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Megan A Rees et al.
Journal of proteome research, 14(1), 120-132 (2014-10-21)
Interactions between a host and a bacterial pathogen are mediated by cross-talk between molecules present on, or secreted by, pathogens and host binding-molecules. Identifying proteins involved at this interface would provide substantial insights into this interaction. Although numerous studies have
C Riemenschneider et al.
Bioresource technology, 170, 303-309 (2014-08-26)
A new analytical method for the determination of colistin in fermenter samples was developed followed by a study on the behavior of this substance during anaerobic fermentation. Analysis of colistin A and B was carried out by liquid chromatography-tandem mass
Ana de Castro et al.
Drug testing and analysis, 6(10), 1011-1019 (2014-01-24)
Since the implementation of mandatory drug testing in drivers' oral fluid, several solutions to avoid an onsite positive result can be found on drug users' forums, especially for marijuana, including the use of different mouthwashes. Recently, a product for personal
Hui Chan Kwak et al.
Biochemical pharmacology, 96(3), 256-266 (2015-06-07)
The present study was aimed to investigate the metabolomics of sulfur amino acids in Zucker diabetic fatty (ZDF) rats, an obese type 2 diabetic animal model. Plasma levels of total cysteine, homocysteine and methionine, but not glutathione (GSH) were markedly
Isolating lipid droplets from multiple species
Ding Y, et al.
Nature Protocols, 8(1), 43-43 (2013)
S Guerrero et al.
The Analyst, 140(22), 7527-7533 (2015-08-11)
The first electrochemical immunosensor for the determination of peptide YY is reported in this paper. A novel electrochemical platform, prepared by the electrochemical grafting of the diazonium salt of 4-aminobenzoic acid onto a reduced graphene oxide-modified glassy carbon electrode, was
Won Il Choi et al.
Nanomedicine : nanotechnology, biology, and medicine, 11(2), 359-368 (2014-09-30)
In this study, we prepared iron oxide nanoparticle and doxorubicin-loaded multifunctional nano-carrier (IONP/DOX-MFNC), capable of simultaneous cancer targeting via a herceptin monoclonal antibody, controlled anticancer drug delivery, as well as imaging modalities of magnetic resonance imaging (MRI) and near-infrared fluorescence
Chee Shan Lim et al.
Nanoscale, 7(29), 12527-12534 (2015-07-04)
Layered transition metal diborides (TMDB), amongst other refractory metal borides, are commonly employed for material fabrication such as wear- and corrosion-resistant coatings due to their impressive chemical stability and thermal conductivity. In spite of the wide scope of studies carried
Gabriella Costabile et al.
Molecular pharmaceutics, 12(8), 2604-2617 (2015-05-15)
Inhaled antivirulence drugs are currently considered a promising therapeutic option to treat Pseudomonas aeruginosa lung infections in cystic fibrosis (CF). We have recently shown that the anthelmintic drug niclosamide (NCL) has strong quorum sensing (QS) inhibiting activity against P. aeruginosa
Genye He et al.
Journal of chromatographic science, 52(8), 848-851 (2013-09-14)
Formoterol is a new threshold substance in the prohibited list 2012 according to World Anti-Doping Agency. Extracted by ethyl acetate using formoterol-D6 as internal standard, formoterol underwent a constant flow rate gradient elution separation in reversed-phase liquid chromatography. Subsequently, mass
Farid A Badria et al.
ChemistryOpen, 8(10), 1288-1297 (2019-10-28)
The Michael addition reaction of barbituric acid with chalcones incorporating the indole scaffold was achieved by using a highly efficient bimetallic Iron-palladium catalyst in the presence of acetylacetone (acac). This catalytic approach produced the desired products in a simple operation
Josephine Al-Alam et al.
Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes, 50(11), 788-796 (2015-09-12)
Pesticides are a real concern for the society as their use has become critical, leading sometimes to their accumulation as residues in fruits and vegetables. After examining the pesticides sold in Northern Lebanon, this study is focused on the analysis
Abdulselam Ertas et al.
Pharmaceutical biology, 53(3), 334-339 (2014-10-22)
In Turkey, Veronica species (Plantaginaceae) have been used as a diuretic and for wound healing in traditional medicine. To examine the fatty acid and essential oil profiles, the antioxidant, anticholinesterase, antimicrobial, and DNA damage effects of Veronica thymoides P.H. Davis
Ewa Oledzka et al.
International journal of molecular sciences, 16(9), 22205-22222 (2015-09-22)
The present study evaluated a new concept of combined scaffolds as a promising bone replacement material for patients with a bone tumour or bone metastasis. The scaffolds were composed of hydroxyapatite doped with selenium ions and a biodegradable polymer (linear
Devbarna Sinha et al.
Bio-protocol, 8(18), e3020-e3020 (2018-09-20)
Bioluminescence imaging (BLI) technology is an advanced method of carrying out molecular imaging on live laboratory animals in vivo. This powerful technique is widely-used in studying a variety of biological processes, and it has been an ideal tool in exploring
Axel Rydevik et al.
Drug testing and analysis, 7(7), 626-633 (2014-09-12)
A new model is presented that can be used to screen for bioactivation of drugs. The evaluation of toxicity is an important step in the development of new drugs. One way to detect possible toxic metabolites is to use trapping
Nungruthai Suphrom et al.
The Journal of pharmacy and pharmacology, 66(9), 1282-1293 (2014-06-07)
Curcuma aeruginosa Roxb. extract is a 5α-reductase antagonist that can be used to treat hair loss. We aimed to study the stability of antiandrogenic constituents, germacrone and other sesquiterpene components in the extract. Germacrone and the extract were analyzed as solid
Amanda L Patchett et al.
Developmental and comparative immunology, 53(1), 123-133 (2015-07-18)
Devil facial tumour disease (DFTD) is a fatally transmissible cancer that threatens the Tasmanian devil population. As Tasmanian devils do not produce an immune response against DFTD cells, an effective vaccine will require a strong adjuvant. Activation of innate immune
Sandeep Deshmukh et al.
Journal of chromatography. A, 1388, 1-8 (2015-03-01)
Accurate quantitation of compounds in samples of biological origin is often hampered by matrix interferences one of which occurs in GC-MS analysis from the presence of highly abundant phosphate. Consequently, high concentrations of phosphate need to be removed before sample
Charles W Kimbrough et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 21(20), 4576-4585 (2015-07-01)
pH-low insertion peptides (pHLIP) can serve as a targeting moiety that enables pH-sensitive probes to detect solid tumors. Using these probes in conjunction with multispectral optoacoustic tomography (MSOT) is a promising approach to improve imaging for pancreatic cancer. A pH-sensitive
Omar Sarheed et al.
AAPS PharmSciTech, 16(3), 601-609 (2014-11-27)
The purpose of this study was to investigate the effect of combined Ca(2+) cross-linking and freeze-thawing cycle method on metronidazole (model drug) drug release and prepare a wound film dressing with improved swelling property. The hydrogel films were prepared with
Michele A Steffey et al.
Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association, 56(3), 278-285 (2014-12-30)
Objectives of this prospective study were to describe effects of varying technical components that may contribute to an optimal protocol for computed tomographic pneumocolonography (CTP) in dogs, and to develop a standardized methodology for CTP as a future potential diagnostic
Gülsel Yurtdaş Kırımlıoğlu et al.
International journal of pharmaceutics, 495(2), 816-826 (2015-09-22)
Gamma-aminobutyric acid (GABA) is a key neurotransmitter where it usually inhibits impulse transmission. GABA release blockage or postsynaptic reaction were determined to provoke epileptic convulsions. The aim of the present study was the development of brain-targeted, nanosized, nontoxic, biocompatible, highly
Jackson Travis Del Bonis-O'Donnell et al.
The Analyst, 140(5), 1609-1615 (2015-01-21)
DNA-stabilized fluorescent silver nanoclusters (AgNC DNA) are a new class of fluorophore that are formed by sequence specific interactions between silver and single-stranded DNA. By incorporating both target-binding and fluorescent-reporting sequences into a single synthetic DNA oligomer, AgNC DNA probes
Heba F Salem et al.
Drug design, development and therapy, 9, 3705-3727 (2015-08-01)
The blood-brain barrier prevents many drug moieties from reaching the central nervous system. Therefore, glutathione-modulated nanoliposomes have been engineered to enhance the targeting of flucytosine to the brain. Glutathione-modulated nanoliposomes were prepared by thin-film hydration technique and evaluated in the
James A Woo et al.
Journal of chromatography. A, 1407, 58-68 (2015-07-15)
A homologous ligand library based on the commercially-available Nuvia cPrime ligand was generated to systematically explore various features of a multimodal cation-exchange ligand and to identify structural variants that had significantly altered chromatographic selectivity. Substitution of the polar amide bond
Binbin Zhang et al.
Biofouling, 31(6), 493-502 (2015-07-29)
Diatoms are a major component of microbial biofouling layers that develop on man-made surfaces placed in aquatic environments, resulting in significant economic and environmental impacts. This paper describes surface functionalisation of the inherently conducting polymers (ICPs) polypyrrole (PPy) and polyaniline
H T P Nguyen et al.
Nanotechnology, 26(25), 255101-255101 (2015-06-03)
The cutaneous penetration of hydrophobic active molecules is of foremost concern in the dermatology and cosmetic formulation fields. The poor solubility in water of those molecules limits their use in hydrophilic forms such as gels, which are favored by patients
Jenna L Terebetski et al.
AAPS PharmSciTech, 15(5), 1334-1344 (2014-06-13)
To maximize the pharmacological effect of a pain reliever such as ibuprofen, early onset of action is critical. Unfortunately, the acidic nature of ibuprofen minimizes the amount of drug that can be solubilized under gastric conditions and would be available
Lizhen Qiao et al.
Journal of chromatography. A, 1360, 240-247 (2014-08-19)
Glucaminium-based ionic liquids are a new class of recently developed ionic liquids and prepared by functionalizing the amine group of N-methyl-d-glucamine, which renders them good hydrophilicity due to the presence of the glucose structure and charged quaternary ammonium group. In
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