon Kim et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(1), 300-313 (2014-10-30)
Polycomb protein chromobox homolog 7 (CBX7) is involved in several biologic processes including stem cell regulation and cancer development, but its roles in breast cancer remain unknown. Here, we demonstrate that CBX7 negatively regulates breast tumor initiation. CD44(+)/CD24(-)/ESA(+) breast stem-like...
Fernando H C de Souza et al.
Clinical and experimental rheumatology, 33(1), 44-49 (2015-01-13)
To assess ovarian reserve markers and anti-corpus luteum (anti-CoL) antibodies in dermatomyositis (DM) patients. Forty female DM patients were invited to participate. Exclusion criteria included hormonal contraceptive use within the last six months, neoplasia associations, overlapped systemic autoimmune diseases, current...
D S Stenbæk et al.
Human reproduction (Oxford, England), 30(1), 103-110 (2014-11-16)
Do mental distress and mood fluctuations in women undergoing GnRH agonist and GnRH antagonist protocols for assisted reproductive technology (ART) differ depending on protocol and the personality trait, neuroticism? ART treatment did not induce elevated levels of mental distress in...
Kara J Connelly et al.
Endocrinology, 156(1), 193-202 (2014-10-21)
Peak bone mass, one of the most important predictors for fracture risk later in life, is attained during puberty and adolescence and influenced by neonatal and pubertal sex-specific gonadal hormones and GH-IGF-I secretion patterns. This study examined the effects of...
Maria T Hultman et al.
Aquatic toxicology (Amsterdam, Netherlands), 159, 233-244 (2015-01-07)
Vitellogenin (Vtg) induction in primary fish hepatocytes has been proposed as an in vitro screening assay for ER agonists and antagonists, but has not yet been used extensively as a high-throughput screening tool due to poor reproducibility, sensitivity and overall...
Baojian Xue et al.
American journal of physiology. Heart and circulatory physiology, 307(2), H191-H198 (2014-05-27)
This study investigated sex differences in the sensitization of angiotensin (ANG) II-induced hypertension and the role of central estrogen and ANG-(1-7) in this process. Male and female rats were implanted for telemetered blood pressure (BP) recording. A subcutaneous subpressor dose...
Joanna H Sliwowska et al.
Alcoholism, clinical and experimental research, 38(11), 2780-2789 (2014-11-26)
Prenatal alcohol exposure (PAE) has adverse effects on reproductive function and hypothalamic-pituitary-gonadal (HPG) activity. Kisspeptin neurons play a role in mediating feedback effects of estradiol (E2 ) and progesterone (P4 ) on the HPG axis. We hypothesized that PAE will...
Yayun Liang et al.
Breast cancer research and treatment, 146(1), 51-62 (2014-06-01)
In most human breast cancers, tumor cell proliferation is estrogen dependent. Although hormone-responsive tumors initially respond to anti-estrogen therapies, most of them eventually develop resistance. Our goal was to identify alternative targets that might be regulated to control breast cancer...
Richard H Lindberg et al.
Water research, 58, 221-229 (2014-04-29)
The concentrations and behaviour of 105 different active pharmaceutical ingredients (APIs) in the aqueous phase of sewage water within a municipal sewer collection system have been investigated. Sewage water samples were gathered from seven pump stations (one of which was...
Shuuji Mawaribuchi et al.
Endocrinology, 155(10), 3996-4005 (2014-07-23)
The African clawed frog, Xenopus laevis, has a ZZ/ZW-type sex-determination system. We previously reported that a W-linked gene, Dm-W, can determine development as a female. However, the mechanisms of early sex differentiation remain unclear. We used microarrays to screen for...
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