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Priyankar Dey et al.
Chemico-biological interactions, 235, 37-46 (2015-04-15)
CCl4 is a potent environmental toxin which cause liver damage through free radical mediated inflammatory processes. In this study, hepatoprotective capacity of Nerium indicum leaf extract (NILE) was evaluated on CCl4 induced acute hepatotoxicity in murine model. Animals were divided
Muneeb U Rehman et al.
Pharmacological reports : PR, 66(6), 1050-1059 (2014-12-03)
Cisplatin is an effective and extensively used chemotherapeutic agent to treat range of malignancies, but its therapeutic use is limited because of dose-dependent nephrotoxicity and hepatotoxicity. Several published reports advocate that supplementation with antioxidant can influence cisplatin induced hepatic damage.
Intidhar Ben Salem et al.
Environmental science and pollution research international, 22(23), 19069-19076 (2015-08-04)
Zearalenone (ZEN) is a mycotoxin from Fusarium species commonly found in many food commodities and known to cause reproductive disorders. Several studies have shown that ZEN is hematotoxic and hepatotoxic and causes several alterations of immunological parameters. In the present
Priyanka D Pinky et al.
Heliyon, 7(4), e06730-e06730 (2021-04-30)
Cannabis is the most commonly used illicit drug worldwide. Recently, cannabis use among young pregnant women has greatly increased. However, prenatal cannabinoid exposure leads to long-lasting cognitive, motor, and behavioral deficits in the offspring and alterations in neural circuitry through
Elena R Andreeva et al.
Cells, tissues, organs, 200(5), 307-315 (2015-09-26)
A microenvironment low in O2 ('physiological' hypoxia) governs the functions of perivascular multipotent mesenchymal stromal cells, defining their involvement in tissue physiological homeostasis and regenerative remodelling. Acute hypoxic stress is considered as one of the important factors inducing tissue damage.
Lucio G Costa et al.
Neurotoxicology, 48, 68-76 (2015-03-24)
Polybrominated diphenyl ethers (PBDEs), used for decades as flame retardants, have become widespread environmental contaminants. Exposure is believed to occur primarily through diet and dust, and infants and toddlers have the highest body burden, raising concern for potential developmental neurotoxicity.
N Greeshma et al.
Chemico-biological interactions, 238, 118-128 (2015-06-24)
Hyperalgesia, allodynia, delayed motor nerve conduction velocity, oxidative stress and axonal damage are signs and symptoms of chemotherapy induced peripheral neuropathy (CIPN). Present treatment/preventive strategies of CIPN are futile and the neuropathy may even lead to discontinuation of chemotherapy. In
K M Sadek
Andrologia, 46(9), 1047-1054 (2013-11-13)
This study was conducted to determine the mechanism underlying the chemotherapeutic efficacy of an ethanolic Moringa oleifera leaf extract (MOLEE) against chromium-induced impairments of rat testes using biochemical methods. Twenty male Wistar rats were divided into four groups of five
Xin Jin et al.
European journal of medicinal chemistry, 56, 203-209 (2012-09-18)
Four novel series of compounds, including the l-phenylalanine-derived C5-substituted rhodanine (6a-q, 7a-j) and chalcone derivatives containing thiobarbituric acid or 2-thioxo-4-thiazolidinone (9a-e, 11a-e) have been designed, synthesized, characterized, and evaluated for their antibacterial activity. Some of these compounds showed significant antibacterial
Tingting Wang et al.
Toxicology and applied pharmacology, 280(1), 169-176 (2014-06-27)
Chronic exposure to low-levels of organophosphate (OP) compounds, such as chlorpyrifos (CPF), induces oxidative stress and could be related to neurological disorders. Hydrogen has been identified as a novel antioxidant which could selectively scavenge hydroxyl radicals. We explore whether intake
Makoto Shirai et al.
The Journal of toxicological sciences, 40(4), 509-521 (2015-07-15)
We previously reported that hepatic necrosis induced by thioacetamide (TA), a hepatotoxicant, was attenuated in mice fed a high-fat diet (HFD mice) in comparison with mice fed a normal rodent diet (ND mice). In this study, we focused on investigation
Patrick Osei-Owusu et al.
Infection and immunity, 83(4), 1507-1522 (2015-02-04)
The type III secretion system is employed by many pathogens, including the genera Yersinia, Shigella, Pseudomonas, and Salmonella, to deliver effector proteins into eukaryotic cells. The injectisome needle is formed by the polymerization of a single protein, e.g., YscF (Yersinia
Arpan Dey Bhowmik et al.
Ecotoxicology and environmental safety, 202, 110962-110962 (2020-08-18)
Chronic exposure to fluoride (F) beyond the permissible limit (1.5 ppm) is known to cause detrimental health effects by induction of oxidative stress-mediated DNA damage overpowering the DNA repair machinery. In the present study, we assessed F induced oxidative stress through
R V Hrytsaĭ et al.
Mikrobiolohichnyi zhurnal (Kiev, Ukraine : 1993), 74(5), 16-21 (2012-11-06)
By immunochemical investigations of eight strains of Ralstonia solanacearum six strains were attributed to four serogroups. Two of them are formed by pairs of R. solanacearum strains 4 and 526; 758 and 7954; two others are represented by single strains--TX1
Fabricio E L Carvalho et al.
Plant, cell & environment, 38(12), 2603-2617 (2015-05-28)
The amount of light plants can tolerate during different phases of ontogenesis remains largely unknown. This was addressed here employing a novel methodology that uses the coefficient of photochemical quenching (qP) to assess the intactness of photosystem II reaction centres.
Efstathios P Papadakis et al.
Journal of minimally invasive gynecology, 22(7), 1203-1207 (2015-07-01)
To evaluate the feasibility and impact of levonorgestrel intrauterine system (LNG-IUS) on treatment failure after endometrial ablation (EA) in women with heavy menstrual bleeding (HMB) and dysmenorrhea at 4 years. Cohort study (Canadian Task Force II-2). An academic institution in
Meyliana Wulandari et al.
Analytical and bioanalytical chemistry, 407(3), 803-812 (2014-07-25)
This paper describes the synthesis of novel molecularly imprinted polymers (MIPs), prepared by a noncovalent imprinting approach, for cleanup and preconcentration of curcumin (CUR) and bisdemethoxycurcumin (BDMC) from medicinal herbal extracts and further analysis by high-performance liquid chromatography with fluorescence
Mohammad Haaris Ajmal Khan et al.
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), 31, 53-60 (2015-05-26)
Cadmium (Cd) induces neurotoxicity owing to its highly deleterious capacity to cross the blood brain barrier (BBB). Recent studies have provided insights on antioxidant properties of bioflavonoids which have emerged as potential therapeutic and nutraceutical agents. The aim of our
C P Teixeira et al.
Climacteric : the journal of the International Menopause Society, 17(4), 402-409 (2013-10-26)
To evaluate the effects of soy isoflavone extract in the pro-oxidant/antioxidant balance in the uterus of ovariectomized rats. Twenty 3-month-old adult female Wistar rats were divided into four equal groups: GI: sham-operated (estrous phase); GII: control ovariectomized rats; GIII: ovariectomized
Rajendra Karki et al.
Free radical biology & medicine, 71, 256-269 (2014-03-19)
To study the role of c-Src kinase in pro-oxidant-induced stimulation of Toll-like receptor 4 (TLR4), we used lipopolysaccharide from Escherichia coli K12 (LPS-EK) and monophosphoryl lipid A, as TLR4-specific agonists and positive controls, and SIN-1 and potassium peroxychromate as pro-oxidant
Song-Xue Guo et al.
Marine drugs, 13(4), 2105-2123 (2015-04-15)
Early acute kidney injury (AKI) is a devastating complication in critical burn patients, and it is associated with severe morbidity and mortality. The mechanism of AKI is multifactorial. Astaxanthin (ATX) is a natural compound that is widely distributed in marine
Harshad K Shete et al.
International journal of pharmaceutics, 468(1-2), 1-14 (2014-04-08)
A novel approach of enhancing the Tamoxifen uptake via Intestinal Lymphatic System is executed by developing long chain lipid and oil based nanostructured lipid carrier system (Tmx-NLC). The aim was to achieve improved systemic bioavailability of Tamoxifen, prevent systemic and
Esther T Menze et al.
PloS one, 10(2), e0117223-e0117223 (2015-02-13)
Huntington's disease (HD) is a progressive neurodegenerative disorder. The pre-motor symptomatic stages of the disease are commonly characterized by cognitive problems including memory loss. 3-Nitropropionic acid (3-NPA) is a mitochondrial toxin that produces selective lesions in the brain similar to
Emel Kiyak Caglayan et al.
European journal of obstetrics, gynecology, and reproductive biology, 182, 154-159 (2014-10-08)
To investigate the protective effect of ethyl pyruvate (EP), an anti-oxidant agent, against ischemia-reperfusion injury in a rat model of ovarian torsion, considering biochemical and histopathological aspects. Forty Wistar Albino rats were divided into five groups: Group I, sham operation;
Heidi E Banse et al.
Canadian journal of veterinary research = Revue canadienne de recherche veterinaire, 79(4), 329-338 (2015-10-02)
In horses, hyperinsulinemia and insulin resistance (insulin dysregulation) are associated with the development of laminitis. Although obesity is associated with insulin dysregulation, the mechanism of obesity-associated insulin dysregulation remains to be established. We hypothesized that oxidative stress in skeletal muscle
Neha et al.
Naunyn-Schmiedeberg's archives of pharmacology, 387(8), 777-787 (2014-05-29)
A huge body evidences suggest that obesity is the single great risk factor for the development of dementia. Recently, silymarin, a flavonoid, clinically in use as a hepatoprotectant, has been reported to prevent amyloid beta-induced memory impairment by reducing oxidative
Shashi Sharma et al.
Clinical & experimental ophthalmology, 43(5), 429-436 (2015-02-14)
The aim of the study was to determine plasma nitric oxide (NO) and lipid peroxide (LPO) levels in diabetic retinopathy and its association with severity of disease. Prospective observational study. A total of 60 consecutive cases and 20 healthy controls
Sanjay B Kasture et al.
Behavioural pharmacology, 26(1-2), 125-132 (2014-08-22)
Tea is the most popular beverage worldwide. Caffeine, the psychoactive principle of tea, pharmacologically interacts with several drugs and bioactive molecules. Epigallocatechin gallate (EGCG) is a major component of tea and its known interactions with caffeine make it worthwhile to
Israr Ahmad et al.
Molecular and cellular biochemistry, 393(1-2), 209-222 (2014-04-29)
Cytochrome P4502E1 (CYP2E1), glutathione-S-transferase A4-4 (GSTA4-4), and inducible nitric oxide synthase (iNOS) are implicated in maneb- and paraquat-induced toxicity leading to various pathological conditions. The study aimed to investigate the role of CYP2E1 in maneb- and paraquat-induced oxidative stress in
Gurbuz Gunes et al.
TheScientificWorldJournal, 2012, 274219-274219 (2012-05-09)
Combined effects of gamma irradiation and concentrations of O(2) (0, 5, 21%) and CO(2) (0, 50%) on survival of Escherichia coli O157:H7, Salmonella enteritidis, Listeria monocytogenes, lipid oxidation, and color changes in ready-to-cook seasoned ground beef (meatball) during refrigerated storage
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