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PHR1359

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Juliano Boufleur Farinha et al.
Life sciences, 121, 152-157 (2014-12-17)
The aim of this study was to investigate the effects of an active lifestyle on mitochondrial functioning, viability, bioenergetics, and redox status markers in peripheral blood mononuclear cells (PBMC) of overweight/ obese postmenopausal women. We performed a cross-sectional study with...
Yilin Wang et al.
Journal of proteomics, 108, 484-493 (2014-06-24)
Plant receptor-like kinases (RLKs) constitute a large family of receptors coordinating developmental programs with adaptation to environmental stresses including immune defenses. BRI1-ASSOCIATED KINASE 1 (BAK1), a member of the plant RLK family, forms receptor complexes with multiple RLK proteins including...
Danzil Joseph et al.
Life sciences, 105(1-2), 31-42 (2014-04-22)
Although acute hyperglycemic (AHG) episodes are linked to lower glucose uptake, underlying mechanisms remain unclear. We hypothesized that AHG triggers reactive oxygen species (ROS) production and increases non-oxidative glucose pathway (NOGP) activation, i.e. stimulation of advanced glycation end products (AGE)...
Doriane Lorendeau et al.
Biochemical pharmacology, 90(3), 235-245 (2014-05-31)
The multidrug resistance protein 1 (MRP1) is involved in multidrug resistance of cancer cells by mediating drug efflux out of cells, often in co-transport with glutathione (GSH). GSH efflux mediated by MRP1 can be stimulated by verapamil. In cells overexpressing...
Yanzhong Yang et al.
Nature communications, 6, 6428-6428 (2015-03-05)
The human genome encodes a family of nine protein arginine methyltransferases (PRMT1-9), whose members can catalyse three distinct types of methylation on arginine residues. Here we identify two spliceosome-associated proteins-SAP145 and SAP49-as PRMT9-binding partners, linking PRMT9 to U2 snRNP maturation....
Jenna Oberstaller et al.
Nucleic acids research, 42(13), 8271-8284 (2014-06-25)
We provide the first comprehensive analysis of any transcription factor family in Cryptosporidium, a basal-branching apicomplexan that is the second leading cause of infant diarrhea globally. AP2 domain-containing proteins have evolved to be the major regulatory family in the phylum...
Jie Zhang et al.
PloS one, 9(9), e107478-e107478 (2014-09-13)
To interrogate why redox homeostasis and glutathione S-transferase P (GSTP) are important in regulating bone marrow cell proliferation and migration, we isolated crude bone marrow, lineage negative and bone marrow derived-dendritic cells (BMDDCs) from both wild type (WT) and knockout...
Leyi Wang et al.
Biomaterials, 35(29), 8427-8438 (2014-07-06)
Many viral structural proteins and their truncated domains share a common feature of homotypic interaction forming dimers, trimers, and/or oligomers with various valences. We reported previously a simple strategy for construction of linear and network polymers through the dimerization feature...
Henriette Franz et al.
Oncotarget, 6(7), 4773-4789 (2015-03-10)
The histone code reader Spindlin1 (SPIN1) has been implicated in tumorigenesis and tumor growth, but the underlying molecular mechanisms remain poorly understood. Here, we show that reducing SPIN1 levels strongly impairs proliferation and increases apoptosis of liposarcoma cells in vitro...
Fariha Khan et al.
Nucleic acids research, 42(13), 8705-8718 (2014-06-25)
Glycine-rich RNA-binding proteins (GR-RBPs) are involved in cold shock response of plants as RNA chaperones facilitating mRNA transport, splicing and translation. GR-RBPs are bipartite proteins containing a RNA recognition motif (RRM) followed by a glycine-rich region. Here, we studied the...
Jessica Healy et al.
Biochemistry, 53(12), 1982-1992 (2014-03-08)
The potassium efflux system, Kef, protects bacteria against the detrimental effects of electrophilic compounds via acidification of the cytoplasm. Kef is inhibited by glutathione (GSH) but activated by glutathione-S-conjugates (GS-X) formed in the presence of electrophiles. GSH and GS-X bind...
Ahmadreza Sardarian et al.
Toxicology mechanisms and methods, 25(2), 98-104 (2014-11-25)
Cyclosporine A (CsA) is an immunosuppressive agent administered to transplant patients. A well-known reported oral side effect of CsA consumption is gingival overgrowth (GO). Changes in the expression of integrins occurring in the gingiva following CsA treatment have been reported...
Rieko Chiba et al.
Microbes and infection, 16(8), 702-706 (2014-06-18)
Visceral leishmaniasis is protozoonosis that occurs worldwide and still requires effective therapies with less toxicity. In this study, we examined the antileishmanial effect of nerve growth factor (NGF) using a murine infection model. NGF blocked the infection of macrophages by...
Simona Panni et al.
Journal of biochemistry, 157(2), 101-111 (2014-09-28)
Proline-rich motifs are widely distributed in eukaryotic proteomes and are usually involved in the assembly of functional complexes through interaction with specific binding modules. The tumour-suppressor p53 protein presents a proline-rich region that is crucial for regulating apoptosis by connecting...
Liang Zheng et al.
Nature communications, 6, 6001-6001 (2015-01-24)
Mutations in the tricarboxylic acid (TCA) cycle enzyme fumarate hydratase (FH) are associated with a highly malignant form of renal cancer. We combined analytical chemistry and metabolic computational modelling to investigate the metabolic implications of FH loss in immortalized and...
Ling Liu et al.
Environmental toxicology and pharmacology, 39(1), 229-236 (2014-12-22)
Cadmium (Cd), a non-essential heavy metal, is one of the major environmental contaminants with grave toxicological consequences globally. In the present study, the effects of Cd on hepatic oxidative stress and inflammatory responses in mice were evaluated. Male adult mice...
Poyil Pratheeshkumar et al.
Toxicology and applied pharmacology, 281(2), 230-241 (2014-12-03)
Hexavalent chromium [Cr(VI)] is a well-known human carcinogen associated with the incidence of lung cancer. Inhibition of metal induced carcinogenesis by a dietary antioxidant is a novel approach. Luteolin, a natural dietary flavonoid found in fruits and vegetables, possesses potent...
B Li et al.
Free radical research, 48(7), 758-768 (2014-04-12)
Stromal interaction molecule (STIM) proteins are parts of elaborate eukaryotic Ca(2+) signaling systems and are considered to be important players in regulating neuronal Ca(2+) homeostasis under normal ageing and pathological conditions. Here, we investigated the potential role of STIM1 in...
Yao-Tsung Yeh et al.
Free radical biology & medicine, 74, 1-13 (2014-06-22)
Phenethyl isothiocyanate (PEITC) is a naturally occurring cruciferous vegetable-derived compound that inhibits cell growth and induces apoptosis in oral cancer cells. However, the exact mechanism of PEITC action has not been fully elucidated. This study investigated the molecular mechanism and...
Elisabeth Zapatero-Solana et al.
Orphanet journal of rare diseases, 9, 211-211 (2014-12-22)
Kindler Syndrome (KS) is an autosomal recessive skin disorder characterized by skin blistering, photosensitivity, premature aging, and propensity to skin cancer. In spite of the knowledge underlying cause of this disease involving mutations of FERMT1 (fermitin family member 1), and...
Yukio Akasaki et al.
Arthritis & rheumatology (Hoboken, N.J.), 66(12), 3349-3358 (2014-09-05)
A major signaling pathway that regulates cellular aging is the insulin/insulin-like growth factor 1 (IGF-1)/phosphatidylinositol 3-kinase (PI3K)/Akt/FoxO transcription factor axis. We previously observed that FoxO transcription factors are dysregulated in aged and OA cartilage. The objective of this study was...
Yong-Cheng Ma et al.
Toxicology and applied pharmacology, 282(2), 227-236 (2014-12-03)
Jaridonin, a novel diterpenoid from Isodon rubescens, has been shown previously to inhibit proliferation of esophageal squamous cancer cells (ESCC) through G2/M phase cell cycle arrest. However, the involved mechanism is not fully understood. In this study, we found that...
A Dadkhah et al.
Pharmaceutical biology, 53(2), 220-227 (2014-09-23)
Achillea wilhelmsii C. Koch (Asteraceae) is widely used in Iranian traditional medicine. This in vivo study evaluates the hepatoprotective role of Iranian A. wilhelmsii oils against acetaminophen-induced oxidative damages in rats. The animals were divided into five groups: in negative...
Ling Gu et al.
Cellular and molecular life sciences : CMLS, 72(2), 251-271 (2014-10-05)
Obesity, diabetes, and related metabolic disorders are major health issues worldwide. As the epidemic of metabolic disorders continues, the associated medical co-morbidities, including the detrimental impact on reproduction, increase as well. Emerging evidence suggests that the effects of maternal nutrition...
Yasutada Akiba et al.
The Journal of physiology, 593(3), 585-599 (2014-11-30)
Luminal lipid in the duodenum modulates gastroduodenal functions via the release of gut hormones and mediators such as cholecystokinin and 5-HT. The effects of luminal short-chain fatty acids (SCFAs) in the foregut are unknown. Free fatty acid receptors (FFARs) for...
Junyan Han et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 70, 100-106 (2014-05-07)
We attempted to determine whether betanin (from natural pigments) that has anti-oxidant properties would be protective against paraquat-induced liver injury in Sprague-Dawley rats. Paraquat was injected intraperitoneally into rats to induce liver toxicity. The rats were randomly divided into four...
Mohd Asgher et al.
Ecotoxicology and environmental safety, 106, 54-61 (2014-05-20)
We studied the response of ethylene-sensitive (Pusa Jai Kisan) and ethylene-insensitive (SS2) mustard (Brassica juncea) cultivars to 0, 0.5, 1.0 and 2.0 mM SO₄(2-), and the effect of 1.0 mM SO₄(2-) was studied in the amelioration of 50 µM cadmium...
Miki Watanabe-Matsui et al.
Archives of biochemistry and biophysics, 565, 25-31 (2014-12-03)
The transcriptional repressor Bach2 regulates humoral and cellular immunity, including antibody class switching. It possesses a basic leucine zipper domain that mediates DNA binding. Heme inhibits the DNA-binding activity of Bach2 in vitro and induces the degradation of Bach2 in...
Alakesh Bera et al.
PloS one, 9(8), e104640-e104640 (2014-08-15)
Herpesvirus capsids are regular icosahedrons with a diameter of a 125 nm and are made up of 162 capsomeres arranged on a T = 16 lattice. The capsomeres (VP5) interact with the triplex structure, which is a unique structural feature...
Maurizio Pulici et al.
ChemMedChem, 10(2), 276-295 (2014-11-29)
Aberrant activation of the mitogen-activated protein kinase (MAPK)-mediated pathway components, RAF-MEK-ERK, is frequently observed in human cancers and clearly contributes to oncogenesis. As part of a project aimed at finding inhibitors of B-Raf, a key player in the MAPK cascade...
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