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Joana Soares et al.
Pharmacological research, 95-96, 42-52 (2015-03-31)
Inactivation of the p53 tumor suppressor protein by interaction with murine double minute (MDM) proteins, MDM2 and MDMX, is a common event in human tumors expressing wild-type p53. In these tumors, the simultaneous inhibition of these interactions with MDMs, for...
Lucian Farcal et al.
PloS one, 10(5), e0127174-e0127174 (2015-05-23)
Nanomaterials (NMs) display many unique and useful physico-chemical properties. However, reliable approaches are needed for risk assessment of NMs. The present study was performed in the FP7-MARINA project, with the objective to identify and evaluate in vitro test methods for...
Sachiko Kitamoto et al.
Mutation research. Genetic toxicology and environmental mutagenesis, 786-788, 129-136 (2015-07-28)
The in vivo rodent alkaline comet assay (comet assay) is a promising technique to evaluate DNA damage in vivo. However, there is no agreement on a method to evaluate DNA damage in organs where cytotoxicity is observed. As a part...
Brandon T Gufford et al.
Drug metabolism and disposition: the biological fate of chemicals, 43(9), 1353-1359 (2015-06-14)
Women at high risk of developing breast cancer are prescribed selective estrogen response modulators, including raloxifene, as chemoprevention. Patients often seek complementary and alternative treatment modalities, including herbal products, to supplement prescribed medications. Milk thistle preparations, including silibinin and silymarin...
Florian Labarrade et al.
Journal of cosmetic dermatology, 14(3), 191-203 (2015-07-17)
The chromosomal passenger complex (CPC) is an assembly made of four interacting proteins: survivin, borealin, INCENP, and aurora kinase B. CPC is the key regulatory complex responsible for the correct development of cellular mitosis, accompanying each step of the chromosomal...
Gökçen Birlik Demirel
Chemphyschem : a European journal of chemical physics and physical chemistry, 15(8), 1693-1699 (2014-03-22)
A simple strategy for the immobilization of Cy3-labeled single strand DNA (Cy3-ssDNA) on a Si(001) surface and its release under control of both light and pH stimuli is presented. In order to prepare a dual pH/light-triggered surface, positively chargeable azobenzene...
P J Schuler et al.
Clinical and experimental immunology, 177(2), 531-543 (2014-04-23)
While murine CD4(+) CD39(+) regulatory T cells (T(reg)) co-express CD73 and hydrolyze exogenous (e) adenosine triphosphate (ATP) to immunosuppressive adenosine (ADO), surface co-expression of CD73 on human circulating CD4(+) CD39(+) T(reg) is rare. Therefore, the ability of human T(reg) to...
Xue Qiu et al.
ACS nano, 9(8), 8449-8457 (2015-07-21)
The detection of next generation microRNA (miRNA) biomarkers has become a highly important aspect for clinical diagnostics. We use multiplexed Förster resonance energy transfer (FRET) between a luminescent Tb complex and three different semiconductor quantum dots (QDs) to sensitively detect...
Towards a blocking-free electrochemical immunosensing strategy for anti-transglutaminase antibodies using screen-printed electrodes.
Daniel Martín-Yerga et al.
Bioelectrochemistry (Amsterdam, Netherlands), 105, 88-94 (2015-06-05)
Dominique E Williams et al.
Chembiochem : a European journal of chemical biology, 16(10), 1474-1482 (2015-05-09)
With the goal of designing a lysosomal phospholipase mimic, we optimized experimental variables to enhance Ce(IV) -assisted hydrolysis of phosphatidylcholine (PC) liposomes. Our best result was obtained with the chelating agent bis-tris propane (BTP). Similar to the hydrolytic enzyme, Ce(IV)...
Gerson A Acasigua et al.
Oral oncology, 51(9), 839-847 (2015-07-01)
To evaluate the anti-tumor effect of BM-1197, a new potent and highly specific small molecule inhibitor of Bcl-2/Bcl-xL, in preclinical models of human adenoid cystic carcinoma (ACC). Low passage primary human adenoid cystic carcinoma cells (UM-HACC-2A,-2B,-5,-6) and patient-derived xenograft (PDX)...
Shunsuke Izaki et al.
Journal of pharmaceutical sciences, 104(6), 1929-1937 (2015-03-27)
Development of high-concentration antibody formulations for subcutaneous administration remains challenging. Recently, a precipitation-redissolution method was proposed to prepare suspensions or precipitates of salt-dissociable protein-poly(amino acid) complexes. To elucidate the utility of this method for protein therapy, we investigated the feasibility...
Giovanni Candiano et al.
Analytical chemistry, 87(9), 4814-4820 (2015-04-10)
Combinatorial peptide ligand libraries (CPLLs) tend to bind complex molecules such as dyes due to their aromatic, heterocyclic, hydrophobic, and ionic nature that may affect the protein capture specificity. In this experimental work Alcian Blue 8GX, a positively charged phthalocyanine...
Salwa M Maria et al.
Acta biomaterialia, 20, 140-146 (2015-04-02)
Bone resorbing osteoclasts represent an important therapeutic target for diseases associated with bone and joint destruction, such as rheumatoid arthritis, periodontitis, and osteoporosis. The quantification of osteoclast resorptive activity in vitro is widely used for screening new anti-resorptive medications. The...
Karla B Schallies et al.
Journal of bacteriology, 197(13), 2139-2149 (2015-04-22)
CbrA is a DivJ/PleC-like histidine kinase of DivK that is required for cell cycle progression and symbiosis in the alphaproteobacterium Sinorhizobium meliloti. Loss of cbrA results in increased levels of CtrA as well as its phosphorylation. While many of the...
Azad Behnan Sabow et al.
Animal science journal = Nihon chikusan Gakkaiho, 86(12), 981-991 (2015-07-25)
This study assessed the effect of halal slaughter and anesthesia pre-slaughter followed by bleeding on meat quality characteristics of goats. Eleven male Boer cross goats were divided into two groups and subjected to either halal slaughter (HS) or anesthesia with...
Caifen Wang et al.
Journal of chromatography. A, 1359, 287-295 (2014-07-30)
The kinetics of the dissociation is fundamental to the formation and the in vivo performance of cyclodextrin supramolecules. The individual determination of the apparent dissociation rate constant (kd,app) using high performance affinity chromatography (HPAC) is a tedious process requiring numerous...
Ana Sofia Coelho et al.
Odontology, 108(2), 260-270 (2019-10-19)
The aim of this study was to evaluate the cytotoxic effects of an enzymatic mouthwash and of a chlorhexidine mouthwash on human gingival fibroblasts. The metabolic activity of the fibroblasts exposed to each mouthwash was assessed by the MTT assay...
Julien L Marcadier et al.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 187(2), 102-107 (2014-12-03)
Congenital sucrase-isomaltase deficiency is a rare hereditary cause of chronic diarrhea in children. People with this condition lack the intestinal brush-border enzyme required for digestion of di- and oligosaccharides, including sucrose and isomaltose, leading to malabsorption. Although the condition is...
Rong-Cing Huang et al.
ACS applied materials & interfaces, 6(24), 21780-21787 (2014-04-16)
In this study, we developed a label-free, ultrasensitive graphene oxide (GO)-based probe for the detection of oligonucleotides by laser desorption/ionization mass spectrometry (LDI-MS). On the basis of simple π-π stacking and electrostatic interactions between rhodamine 6G (R6G) and GO, we...
Victorien Decoin et al.
BMC microbiology, 15, 72-72 (2015-04-18)
Pseudomonas fluorescens strain MFE01 secretes in abundance two Hcp proteins (haemolysin co-regulated proteins) Hcp1 and Hcp2, characteristic of a functional type 6 secretion system. Phenotypic studies have shown that MFE01 has antibacterial activity against a wide range of competitor bacteria...
Roman A Barco et al.
Applied and environmental microbiology, 81(17), 5927-5937 (2015-06-21)
Microaerophilic, neutrophilic, iron-oxidizing bacteria (FeOB) grow via the oxidation of reduced Fe(II) at or near neutral pH, in the presence of oxygen, making them relevant in numerous environments with elevated Fe(II) concentrations. However, the biochemical mechanisms for Fe(II) oxidation by...
Peter Joseph Durcan et al.
BMC physiology, 14, 11-11 (2014-12-10)
Multiple cell types including trophoblasts, osteoclasts and myoblasts require somatic cell fusion events as part of their physiological functions. In Drosophila Melanogaster the paralogus type 1 transmembrane receptors and members of the immunoglobulin superfamily Kin of Irre (Kirre) and roughest...
Olga Gordeeva et al.
Archives of toxicology, 95(1), 253-269 (2020-09-15)
Pluripotent stem cells recapitulate in vitro the early developmental stages and are considered promising cell models for predictive developmental toxicity studies. To investigate the consistency between adverse drug effects on early development and the early stages of embryonic stem cell...
Variation of anthocyanin and carotenoid contents and associated antioxidant values in potato breeding lines.
Brown CR et al
J. Am. Soc. Hort. Sci., 130(2), 174-180 (2005)
Marcel E Sayre et al.
The Journal of comparative neurology, 527(14), 2371-2387 (2019-03-13)
Paired centers in the forebrain of insects, called the mushroom bodies, have become the most investigated brain region of any invertebrate due to novel genetic strategies that relate unique morphological attributes of these centers to their functional roles in learning...
Allan J Alla et al.
Journal of chromatography. A, 1423, 19-30 (2015-11-12)
The surface of nanoporous gold (np-Au) monoliths was modified via a flow method with the lectin Concanavalin A (Con A) to develop a substrate for separation and extraction of glycoproteins. Self-assembled monolayers (SAMs) of α-lipoic acid (LA) on the np-Au...
Liuxing Feng et al.
Analytica chimica acta, 884, 19-25 (2015-06-16)
Species-specific (SS) isotope dilution analysis with gel electrophoresis (GE)-laser ablation (LA)-ICP-MS is a promising technique for the quantification of particular metal-binding proteins in biological samples. However, unavailable isotopically enriched spike and metal losses in GE separation are main limitations for...
Maria G A Hägglund et al.
Journal of molecular biology, 427(6 Pt B), 1495-1512 (2014-12-03)
Glutamine transporters are important for regulating levels of glutamate and GABA in the brain. To date, six members of the SLC38 family (SNATs) have been characterized and functionally subdivided them into System A (SNAT1, SNAT2 and SNAT4) and System N...
Christian Vogl et al.
The European journal of neuroscience, 41(4), 398-409 (2014-12-09)
Synaptic vesicle glycoprotein (SV)2A is a transmembrane protein found in secretory vesicles and is critical for Ca(2+) -dependent exocytosis in central neurons, although its mechanism of action remains uncertain. Previous studies have proposed, variously, a role of SV2 in the...
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