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Fernando Galdino Ricci et al.
Toxins, 13(1) (2020-12-31)
Ochratoxin A (OTA) is a mycotoxin produced by species of Penicillium and Aspergillus that can contaminate products of plant origin that are used as animal feed. Through oral exposure, this mycotoxin primarily affects the chicken gastrointestinal system. The present study...
Jian Jin et al.
Journal of the science of food and agriculture, 95(12), 2501-2509 (2014-11-05)
Under the situation that the shortage of proteins and large quantity of corn gluten meal (CGM), which is a superior protein resource, is under-exploited, the enzymatic hydrolysis of CGM was employed to improve its bioavailability because of its special amino...
Alessio Innocenti et al.
Bioorganic & medicinal chemistry letters, 20(5), 1701-1704 (2010-02-05)
The protein encoded by the NCE103 gene of Candida glabrata, a beta-carbonic anhydrase (CA, EC designated as CgCA, was investigated for its activation with amines and amino acids. CgCA was weakly activated by amino acids such as l-/d-His, l-Phe...
L A Rohoza et al.
Ukrains'kyi biokhimichnyi zhurnal (1999 ), 85(2), 78-83 (2013-07-03)
It is known that extracts of cryopreserved organ fragments of pigs and piglets stimulate the processes of reparative regeneration. Therefore, the study of the extracts is essential for understanding the mechanism of their biological effects. In this paper was studied...
Rafat M Mohareb et al.
Bioorganic & medicinal chemistry, 19(9), 2966-2974 (2011-04-16)
There is a great deal of interest in neurotrophin therapy to prevent neuronal degeneration. The present study aimed at synthesizing new functionalized indole derivatives with structures justifying neuroprotective activity using L-tryptophan (TRP) as starting material. The potential neuroprotective effect of...
Man Qiao et al.
Luminescence : the journal of biological and chemical luminescence, 30(7), 1159-1166 (2015-03-05)
A simple and sensitive resonance Rayleigh scattering (RRS) spectra method was developed for the determination of calf thymus DNA (ctDNA). The enhanced RRS signals were based on the interactions between ctDNA and aminoglycoside antibiotics (AGs) including kanamycin (KANA), tobramycin (TOB)...
J M Garcia et al.
The Journal of clinical endocrinology and metabolism, 98(6), 2422-2429 (2013-04-06)
In the absence of panhypopituitarism and low serum IGF-I levels, the diagnosis of adult GH deficiency (AGHD) requires confirmation with a GH stimulation test. Macimorelin is a novel, orally active ghrelin mimetic that stimulates GH secretion. The objective of the...
David Buttar et al.
Bioorganic & medicinal chemistry, 18(21), 7486-7496 (2010-09-28)
The displacement of probes that bind selectively to subdomains IIA or IIIA on human serum albumin (HSA) by competing compounds has been followed using fluorescence spectroscopy, and has therefore been used to assign a primary binding site for these compounds...
Alessio Innocenti et al.
Bioorganic & medicinal chemistry letters, 18(23), 6194-6198 (2008-10-22)
Activation of the archaeal beta-class (Cab) and gamma-class (Cam) carbonic anhydrases (CAs, EC with a series of natural and non-natural amino acids and aromatic/heterocyclic amines has been investigated. Cab, Zn-Cam and Co-Cam showed an activation profile with natural, L-...
ppGpp Coordinates Nucleotide and Amino-Acid Synthesis in E. coli During Starvation.
Wang, et al.
Molecular Cell, 80, 29-42 (2020)
Diane C Chugani
Biomarkers in medicine, 5(5), 567-575 (2011-10-19)
The purpose of this paper is to discuss the mechanisms of α-[(11)C]methyl-L-tryptophan (AMT) PET as an in vivo biomarker for detection of epileptogenic cortex. AMT was originally designed as a tracer to measure the serotonin synthesis rate. This tracer was...
D Riemann et al.
Fortschritte der Medizin, 116(32), 40-42 (1999-01-09)
Since the nineteen-sixties, L-tryptophan has been used to treat depression and sleep-disorders. It appears to be suitable for the the treatment of mild forms of depression and of special forms, such as depressive mood associated with the climacteric. In a...
Nicola J Harris et al.
Journal of molecular biology, 426(8), 1812-1825 (2014-02-18)
There is a limited understanding of the folding of multidomain membrane proteins. Lactose permease (LacY) of Escherichia coli is an archetypal member of the major facilitator superfamily of membrane transport proteins, which contain two domains of six transmembrane helices each....
Timothy H Yosca et al.
Science (New York, N.Y.), 342(6160), 825-829 (2013-11-16)
Cytochrome P450 enzymes activate oxygen at heme iron centers to oxidize relatively inert substrate carbon-hydrogen bonds. Cysteine thiolate coordination to iron is posited to increase the pK(a) (where K(a) is the acid dissociation constant) of compound II, an iron(IV)hydroxide complex...
Ingvar J Rognum et al.
Journal of neuropathology and experimental neurology, 73(2), 115-122 (2014-01-16)
Forensic biomarkers are needed in sudden infant death syndrome (SIDS) to help identify this group among other sudden unexpected deaths in infancy. Previously, we reported multiple serotonergic (5-HT) abnormalities in nuclei of the medulla oblongata that help mediate protective responses...
Jiafeng Geng et al.
Archives of biochemistry and biophysics, 544, 18-26 (2013-12-04)
L-Tryptophan is an essential amino acid for mammals. It is utilized not only for protein synthesis but also for the biosynthesis of serotonin and melatonin by the serotonin pathway as well as nicotinamide adenine dinucleotide by the kynurenine pathway. Although...
Phedias Diamandis et al.
Nature chemical biology, 3(5), 268-273 (2007-04-10)
The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways that governs the...
Dan Song et al.
Journal of neuroscience research, 93(1), 130-139 (2014-08-16)
The cotransporter of Na(+) , K(+) , 2Cl(-) , and water, NKKC1, is activated under two conditions in the brain, exposure to highly elevated extracellular K(+) concentrations, causing astrocytic swelling, and regulatory volume increase in cells shrunk in response to...
Alessio Innocenti et al.
Bioorganic & medicinal chemistry, 18(3), 1034-1037 (2010-01-12)
The proteins encoded by the Nce103 genes of Candida albicans and Cryptococcus neoformans are catalytically active beta-carbonic anhydrases (CAs, EC playing various roles in the life cycle of these fungal pathogens, such as CO(2) sensing, regulation of capsule biosynthesis...
Semra Isik et al.
Bioorganic & medicinal chemistry letters, 19(6), 1662-1665 (2009-02-24)
The protein encoded by the Nce103 gene of Saccharomyces cerevisiae, a beta-carbonic anhydrase (CA, EC designated as scCA, was investigated for its activation with amines and amino acids. scCA was poorly activated by amino acids such as l-/d-His, Phe...
Minh Truong Do et al.
Toxicology and applied pharmacology, 280(1), 138-148 (2014-08-12)
Induction of cytochrome P450 (CYP) 1A1 and CYP1B1 by environmental xenobiotic chemicals or endogenous ligands through the activation of the aryl hydrocarbon receptor (AhR) has been implicated in a variety of cellular processes related to cancer, such as transformation and...
Hanne Sørup Tastesen et al.
PloS one, 9(11), e112859-e112859 (2014-11-13)
Low-protein and high-protein diets regulate energy metabolism in animals and humans. To evaluate whether different dietary protein sources modulate energy balance when ingested at average levels obesity-prone male C57BL/6J mice were pair-fed high-fat diets (67 energy percent fat, 18 energy...
Michael Platten et al.
Cancer research, 72(21), 5435-5440 (2012-10-24)
Tryptophan catabolism in cancer is increasingly being recognized as an important microenvironmental factor that suppresses antitumor immune responses. It has been proposed that the essential amino acid tryptophan is catabolized in the tumor tissue by the rate-limiting enzyme indoleamine-2,3-dioxygenase (IDO)...
Asta Rós Sigtryggsdóttir et al.
Biochimica et biophysica acta, 1844(4), 705-712 (2014-02-25)
The subtilisin-like serine proteinases, VPR, from a psychrotrophic Vibrio species and aqualysin I (AQUI) from the thermophile Thermus aquaticus, are structural homologues, but differ significantly with respect to stability and catalytic properties. It has been postulated that the higher catalytic...
Mohammad Mahdi Moein et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 995-996, 38-45 (2015-05-30)
In the present study, the modification of a polysulfone hollow fiber membrane with in situ molecularly imprinted sol-gel process (as a novel and one-step method) was prepared and investigated. 3-(propylmethacrylate)trimethoxysilane (3PMTMOS) as an inorganic precursor was used for preparation of...
Gokce Nardemir et al.
Toxicology and industrial health, 31(7), 602-613 (2013-03-05)
Now-a-days, there is a big need to reduce genotoxic effects of mutagenic and carcinogenic agents in environment, which are increased by the technological development. Lichens produce a wide variety of unique metabolites due to being in various extreme areas and...
Elnaz Yaghini et al.
Small (Weinheim an der Bergstrasse, Germany), 10(24), 5106-5115 (2014-08-29)
Photocatalytic generation of reactive oxygen species (ROS) from quantum dots (QDs) has been widely reported yet quantitative studies of ROS formation and their quantum yields are lacking. This study investigates the generation of ROS by water soluble PEGylated CdSe/ZnS QDs...
Jian-Zhuang Tan et al.
Journal of the science of food and agriculture, 95(1), 126-135 (2014-04-15)
The effects of dietary l-arginine (Arg) on immunosuppression following infectious bursal disease virus (IBDV) inoculation in broiler chickens were evaluated. The design of this study was a 5 × 2 factorial arrangement (n = 5) with five Arg concentrations (starter:...
Julie M Fox et al.
The Journal of general virology, 94(Pt 7), 1451-1461 (2013-04-13)
Influenza infection induces an increase in the level of indoleamine 2,3-dioxygenase (IDO) activity in the lung parenchyma. IDO is the first and rate-limiting step in the kynurenine pathway where tryptophan is reduced to kynurenine and other metabolites. The depletion of...
Ting-Fang He et al.
Biochemistry, 52(51), 9120-9128 (2013-12-03)
Intraprotein electron transfer (ET) in flavoproteins is important for understanding the correlation of their redox, configuration, and reactivity at the active site. Here, we used oxidized flavodoxin as a model system and report our complete characterization of a photoinduced redox...
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