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Venkadesaperumal Gopu et al.
PloS one, 10(8), e0134684-e0134684 (2015-08-08)
Quorum sensing (QS) plays a vital role in regulating the virulence factor of many food borne pathogens, which causes severe public health risk. Therefore, interrupting the QS signaling pathway may be an attractive strategy to combat microbial infections. In the
Milena K Bulla et al.
Photochemistry and photobiology, 91(3), 558-566 (2015-01-13)
Schinus terebinthifolius is a plant rich in phenolic compounds, which have antioxidant properties and can provide new opportunities for treatment and prevention of diseases mediated by ultraviolet radiation like photoaging and skin cancer. The aim of this study was to
Nurcan Değirmencioğlu et al.
Food chemistry, 194, 587-594 (2015-10-17)
In this study, the changes in phenolic composition, total phenolic content, and antioxidant capacity of tarhanas supplemented with oat flour (OF) at the levels of 20-100% (w/w) after three drying treatments (sun-, oven-, and microwave drying) were investigated. A total
Ayokunle O Ademosun et al.
Journal of basic and clinical physiology and pharmacology, 26(5), 471-477 (2015-06-02)
Citrus peels are consumed in the form of infusions, candy or wine, based on their well-documented nutritional and medicinal properties. This study sought to investigate the effect of some citrus peels' [grapefruit (Citrus paradisii), orange (Citrus sinensis) and shaddock (Citrus
Zohar Ben-Simhon et al.
PloS one, 10(11), e0142777-e0142777 (2015-11-19)
Color is an important determinant of pomegranate fruit quality and commercial value. To understand the genetic factors controlling color in pomegranate, chemical, molecular and genetic characterization of a "white" pomegranate was performed. This unique accession is lacking the typical pomegranate
Francesco Menichini et al.
Journal of enzyme inhibition and medicinal chemistry, 29(5), 677-685 (2013-10-10)
Cardiospermum halicacabum is widely used in traditional medicine. Previous studies have focused on the aerial parts, while the seeds have been poorly investigated. This work aimed to analyse the chemical composition of extracts from aerial parts and seeds obtained using
Nayyer Golabi-Habashi et al.
Toxicology reports, 8, 1569-1575 (2021-08-26)
The protective effects of Quercetin (QCN) on Benzene (BNZ)-induced hemato- and hepatotoxicy were investigated. To reach this goal, 36 adult male mice were divided into 6 groups (n = 6). The control group was not exposed to BNZ, while animals
Wioleta Jesionek et al.
Journal of AOAC International, 98(4), 1013-1020 (2015-08-14)
Fast high-throughput TLC-direct bioautography (DB) is an effect-directed analysis method that enables searching for biologically active (e.g., antimicrobial) substances in complex mixtures like plant extracts. The principle of the method is that separation and detection of biological properties of given
Tetyana Kobets et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 115, 228-243 (2018-03-20)
Genotoxicity of flavor and fragrance materials was assessed in Turkey Egg Genotoxicity Assay (TEGA) using 32P-nucleotide postlabeling (NPL) and comet assays to detect hepatic DNA adducts and strand breaks. Twenty materials having results in GADD45a-Gluc 'BlueScreen HC' genotoxicity assay, and
Roberta Ruotolo et al.
Archives of biochemistry and biophysics, 559, 62-67 (2014-03-25)
Several plant-derived molecules, referred to as phytoestrogens, are thought to mimic the actions of endogenous estrogens. Among these, quercetin, one of the most widespread flavonoids in the plant kingdom, has been reported as estrogenic in some occasions. However, quercetin occurs
Periasamy Ramyaa et al.
Biochimica et biophysica acta, 1840(1), 681-692 (2013-10-29)
Ochratoxin A (OTA), a mycotoxin, causes extensive cell damage, affecting liver and kidney cells. OTA toxicity is fairly well characterized where oxidative stress is believed to play a role, however, the sequence of molecular events after OTA-exposure, have not been
Yanmang Cui et al.
Chemico-biological interactions, 220, 75-83 (2014-06-29)
The study was to characterize the polyphenolic composition, antioxidant properties, and hepatoprotective effects of a polyphenols-enriched extract (HMTP) from Huangshan Maofeng green tea. HPLC analysis showed that three predominantly polyphenolic compounds present in HMTP were epigallocatechin (271.2 μg/mg extract), rutin
Jafar Ezzati Nazhad Dolatabadi
International journal of biological macromolecules, 48(2), 227-233 (2010-12-01)
Flavonoids occupy an important position in chemistry and pharmacology. Various flavonoids, particularly quercetin have potential to form molecular complexes with nucleic acid structure and have attracted recent attention for their prospective clinical and pharmacological utility. This review highlights the properties
William Y Boadi et al.
Journal of dietary supplements, 11(3), 272-287 (2014-07-16)
Protein-bound carbonyls have been shown to increase with age as well as in numerous diseases including rheumatoid arthritis, adult respiratory syndrome pulmonary fibrosis, diabetes, Parkinson's disease, and Alzheimer's just to mention a few. The effects of the flavonoids quercetin and
Diego V Beckmann et al.
Life sciences, 103(2), 79-87 (2014-04-15)
The purpose of this study was to investigate whether the flavonoid quercetin can prevent alterations in the behavioral tests and of cholinergic neurotransmission in rats submitted to the ethidium bromide (EB) experimental demyelination model during events of demyelination and remyelination.
Slawomir Mandziuk et al.
Drug and chemical toxicology, 38(1), 1-8 (2014-03-04)
The delayed cardiomyopathy caused by doxorubicin - an chemotherapeutic drug with broad spectrum of anticancer activity - is mainly triggered by oxidative stress. The aim of this study was to assess an effect of Mutellina purpurea methanolic extract fraction and
Nu Ry Song et al.
Food chemistry, 142, 66-71 (2013-09-05)
Quercetin is a major flavonoid compound found in red wine at a much higher concentration than the phytoalexin resveratrol. In this study, we examined potential anti-metastatic effects and found that compared to resveratrol, quercetin more potently inhibits H-Ras-induced invasion and
Jakub P Piwowarski et al.
Journal of natural medicines, 69(1), 100-110 (2014-10-29)
The herb Lythrum salicaria L. (Lythraceae) is used in traditional medicine to treat diseases with an inflammatory background, such as haemorrhoidal disease, dysentery, chronic intestinal catarrh, eczema, varicose veins, periodontosis and gingivitis. Because these diseases are closely associated with an
Jeremy S Barnes et al.
Journal of the American Society for Mass Spectrometry, 24(10), 1513-1522 (2013-08-13)
Thermally accelerated oxidative degradation of aqueous quercetin at pH 5.9 and 7.4 was kinetically measured using an in-house built online continuous flow device made of concentric capillary tubes, modified to fit to the inlet of an electrospray ionization-ion trap-time-of-flight-mass spectrometer (ESI-IT-TOF-MS).
Sudhanshu Sudan et al.
Experimental biology and medicine (Maywood, N.J.), 240(11), 1452-1464 (2015-02-15)
Despite their strong role in human health, poor bioavailability of flavonoids limits their biological effects in vivo. Enzymatically catalyzed acylation of fatty acids to flavonoids is one of the approaches of increasing cellular permeability and hence, biological activities. In this
Gen Wang et al.
Journal of pharmaceutical and biomedical analysis, 170, 285-294 (2019-04-06)
In the face of the many shortcomings of conventional organic solvents in the age of green chemistry, deep eutectic solvents (DESs) appear under the spotlight of natural product extraction because of its outstanding advantages. In this study, the extraction of
Mario J Simirgiotis et al.
Molecules (Basel, Switzerland), 20(6), 11490-11507 (2015-06-26)
The antioxidant features, polyphenolic composition and chromatographic fingerprints of the aerial parts from three Chilean endemic plants from the Paposo Valley located on the cost of the Atacama Desert were investigated for the first time using high pressure liquid chromatography
Naiani Ferreira Marques et al.
Neurochemical research, 40(6), 1197-1210 (2015-04-24)
Oxidative stress has been implicated in several pathologies including neurological disorders. Centella asiatica is a popular medicinal plant which has long been used to treat neurological disturbances in Ayurvedic medicine. In the present study, we quantified of compounds by high
Peng Zhao et al.
Oncology letters, 8(2), 765-769 (2014-07-11)
Quercetin can inhibit the growth of cancer cells with the ability to act as a 'chemopreventer'. Its cancer-preventive effect has been attributed to various mechanisms, including the induction of cell-cycle arrest and/or apoptosis, as well as its antioxidant functions. Quercetin
J Phie et al.
BJS open, 5(1) (2021-02-21)
There are currently few effective drugs to treat the leg symptoms of peripheral arterial disease (PAD). Previous studies have suggested that the nutraceutical, quercetin, can improve exercise performance and reduce pain sensitivity in healthy mice and improve blood supply in
Susan J Zunino et al.
The British journal of nutrition, 112(3), 369-380 (2014-05-17)
Obese individuals are at an increased risk of developing CVD, hypertension, type 2 diabetes, and bacterial and viral infections when compared with the normal-weight population. In a 9-week randomised, double-blind, cross-over study, twenty-four obese subjects aged between 20 and 60
Javier E Ramirez et al.
Food chemistry, 176, 106-114 (2015-01-28)
The HPLC profiles of six fruits endemic of the VIII region of Chile were investigated using high resolution mass analysis (HR-ToF-ESI-MS). The anthocyanin fingerprints generated for the fruits were compared and the antioxidant capacities measured by the scavenging of the
Nahid Dayyani et al.
European journal of medicinal chemistry, 98, 190-202 (2015-05-30)
Novel pH-sensitive, biocompatible and biodegradable magneto-dendrimers with OH and/or NH2 functional groups based on poly amino-ester were synthesized for delivery of anti-cancer drugs. Magnetite nanoparticles (MNPs) were synthesized by the co-precipitation method and their surfaces were modified by 3-aminopropyl triethoxysilane.
C U F Kelly Hill et al.
Cancer chemotherapy and pharmacology, 76(1), 179-185 (2015-05-29)
TMFol (3',4',5'-trimethoxyflavonol) is a synthetic analogue of the naturally occurring flavonol fisetin and quercetin, which have been considered of potential usefulness in the management of prostate cancer. We investigated whether TMFol may have preclinical features superior to those of its
Geon-Hee Kim et al.
International journal of molecular sciences, 21(18) (2020-09-17)
Constitutive activation of the β-catenin dependent canonical Wnt signaling pathway, which enhances tumor growth and progression in multiple types of cancer, is commonly observed in melanoma. LEF1 activates β-catenin/TCF4 transcriptional activity, promoting tumor growth and progression. Although several reports have
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