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Mohammed M Safhi et al.
Journal of ethnopharmacology, 156, 102-106 (2014-08-26)
Cathinone hydrochloride is an active principle of the khat plant (Catha edulis) that produces pleasurable and stimulating effects in khat chewers. To the best of our knowledge no data of cathinone on oxidative stress in limbic areas of mice is
Hitomi Kanno et al.
PloS one, 9(12), e116275-e116275 (2015-01-01)
Effects of the kampo medicine yokukansan on gene expression of the cystine/glutamate antiporter system Xc-, which protects against glutamate-induced cytotoxicity, were examined in Pheochromocytoma cells (PC12 cells). Yokukansan inhibited glutamate-induced PC12 cell death. Similar cytoprotective effects were found in Uncaria
Bin Liu et al.
Scientific reports, 4, 7041-7041 (2014-11-14)
Reactive oxygen species (ROS) and cellular oxidant stress are considered inducers of carcinogenesis. However, the association of ROS with cancer is both complex and, at times, paradoxical. We assessed the effects of dihydromyricetin (DHM) on the induction of ROS accumulation
Hong-Bo Wang et al.
Nature communications, 6, 6240-6240 (2015-02-12)
Epstein-Barr virus (EBV) is implicated as an aetiological factor in B lymphomas and nasopharyngeal carcinoma. The mechanisms of cell-free EBV infection of nasopharyngeal epithelial cells remain elusive. EBV glycoprotein B (gB) is the critical fusion protein for infection of both
Milo B Fasken et al.
PLoS genetics, 11(3), e1005044-e1005044 (2015-03-17)
Non-coding RNAs (ncRNAs) play critical roles in gene regulation. In eukaryotic cells, ncRNAs are processed and/or degraded by the nuclear exosome, a ribonuclease complex containing catalytic subunits Dis3 and Rrp6. The TRAMP (Trf4/5-Air1/2-Mtr4 polyadenylation) complex is a critical exosome cofactor
Shannon N Moonah et al.
Infection and immunity, 82(9), 3523-3530 (2014-05-14)
The host inflammatory response contributes to the tissue damage that occurs during amebic colitis, with tumor necrosis factor alpha (TNF-α) being a key mediator of the gut inflammation observed. Mammalian macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine that
Yi-Syuan Lai et al.
Journal of agricultural and food chemistry, 62(25), 5897-5906 (2014-05-27)
This study investigated the protective properties of garlic essential oil (GEO) and its major organosulfur component (diallyl disulfide, DADS) against the development of nonalcoholic fatty liver disease (NAFLD). C57BL/6J mice were fed a normal or high-fat diet (HFD) with/without GEO
Constantine Chrysostomou et al.
ACS chemical biology, 10(3), 875-882 (2014-12-18)
Microbial arsenate resistance is known to be conferred by specialized oxidoreductase enzymes termed arsenate reductases. We carried out a genetic selection on media supplemented with sodium arsenate for multicopy genes that can confer growth to E. coli mutant cells lacking
James M Kuczmarski et al.
Journal of applied physiology (Bethesda, Md. : 1985), 117(5), 482-491 (2014-07-26)
The purpose of this investigation was to determine the effect of 4 wk of voluntary wheel running on cardiac performance in the 5/6 ablation-infarction (AI) rat model of chronic kidney disease (CKD). We hypothesized that voluntary wheel running would be
B Uzun et al.
Human & experimental toxicology, 34(4), 415-429 (2014-07-19)
Nonsteroidal anti-inflammatory drugs that are cyclooxygenase (COX) enzyme inhibitors have generally been used in short-term pain management and also to treat inflammation chronically. It is known that COX enzyme and prostaglandins play important roles in the regulation of reproductive functions
Miruna S Stan et al.
Chemico-biological interactions, 220, 102-115 (2014-07-06)
Si/SiO2 quantum dots (QDs) are novel particles with unique physicochemical properties that promote them as potential candidates for biomedical applications. Although their interaction with human cells has been poorly investigated, oxidative stress appears to be the main factor involved in
Linsey E Haswell et al.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 19(5), 356-367 (2014-05-24)
Biomarkers of biological effect (BOBE) have been proposed as potential tools to assess tobacco product use, toxicity and disease risk. To determine if candidate BOBE can distinguish between smokers, never-smokers and former smokers. Biomarker levels were compared from 143 smokers
T Rajah et al.
Toxicology and applied pharmacology, 278(2), 100-106 (2014-04-29)
The caspase inhibitor benzyloxycarbony (Cbz)-l-Val-Ala-Asp (OMe)-fluoromethylketone (z-VAD-FMK) has recently been shown to inhibit T cell proliferation without blocking caspase-8 and caspase-3 activation in primary T cells. We showed in this study that z-VAD-FMK treatment leads to a decrease in intracellular
Jochen J Frietsch et al.
Oncotarget, 5(14), 5257-5271 (2014-06-11)
Chronic myeloid leukemia (CML) is characterized by a genomic translocation generating a permanently active BCR-ABL oncogene with a complex pattern of atypically tyrosine-phosphorylated proteins that drive the malignant phenotype of CML. Recently, the LIM and SH3 domain protein 1 (LASP1)
Semih Can Akıncılar et al.
FEBS letters, 589(9), 974-984 (2015-03-10)
Besides its canonical function of catalyzing the formation of telomeric repeats, many groups have recently reported non-canonical functions of hTERT in particular, and telomerase in general. Regulating transcription is the central basis of non-canonical functions of telomerase. However, unlike reverse
Shu-Han Miao et al.
CNS neuroscience & therapeutics, 20(8), 754-762 (2014-03-19)
To investigate the role of astrocytic JWA expression in dopaminergic (DA) neuron degeneration and in the pathogenesis of Parkinson's disease (PD). Conditional astrocytic JWA null (JWA∆2/∆2/GFAP-Cre) mice and U251 glioma cells were used to evaluate the effects of JWA gene
Prabhakar Tiwari et al.
Nature communications, 6, 6059-6059 (2015-01-23)
Toxin-antitoxin (TA) systems are highly conserved in members of the Mycobacterium tuberculosis (Mtb) complex and have been proposed to play an important role in physiology and virulence. Nine of these TA systems belong to the mazEF family, encoding the intracellular
Xing Tian et al.
Cellular and molecular neurobiology, 35(3), 335-344 (2014-10-30)
Accumulated evidence has shown that excessive reactive oxygen species (ROS) have been implicated in neuronal cell death related with various chronic neurodegenerative disorders. This study was designed to explore neuroprotective effects of ethyl acetate extract of Arctium lappa L. roots
Chun-Yan Zheng et al.
International journal of oncology, 46(3), 1067-1078 (2015-01-13)
Arsenic trioxide (ATO) has demonstrated anticancer activity in different malignancies, especially acute promyelocytic leukemia, with a wide array of putative mechanisms. In this study, we aimed to elucidate the activity and mechanisms of ATO in small cell lung cancer (SCLC).
Celia Fernández-Blanco et al.
Toxicology letters, 235(2), 61-66 (2015-04-02)
Oxidative stress occurs as a consequence of an imbalance between the prooxidant/antioxidant systems, causing an increase of intracellular generation of reactive oxygen species. Alternariol (AOH), a mycotoxin produced by Alternaria sp. can alter the action of glutathione (GSH) and the
Muneeb U Rehman et al.
Pharmacological reports : PR, 66(6), 1050-1059 (2014-12-03)
Cisplatin is an effective and extensively used chemotherapeutic agent to treat range of malignancies, but its therapeutic use is limited because of dose-dependent nephrotoxicity and hepatotoxicity. Several published reports advocate that supplementation with antioxidant can influence cisplatin induced hepatic damage.
Naoko H Tomioka et al.
Nature communications, 5, 4501-4501 (2014-07-23)
GABAergic interneurons are highly heterogeneous, and much is unknown about the specification and functional roles of their neural circuits. Here we show that a transinteraction of Elfn1 and mGluR7 controls targeted interneuron synapse development and that loss of Elfn1 results
Zhenhua Guo et al.
Microbes and infection, 16(3), 225-236 (2013-11-30)
Successful infection by the opportunistic pathogen Legionella pneumophila requires the collective activity of hundreds of virulence proteins delivered into the host cell by the Dot/Icm type IV secretion system. These virulence proteins, also called effectors modulate distinct host cellular processes
Raj Kumar Koiri et al.
Biochimie, 110, 52-61 (2015-01-13)
There is a general agreement that most of the cancer cells switch over to aerobic glycolysis (Warburg effect) and upregulate antioxidant enzymes to prevent oxidative stress induced apoptosis. Thus, there is an evolving view to target these metabolic alterations by
Anna L Greenshields et al.
Cancer letters, 357(1), 129-140 (2014-12-03)
Piperine, an alkaloid from black pepper, is reported to have anticancer activities. In this study, we investigated the effect of piperine on the growth and motility of triple-negative breast cancer (TNBC) cells. Piperine inhibited the in vitro growth of TNBC
Svend Høime Hansen et al.
Advances in experimental medicine and biology, 776, 3-12 (2013-02-09)
Biochemistry textbook presentations of bioenergetics and mitochondrial function normally focus on the chemiosmotic theory with introduction of the tricarboxylic acid cycle and the electron transport chain, the proton and electrical gradients and subsequent oxidative phosphorylation and ATP-production by ATP synthase.
Suzanna J Logan et al.
Basic research in cardiology, 110(2), 19-19 (2015-03-03)
Ischemic heart disease (IHD) is a leading cause of death worldwide, and regenerative therapies through exogenous stem cell delivery hold promising potential. One limitation of such therapies is the vulnerability of stem cells to the oxidative environment associated with IHD.
Wen Kong et al.
Experimental biology and medicine (Maywood, N.J.), 240(2), 220-229 (2014-09-18)
Resveratrol (RSV), a natural compound, is known for its effects on energy homeostasis. Here we investigated the effects of RSV and possible mechanism in insulin secretion of high-fat diet rats. Rats were randomly divided into three groups as follows: NC
Sema Demirci Çekiç et al.
Analytica chimica acta, 865, 60-70 (2015-03-04)
A colourimetric sensor capable of simultaneously measuring oxidative status (OS) in terms of the hazard produced by reactive oxygen species (ROS) and antioxidant activity (AOA) in regard to ROS-scavenging ability of antioxidant compounds was developed. The coloured cationic semi-quinone derivatives
Sebastian Mana-Capelli et al.
Molecular biology of the cell, 25(10), 1676-1685 (2014-03-22)
The Hippo pathway regulates the transcriptional coactivator YAP to control cell proliferation, organ size, and stem cell maintenance. Multiple factors, such as substrate stiffness, cell density, and G protein-coupled receptor signaling, regulate YAP through their effects on the F-actin cytoskeleton
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