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Radiation alters the cargo of exosomes released from squamous head and neck cancer cells to promote migration of recipient cells.
Mutschelknaus L, et al.
Scientific Reports, 7(1), 12423-12423 (2017)
Lisa Mutschelknaus et al.
Scientific reports, 7(1), 12423-12423 (2017-10-01)
Radiation is a highly efficient therapy in squamous head and neck carcinoma (HNSCC) treatment. However, local recurrence and metastasis are common complications. Recent evidence shows that cancer-cell-derived exosomes modify tumour cell movement and metastasis. In this study, we link radiation-induced...
Wei Huo et al.
Cancer cell international, 20, 64-64 (2020-03-07)
Dysregulation of long non-coding RNAs (lncRNAs) is involved in development of prostate cancer. However, the molecular mechanisms of many lncRNAs in prostate cancer have not been studied yet. The lncRNA Fer-1-like protein 4 (FER1L4) expression was explored in prostate tumors...
Peter Wild et al.
F1000Research, 8, 198-198 (2019-06-30)
Background: Capsids of herpes simplex virus 1 (HSV-1) are assembled in the nucleus, translocated either to the perinuclear space by budding at the inner nuclear membrane acquiring tegument and envelope, or released to the cytosol in a "naked" state via...
Xinjun Lin et al.
Experimental and therapeutic medicine, 16(1), 204-212 (2018-06-14)
The present study aimed to evaluate the impact of dendrobium mixture (DMix) on the gene and protein expression of insulin signaling pathway-associated factors in the livers of diabetic rats. The molecular mechanisms by which DMix inhibits gluconeogenesis were also investigated....
Ravindra Pramod Deshpande et al.
The International journal of neuroscience, 129(2), 171-178 (2018-08-28)
Astrocytoma represents most noted malignancy of the brain. The overall survival rate of patients with progressive form remains dismal despite of the present clinical advancements. Search for biomarkers can open new avenues of therapeutic measures to curb the progressive astrocytic...
Exosomes Derived from Squamous Head and Neck Cancer Promote Cell Survival after Ionizing Radiation.
Lisa M, et al.
PLoS ONE, 11(3), e0152213-e0152213 (2016)
Tina M Bunnell et al.
Molecular biology of the cell, 22(21), 4047-4058 (2011-09-09)
Ubiquitously expressed β-actin and γ-actin isoforms play critical roles in most cellular processes; however, their unique contributions are not well understood. We generated whole-body β-actin-knockout (Actb(-/-)) mice and demonstrated that β-actin is required for early embryonic development. Lethality of Actb(-/-)...
7p22.1 microdeletions involving ACTB associated with developmental delay, short stature, and microcephaly.
Shimojima K, et al.
European Journal of Medical Genetics, 59(10), 502-506 (2016)
Petter Holland et al.
Nature communications, 7, 13889-13889 (2016-12-23)
A fundamental question is how autophagosome formation is regulated. Here we show that the PX domain protein HS1BP3 is a negative regulator of autophagosome formation. HS1BP3 depletion increased the formation of LC3-positive autophagosomes and degradation of cargo both in human...
ACTB Loss-of-Function Mutations Result in a Pleiotropic Developmental Disorder.
Cuvertino S, et al.
American Journal of Human Genetics, 101(6), 1021-1033 (2017)
Lisa Mutschelknaus et al.
PloS one, 11(3), e0152213-e0152213 (2016-03-24)
Exosomes are nanometer-sized extracellular vesicles that are believed to function as intercellular communicators. Here, we report that exosomes are able to modify the radiation response of the head and neck cancer cell lines BHY and FaDu. Exosomes were isolated from...
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