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Nargis Jamila et al.
Journal of enzyme inhibition and medicinal chemistry, 30(1), 133-139 (2014-03-29)
Context: Garcinia hombroniana Pierre, known as manggis hutan in Malaysia is a rich source of xanthones and benzophenones. This study was aimed to isolate and characterize potential cholinesterase inhibitors from the extracts of G. hombroniana bark and investigate their interactions
Berenice Fernández-Rojas et al.
Molecular and cellular biochemistry, 406(1-2), 183-197 (2015-05-15)
The potential of C-phycocyanin (C-PC) to prevent cisplatin (CP)-induced kidney mitochondrial dysfunction was determined in CD-1 male mice. The CP-induced mitochondrial dysfunction was characterized by ultrastructural abnormalities and by decrease in the following parameters in isolated kidney mitochondria: adenosine diphosphate
F Kazazi-Hyseni et al.
International journal of pharmaceutics, 482(1-2), 99-109 (2014-12-17)
Poly(D,L-lactic-co-hydroxymethyl glycolic acid) (PLHMGA) is a biodegradable copolymer with potential as a novel carrier in polymeric drug delivery systems. In this study, the biocompatibility of PLHMGA microspheres (PLHMGA-ms) was investigated both in vitro in three different cell types (PK-84, HK-2
Jacqueline Ramírez et al.
Drug metabolism and disposition: the biological fate of chemicals, 43(7), 928-935 (2015-04-15)
OTS167 is a potent maternal embryonic leucine zipper kinase inhibitor undergoing clinical testing as antineoplastic agent. We aimed to identify the UDP-glucuronosyltransferases (UGTs) involved in OTS167 metabolism, study the relationship between UGT genetic polymorphisms and hepatic OTS167 glucuronidation, and investigate
Haiping Wang et al.
Journal of the science of food and agriculture, 95(9), 1838-1844 (2014-09-11)
Garlic is one of the most important bulb vegetables and is mainly used as a spice or flavoring agent for foods. It is also cultivated for its medicinal properties, attributable to sulfur compounds, of which allicin is the most important.
Yingying Wen et al.
Journal of chromatography. A, 1368, 18-25 (2014-12-03)
A modified Quick, Easy, Cheap, Effective, Rugged and Safe (QuEChERS) method based on the dispersive solid-phase extraction (dSPE) combined with high performance liquid chromatography (HPLC) was developed for the determination of non-steroidal estrogens in water samples. In this study, graphene
Żaneta Rembisz et al.
Journal of chromatography. A, 1407, 184-192 (2015-07-15)
A high-performance liquid chromatography method based on pre-column derivatization with the pyrylium salts (4-[p-(N,N-dimethylamino)phenyl]-2,6-diphenylpyrylium perchlorate (LN1) and 2,4,6-triphenylpyrylium tetrafluoroborate (L1)) has been developed for the determination of sulfide. After the reaction of sulfide ions with LN1 or L1 aiming at
Yiran Xia et al.
Pharmaceutical development and technology, 20(3), 375-379 (2014-02-04)
The aim of this research was to develop and assess a new dissolution apparatus for orodispersible films (ODFs). The new apparatus was based on a flow-through cell design which requires only a limited amount of dissolution medium and can automatically
G Astrid Garzón et al.
Journal of agricultural and food chemistry, 63(6), 1803-1811 (2015-02-11)
The contents and profile of polyphenols were analyzed in edible petals of nasturtium flowers (Tropaeolum majus) of three colors, and their oxygen radical absorbance capacities (ORAC) were compared. Three primary anthocyanins (ACNs) and 15 non-ACN phenolic compounds including hydroxycinammic acids
M Giorgi et al.
Journal of veterinary pharmacology and therapeutics, 38(5), 488-496 (2015-01-28)
In reptiles, administration of opioid drugs has yielded unexpected results with respect to analgesia. The aims of this study were to assess the pharmacokinetic/pharmacodynamic (PK/PD) properties of tramadol and its active metabolite M1 and to evaluate the effect of the
Antonina Gucciardi et al.
Biomedical chromatography : BMC, 28(8), 1131-1139 (2014-01-23)
Lysosomal storage disorders comprise a group of rare genetic diseases in which a deficit of specific hydrolases leads to the storage of undegraded substrates in lysosomes. Impaired enzyme activities can be assessed by MS/MS quantification of the reaction products obtained
Xu Wang et al.
The Analyst, 140(5), 1453-1458 (2015-01-21)
A simple, sensitive and cost-effective method for the analysis of the mycotoxin aflatoxin B1 (AFB1) has been established based on controlled growth of immunogold. AFB1-BSA conjugate modified magnetic beads were employed as capture probe and anti-AFB1 antibody-coated gold colloids were
Hiroki Kinouchi et al.
Analytical biochemistry, 492, 43-48 (2015-09-20)
We developed a surface plasmon resonance (SPR) assay to estimate the competitive inhibition by pharmaceuticals for thyroxine (T4) binding to thyroid hormone transport proteins, transthyretin (TTR) and thyroxine binding globulin (TBG). In this SPR assay, the competitive inhibition of pharmaceuticals
R Kanďár et al.
Andrologia, 46(10), 1079-1088 (2013-10-16)
A method is described here for the determination of total glutathione (TGSH) and glutathione disulphide (GSSG) in the seminal plasma of the male partners of couples requesting a fertility evaluation. A suitable sample preparation procedure prior to high-performance liquid chromatography
Jake Chng et al.
mAbs, 7(2), 403-412 (2015-01-27)
Linking the heavy chain (HC) and light chain (LC) genes required for monoclonal antibodies (mAb) production on a single cassette using 2A peptides allows control of LC and HC ratio and reduces non-expressing cells. Four 2A peptides derived from the
Zhengming Gu et al.
Archives of pathology & laboratory medicine, 138(11), 1474-1480 (2014-10-31)
Invasive fungal infections are an important cause of morbidity and mortality among immunocompromised patients. To design and evaluate a multiplexed assay aimed at quantitative detection and differentiation of the 5 molds that are most commonly responsible for pulmonary infections. Using
Chiara Francesca Magistrali et al.
Anaerobe, 33, 42-47 (2015-02-02)
The aim of this study is to describe the prevalence and risk factors of Clostridium difficile shedding in six farms belonging to two companies in Northern Italy. Four hundred and twenty veal calves, randomly selected and individually identified, were sampled
Xinyi Chia et al.
ACS nano, 9(5), 5164-5179 (2015-04-22)
Layered transition metal dichalcogenides (TMDs) have been the center of attention in the scientific community due to their properties that can be tapped on for applications in electrochemistry and hydrogen evolution reaction (HER) catalysis. We report on the effect of
Adam M Gonzalez et al.
Journal of sports science & medicine, 14(2), 322-332 (2015-05-20)
This study compared caffeine pharmacokinetics, glycerol concentrations, metabolic rate, and performance measures following ingestion of a time-release caffeine containing supplement (TR-CAF) versus a regular caffeine capsule (CAF) and a placebo (PL). Following a double-blind, placebo-controlled, randomized, cross-over design, ten males
Che-Fan Huang et al.
Journal of peptide science : an official publication of the European Peptide Society, 21(2), 114-119 (2015-01-06)
Protein oxidation by reactive oxygen species has been associated with aging and neurodegenerative disorders, and histidine is one of the major oxidation targets due to its metal-chelating property and susceptibility to metal-catalyzed oxidation. 2-Oxohistidine, the major product of histidine oxidation
Rao Mukkavilli et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 77, 90-99 (2015-06-01)
Noscapine (Nos), an antitussive benzylisoquinoline opium alkaloid, is a non-toxic tubulin-binding agent currently in Phase II clinical trials for cancer chemotherapy. While preclinical studies have established its tumor-inhibitory properties in various cancers, poor absorptivity and rapid first-pass metabolism producing several
Erica L Unger et al.
Experimental neurology, 261, 462-468 (2014-07-08)
Iron deficiency (ID) in rodents leads to decreased ventral midbrain (VMB) iron concentrations and to changes in the dopamine (DA) system that mimic many of the dopaminergic changes seen in RLS patient where low substantia nigra iron is a known
Tarek A Ahmed et al.
AAPS PharmSciTech, 15(3), 772-780 (2014-03-22)
The objective of this study was to investigate the sustained release of a hydrophilic drug, montelukast (MK), from two biodegradable polymeric drug delivery systems, in situ implant (ISI) and in situ microparticles (ISM). N-Methyl pyrrolidone (NMP), dimethyl sulfoxide (DMSO), triacetin
Edina Lump et al.
eLife, 4 (2015-08-19)
Semen is the main vector for HIV transmission and contains amyloid fibrils that enhance viral infection. Available microbicides that target viral components have proven largely ineffective in preventing sexual virus transmission. In this study, we establish that CLR01, a 'molecular
Chieh-Jui Tsou et al.
Nanoscale, 7(9), 4217-4225 (2015-02-13)
Continuous and simultaneous 3D single-particle movement and local pH detection in HeLa cells were demonstrated for the first time by combining fluorescent mesoporous silica nanoparticles (FMSNs) and a single-particle tracking (SPT) technique with a precision of ∼10 nm. FMSNs, synthesized
Miaomiao Jiang et al.
BMC complementary and alternative medicine, 14, 350-350 (2014-09-25)
Metabonomics is a useful tool for studying mechanisms of drug treatment using systematic metabolite profiles. Ginsenosides Rg1 and Rb1, ophiopogonin D, and schizandrin are the main bioactive components of a traditional Chinese formula (Sheng-Mai San) widely used for the treatment
Smita Joel et al.
ACS chemical biology, 9(7), 1595-1602 (2014-05-21)
Advancements in biotechnology have allowed for the preparation of designer proteins with a wide spectrum of unprecedented chemical and physical properties. A variety of chemical and genetic methods can be employed to tailor the protein's properties, including its stability and
Athiporn Doomkaew et al.
Journal of pharmaceutical and biomedical analysis, 102, 119-128 (2014-09-27)
A stability indicating-micellar electrokinetic chromatography method was developed and validated for the determination of gliclazide (GCZ) and its specified impurities, gliclazide impurities B (GZB) and F (GZF) in bulk and tablets. The analytes were well separated (Rs>2.1) in 5 min
Ying Hou et al.
Biotechnology progress, 31(4), 974-982 (2015-05-29)
Protein A chromatography is widely employed for the capture and purification of monoclonal antibodies (mAbs). Because of the high cost of protein A resins, there is a significant economic driving force to seek new downstream processing strategies. Membrane chromatography has
Mélanie Merbah et al.
Journal of immunological methods, 487, 112874-112874 (2020-10-07)
Genus Flavivirus, which includes 53 virus species, is the leading cause of arthropod-borne diseases in humans. Diagnosis of these viral diseases is complicated by their overlapping epidemiology and clinical manifestations, and the fact that cross-reactive antibody responses are frequently elicited
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