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Varalakshmi Katuri et al.
Oncotarget, 5(9), 2436-2449 (2014-05-09)
Angiogenesis is required for tumor growth. WT1, a protein that affects both mRNA transcription and splicing, has recently been shown to regulate expression of vascular endothelial growth factor (VEGF), one of the major mediators of angiogenesis. In the present study
Aghil Sharifzadeh et al.
Mycoses, 58(8), 478-484 (2015-07-15)
The purposes of this study were to investigate the enzymatic activity of different Candida species and their antifungal susceptibility patterns. The study involved a total of 83 isolates of Candida from the genital tract of the female Camelus dromedarius. After
Petr Chlanda et al.
Journal of virology, 89(17), 8957-8966 (2015-06-19)
The assembly of influenza A virus at the plasma membrane of infected cells leads to release of enveloped virions that are typically round in tissue culture-adapted strains but filamentous in strains isolated from patients. The viral proteins hemagglutinin (HA), neuraminidase
Joseph Dopie et al.
Journal of cell science, 128(13), 2388-2400 (2015-05-30)
Nuclear actin plays an important role in many processes that regulate gene expression. Cytoplasmic actin dynamics are tightly controlled by numerous actin-binding proteins, but regulation of nuclear actin has remained unclear. Here, we performed a genome-wide RNA interference (RNAi) screen
Bombi Lee et al.
BMC complementary and alternative medicine, 15, 210-210 (2015-07-04)
Repeated injection of corticosterone (CORT) induces dysregulation in the hypothalamic-pituitary-adrenal (HPA) axis, resulting in depression. We examined the effects of Angelica gigas extract (AGN) treatment in a rat model of depressive and anxiety-like behaviors, induced by chronic CORT exposure. Male
Michele Sessolo et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(26), 9544-9557 (2015-07-03)
Parvalbumin (Pv)-positive inhibitory interneurons effectively control network excitability, and their optogenetic activation has been reported to block epileptic seizures. An intense activity in GABAergic interneurons, including Pv interneurons, before seizures has been described in different experimental models of epilepsy, raising
Agnieszka Chocyk et al.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 44, 33-47 (2015-05-20)
Clinical studies have suggested that early-life stress (ELS) increases the risk of psychopathologies that are strongly associated with dysfunction of dopaminergic neurotransmission. Thus, ELS may interfere with the development and maturation of the dopaminergic system; however, the mechanisms involved in
F De Vadder et al.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 27(3), 443-448 (2015-01-15)
Intestinal gluconeogenesis (IGN) promotes metabolic benefits through activation of a gut-brain neural axis. However, the local mediator activating gluconeogenic genes in the enterocytes remains unknown. We show that (i) vasoactive intestinal peptide (VIP) signaling through VPAC1 receptor activates the intestinal
Elena Gavilán et al.
Neurobiology of aging, 36(5), 1953-1963 (2015-03-31)
Autophagy plays a key role in the maintenance of cellular homeostasis, and autophagy deregulation gives rise to severe disorders. Many of the signaling pathways regulating autophagy under stress conditions are still poorly understood. Using a model of proteasome stress in
Ester Verdaguer et al.
Experimental gerontology, 69, 176-188 (2015-06-24)
The pathogenesis of Alzheimer disease (AD) is characterized by accumulation of β-amyloid protein in the brain (in both soluble and insoluble forms) and by the presence of intracellular neurofibrillary tangles (NFTs), leading to neurotoxicity. The exact mechanisms whereby Aβ triggers
Lourdes Cruz-Garcia et al.
Journal of lipid research, 55(9), 1944-1958 (2014-07-18)
Liver X receptors (Lxrs) are master regulators of cholesterol catabolism, driving the elimination of cholesterol from the periphery to the lumen of the intestine. Development of pharmacological agents to activate Lxrs has been hindered by synthetic Lxr agonists' induction of
Hao Pang et al.
Current topics in medicinal chemistry, 13(10), 1234-1241 (2013-05-08)
Sucrose hydrolytic enzymes, widely used in a variety of food industries, employ sucrose as a substrate. In addition to their hydrolysis activities, they have other recently discovered characteristics that should make them useful for medical applications. Here, the two enzymes
Reza Mehran et al.
Cancer research, 74(10), 2731-2741 (2014-03-15)
Circulating endothelial cells (CEC) are derived from multiple sources, including bone marrow (circulating endothelial progenitors; CEP), and established vasculature (mature CEC). Although CECs have shown promise as a biomarker for patients with cancer, their utility has been limited, in part
Yuval Silberman et al.
Alcoholism, clinical and experimental research, 39(11), 2154-2162 (2015-10-28)
Ethanol (EtOH) modulation of central amygdala (CeA) neurocircuitry plays a key role in the development of alcoholism via activation of the corticotropin-releasing factor (CRF) receptor (CRFR) system. Previous work has predominantly focused on EtOH × CRF interactions on the CeA GABA circuitry;
Yun Fa et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1001, 169-173 (2015-08-19)
A capillary ion chromatography-mass spectrometry (MS) method was proposed to determine glucosylglycerol (GG), sucrose, and five other carbohydrates. MS conditions and make-up flow parameters were optimized. This method is accurate and sensitive for simultaneous analysis of carbohydrates, with mean correlation
Kyungjoon Park et al.
Scientific reports, 5, 17796-17796 (2015-12-05)
Neuronal loss caused by neurodegenerative diseases, traumatic brain injury and stroke results in cognitive dysfunctioning. Implantation of neural stem/precursor cells (NPCs) can improve the brain function by replacing lost neurons. Proper synaptic integration following neuronal differentiation of implanted cells is
Hélène Bon et al.
Molecular cancer research : MCR, 13(4), 620-635 (2014-12-31)
Salt-inducible kinase 2 (SIK2) is a multifunctional kinase of the AMPK family that plays a role in CREB1-mediated gene transcription and was recently reported to have therapeutic potential in ovarian cancer. The expression of this kinase was investigated in prostate
Miaomiao Mao et al.
Journal of the Association for Research in Otolaryngology : JARO, 16(4), 473-486 (2015-05-20)
The dorsal cochlear nucleus (DCN) is a major subdivision of the mammalian cochlear nucleus (CN) that is thought to be involved in sound localization in the vertical plane and in feature extraction of sound stimuli. The main principal cell type
Chen Su et al.
Molecular brain, 8, 46-46 (2015-08-12)
A variety of pain conditions have been found to be associated with depressed mood in clinical studies. Depression-like behaviors have also been described in animal models of persistent or chronic pain. In rodent chronic neuropathic pain models, elevated levels of
Dong Tang et al.
American journal of physiology. Gastrointestinal and liver physiology, 308(9), G767-G778 (2015-03-21)
Visceral hypersensitivity represents an important hallmark in the pathophysiology of irritable bowel syndrome (IBS), of which the mechanisms remain elusive. The present study was designed to examine whether cation-chloride cotransporter (CCC)-mediated chloride (Cl(-)) homeostasis of the spinal cord is involved
Marta Bueno et al.
The Journal of clinical investigation, 125(2), 521-538 (2015-01-07)
Although aging is a known risk factor for idiopathic pulmonary fibrosis (IPF), the pathogenic mechanisms that underlie the effects of advancing age remain largely unexplained. Some age-related neurodegenerative diseases have an etiology that is related to mitochondrial dysfunction. Here, we
Albert Alé et al.
Neurotoxicity research, 27(4), 430-440 (2015-01-16)
The proteasome inhibitor bortezomib is nowadays first line treatment for multiple myeloma. One of the most significant adverse events is peripheral neuropathy, mainly involving sensory nerve fibers that can lead to withdrawal of treatment. Here we develop an in vitro
Yoshiaki Kita et al.
Developmental neurobiology, 75(9), 927-934 (2014-12-23)
During development, growing axons must locate target cells to form synapses. This is not easy, since target cells are also growing and even actively migrating. In some brain regions, such axons have been reported to wait for the timing when
Sarah M Connaughton et al.
Vaccine, 33(36), 4586-4593 (2015-07-19)
Mumps vaccines are live attenuated viruses. They are known to vary in effectiveness, degree of attenuation and adverse event profile. However, the underlying reasons are poorly understood. We studied two closely related mumps vaccines which originate from the same attenuated
Scott Wushke et al.
Applied and environmental microbiology, 81(16), 5567-5573 (2015-06-07)
Development of a designed coculture that can achieve aerotolerant ethanogenic biofuel production from cellulose can reduce the costs of maintaining anaerobic conditions during industrial consolidated bioprocessing (CBP). To this end, a strain of Caldibacillus debilis isolated from an air-tolerant cellulolytic
Xinping Hao et al.
PloS one, 9(6), e97389-e97389 (2014-06-03)
Age-related hearing loss (presbycusis) is a common human disorder, affecting one in three Americans aged 60 and over. Previous studies have shown that presbyacusis is associated with a loss of non-sensory cells in the cochlear lateral wall. Sox10 is a
Takako Naganuma et al.
PloS one, 9(11), e112326-e112326 (2014-11-07)
Nacreous layers of pearl oyster are one of the major functional biominerals. By participating in organic compound-crystal interactions, they assemble into consecutive mineral lamellae-like photonic crystals. Their biomineralization mechanisms are controlled by macromolecules; however, they are largely unknown. Here, we
Tatiana Cucu et al.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 32(9), 1406-1415 (2015-07-28)
Sucrose esters (E 473) are emulsifiers used in foods to improve different technological properties. They should conform to the specifications laid down in Commission Regulation No. 231/2012 and be used at amounts not exceeding the maximal ones set by Commission
Jessica T Y Yue et al.
Nature communications, 6, 5970-5970 (2015-01-13)
The brain emerges as a regulator of hepatic triglyceride-rich very-low-density lipoproteins (VLDL-TG). The neurocircuitry involved as well as the ability of fatty acids to trigger a neuronal network to regulate VLDL-TG remain unknown. Here we demonstrate that infusion of oleic
Josselin Montarry et al.
Molecular ecology, 24(8), 1654-1677 (2015-03-05)
Deviations of genotypic frequencies from Hardy-Weinberg equilibrium (HWE) expectations could reveal important aspects of the biology of populations. Deviations from HWE due to heterozygote deficits have been recorded for three plant-parasitic nematode species. However, it has never been determined whether
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