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David-Alexandre Trégouet et al.
Diabetes, 57(10), 2843-2850 (2008-07-18)
Genetic and environmental factors modulate the susceptibility to diabetic nephropathy, as initiating and/or progression factors. The objective of the European Rational Approach for the Genetics of Diabetic Complications (EURAGEDIC) study is to identify nephropathy susceptibility genes. We report molecular genetic
Ahmed Mosa et al.
Infection and immunity, 77(7), 2908-2918 (2009-04-29)
We analyzed the defensive role of the cytosolic innate recognition receptor nucleotide oligomerization domain 1 (NOD1) during infection with Listeria monocytogenes. Mice lacking NOD1 showed increased susceptibility to systemic intraperitoneal and intravenous infection with high or low doses of L.
Shiv Gandhi et al.
Cell chemical biology, 27(11), 1410-1424 (2020-09-06)
Rhomboid intramembrane proteases regulate pathophysiological processes, but their targeting in a disease context has never been achieved. We decoded the atypical substrate specificity of malaria rhomboid PfROM4, but found, unexpectedly, that it results from "steric exclusion": PfROM4 and canonical rhomboid
Hepatitis C virus present in the sera of infected patients interferes with the autophagic process of monocytes impairing their in-vitro differentiation into dendritic cells.
Granato M, Lacconi V, Peddis M, et al.
Biochimica et Biophysica Acta, 1843(7), 1348-1355 (2014)
Li Wang et al.
PloS one, 6(11), e27289-e27289 (2011-11-17)
Our previous work showed that mice immunized with attenuated activated syngeneic T cells (aTCV) led to damping Treg function which resulted in enhancing anti-tumor immunity. It is well known that DC plays a very important role in controlling Th cell
Carley Tasker et al.
The AAPS journal, 23(2), 26-26 (2021-01-19)
Accurate assessment of antigen-specific immune responses is critical in the development of safe and efficacious biotherapeutics and vaccines. Endosomal processing of a protein antigen followed by presentation on major histocompatibility complex (MHC) class II constitute necessary steps in the induction
F Oakley et al.
The Journal of physiology, 561(Pt 2), 525-534 (2004-10-16)
The uptake of 65Zn by human erythrocytes was investigated in the presence of high (40 mM) and low (5 mM) concentrations of histidine and 0-500 microM cobalt, nickel, manganese and zinc. Varying concentrations of metal mono- and bis-histidine complexes will
Umut Gazi et al.
The Journal of biological chemistry, 286(10), 7822-7829 (2011-01-06)
The mannose receptor (MR) is an endocytic type I membrane molecule with a broad ligand specificity that is involved in both hemostasis and pathogen recognition. Membrane-anchored MR is cleaved by a metalloproteinase into functional soluble MR (sMR) composed of the
L Rojas et al.
Biomedical materials (Bristol, England), 10(5), 055015-055015 (2015-10-21)
Simple surface modification of nano-hydroxyapatite, through acid-basic reactions, allows expanding the properties of this material. Introduction of organic groups such as hydrophobic alkyl chains, carboxylic acid, and amide or amine basic groups on the hydroxyapatite surface systematically change the polarity
John C Dawson et al.
Molecular cancer therapeutics, 19(2), 637-649 (2019-12-01)
We mutated the focal adhesion kinase (FAK) catalytic domain to inhibit binding of the chaperone Cdc37 and ATP, mimicking the actions of a FAK kinase inhibitor. We reexpressed mutant and wild-type FAK in squamous cell carcinoma (SCC) cells from which
Charlotte Lübow et al.
Biochemical pharmacology, 175, 113864-113864 (2020-02-24)
Interleukin (IL)-1 signaling leads to production of pro-inflammatory mediators and is regulated by receptor endocytosis. Lysosomotropic drugs have been linked to increased pro-inflammatory responses under sterile inflammatory conditions but the underlying mechanisms have not been fully elucidated. Here, we report
Sarah Hutchinson et al.
PloS one, 6(2), e14646-e14646 (2011-02-10)
Murine cytomegalovirus (MCMV) is an important animal model of human cytomegalovirus (HCMV), a β-Herpesvirus that infects the majority of the world's population and causes disease in neonates and immunocompromised adults. CD8(+) T cells are a major part of the immune
Eduardo Lasalvia-Prisco et al.
Biologics : targets & therapy, 2(3), 555-561 (2009-08-27)
The purpose of this study was to compare chemotherapy-naive patients with stage IV nonsmall cell lung cancer patients treated with chemotherapy or chemoimmunotherapy. We tested doxetacel plus cisplatinum as chemotherapy protocol. An immunomodulatory adjuvant system was added as chemoimmunotherapy to
Yasin Kurmoo et al.
Biomaterials science, 8(5), 1464-1477 (2020-01-23)
Real time monitoring of bacterial attachment to medical devices provides opportunities to detect early biofilm formation and instigate appropriate interventions before infection develops. This study utilises long period grating (LPG) optical fibre sensors, incorporated into the lumen of endotracheal tubes
Jennifer H R Kenty et al.
PloS one, 10(4), e0122044-e0122044 (2015-04-09)
Studying the response of islet cells to glucose stimulation is important for understanding cell function in healthy and disease states. Most functional assays are performed on whole islets or cell populations, resulting in averaged observations and loss of information at
Kevin J Roberts et al.
Scientific reports, 11(1), 19422-19422 (2021-10-02)
Anti-TNFα and anti-IL-23 antibodies are highly effective therapies for Crohn's disease or ulcerative colitis in a proportion of patients. V56B2 is a novel bispecific domain antibody in which a llama-derived IL-23p19-specific domain antibody, humanised and engineered for intestinal protease resistance
Roberta Gonnella et al.
Biomedicines, 9(2) (2021-01-31)
Primary Effusion Lymphoma (PEL) is a highly aggressive B cell lymphoma associated with Kaposi's Sarcoma-associated Herpesvirus (KSHV). It is characterized by a high level of basal Endoplasmic Reticulum (ER) stress, Unfolded Protein Response (UPR) activation and constitutive phosphorylation of oncogenic
Ahmet Tektemur et al.
Journal of cancer research and clinical oncology, 145(5), 1297-1311 (2019-03-20)
Transient receptor potential melastatin 2 (TRPM2), a calcium-permeable ion channel, is shown as a prognostic marker candidate in prostate cancer (PCa) and an important regulator of autophagy. We aimed to determine the changes in TRPM2 and autophagic-apoptotic gene expression levels
Lilla Ozgyin et al.
Scientific reports, 9(1), 4889-4889 (2019-03-22)
Genotyped human B-lymphoblastoid cell lines (LCLs) are widely used models in mapping quantitative trait loci for chromatin features, gene expression, and drug response. The extent of genotype-independent functional genomic variability of the LCL model, although largely overlooked, may inform association
K Zomorodian et al.
Pharmacognosy magazine, 7(25), 53-59 (2011-04-08)
Zataria multiflora Boiss. is a traditional and popular spice in Iran. The effects of 3 ecotypes (ECTPs) of Z. multiflora essential oils (EOs) against most common causes of food-borne and nosocomial infections were evaluated. The antimicrobial activities of the EOs
Antonella Tomassetti et al.
Neoplasia (New York, N.Y.), 10(12), 1481-1492 (2008-12-03)
Ovarian carcinoma arises from the ovarian surface epithelium, which undergoes phenotypic changes characteristic of müllerian epithelium during the first stages of tumorigenesis. The variant isoform of the hepatocyte nuclear factor 1 (vHNF1) is a transcription factor involved in the development
Zhuo Fu et al.
European journal of pharmacology, 616(1-3), 321-327 (2009-06-23)
We recently found that genistein, a plant-derived natural compound, is a novel cAMP signaling agonist in pancreatic beta-cells. In the present study, we further show that exposure of clonal insulin secreting (INS-1E) cells to genistein for 48 h enhanced glucose-stimulated
Seyhan Turk et al.
PloS one, 15(11), e0242497-e0242497 (2020-11-26)
Despite the availability of various treatment protocols, response to therapy in patients with Acute Myeloid Leukemia (AML) remains largely unpredictable. Transcriptomic profiling studies have thus far revealed the presence of molecular subtypes of AML that are not accounted for by
Adela Ngwewondo et al.
PLoS neglected tropical diseases, 12(6), e0006565-e0006565 (2018-06-14)
Ivermectin is the only drug currently recommended for the treatment of onchocerciasis, the second leading infectious cause of blindness in the world. This drug kills only the first stage larvae-microfilariae (mf) of Onchocerca volvulus and is to be used cautiously
Meng Zhao et al.
PloS one, 4(8), e6552-e6552 (2009-08-08)
The precise regulation and maintenance of balance between cell proliferation, differentiation and death in metazoan are critical for tissue homeostasis. CCAAT/enhancer-binding protein alpha (C/EBPalpha) has been implicated as a key regulator of differentiation and proliferation in various cell types. Here
Francis M Kobia et al.
PLoS biology, 18(10), e3000850-e3000850 (2020-10-06)
Cooperative DNA binding is a key feature of transcriptional regulation. Here we examined the role of cooperativity in Notch signaling by CRISPR-mediated engineering of mice in which neither Notch1 nor Notch2 can homo- or heterodimerize, essential for cooperative binding to
Steven C Pino et al.
Cell stress & chaperones, 13(4), 421-434 (2008-04-18)
T cell receptor (TCR) ligation (signal one) in the presence of co-stimulation (signal two) results in downstream signals that increase protein production enabling naïve T cells to fully activate and gain effector function. Enhanced production of proteins by a cell
Grzegorz Sumara et al.
Cell, 136(2), 235-248 (2009-01-13)
Dysfunction and loss of insulin-producing pancreatic beta cells represent hallmarks of diabetes mellitus. Here, we show that mice lacking the mitogen-activated protein kinase (MAPK) p38delta display improved glucose tolerance due to enhanced insulin secretion from pancreatic beta cells. Deletion of
Eszter Posfai et al.
Nature cell biology, 23(1), 49-60 (2021-01-10)
Totipotency is the ability of a single cell to give rise to all of the differentiated cell types that build the conceptus, yet how to capture this property in vitro remains incompletely understood. Defining totipotency relies on a variety of
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