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Mark G Jones et al.
Clinica chimica acta; international journal of clinical chemistry, 361(1-2), 150-158 (2005-07-05)
Previous work by others have suggested the occurrence of one or more chemical or metabolic 'markers' for ME/CFS including specific amino acids and organic acids and a number of unidentified compounds (CFSUM1, CFSUM2). We have shown elsewhere that CFSUM1 is...
Marlene Wewalka et al.
The Journal of clinical endocrinology and metabolism, 99(4), 1442-1451 (2014-01-18)
Bile acids (BAs) are newly recognized signaling molecules in glucose and energy homeostasis. Differences in BA profiles with type 2 diabetes mellitus (T2D) remain incompletely understood. The objective of the study was to assess serum BA composition in impaired glucose-tolerant...
Denis V Abramochkin et al.
Naunyn-Schmiedeberg's archives of pharmacology, 388(10), 1105-1112 (2015-06-25)
A new class III antiarrhythmic drug niferidil has been recently introduced as a highly effective therapy cure for cases of persistent atrial fibrillation, but ionic mechanisms of its action are still unknown. Effects of niferidil on action potential (AP) waveform...
Yin-jie Li et al.
Analytical and bioanalytical chemistry, 407(14), 4143-4153 (2015-04-10)
The quantitative analysis of taurine and edaravone in biological sample is critical in pharmaceutical studies. Although each of them can be individually analyzed by different approaches, concurrent quantification is still a highly challenging task with respect to their great polarity...
Prashanth Sirigeri Jois et al.
Reproductive biology and endocrinology : RB&E, 13, 64-64 (2015-06-19)
Bovine BSP5 is a multifunctional protein primarily involved in sperm capacitation. BSP5 consists of long N-terminal part followed by two similar and highly conserved fibronectin type II domains designated A and B. In order to assess the role of these...
Cory J Knoot et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(2), 388-393 (2014-12-31)
Intradiol aromatic ring-cleaving dioxygenases use an active site, nonheme Fe(3+) to activate O2 and catecholic substrates for reaction. The inability of Fe(3+) to directly bind O2 presents a mechanistic conundrum. The reaction mechanism of protocatechuate 3,4-dioxygenase is investigated here using...
Seok-Min Kang et al.
Clinical biochemistry, 44(4), 293-299 (2010-12-21)
We sought to identify metabolic pathways characterizing human heart failure (HF) using ¹NMR based urinary metabolomic analysis in conjunction with multivariate statistics. Patients with systolic HF of ischemic origin (n=15) and healthy controls (n=20) participated in this study. Patients with...
Mengmeng Yu et al.
Journal of agricultural and food chemistry, 67(7), 1927-1936 (2019-01-27)
Taurine, a β-aminosulfonic acid, exerts many cellular physiological functions. It is still unknown whether taurine can regulate milk synthesis in the mammary gland. Therefore, in this study we investigated the effects and mechanism of taurine on milk synthesis in mammary...
J D Kopple et al.
The American journal of clinical nutrition, 52(5), 846-853 (1990-11-01)
Thirty-four adults undergoing long-term parenteral nutrition (TPN) were treated either with or without intravenous taurine for less than or equal to 24 mo. Statistical comparisons were carried out in eight patients randomly assigned to receive intravenous taurine, usually 10
Xiaobo Li et al.
Environment international, 136, 105487-105487 (2020-01-31)
The major components of traffic pollution particulate matter, diesel exhaust particles (DEPs), are airborne ultrafine particles (UFPs). DEPs can enter the central nervous system (CNS), where they may cause neurotoxicity. We established murine models with intranasal DEPs instillation in male...
Benedikt Kortüm et al.
Gut, 64(12), 1905-1912 (2014-11-28)
Lynch syndrome is caused by germline mutations in DNA mismatch repair genes leading to microsatellite instability (MSI) and colorectal cancer. Mesalazine, commonly used for the treatment of UC, reduces MSI in vitro. Here, we tested natural compounds for such activity...
Britney O Pennington et al.
Stem cells translational medicine, 4(2), 165-177 (2015-01-17)
Age-related macular degeneration (AMD), a leading cause of blindness, is characterized by the death of the retinal pigmented epithelium (RPE), which is a monolayer posterior to the retina that supports the photoreceptors. Human embryonic stem cells (hESCs) can generate an...
Dao-quan Tang et al.
Biomedical chromatography : BMC, 29(8), 1137-1145 (2014-12-30)
In this work, two high-performance liquid chromatography (HPLC) assays were developed and validated for the independent determination of edaravone and taurine using 3-methyl-1-p-tolyl-5-pyrazolone and L-glutamine as internal standards. In in vitro experiments, human plasma was separately spiked with a mixture...
Hanna Österman et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 309(10), R1204-R1214 (2015-10-02)
Fetal growth restriction programs an increased risk of cardiovascular disease in adulthood, but the actual mechanisms of this developmental programming are not fully understood. Previous studies in mammalian models suggest that hearts of growth-restricted fetuses have reduced cardiomyocyte number due...
István Télessy
Orvosi hetilap, 155(51), 2021-2027 (2014-12-17)
Reviewing the literature of nutrition therapy one can conclude that during the last decade the pharmacological action of several nutrients has been demonstrated. However, research activity is still at the beginning and it could be verified in a restricted number...
A Hernández-Sánchez et al.
European journal of clinical nutrition, 67(3), 230-238 (2013-02-14)
Aluminium (Al) toxicity problem in parenteral nutrition solutions (PNS) is decades old and is still unresolved. The aim of this review is to gather updated information about this matter, regarding legislation, manifestations, diagnostics and treatment, patient population at risk and...
Sun Hee Cheong et al.
Advances in experimental medicine and biology, 775, 311-320 (2013-02-09)
Taurine (2-aminoethanesulfonic acid), a sulfur-containing β-amino acid, is found in all animal cells at millimolar concentrations and has been reported to show various health promoting activities including antidiabetic properties. The beneficial effects of taurine in diabetes mellitus have been known....
Ozge Tugce Pasaoglu et al.
Inflammation, 37(5), 1439-1443 (2014-03-08)
The aim of our study was to investigate the effect of taurine on the relationship between nitric oxide (NO), asymmetric dimethylarginine (ADMA) and homocysteine (Hcy) in endotoxin-induced human umblical vein endothelial cell (HUVEC) cultures. For this reason, four groups were...
Zhenfei Chen et al.
International journal of clinical and experimental pathology, 8(5), 4614-4626 (2015-07-21)
MicroRNA-22 (miR-22) was previously reported to elicit cardiac myocyte hypertrophy and had an anti-apoptotic effect on neurons. However, its effects on cardiac myocyte apoptosis and cardiac function during ischemia and reperfusion (I/R) are not clear. In the present study, we...
Shuping Wu et al.
Food chemistry, 148, 196-203 (2013-11-23)
The structure, UV absorbance, browning intensity, fluorescence changes, antioxidant activity and antimicrobial assessment of Maillard reaction products (MRPs) derived from xylan with chitosan, chitooligomer, glucosamine hydrochloride and taurine model systems were evaluated. The results revealed that all MRPs had similar...
[Pharmacological profiles and clinical roles of acamprosate (Regtect(®) tablets 333 mg) for the maintenance of abstinence in alcohol-dependent patients].
Tsuneharu Ohhara et al.
Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 144(1), 34-41 (2014-07-11)
S Ishiwata et al.
The Tohoku journal of experimental medicine, 176(1), 61-68 (1995-05-01)
To evaluate the clinical usefulness of serum 1-methyladenosine, several modifications have been made in our previously established inhibition ELISA system. Horseradish peroxidase (HRP) labeled anti-mouse IgG and 3,3',5,5'-tetramethylbenzidine (TMBZ) were used as a secondary antibody and a substrate, respectively. The...
Chun-Yu Chang et al.
Toxicology and applied pharmacology, 279(3), 351-363 (2014-07-16)
Oxidized LDL (oxLDL) induces a pro-oxidative environment and promotes apoptosis, causing the progression of renal diseases in humans. Taurine is a semi-essential amino acid in mammals and has been shown to be a potent endogenous antioxidant. The kidney plays a...
Søren Grubb et al.
American journal of physiology. Heart and circulatory physiology, 309(3), H481-H489 (2015-06-10)
Inherited ion channelopathies and electrical remodeling in heart disease alter the cardiac action potential with important consequences for excitation-contraction coupling. Potassium channel-interacting protein 2 (KChIP2) is reduced in heart failure and interacts under physiological conditions with both Kv4 to conduct...
Hussain Bahbahani et al.
Scientific reports, 5, 11729-11729 (2015-07-02)
The small East African Shorthorn Zebu (EASZ) is the main indigenous cattle across East Africa. A recent genome wide SNP analysis revealed an ancient stable African taurine x Asian zebu admixture. Here, we assess the presence of candidate signatures of...
Arpita Roychoudhury et al.
Biological chemistry, 394(11), 1465-1474 (2013-09-12)
Compatible solutes are small, uncharged, zwitter ionic, osmotically active molecules produced and accumulated by microorganisms inside their cell to counteract different kinds of environmental stress. They enhance protein stability without interfering with the metabolic pathways even at molar concentrations. In...
Kine S N Dervola et al.
Neurotoxicology, 50, 38-45 (2015-07-29)
Polychlorinated biphenyls (PCBs) are present as ortho- and non-ortho-substituted PCBs, with most of the ortho-substituted congeners being neurotoxic. The present study examined effects of the ortho-substituted PCB 153 on dopamine, serotonin and amino acid neurotransmitters in the neostriatum of both...
Chenphop Sawangmake et al.
Biochemical and biophysical research communications, 452(3), 581-587 (2014-09-03)
Dental tissue-derived mesenchymal stem cells have been proposed as an alternative source for mesenchymal stem cells. Here, we investigated the differentiation ability toward insulin producing cells (IPCs) of human dental pulp stem cells (hDPSCs) and human periodontal ligament stem cells...
An alternative treatment for muscle cramps in patients with liver cirrhosis.
Dileep K Atluri et al.
Liver international : official journal of the International Association for the Study of the Liver, 33(3), 496-497 (2013-02-14)
J T Atosuo et al.
TheScientificWorldJournal, 11, 2382-2390 (2011-12-24)
A recombinant Escherichia coli K-12 strain, transformed with a modified bacterial luciferase gene (luxABCDE) from Photorhabdus luminescens, was constructed in order to monitor the activity of various antimicrobial agents on a real-time basis. This E. coli-lux emitted, without any addition...
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