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Harsh Panwar et al.
European journal of nutrition, 53(7), 1465-1474 (2014-01-15)
Inhibitors of intestinal alpha-glucosidases are used therapeutically to treat type 2 diabetes mellitus. Bacteria such as Actinoplanes sp. naturally produce potent alpha-glucosidase inhibitor compounds, including the most widely available drug acarbose. It is not known whether lactic acid bacteria (LAB)
Anna Zajakina et al.
BMC cancer, 14, 460-460 (2014-06-22)
The combination of virotherapy and chemotherapy may enable efficient tumor regression that would be unachievable using either therapy alone. In this study, we investigated the efficiency of transgene delivery and the cytotoxic effects of alphaviral vector in combination with 5-fluorouracil
Athanasios K Anagnostopoulos et al.
Journal of proteome research, 14(2), 1076-1088 (2014-12-30)
CNS tumors are the leading cause of cancer-related death in children. Medulloblastoma is the commonest pediatric CNS malignancy, wherein, despite multimodal therapy with surgery, radiation, and chemotherapy, 5 year survival rates merely approach 60%. Until present, gene expression and cytogenetic
Fujun Zhou et al.
PloS one, 9(4), e95396-e95396 (2014-04-17)
Essentially all aboveground plant tissues develop from the stem cells in the primary shoot apical meristem. Proliferation of the stem cell population in the Arabidopsis shoot apical meristem is tightly controlled by a feedback loop formed primarily by the homeodomain
Kou Takahashi et al.
The Journal of experimental medicine, 212(3), 319-332 (2015-02-26)
Glutamatergic systems play a critical role in cognitive functions and are known to be defective in Alzheimer's disease (AD) patients. Previous literature has indicated that glial glutamate transporter EAAT2 plays an essential role in cognitive functions and that loss of
Franco A Rossato et al.
PloS one, 9(6), e101060-e101060 (2014-06-26)
The metabolic enzyme fatty acid synthase (FASN) is responsible for the endogenous synthesis of palmitate, a saturated long-chain fatty acid. In contrast to most normal tissues, a variety of human cancers overexpress FASN. One such cancer is cutaneous melanoma, in
Andrea Krähmer et al.
Food chemistry, 181, 152-159 (2015-03-22)
The qualitative heterogeneity and increasing consumption of cocoa products require fast and efficient methods for quality assessment of fermented cocoa with regard to fermentation quality and flavor potential. To date, quality control is achieved by visual inspection (e.g., "cut test")
Chiara Appocher et al.
Human molecular genetics, 23(25), 6762-6772 (2014-08-07)
Pathological modifications in the microtubule-associated protein Tau is a common characteristic observed in different neurological diseases, suggesting that analogous metabolic pathways might be similarly affected during neurodegeneration. To identify these molecules and mechanisms, we utilized Drosophila models of human Tau-mediated
Hidetaka Akita et al.
Journal of controlled release : official journal of the Controlled Release Society, 200, 97-105 (2014-12-30)
A renal cell carcinoma (RCC) is one of the refractory tumors, since it readily acquires resistance against chemotherapy. Thus, alternative therapeutic approaches such as obstructing the neovasculature are needed. We previously reported on the development of a plasmid DNA (pDNA)-encapsulating
Tobias Eisenberg et al.
BMC microbiology, 15, 42-42 (2015-04-19)
The zoonotic bacterium Corynebacterium ulcerans may be pathogenic both in humans and animals: toxigenic strains can cause diphtheria or diphtheria-like disease in humans via diphtheria toxin, while strains producing the dermonecrotic exotoxin phospholipase D may lead to caseous lymphadenitis primarily
[Production and characterization of Methylomicrobium alcaliphilum 20Z knockout mutants, which has sucrose and ectoin synthesis defective genes].
S Iu But et al.
Mikrobiologiia, 82(2), 251-253 (2013-07-03)
Cynthia Stretch et al.
The Journal of nutrition, 142(1), 14-21 (2011-12-14)
Urine and plasma metabolites originate from endogenous metabolic pathways in different organs and exogenous sources (diet). Urine and plasma were obtained from advanced cancer patients and investigated to determine if variations in lean and fat mass, dietary intake, and energy
James M Doherty et al.
Alcoholism, clinical and experimental research, 39(3), 485-495 (2015-02-24)
Little is known regarding mechanisms regulating ethanol (EtOH) self-administration during adolescence or if the mechanisms differ from adults. One of the best models of abuse liability is operant self-administration. Therefore, we characterized operant sweetened EtOH self-administration behavior in adolescent and
Lei Cheng et al.
Molecular medicine reports, 10(5), 2263-2270 (2014-09-02)
Gamma knife surgery (GKS) is used for the treatment of various brain diseases. However, the mechanisms underlying brain injury following irradiation remain to be elucidated. Given that vascular endothelial growth factor (VEGF) is closely associated with pathological angiogenesis and the
Sarah Moyon et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(1), 4-20 (2015-01-09)
The declining efficiency of myelin regeneration in individuals with multiple sclerosis has stimulated a search for ways by which it might be therapeutically enhanced. Here we have used gene expression profiling on purified murine oligodendrocyte progenitor cells (OPCs), the remyelinating
Songul Yasar Yildiz et al.
Applied microbiology and biotechnology, 99(5), 2277-2289 (2015-02-24)
Brevibacillus thermoruber 423 is a Gram-positive, motile, red-pigmented, spore-forming, aerobic, and thermophilic bacterium that is known to produce high levels of exopolysaccharide (EPS) with many potential uses in food, feed, cosmetics, and pharmaceutical and chemical industries. This bacterium not only
Kenneth T Lewis et al.
Journal of cellular and molecular medicine, 18(10), 1927-1937 (2014-09-17)
Cup-shaped lipoprotein structures called porosomes are the universal secretory portals at the cell plasma membrane, where secretory vesicles transiently dock and fuse to release intravesicular contents. In neurons, porosomes measure ~15 nm and are comprised of nearly 40 proteins, among
James N Francis et al.
Vaccine, 33(2), 396-402 (2014-06-15)
FP-01.1 is a novel synthetic influenza A vaccine consisting of six fluorocarbon-modified 35-mer peptides that encapsulate multiple CD4+ and CD8+ T-cell epitopes and is designed to induce an immune response across a broad population. FP-01.1 was evaluated for safety and
Minming Wu et al.
Materials science & engineering. C, Materials for biological applications, 45, 162-169 (2014-12-11)
Novel biomimetic amphiphilic chitosan derivative, deoxycholic acid-phosphorylcholine-chitosan conjugate (DCA-PCCs) was synthesized based on the combination of Atherton-Todd reaction for coupling phosphorylcholine (PC) and carbodiimide coupling reaction for linking deoxycholic acid (DCA) to chitosan. The chemical structure of DCA-PCCs was characterized
Atsushi Kawase et al.
Journal of pharmaceutical sciences, 103(12), 4058-4065 (2014-10-22)
Pathophysiological changes are associated with alterations in the expression and function of numerous ADME-related proteins. We have previously demonstrated that the membrane localization of ATP-binding cassette (ABC) transporters in liver was decreased without change of total expression levels in adjuvant-induced
Daniel R Schmehl et al.
Journal of insect physiology, 71, 177-190 (2014-12-03)
Populations of pollinators are in decline worldwide. These declines are best documented in honey bees and are due to a combination of stressors. In particular, pesticides have been linked to decreased longevity and performance in honey bees; however, the molecular
Andrés E Chávez et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(50), 16621-16629 (2014-12-17)
The transient receptor potential TRPV1 or vanilloid receptor is a nonselective ligand-gated channel highly expressed in primary sensory neurons where it mediates nociception. TRPV1 is also expressed in the brain where its activation depresses excitatory synaptic transmission. Whether TRPV1 also
Jenni Neubert et al.
International journal of nanomedicine, 10, 2033-2049 (2015-03-21)
The physicochemical properties of superparamagnetic iron oxide nanoparticles (SPIOs) enable their application in the diagnostics and therapy of central nervous system diseases. However, since crucial information regarding side effects of particle-cell interactions within the central nervous system is still lacking
Malte Feja et al.
Progress in neuro-psychopharmacology & biological psychiatry, 54, 31-42 (2014-05-09)
Impulsivity is a multifactorial phenomenon, determined by deficits in decision-making (impulsive choice) and impulse control (impulsive action). Recent findings indicate that impulsive behaviour is not only top-down controlled by cortical areas, but also modulated at subcortical level. The nucleus accumbens
Radek Šachl et al.
Biochimica et biophysica acta, 1853(4), 850-857 (2014-08-08)
Gangliosides located at the outer leaflet of plasma membrane are molecules that either participate in recognizing of exogenous ligand molecules or exhibit their own receptor activity, which are both essential phenomena for cell communication and signaling as well as for
Maria Weidner et al.
PloS one, 8(3), e60484-e60484 (2013-04-02)
The trichothecene mycotoxin T-2 toxin is a common contaminant of food and feed and is also present in processed cereal derived products. Cytotoxic effects of T-2 toxin and its main metabolite HT-2 toxin are already well described with apoptosis being
P T Reidy et al.
Journal of applied physiology (Bethesda, Md. : 1985), 116(11), 1353-1364 (2014-04-05)
Increasing amino acid availability (via infusion or ingestion) at rest or postexercise enhances amino acid transport into human skeletal muscle. It is unknown whether alterations in amino acid availability, from ingesting different dietary proteins, can enhance amino acid transport rates
Xavier Tréton et al.
PloS one, 9(7), e101669-e101669 (2014-07-12)
Ulcerative colitis (UC) is a chronic inflammatory bowel disease affecting the rectum which progressively extents. Its etiology remains unknown and the number of treatments available is limited. Studies of UC patients have identified an unbalanced endoplasmic reticulum (ER) stress in
Dena B Dubal et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(6), 2358-2371 (2015-02-13)
Aging is the principal demographic risk factor for Alzheimer disease (AD), the most common neurodegenerative disorder. Klotho is a key modulator of the aging process and, when overexpressed, extends mammalian lifespan, increases synaptic plasticity, and enhances cognition. Whether klotho can
Christian D S Nelson et al.
Journal of virology, 89(7), 3910-3921 (2015-01-23)
JC polyomavirus (JCPyV) infection of immunocompromised individuals results in the fatal demyelinating disease progressive multifocal leukoencephalopathy (PML). The viral capsid of JCPyV is composed primarily of the major capsid protein virus protein 1 (VP1), and pentameric arrangement of VP1 monomers
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