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PHR1533

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Motohiro Sekiya et al.
Journal of lipid research, 55(10), 2082-2092 (2014-06-04)
An excess of cholesterol and/or oxysterols induces apoptosis in macrophages, contributing to the development of advanced atherosclerotic lesions. In foam cells, these sterols are stored in esterified forms, which are hydrolyzed by two enzymes: neutral cholesterol ester hydrolase 1 (Nceh1)
Amandine L Lépinay et al.
Psychoneuroendocrinology, 53, 82-93 (2015-01-24)
Epidemiological observations report an increase in fat consumption associated with low intake of n-3 relative to n-6 polyunsaturated fatty acids (PUFAs) in women of childbearing age. However, the impact of these maternal feeding habits on cognitive function in the offspring
Xabier Osteikoetxea et al.
PloS one, 10(3), e0121184-e0121184 (2015-03-24)
In recent years the study of extracellular vesicles has gathered much scientific and clinical interest. As the field is expanding, it is becoming clear that better methods for characterization and quantification of extracellular vesicles as well as better standards to
Yanuar Dwi Putra Limasale et al.
International journal of pharmaceutics, 479(2), 364-373 (2015-01-18)
Cyclooxygenase-2 (COX-2) is highly expressed in many different cancers. Therefore, the inhibition of the COX-2 pathway by a selective COX-2 inhibitor, celecoxib (CLX), may be an alternative strategy for cancer prevention and therapy. Liposomal drug delivery systems can be used
Ratchada Cressey et al.
Indian journal of experimental biology, 52(12), 1173-1181 (2015-02-06)
In this study, we explored the effects of consumption of banana in thirty hypercholesterolemic and fifteen type 2 diabetic subjects. They were given a daily dose of 250 or 500 grams of banana for breakfast for 12 weeks. Fasting serum
Gemma Moiset et al.
Journal of the American Chemical Society, 136(46), 16167-16175 (2014-10-16)
Disaccharides are well-known for their membrane protective ability. Interaction between sugars and multicomponent membranes, however, remains largely unexplored. Here, we combine molecular dynamics simulations and fluorescence microscopy to study the effect of mono- and disaccharides on membranes that phase separate
Koushik Roy et al.
Journal of immunology (Baltimore, Md. : 1950), 192(12), 5873-5880 (2014-05-23)
We show that Leishmania donovani-infected macrophages (MΦs) are capable of stimulating MHC class II (MHC-II)-restricted T cells at 6 h of infection. At 48 h, infected MΦs (I-MΦs) failed to stimulate MHC-II-restricted T cells but not MHC class I-restricted ones
S Demirkol et al.
International journal of impotence research, 26(4), 124-127 (2013-12-20)
Although the origin of cardiac syndrome X (CSX) is still debated, endothelial dysfunction leading to reduced coronary microvascular dilatory response and increased coronary resistance is thought to have an important role in the pathogenesis. Erectile dysfunction (ED) is associated with
Desiree Van Haute et al.
International journal of pharmaceutics, 569, 118603-118603 (2019-08-12)
Conventional quantitation of drug content in the liposome formulation involves the breakdown of bulk liposomes, which ignores details on the distribution of the active pharmaceutical ingredient (API) and excipients in liposomes of different sizes. The objective of this study is
Cecilia Augustsson et al.
Thrombosis research, 134(1), 132-137 (2014-05-03)
Tissue factor pathway inhibitor (TFPI) is present in plasma as full-length free TFPI (TFPIα) and as C-terminally degraded forms mainly associated with low-density lipoprotein particles (LDL-TFPI). Addition of TFPIα to plasma induces a prolongation of the clotting time when tested
Andrés Castellanos-Martín et al.
Genome biology, 16, 40-40 (2015-04-09)
An essential question in cancer is why individuals with the same disease have different clinical outcomes. Progress toward a more personalized medicine in cancer patients requires taking into account the underlying heterogeneity at different molecular levels. Here, we present a
Anand Rohatgi et al.
The New England journal of medicine, 371(25), 2383-2393 (2014-11-19)
It is unclear whether high-density lipoprotein (HDL) cholesterol concentration plays a causal role in atherosclerosis. A more important factor may be HDL cholesterol efflux capacity, the ability of HDL to accept cholesterol from macrophages, which is a key step in
S Morel et al.
Thrombosis and haemostasis, 112(2), 390-401 (2014-05-16)
Ubiquitous reduction of the gap junction protein Connexin43 (Cx43) in mice provides beneficial effects on progression and composition of atherosclerotic lesions. Cx43 is expressed in multiple atheroma-associated cells but its function in each cell type is not known. To examine
Tomoya Araki et al.
Journal of controlled release : official journal of the Controlled Release Society, 200, 106-114 (2015-01-03)
The effects of photo-triggered tumor vascular treatment (PVT) on the structural and functional properties of tumor vasculature were assessed in Colon-26 (C26) and B16/BL6 (B16) tumor-bearing mice. Furthermore, anti-tumor efficacy of subsequently injected PEG liposomal paclitaxel (PL-PTX) was also evaluated.
Hyun Kang et al.
Pharmaceutical biology, 53(3), 414-422 (2014-10-02)
Houttuynia cordata Thunb. (Saururaceae) is used traditionally in Asian countries to treat various disease symptoms. To study the effect of H. cordata ethyl acetate (HC-EA) extract on high-fat diet (HFD)-induced hepatic steatosis. HFD fed rats were orally dosed with HC-EA
Yoshiteru Kagawa et al.
Glia, 63(5), 780-794 (2015-01-21)
Fatty acid-binding proteins (FABPs) bind and solubilize long-chain fatty acids, controlling intracellular lipid dynamics. FABP7 is expressed by astrocytes in the developing brain, and suggested to be involved in the control of astrocyte lipid homeostasis. In this study, we sought
Eirini Manthou et al.
Journal of physical activity & health, 12(1), 80-86 (2014-06-05)
This study investigated health-related effects of exercise programs with exercise sessions of similar intensity but different frequency and duration. Thirty-four overweight women were randomized into either long-bout (LB) or short-bout (SB) exercise groups. Participants performed an 8-week supervised program, with
Ravi V Shah et al.
The American journal of cardiology, 115(1), 27-33 (2014-12-03)
A standard ("core") implementation of American College of Cardiology/American Heart Association 2013 lipid guidelines (based on 10-year risk) dramatically increases the statin-eligible population in older Americans, raising controversy in the cardiovascular community. The guidelines also endorse a more "comprehensive" risk
A P Sykes et al.
Diabetes, obesity & metabolism, 17(1), 94-97 (2014-09-17)
We compared the efficacy of twice-daily doses of remogliflozin etabonate (RE) and once-daily pioglitazone with placebo for reduction in glycated haemoglobin (HbA1c) concentration. In this 12-week, double-blind, randomized, active- and placebo-controlled trial, 336 treatment-naïve subjects with type 2 diabetes and
Jun Zhou et al.
Journal of ethnopharmacology, 164, 229-238 (2015-02-24)
Rehmannia glutinosa (Gaertn.) DC. (RG) has been widely used as traditional Chinese herbal medicine for treatment of diabetes and its complications. The polysaccharide fraction of RG has been proposed to possess hypoglycemic effect by intraperitoneal administration, however, the mechanisms responsible
Nobuyuki Miyatake et al.
Environmental health and preventive medicine, 19(5), 362-366 (2014-07-23)
The aim of this study was to evaluate the link between circulating leptin levels and physical activity and/or physical fitness in apparently healthy Japanese. A total of 85 men and 111 women who were not taking any medication were enrolled
Ming Cui et al.
Cancer research, 75(5), 846-857 (2015-01-17)
HULC is a long noncoding RNA overexpressed in hepatocellular carcinoma (HCC), but its functional contributions in this setting have not been determined. In this study, we explored the hypothesis that HULC contributes to malignant development by supporting abnormal lipid metabolism
Nobuya Inagaki et al.
Journal of diabetes investigation, 6(2), 210-218 (2015-03-25)
Canagliflozin is a sodium-glucose cotransporter 2 inhibitor under development for the treatment of type 2 diabetes. Our aim was to examine its efficacy and safety as monotherapy or in combination with commonly used oral antihyperglycemic drugs in Japanese patients with
Mohammad M H Abdullah et al.
The British journal of nutrition, 113(3), 435-444 (2015-01-23)
Dairy products are rich sources of an array of fatty acids (FA) that have been shown individually and in certain clusters to exert varying effects on cardiovascular health, for which the circulating lipid profile is a powerful biomarker. Whether the
Louise E See Hoe et al.
American journal of physiology. Heart and circulatory physiology, 307(6), H895-H903 (2014-07-27)
Cholesterol-rich caveolar microdomains and associated caveolins influence sarcolemmal ion channel and receptor function and protective stress signaling. However, the importance of membrane cholesterol content to cardiovascular function and myocardial responses to ischemia-reperfusion (I/R) and cardioprotective stimuli are unclear. We assessed
Sheida Shariat et al.
Cancer letters, 355(1), 54-60 (2014-09-17)
Vaccines containing synthetic peptides derived from tumor-associated antigens (TAA) can elicit potent cytotoxic T lymphocyte (CTL) response if they are formulated in an optimal vaccine delivery system. The aim of this study was to develop a simple and effective lipid-based
Jiang Ma et al.
Journal of ethnopharmacology, 162, 61-68 (2015-01-06)
Polygoni Multiflori Radix (PMR) has been traditionally used as a tonic and an anti-aging remedy for centuries; however, hepatic lesions linked to PMR have been frequently reported. This work attempted to investigate the hepatotoxic potential of PMR extract and the
C K H Wong et al.
Diabetes, obesity & metabolism, 17(2), 128-135 (2014-09-25)
To assess whether a structured diabetes education programme, the Patient Empowerment Programme (PEP), was associated with a lower risk of first cardiovascular disease (CVD) event and all-cause mortality in a population-based cohort of patients with type 2 diabetes mellitus (T2DM)
Zachary B Armstrong et al.
The Canadian journal of cardiology, 30(9), 1096-1103 (2014-04-15)
Aortic valve sclerosis (AVS) is a chronic progressive disease involving lipid infiltration, inflammation, and tissue calcification. Despite its high prevalence, there are currently no clinically approved pharmaceuticals for the management of AVS. The objective of the current study was to
You-Cheol Hwang et al.
Acta diabetologica, 51(6), 941-946 (2014-05-13)
The association between atherogenic dyslipidemia (AD) and incident type 2 diabetes (T2D) in the low-risk group for T2D has not yet been determined. The aims of this study were to investigate whether AD, characterized by increased serum apoB and non-HDL
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