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Lori S Tillmans et al.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 24(4), 713-719 (2015-02-05)
Cigarette smoking (smoking), hormone therapy (MHT), and folate intake (folate) are each thought to influence colorectal cancer risk, but the underlying molecular mechanisms remain incompletely defined. Expression of estrogen receptor β (ESR2) has been associated with colorectal cancer stage and
Rebecca K Golley et al.
The Journal of nutrition, 145(1), 128-133 (2014-12-21)
Whether dietary indexes are associated with biomarkers of children's dietary intake is unclear. The study aim was to examine the relations between diet quality and selected plasma biomarkers of dietary intake and serum lipid profile. The study sample consisted of
Yonghe Fei et al.
Food chemistry, 187, 385-390 (2015-05-16)
Three new monoterpene glycosides (1-3) and eleven known compounds (4-14) were isolated from seeds of Helianthus annuus L. (sunflower). Their structures were determined by spectroscopic and chemical methods. All the compounds were isolated from sunflower seeds for the first time.
Denis Fourches et al.
Chemical research in toxicology, 23(1), 171-183 (2009-12-18)
Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental drug discovery projects toward safer medicines. In this
Bénédicte M J Merle et al.
PloS one, 10(7), e0130816-e0130816 (2015-07-02)
Genetic susceptibility could be modified by environmental factors and may also influence differential responses to treatments for age-related macular degeneration (AMD). We investigated whether genotype could influence response to docosahexaenoic acid (DHA)-supplementation in the occurrence of choroidal new vessels (CNV).
G A Casas et al.
Journal of animal science, 93(7), 3441-3448 (2015-10-07)
The objectives of this experiment were to determine the apparent total tract digestibility (ATTD) and the standardized total tract digestibility (STTD) of P and the effect of microbial phytase on ATTD and STTD of P in full-fat rice bran (FFRB)
Antoinette Chougnet et al.
Chimia, 64(5), 303-308 (2010-12-09)
We report here on our efforts to develop new strategies for the synthesis of alpha-tocopherol, the biologically most significant member of the vitamin E family. This review comprises five new methods to generate the chiral chromane of alpha-tocopherol with overall
I A Alhidary et al.
Journal of animal science, 93(2), 576-588 (2015-05-29)
Forty-two 7-mo-old Australian Merino wethers were used in a 50-d trial to investigate the effects of Se and vitamin E on the performance and physiological responses of heat-stressed sheep. Sheep were exposed to thermoneutral conditions (maximum = 24°C and minimum
S Engelborghs et al.
Neurochemical research, 28(8), 1145-1150 (2003-07-02)
To study changes in amino acid metabolism and biogenic amines in Parkinson's disease, we set up a prospective study and measured biogenic amines, their main metabolites, and 22 different amino acids, in cerebrospinal fluid of Parkinson's disease patients (n =
M V Dolgushin et al.
Biomeditsinskaia khimiia, 59(1), 97-103 (2013-05-09)
The chronic stress in albino rats caused by exposure to the whole-body vibration induced the significant changes in the functional-metabolic status of the blood cells. It involved the phagocytosis level and the lysosomal cationic proteins in the neutrophils, oxidative and
Robert N Cole et al.
The Journal of nutrition, 143(10), 1540-1548 (2013-08-24)
Micronutrient deficiencies are common in undernourished societies yet remain inadequately assessed due to the complexity and costs of existing assays. A plasma proteomics-based approach holds promise in quantifying multiple nutrient:protein associations that reflect biological function and nutritional status. To validate
M Veera Narayana Reddy et al.
European journal of medicinal chemistry, 45(5), 1828-1832 (2010-02-04)
Synthesis of 3,3'-(1,4-phenylene)-bis[2-alkoxycarbonyl-alkyl)-2-thio-benzoxaphos-phinines] (3a-j) were accomplished via two step process. It involves the prior preparation of monochloride intermediate (2) and its subsequent reaction with the amino acid esters in dry tetrahydrofuran-toluene in the presence of triethylamine at reflux temperature. These
Md Maniruzzaman Manir et al.
Bioorganic & medicinal chemistry, 20(7), 2376-2381 (2012-03-02)
Four new quercetin acylglycosides, designated camelliquercetisides A-D, quercetin 3-O-[α-L-arabinopyranosyl(1→3)][2-O″-(E)-p-coumaroyl][β-D-glucopyranosyl(1→3)-α-L-rhamnopyranosyl(1→6)]-β-D-glucoside (17), quercetin 3-O-[2-O″-(E)-p-coumaroyl][β-D-glucopyranosyl(1→3)-α-L-rhamnopyranosyl(1→6)]-β-D-glucoside (18), quercetin 3-O-[α-L-arabinopyranosyl(1→3)][2-O″-(E)-p-coumaroyl][α-L-rhamnopyranosyl(1→6)]-β-d-glucoside (19), and quercetin 3-O-[2-O″-(E)-p-coumaroyl][α-L-rhamnopyranosyl(1→6)]-β-D-glucoside (20), together with caffeine and known catechins, and flavonoids (1-16) were isolated from the leaves of Camellia sinensis. Their structures were
Francisca Rodrigues et al.
Food & function, 6(8), 2854-2860 (2015-07-21)
The present study was aimed to assess the macronutrient composition and the amino acid and vitamin E profiles of Castanea sativa shell from different production regions of Portugal (Minho, Trás-os-Montes and Beira-Alta). The nutritional composition was similar for all samples
A I Rey et al.
Food chemistry, 142, 342-348 (2013-09-05)
The use of stereoisomers of α-tocopherol to correctly classify Iberian pig fat samples according to their feeding system was investigated. Samples were obtained over two different seasons in controlled farms from the four categories of pigs described in the Industry
Gloria V López et al.
Bioorganic & medicinal chemistry, 17(24), 8143-8148 (2009-11-10)
Nitric oxide-releasing alpha-tocopherol mimetics with LDL-protective activity were designed to maintain the tocopherol substructure necessary for its biochemical recognition by alpha-tocopherol transfer protein. In order to study the molecular interactions to alpha-TTP, theoretical binding studies by means of docking techniques
Tae Heung Kang et al.
PloS one, 9(7), e103562-e103562 (2014-07-30)
Vitamin E has been shown to have strong anticarcinogenic properties, including antioxidant characteristics, making it an ideal candidate for use in combination with immunotherapies that modify the tumor microenvironment. The tumor microenvironment contains immunosuppressive components, which can be diminished, and
Hatem Braham et al.
Journal of natural products, 68(4), 517-522 (2005-04-23)
The new phenolic glycosides quercetin 3,4'-di-O-beta-d-glucopyranoside-7-O-alpha-l-rhamnopyranoside (moricandin) (1), beta-d-glucopyranosyl 4-O-beta-d-glucopyranosylcaffeate (2), methyl 3-O-beta-d-glucopyranosyl-5-hydroxycinnamate (3), and beta-d-glucopyranosyl 4-O-beta-d-glucopyranosylbenzoate (4), together with the previously known beta-d-glucopyranosyl 4-hydroxybenzoate (5), methyl 4-O-beta-d-glucopyranosylcaffeate (6), 1-O-caffeoyl-beta-d-glucopyranoside (7), and 2-phenylethyl-beta-d-glucopyranoside (8), were isolated from the flowers of
O A Vrzhesinskaia et al.
Voprosy pitaniia, 82(1), 45-52 (2013-07-03)
Using the model of combined vitamin deficiency based on 5-fold reduction of the amount of vitamin mixture in semi-synthetic diet and on vitamin E exclusion from the mixture, the influence of omega-3 polyunsaturated fatty acids (PUFA) on vitamin and antioxidant
Jun Lu et al.
Bioorganic & medicinal chemistry, 18(21), 7628-7638 (2010-10-05)
An efficient synthesis has provided access to a novel α-tocopherol analogue (2), as well as its trifluoroacetate salt and acetate ester. An annulation reaction was used to establish the pyridinol core structure and a Stille coupling reaction was employed for
Michael Piper et al.
Neural development, 10, 3-3 (2015-04-18)
Local protein synthesis (LPS) via receptor-mediated signaling plays a role in the directional responses of axons to extrinsic cues. An intact cytoskeleton is critical to enact these responses, but it is not known whether the two major cytoskeletal elements, F-actin
Jarmo Virtamo et al.
International journal of cancer, 135(1), 178-185 (2013-12-18)
In the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study among 29,133 Finnish male smokers aged 50-69 years, daily α-tocopherol (50 mg) for a median of 6.1 years decreased the risk of prostate cancer, whereas β-carotene (20 mg) increased risk of lung cancer
Stephanie E Martinez et al.
Canadian journal of veterinary research = Revue canadienne de recherche veterinaire, 79(3), 241-249 (2015-07-02)
Multicomponent nutraceuticals are becoming increasingly popular treatments or adjunctive therapies for osteoarthritis in veterinary medicine despite lack of evidence of efficacy for many products. The objective of this study was to evaluate the anti-inflammatory and antioxidant activities of a commercially
Stefanie B Murer et al.
The Journal of nutrition, 144(2), 193-201 (2013-12-20)
Oxidative stress and low-grade systemic inflammation may contribute to the pathogenesis of obesity-induced comorbidities, including nonalcoholic fatty liver disease. Increasing intake of dietary antioxidants might be beneficial, but there are few data in obese children. To examine the effect of
Chan Woo Lee et al.
Bioorganic & medicinal chemistry letters, 17(19), 5462-5464 (2007-08-19)
Three tyrosyl gallate derivatives (1-3) with variable hydroxyl substituent at the aromatic ring of tyrosol were synthesized and evaluated as potent inhibitors on tyrosinase activity and melanin formation in melan-a cells. Among three tyrosyl gallate derivatives, 4-hydroxyphenethyl 3,4,5-trihydroxybenote (1) (IC(50)=4.93
Nozomu Kono et al.
Science (New York, N.Y.), 340(6136), 1106-1110 (2013-04-20)
α-Tocopherol (vitamin E) transfer protein (α-TTP) regulates the secretion of α-tocopherol from liver cells. Missense mutations of some arginine residues at the surface of α-TTP cause severe vitamin E deficiency in humans, but the role of these residues is unclear.
Jesús Vioque et al.
Nutrition journal, 12, 26-26 (2013-02-21)
Studies exploring the role of diet during pregnancy are still scarce, in part due to the complexity of measuring diet and to the lack of valid instruments. The aim of this study was to examine the reproducibility and validity (against
Y Dersjant-Li et al.
Journal of animal physiology and animal nutrition, 94(4), 413-421 (2009-08-12)
Alpha-tocopherol derived from natural source is a single stereoisomer (i.e. RRR-alpha-tocopherol), whereas synthetic alpha-tocopherol consists of a mixture of eight stereoisomers, including RRR-, RRS-, RSR-, RSS-alpha-tocopherol (the 2R isomers, R configuration at positions 2' of the phytyl tail) and SRR-
Jessica Josephson et al.
JPEN. Journal of parenteral and enteral nutrition, 39(6), 677-687 (2014-10-19)
Parenteral nutrition (PN)-associated liver disease (PNALD) remains a significant cause of morbidity and mortality for neonates dependent on PN. Total fat emulsion dose and composition, particularly the large amount of ω-6 long-chain polyunsaturated fatty acids in plant oils, have been
Ying Yang et al.
Food chemistry, 141(1), 473-481 (2013-06-19)
Vitamin E is an essential micronutrient for humans and animals due to its antioxidant and non-antioxidant biological activities. The α-tocopherol acetate form is often used in foods and other products due to its high biological activity and chemical stability. In
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