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Hilke Jungen et al.
Journal of analytical toxicology, 37(9), 652-658 (2013-10-09)
Methadone and buprenorphine are commonly used as oral substitutes in opiate maintenance programs to treat persons who are dependent on heroin. During these programs, patients are not allowed to continue using illicit drugs. Abstinence can easily be monitored by urine
Zeus A Antonello et al.
The EMBO journal, 34(15), 2025-2041 (2015-06-17)
The intestinal epithelium is remarkably robust despite perturbations and demand uncertainty. Here, we investigate the basis of such robustness using novel tracing methods that allow simultaneously capturing the dynamics of stem and committed progenitor cells (called enteroblasts) and intestinal cell
Ryan Moazamian et al.
Molecular human reproduction, 21(6), 502-515 (2015-04-04)
Oxidative stress is known to compromise human sperm function and to activate the intrinsic apoptotic cascade in these cells. One of the key features of oxidatively stressed spermatozoa is the induction of a lipid peroxidation process that results in the
Heather N Lavezzi et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 40(3), 676-687 (2014-08-29)
The rostromedial tegmental nucleus (RMTg) is a strong inhibitor of dopamine neurons in the ventral tegmental area (VTA) reported to influence neurobiological and behavioral responses to reward omission, aversive and fear-eliciting stimuli, and certain drugs of abuse. Insofar as previous
Kirsten Allan et al.
FEBS letters, 588(20), 3739-3743 (2014-08-31)
Expression of human amyloid-β (Aβ) in Drosophila is frequently used to investigate its toxicity in vivo. We expressed Aβ1-42 in the fly using a secretion signal derived from the Drosophila necrotic gene, as described in several previous publications. Surface-enhanced laser
Yoko Yazaki-Sugiyama et al.
The European journal of neuroscience, 41(1), 97-108 (2014-10-30)
Genetically targeted approaches that permit acute and reversible manipulation of neuronal circuit activity have enabled an unprecedented understanding of how discrete neuronal circuits control animal behavior. Zebra finch singing behavior has emerged as an excellent model for studying neuronal circuit
Vladimir I Makarov et al.
Electromagnetic biology and medicine, 34(1), 93-104 (2014-04-04)
We studied action of one-dimensional, two-dimensional and three-dimensional low-frequency oscillating electric and magnetic fields on sugar metabolism in Saccharomyces cerevisiae cell culture. S. cerevisiae cells were grown on a minimal medium containing glucose (10%) as a carbon source and salts
Maria Morgan-Bathke et al.
American journal of physiology. Endocrinology and metabolism, 308(9), E830-E846 (2015-03-05)
Adipose tissue fatty acid storage varies according to sex, adipose tissue depot, and degree of fat gain. However, the mechanism(s) for these variations is not completely understood. We examined whether differences in adipose tissue glycerol-3-phosphate acyltransferase (GPAT) might play a
Viola B Morris et al.
Biomaterials, 60, 151-160 (2015-05-23)
Neuronal gene therapy potentially offers an effective therapeutic intervention to cure or slow the progression of neurological diseases. However, neuronal cells are difficult to transfect with nonviral vectors, and in vivo their transport across the blood-brain barrier (BBB) is inefficient. We
Chih-Yuan Ko et al.
Psychoneuroendocrinology, 55, 173-183 (2015-03-17)
Social isolation rearing (SIR) is an early stress paradigm of deprivation of the social contact since weaning. SIR has been used to investigate the mechanisms behind certain mental illnesses with neurodevelopmental origins, including schizophrenia. In schizophrenia, metabolic dysfunction has become
Diletta Scaccabarozzi et al.
PloS one, 10(12), e0143195-e0143195 (2015-12-02)
Malaria-associated acute lung injury (MA-ALI) and its more severe form malaria-associated acute respiratory distress syndrome (MA-ARDS) are common, often fatal complications of severe malaria infections. However, little is known about their pathogenesis. In this study, biochemical alterations of the lipid
Fangfang Ma et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(47), 16967-16972 (2014-11-05)
Improving plant productivity is an important aim for metabolic engineering. There are few comprehensive methods that quantitatively describe leaf metabolism, although such information would be valuable for increasing photosynthetic capacity, enhancing biomass production, and rerouting carbon flux toward desirable end
Troy J Pereira et al.
The Journal of physiology, 593(14), 3181-3197 (2015-04-30)
Maternal obesity is associated with a high risk for gestational diabetes mellitus (GDM), which is a common complication of pregnancy. The influence of maternal obesity and GDM on the metabolic health of the offspring is poorly understood. We hypothesize that
Andrea Matteucci et al.
Experimental eye research, 125, 20-29 (2014-06-01)
Müller cell activation is an early finding in diabetic retinopathy (DR), but its physiopathologic role in the disease is still unclear, especially in the early phases. We investigated on Müller glial activation in primary rat retinal cultures, exposed to High
Daniel M P Ardisson-Araujo et al.
The Journal of general virology, 96(Pt 5), 1150-1160 (2015-01-13)
The serpin family of serine proteinase inhibitors plays key roles in a variety of biochemical pathways. In insects, one of the important functions carried out by serpins is regulation of the phenoloxidase (PO) cascade - a pathway that produces melanin
Toru Maeda et al.
Zoological letters, 1, 35-35 (2015-12-10)
Recently, dRYamides-1 and -2 have been identified as ligands of the neuropeptide Y-like receptor CG5811 in Drosophila melanogaster. It has also been reported in brief that injection of dRYamide-1suppresses the early feeding behavior called proboscis extension reflex (PER) in the
Hoyong Park et al.
Journal of neurophysiology, 113(5), 1493-1500 (2014-12-17)
Lysophosphatidic acid (LPA) is one of the well-characterized, ubiquitous phospholipid molecules. LPA exerts its effect by activating G protein-coupled receptors known as LPA receptors (LPARs). So far, LPAR signaling has been critically implicated during early development stages, including the regulation
Lori S Tillmans et al.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 24(4), 713-719 (2015-02-05)
Cigarette smoking (smoking), hormone therapy (MHT), and folate intake (folate) are each thought to influence colorectal cancer risk, but the underlying molecular mechanisms remain incompletely defined. Expression of estrogen receptor β (ESR2) has been associated with colorectal cancer stage and
Mohamad Abu-Abied et al.
Journal of experimental botany, 66(9), 2813-2824 (2015-03-20)
Induction of adventitious roots (ARs) in recalcitrant plants often culminates in cell division and callus formation rather than root differentiation. Evidence is provided here to suggest that microtubules (MTs) play a role in the shift from cell division to cell
Fang Wu et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 35(12), 1966-1976 (2015-07-02)
The active zone (AZ) is a thickening of the presynaptic membrane where exocytosis takes place. Chemical synapses contain neurotransmitter-loaded synaptic vesicles (SVs) that at rest are tethered away from the synaptic release site, but after the presynaptic inflow of Ca(+2)
Bhavesh S Barot et al.
Pharmaceutical development and technology, 19(5), 513-520 (2013-05-25)
Intravenous polynuclear iron formulations are vital components in the treatment of iron deficiency anemia associated with chronic kidney disease as well as other diseases associated with gastro-intestinal and cardio-vascular system. Intravenous iron preparations consist of iron-carbohydrate nanoparticles with iron-oxyhydroxide as
Akie Shimotohno et al.
Plant & cell physiology, 56(4), 620-630 (2015-02-12)
Boron, an essential micronutrient, is transported in roots of Arabidopsis thaliana mainly by two different types of transporters, BORs and NIPs (nodulin26-like intrinsic proteins). Both are plasma membrane localized, but have distinct transport properties and patterns of cell type-specific accumulation
Nedjla Zehani et al.
Biosensors & bioelectronics, 74, 830-835 (2015-08-02)
A highly sensitive electrochemical biosensor for the detection of Bisphenol A (BPA) in water has been developed by immobilizing tyrosinase onto a diazonium-functionalized boron doped diamond electrode (BDD) modified with multi-walled carbon nanotubes (MWCNTs). The fabricated biosensor exhibits excellent electroactivity
Rahul Kumar et al.
Journal of colloid and interface science, 459, 146-150 (2015-08-19)
Dye sensitized solar cells (DSSCs) have attracted much attention in recent years due to low cost fabrication as compared to silicon-based and thin film solar cells. Though, platinum is an excellent catalytic material for use in preparation of counter electrodes
Elke Rufer et al.
Journal of immunology (Baltimore, Md. : 1950), 195(11), 5482-5494 (2015-11-01)
The transporter associated with Ag processing (TAP) translocates proteasomally derived cytosolic peptides into the endoplasmic reticulum. TAP is a central component of the peptide-loading complex (PLC), to which tapasin (TPN) recruits MHC class I (MHC I) and accessory chaperones. The
Siriwan Panprivech et al.
Molecules (Basel, Switzerland), 20(5), 7974-7989 (2015-05-07)
The impact of increasing cold soak (CS) duration (0, 1, 4, 7, and 10 days at 10 °C) on the extraction of phenolic compounds during the CS period and primary fermentation as well as the final composition of Cabernet Sauvignon
W F Tonnis et al.
Molecular pharmaceutics, 12(3), 684-694 (2015-01-13)
Protein-based biopharmaceuticals are generally produced as aqueous solutions and stored refrigerated to obtain sufficient shelf life. Alternatively, proteins may be freeze-dried in the presence of sugars to allow storage stability at ambient conditions for prolonged periods. However, to act as
Jill Motl et al.
American journal of therapeutics, 21(5), 352-357 (2012-06-21)
Resuscitation from cardiac arrest is partly limited by progressive reduction in left ventricular distensibility, leading to decreased hemodynamic efficacy of cardiopulmonary resuscitation (CPR). Reduction in left ventricular distensibility has been linked to loss of mitochondrial bioenergetic function that can result
Hyo Kyun Chung et al.
Liver international : official journal of the International Association for the Study of the Liver, 35(4), 1341-1353 (2014-12-03)
Nonalcoholic steatohepatitis (NASH) is associated with cirrhosis and hepatocellular carcinoma. Reactive oxygen species (ROS) and reactive nitrogen species (RNS) play key roles in the development of the disease. However, the therapeutic target of NASH has not been fully defined and
Thomas R Silvers et al.
Biochemistry, 52(51), 9367-9374 (2013-11-13)
The formation and stability of protein-protein interfaces are of obvious biological importance. While a large body of literature exists describing the effect of osmolytes on protein folding, very few studies address the effect of osmolytes on protein association and binding.
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