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Deniz Gulfem Ozturk et al.
Autophagy, 15(3), 375-390 (2018-10-07)
Macroautophagy (autophagy) is an evolutionarily conserved recycling and stress response mechanism. Active at basal levels in eukaryotes, autophagy is upregulated under stress providing cells with building blocks such as amino acids. A lysosome-integrated sensor system composed of RRAG GTPases and
Muneeb U Rehman et al.
Pharmacological reports : PR, 66(6), 1050-1059 (2014-12-03)
Cisplatin is an effective and extensively used chemotherapeutic agent to treat range of malignancies, but its therapeutic use is limited because of dose-dependent nephrotoxicity and hepatotoxicity. Several published reports advocate that supplementation with antioxidant can influence cisplatin induced hepatic damage.
Wen-Nee Tan et al.
Fitoterapia, 97, 261-267 (2014-06-14)
A triflavanone, Garcineflavanone A (1) and a biflavonol, Garcineflavonol A (2) have been isolated from the stem bark of Garcinia atroviridis (Clusiaceae), collected in Peninsular Malaysia. Their structures were established using one and two-dimensional NMR, UV, IR and mass spectrometry
Srinivasa M Sammeta et al.
Pharmaceutical development and technology, 20(2), 169-175 (2013-11-14)
The main objective of the present study was to develop formulations of noscapine hydrochloride hydrate with enhanced solubility and bioavailability using co-solvent- and cyclodextrin-based approaches. Different combinations of co-solvents, which were selected on the basis of high-throughput solubility screening, were
Justin P Ludeman et al.
Organic & biomolecular chemistry, 13(7), 2162-2169 (2014-12-24)
Tyrosine sulfation is a widespread post-translational modification that mediates the interactions of secreted and membrane-associated proteins in such varied biological processes as peptide hormone action, adhesion, blood coagulation, complement activation and regulation of leukocyte trafficking. Due to the heterogeneous nature
Jia Wang et al.
Bio-protocol, 9(14), e3309-e3309 (2019-07-20)
Lipid droplets (LDs) are central organelles in maintaining lipid homeostasis. Defective LD growth often results in the development of metabolic disorders. LD fusion and growth mediated by cell death-inducing DNA fragmentation factor alpha (DFFA)-like effector (CIDE) family proteins are crucial
Erika Terzuoli et al.
Cancers, 11(12) (2019-12-11)
Melanoma and non-small-cell lung carcinoma (NSCLC) cell lines are characterized by an intrinsic population of cancer stem-like cells (CSC), and high expression of detoxifying isozymes, the aldehyde dehydrogenases (ALDHs), regulating the redox state. In this study, using melanoma and NSCLC
Yang Yang et al.
Environmental science & technology, 48(20), 12362-12369 (2014-09-16)
Disinfectants inactivate pathogens in source water; however, they also react with organic matter and bromide/iodide to form disinfection byproducts (DBPs). Although only a few DBP classes have been systematically analyzed for toxicity, iodinated and brominated DBPs tend to be the
Rachel A Saylor et al.
Electrophoresis, 36(16), 1912-1919 (2015-05-12)
A method for the separation and detection of analytes in the dopamine metabolic pathway was developed using microchip electrophoresis with electrochemical detection. The microchip consisted of a 5 cm PDMS separation channel in a simple-t configuration. Analytes in the dopamine
Sunil Mathur et al.
Cell chemical biology, 27(1), 74-82 (2019-12-21)
Activity-based protein profiling is an invaluable technique for studying enzyme biology and facilitating the development of therapeutics. Ubiquitin E3 ligases (E3s) are one of the largest enzyme families and regulate a host of (patho)physiological processes. The largest subtype are the
Summer L Gibbs et al.
Molecular imaging, 14 (2015-03-31)
Hematoxylin-eosin (H&E) staining of tissue has been the mainstay of pathology for more than a century. However, the learning curve for H&E tissue interpretation is long, whereas intra- and interobserver variability remain high. Computer-assisted image analysis of H&E sections holds
Miho Nakamura et al.
Biomedical materials (Bristol, England), 10(1), 011001-011001 (2015-01-15)
The surface modification of ceramic biomaterials used for medical devices is expected to improve osteoconductivity through control of the interfaces between the materials and living tissues. Polarisation treatment induced surface charges on hydroxyapatite, β-tricalcium phosphate, carbonate-substituted hydroxyapatite and yttria-stabilized zirconia
Yanyan Jiang et al.
Macromolecular bioscience, 15(7), 965-978 (2015-03-27)
A novel gene transfection vector was fabricated based on the conjugation of human serum albumin (HSA) and maleimide end functionalized poly[(N,N-dimethylamino) ethyl methacrylate] (PDMAEMA). The bioconjugation was achieved in a site-specific manner to yield well-defined polymer-protein conjugates. The biohybrid was
Bradley J Voss et al.
Bio-protocol, 5(8), e1455-e1455 (2015-10-09)
Interactions between pathogenic bacteria and host cells are often mediated by proteins found on the surfaces of the bacteria. The Gram-negative bacterium Helicobacter pylori is predicted to produce at least 50 surface-exposed outer membrane proteins, but there has been relatively
Marcela Filipova et al.
PloS one, 13(10), e0206557-e0206557 (2018-11-01)
Evaluating nanoparticle (NP) toxicity in human cell systems is a fundamental requirement for future NP biomedical applications. In this study, we have designed a screening assay for assessing different types of cell death induced by NPs in human umbilical vein
Markus Kopp et al.
PloS one, 10(11), e0143639-e0143639 (2015-11-26)
Because of minimal data available on folate analysis in dried matrix spots (DMSs), we combined the advantages of stable isotope dilution assays followed by LC-MS/MS analysis with DMS sampling to develop a reliable method for the quantitation of plasma 5-methyltetrahydrofolic
Betul Kul Babur et al.
Cell and tissue research, 361(3), 755-768 (2015-05-01)
Engineered biphasic osteochondral tissues may have utility in cartilage defect repair. As bone-marrow-derived mesenchymal stem/stromal cells (MSC) have the capacity to make both bone-like and cartilage-like tissues, they are an ideal cell population for use in the manufacture of osteochondral
H Gül Akıllıoğlu et al.
Journal of agricultural and food chemistry, 62(46), 11289-11295 (2014-11-05)
This study aimed to investigate the effects of hydrophobic and ionic interactions on glycation of native and high-shear treated casein during heating. Casein-epicatechin and casein-calcium complexes were formed and glycated with glucose at different temperatures ranging from 70 to 150
Richard Jacobson et al.
Thrombosis research, 134(6), 1350-1357 (2014-10-14)
The blood coagulation system is a tightly regulated balance of procoagulant and anticoagulant factors, disruption of which can cause clinical complications. Diabetics are known to have a hypercoagulable phenotype, along with increased circulating levels of methylglyoxal (MGO) and decreased activity
Jonathan Belsey et al.
Current medical research and opinion, 28(12), 1883-1890 (2012-11-10)
It is unclear whether small bowel visibility in video capsule endoscopy (VCE) is enhanced by the use of bowel preparation in addition to pre-procedural fasting. The objective of this study was to clarify this issue by means of a systematic
Adrian M Gospodarek et al.
Journal of chromatography. A, 1355, 238-252 (2014-07-07)
Recent studies with proteins indicate that conformational changes and aggregation can occur during ion exchange chromatography (IEC). Such behavior is not usually expected, but could lead to decreased yield and product degradation from both IEC and multi mode chromatography (MMC)
Wei Ren et al.
Journal of pharmaceutical sciences, 103(6), 1692-1700 (2014-04-10)
Passive and iontophoretic transport of fluoride from three fluoride sources, NaF, sodium monofluorophosphate (MFP), and SnF2 solutions, across bovine enamel was investigated to (1) determine the characteristics of the intrinsic barrier of enamel for ion transport, (2) examine the feasibility
Sima Rahimian et al.
Biomaterials, 61, 33-40 (2015-05-21)
This study investigated the feasibility of the use of polymeric microparticles for sustained and local delivery of immunomodulatory antibodies in immunotherapy of cancer. Local delivery of potent immunomodulatory antibodies avoids unwanted systemic side effects while retaining their anti-tumor effects. Microparticles
[Colokit(®) preparation (sodium phosphate) induced erosive gastritis].
Edith Schir et al.
Therapie, 67(5), 477-479 (2012-12-18)
Maren Kuhne et al.
Journal of immunological methods, 413, 45-56 (2014-07-25)
A novel method that optimizes the screening for antibody-secreting hapten-specific hybridoma cells by using flow cytometry is described. Cell clones specific for five different haptens were analyzed. We selectively double stained and analyzed fixed hybridoma cells with fluorophore-labeled haptens to
Irene Ojeda et al.
Biosensors & bioelectronics, 74, 24-29 (2015-06-21)
An electrochemical immunosensor for adiponectin (APN) using screen printed carbon electrodes (SPCEs) modified with functionalized double-walled carbon nanotubes (DWCNTs) as platforms for immobilization of the specific antibodies is reported. DWCNTs were functionalized by treatment with 4-aminobenzoic acid (HOOC-Phe) in the
Xhorxhi Gjoka et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 972, 48-52 (2014-10-14)
Quantification of monoclonal antibody (mAb) monomer, mAb aggregates, and host cell proteins (HCPs) is critical for the optimization of the mAb production process. The present work describes a single high throughput analytical tool capable of tracking the concentration of mAb
Patrick Fustier et al.
Journal of agricultural and food chemistry, 63(42), 9239-9250 (2015-10-13)
The impact of whey protein isolate (WPI) and fish gelatin (FG) deposited sequentially at concentrations of 0.1, 0.5, and 0.75% on the surface of primary oil-in-water emulsions containing 5% flaxseed oil stabilized with either 0.5% fish gelatin or whey protein
Heleen Kraan et al.
Pharmaceutical research, 31(10), 2618-2629 (2014-04-25)
The aim of current study was to develop a dried inactivated polio vaccine (IPV) formulation with minimal loss during the drying process and improved stability when compared with the conventional liquid IPV. Extensive excipient screening was combined with the use
R Wulff et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 77, 246-253 (2015-06-21)
The objective of this study was to investigate the suitability of "Eudragit® RL/Eudragit® L55" (RL/L55) blend coatings for a pH-independent release of acidic drugs. A coating for ketoprofen and naproxen mini tablets was developed showing constant drug release rate under
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