Search Within
Applied Filters:
Showing 1-30 of 36 results for "


" within Papers
Aleksandra Szczepkowska et al.
Cell and tissue research, 350(1), 157-166 (2012-05-25)
Vascular endothelial growth factor (VEGF-A) plays an important role in maintaining cerebrospinal fluid (CSF) homeostasis and the function of the choroid plexuses (CPs). The objective of the study was to determine the expression of vascular endothelial growth factor (VEGF-A), tyrosine...
Tamar Guy-Haim et al.
PeerJ, 6, e5268-e5268 (2018-07-31)
Aquatic subterranean species often exhibit disjunct distributions, with high level of endemism and small range, shaped by vicariance, limited dispersal, and evolutionary rates. We studied the disjunct biogeographic patterns of an endangered blind cave shrimp, Typhlocaris, and identified the geological...
Adam Swetloff et al.
Molecular biology of the cell, 20(23), 4951-4961 (2009-10-09)
Processing bodies (P-bodies) are cytoplasmic granules involved in the storage and degradation of mRNAs. In somatic cells, their formation involves miRNA-mediated mRNA silencing. Many P-body protein components are also found in germ cell granules, such as in mammalian spermatocytes. In...
Endalkachew A Alemu et al.
Cellular and molecular life sciences : CMLS, 68(11), 1953-1968 (2010-10-19)
The protein kinase C (PKC) family of serine/threonine kinases consists of ten different isoforms grouped into three subfamilies, denoted classical, novel and atypical PKCs (aPKCs). The aPKCs, PKCι/λ and PKCζ serve important roles during development and in processes subverted in...
Fei Xie et al.
Journal of translational medicine, 9, 95-95 (2011-06-24)
Metastasis suppressor-1 (MTSS1) has been proposed to function as a cytoskeletal protein with a role in cancer metastasis. Recent studies have demonstrated the clinical significance of MTSS1 in certain type of cancers, yet the clinical relevance of MTSS1 in oesophageal...
Mengnan Li et al.
Nature communications, 11(1), 1343-1343 (2020-03-14)
Enlarged vestibular aqueduct (EVA) is one of the most commonly identified inner ear malformations in hearing loss patients including Pendred syndrome. While biallelic mutations of the SLC26A4 gene, encoding pendrin, causes non-syndromic hearing loss with EVA or Pendred syndrome, a...
Hadas Bar-Joseph et al.
Reproductive biomedicine online, 41(2), 335-342 (2020-06-14)
Does recombinant pigment epithelium derived factor (PEDF) have potential in treating uterine fibroids? In-vitro models that used human leiomyoma and Eker rat uterine leiomyoma (ELT-3) cell lines. The ELT-3 cell line was used to examine cellular targets after adding recombinant...
Anahit Penesyan et al.
Marine drugs, 11(1), 40-49 (2012-12-29)
A common limitation for the identification of novel activities from functional (meta) genomic screens is the low number of active clones detected relative to the number of clones screened. Here we demonstrate that constructing libraries with strains known to produce...
Yi Zhang et al.
Neural development, 6, 2-2 (2011-01-06)
Serotonin (5-HT) is a potent regulator of adult neurogenesis in the crustacean brain, as in the vertebrate brain. However, there are relatively few data regarding the mechanisms of serotonin's action and which precursor cells are targeted. Therefore, we exploited the...
Pascal Lopez et al.
Molecular and cellular biology, 36(10), 1480-1493 (2016-03-16)
RNA activation (RNAa) is a gene regulation process in which promoter-targeted short double-stranded RNAs (dsRNAs) or microRNAs (miRs) induce target gene expression at the transcriptional level. Here, we investigate the presence of cryptic promoter transcripts within the VEGF promoter. Single-strand...
Vicki Plaks et al.
The Journal of clinical investigation, 118(12), 3954-3965 (2008-11-27)
Implantation is a key stage during pregnancy, as the fate of the embryo is often decided upon its first contact with the maternal endometrium. Around this time, DCs accumulate in the uterus; however, their role in pregnancy and, more specifically...
RNA activation of the vascular endothelial growth factor gene (VEGF) promoter by double-stranded RNA and hypoxia: role of noncoding VEGF promoter transcripts
Lopez P, et al.
Molecular and Cellular Biology, 36(10), 1480-1493 (2016)
Transforming growth factor-beta-inducible early response gene 1 is a novel substrate for atypical protein kinase Cs
Alemu EA, et al.
Cellular and Molecular Life Sciences, 68(11), 1953-1968 (2011)
Survivin promoter polymorphism and cervical carcinogenesis.
A A Borbely, M Murvai, et al.
Journal of Clinical Pathology, march, 303-306 (2007)
Rut Vleugels et al.
PloS one, 8(5), e65052-e65052 (2013-06-07)
Serotonin (5-hydroxytryptamine, 5-HT) is known for its key role in modulating diverse physiological processes and behaviors by binding various 5-HT receptors. However, a lack of pharmacological knowledge impedes studies on invertebrate 5-HT receptors. Moreover, pharmacological information is urgently needed in...
Alyssa A Hoover et al.
BMC cancer, 20(1), 970-970 (2020-10-09)
New treatment options for ovarian cancer are urgently required. Tumor-associated macrophages (TAMs) are an attractive target for therapy; repolarizing TAMs from M2 (pro-tumor) to M1 (anti-tumor) phenotypes represents an important therapeutic goal. We have previously shown that upregulated NF-kappaB (NF-κB)...
Shenglan Li et al.
International journal of oncology, 54(5), 1747-1758 (2019-03-01)
Ehm2 [also known as erythrocyte membrane protein band 4.1‑like protein 4B (EPB41L4B)] is a member of the NF2/ERM/4.1 superfamily. The overexpression of Ehm2 has been observed in metastatic cancer cells. Through alternative splicing, the Ehm2 gene produces two transcript variants that encode...
Sadiye Hayta et al.
Plant methods, 14, 93-93 (2018-11-06)
Genetic transformation is a valuable tool and an important procedure in plant functional genomics contributing to gene discovery, allowing powerful insights into gene function and genetically controlled characteristics. Primulaceae species provide one of the best-known examples of heteromorphic flower development...
Molecular cloning and expression of canine hepcidin
Fry MM, et al.
Veterinary Clinical Pathology / American Society For Veterinary Clinical Pathology, 33(4), 223-227 (2004)
Differential Expression of VEGF121, VEGF165 and VEGF189 in Angiomas and Squamous Cell Carcinoma Cell Lines of the Head and Neck.
Anticancer Research, march, 805-810 (2010)
R Olbromski et al.
Molecular biology reports, 40(2), 1189-1200 (2012-11-28)
Allelic expression imbalance (AEI) is an important genetic factor being the cause of differences in phenotypic traits that can be heritable. Studying AEI can be useful in searching for factors that modulate gene expression and help to understand molecular mechanisms...
Johnathan Yockey et al.
mSphere, 4(3) (2019-06-07)
Rhodotorula yeasts are pink, encapsulated basidiomycetes isolated from a variety of environments and clinical settings. They are increasingly linked with disease, particularly central venous catheter infections and meningitis, in immunocompromised patients. Eight clinical and eight environmental strains molecularly typed as...
Josef Zeinzinger et al.
Applied and environmental microbiology, 78(9), 3352-3360 (2012-02-22)
Salmonellosis is one of the most important food-borne diseases worldwide. For outbreak investigation and infection control, accurate and fast subtyping methods are essential. A triplex gene-scanning assay was developed and evaluated for serotype-specific subtyping of Salmonella enterica isolates based on...
Ganka Nikolova et al.
Genetics, 179(1), 419-427 (2008-05-07)
C57BL/6J (B6) mice containing the Mus domesticus poschiavinus Y chromosome, YPOS, develop ovarian tissue, whereas testicular tissue develops in DBA/2J or 129S1/SvImJ (129) mice containing the YPOS chromosome. To identify genes involved in sex determination, we used a congenic strain...
Katherine L Gross et al.
Molecular endocrinology (Baltimore, Md.), 25(7), 1087-1099 (2011-04-30)
Glucocorticoids regulate a variety of physiological processes and are commonly used to treat disorders of inflammation, autoimmune diseases, and cancer. Glucocorticoid action is predominantly mediated through the classic glucocorticoid receptor (GR)α isoform. Recent data suggest that the mature GRα mRNA...
Aravindan Rangaraj et al.
Experimental and therapeutic medicine, 13(5), 2151-2160 (2017-06-02)
Psoriasin, which is also known as S100A7, is a member of the S100 protein family, a group of calcium-responsive signalling proteins. Psoriasin expression remains high in patients with psoriasis, whereas it is downregulated in patients with invasive breast carcinoma. This...
Quan-Xiang Wei et al.
PloS one, 8(1), e55261-e55261 (2013-02-06)
We previously reported a rare germline variant (c.1-6531) that resulted in allele-specific expression (ASE) of death-associated protein kinase 1 (DAPK1) and predisposition to chronic lymphocytic leukemia (CLL). We investigated a cohort of CLL patients lacking this mutation for the presence...
Junwei Hao et al.
PloS one, 8(2), e57495-e57495 (2013-03-08)
Cigarette smoke exposure markedly compromises the ability of the immune system to protect against invading pathogens and tumorigenesis. Nicotine is a psychoactive component of tobacco products that acts as does the natural neurotransmitter, acetylcholine, on nicotinic receptors (nAChRs). Here we...
Maya Miller et al.
iScience, 23(7), 101262-101262 (2020-06-26)
PhenolaTi is an advanced non-toxic anticancer chemotherapy; this inert bis(phenolato)bis(alkoxo) Ti(IV) complex demonstrates the intriguing combination of high and wide efficacy with no detected toxicity in animals. Here we unravel the cellular pathways involved in its mechanism of action by...
Kylie R Baldwin et al.
Scientific reports, 7(1), 7118-7118 (2017-08-05)
Firemaster® 550 (FM 550) is a commercial flame retardant mixture of brominated and organophosphate compounds applied to polyurethane foam used in furniture and baby products. Due to widespread human exposure, and structural similarities with known endocrine disruptors, concerns have been...
Page 1 of 2
Page 1 of 2