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Sharon Israeli-Rosenberg et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(2), 374-384 (2014-11-05)
β1 integrins (β1) transduce mechanical signals in many cells, including cardiac myocytes (CM). Given their close localization, as well as their role in mechanotransduction and signaling, we hypothesized that caveolin (Cav) proteins might regulate integrins in the CM. β1 localization
Georgia Papacleovoulou et al.
The Journal of clinical investigation, 123(7), 3172-3181 (2013-08-13)
The intrauterine environment is a major contributor to increased rates of metabolic disease in adults. Intrahepatic cholestasis of pregnancy (ICP) is a liver disease of pregnancy that affects 0.5%-2% of pregnant women and is characterized by increased bile acid levels
Ruba Halaoui et al.
Genes & development, 31(15), 1573-1587 (2017-09-10)
Epithelial cancers (carcinoma) account for 80%-90% of all cancers. The development of carcinoma is associated with disrupted epithelial organization and solid ductal structures. The mechanisms underlying the morphological development of carcinoma are poorly understood, but it is thought that loss
Sherri A Rennoll et al.
Biochemical and biophysical research communications, 446(4), 1120-1125 (2014-03-29)
Designer TALEs (dTALEs) are chimeric transcription factors that can be engineered to regulate gene expression in mammalian cells. Whether dTALEs can block gene transcription downstream of signal transduction cascades, however, has yet to be fully explored. Here we tested whether
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Gautam Runwal et al.
Scientific reports, 9(1), 10147-10147 (2019-07-14)
Autophagy is an evolutionarily conserved process across eukaryotes that degrades cargoes like aggregate-prone proteins, pathogens, damaged organelles and macromolecules via delivery to lysosomes. The process involves the formation of double-membraned autophagosomes that engulf the cargoes destined for degradation, sometimes with
Nina Ilic et al.
Proceedings of the National Academy of Sciences of the United States of America, 114(17), E3434-E3443 (2017-04-12)
Oncogenic PIK3CA mutations are found in a significant fraction of human cancers, but therapeutic inhibition of PI3K has only shown limited success in clinical trials. To understand how mutant PIK3CA contributes to cancer cell proliferation, we used genome scale loss-of-function
Ji-Yon Kim et al.
Stem cells international, 2016, 9475981-9475981 (2017-01-21)
The Charcot-Marie-Tooth disease 2F (CMT2F) and distal hereditary motor neuropathy 2B (dHMN2B) are caused by autosomal dominantly inherited mutations of the heat shock 27 kDa protein 1 (HSPB1) gene and there are no specific therapies available yet. Here, we assessed the
Eri Miyagi et al.
Journal of virology, 88(9), 4839-4852 (2014-02-14)
Vif is a lentiviral accessory protein that regulates viral infectivity in part by inducing proteasomal degradation of APOBEC3G (A3G). Recently, CBFβ was found to facilitate Vif-dependent degradation of A3G. However, the exact role of CBFβ remains unclear. Several studies noted
Yevgeniy V Serebrenik et al.
Molecular biology of the cell, 29(11), 1284-1298 (2018-06-01)
In eukaryotic cells, organelle-specific stress-response mechanisms are vital for maintaining cellular homeostasis. The Golgi apparatus, an essential organelle of the secretory system, is the major site of protein modification and sorting within a cell and functions as a platform for
Sreyoshi Mitra et al.
Nature communications, 11(1), 501-501 (2020-01-26)
Centromeres are defined by a self-propagating chromatin structure based on stable inheritance of CENP-A containing nucleosomes. Here, we present a genetic screen coupled to pulse-chase labeling that allow us to identify proteins selectively involved in deposition of nascent CENP-A or
Robert Stein et al.
The Journal of biological chemistry, 291(35), 18419-18429 (2016-07-13)
Caspase-1 is a key player during the initiation of pro-inflammatory innate immune responses, activating pro-IL-1β in so-called inflammasomes. A subset of patients with recurrent febrile episodes and systemic inflammation of unknown origin harbor mutations in CASP1 encoding caspase-1. CASP1 variants
Laura Trapani et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 25(11), 4037-4047 (2011-07-30)
The rate-limiting step of cholesterol biosynthetic pathway is catalyzed by 3-hydroxy-3-methylglutaryl coenzyme reductase (HGMR), whose inhibitors, the statins, widely used in clinical practice to treat hypercholesterolemia, often cause myopathy, and rarely rhabdomyolysis. All studies to date are limited to the
Mariko Aoyagi et al.
Proceedings of the National Academy of Sciences of the United States of America, 107(6), 2640-2645 (2010-02-06)
4EBP1 is phosphorylated by the mTORC1 kinase. When mTORC1 activity is inhibited, hypophosphorylated 4EBP1 binds and sequesters eIF4E, a component of the mRNA cap-binding complex, and blocks translation. As a consequence, mTORC1 activity is needed to maintain active translation. The
Yu Wang et al.
Cancer research, 76(17), 5124-5132 (2016-08-05)
Development of resistance to antiandrogens for treating advanced prostate cancer is a growing concern and extends to recently developed therapeutics, including enzalutamide. Therefore, new strategies to block androgen receptor (AR) function in prostate cancer are required. Here, we report the
María Gabriela Otero et al.
Journal of cell science, 131(11) (2018-05-05)
Alzheimer disease (AD) pathology includes the accumulation of poly-ubiquitylated (also known as poly-ubiquitinated) proteins and failures in proteasome-dependent degradation. Whereas the distribution of proteasomes and its role in synaptic function have been studied, whether proteasome activity regulates the axonal transport
L I Láscarez-Lagunas et al.
Molecular and cellular biology, 34(13), 2499-2516 (2014-04-23)
Apoptosis is an important mechanism for maintaining germ line health. In Caenorhabditis elegans, germ cell apoptosis occurs under normal conditions to sustain gonad homeostasis and oocyte quality. Under stress, germ cell apoptosis can be triggered via different pathways, including the
Silvie Tomankova et al.
Biology open, 6(6), 862-871 (2017-05-10)
Nitric oxide (NO) is a potent radical molecule that participates in various biological processes such as vasodilation, cell proliferation, immune response and neurotransmission. NO mainly activates soluble guanylate cyclase, leading to cGMP production and activation of protein kinase G and
Itzhak Mendel et al.
Digestive diseases and sciences, 61(9), 2545-2553 (2016-04-15)
Previous studies demonstrated that toll-like receptors 4 and 2 (TLR-4 and TLR-2), which are expressed on liver-resident Kupffer, hepatic stellate cells, and circulating monocytes, play a role in nonalcoholic fatty liver disease. Lecinoxoids are oxidized phospholipids that antagonize TLR-2- and
Roberto Ferrari et al.
Molecular cell, 77(3), 475-487 (2019-11-25)
How repetitive elements, epigenetic modifications, and architectural proteins interact ensuring proper genome expression remains poorly understood. Here, we report regulatory mechanisms unveiling a central role of Alu elements (AEs) and RNA polymerase III transcription factor C (TFIIIC) in structurally and
Roderick J Tan et al.
Scientific reports, 6, 36185-36185 (2016-11-03)
The Keap1/Nrf2 pathway is a master regulator of antioxidant, anti-inflammatory, and other cytoprotective mechanisms important in protection from kidney disease. For the first time in kidney disease, we describe the use of Keap1 hypomorphic mice, which possess Nrf2 hyperactivation. We
Naringenin inhibits the aggregation of expanded polyglutamine tract-containing protein through the induction of endoplasmic reticulum chaperone GRP78.
Yamagishi, et al.
Biological & Pharmaceutical Bulletin, 35, 1836-1840 (2019)
Yinglong Zhao et al.
Frontiers in cell and developmental biology, 9, 796902-796902 (2022-02-22)
Microgravity prominently affected cardiovascular health, which was the gravity-dependent physical factor. Deep space exploration had been increasing in frequency, but heart function was susceptible to conspicuous damage and cardiac mass declined in weightlessness. Understanding of the etiology of cardiac atrophy
Mai-Khoi Q Do et al.
American journal of physiology. Cell physiology, 301(5), C1270-C1279 (2011-08-26)
Successful regeneration and remodeling of the intramuscular motoneuron network and neuromuscular connections are critical for restoring skeletal muscle function and physiological properties. The regulatory signals of such coordination remain unclear, although axon-guidance molecules may be involved. Recently, satellite cells, resident
S John Calise et al.
Journal of cell science, 129(15), 3042-3052 (2016-06-28)
'Rods and rings' (RRs) are conserved, non-membrane-bound intracellular polymeric structures composed, in part, of inosine monophosphate dehydrogenase (IMPDH), a key enzyme leading to GMP and GTP biosynthesis. RR formation is induced by IMPDH inhibitors as well as glutamine deprivation. They
Leng-Siew Yeap et al.
Epigenetics & chromatin, 2(1), 12-12 (2009-10-09)
Pluripotency, the capacity for indefinite self-renewal and differentiation into diverse cell types is a unique state exhibited by embryonic stem (ES) cells. Transcriptional regulators, such as Oct4, are critical for pluripotency, but the role of epigenetic modifiers remains to be
Christopher Kasbek et al.
Molecular biology of the cell, 18(11), 4457-4469 (2007-09-07)
Supernumerary centrosomes promote the assembly of abnormal mitotic spindles in many human tumors. In human cells, overexpression of the cyclin-dependent kinase (Cdk)2 partner cyclin A during a prolonged S phase produces extra centrosomes, called centrosome reduplication. Cdk2 activity protects the
Karolina Nader et al.
Brain structure & function, 224(8), 2691-2701 (2019-08-04)
Serum response factor (SRF) is a major transcription factor that regulates the expression of several plasticity-associated genes in the brain. Although the developmental expression of SRF in excitatory neurons is crucial for establishing proper hippocampal circuitry, no substantial evidence of
Xavier Gaume et al.
Cell cycle (Georgetown, Tex.), 14(6), 902-919 (2015-01-16)
Nucleolin is a pleiotropic protein involved in a variety of cellular processes. Although multipolar spindle formation has been observed after nucleolin depletion, the roles of nucleolin in centrosome regulation and functions have not been addressed. Here we report using immunofluorescence
Ouma Cisse et al.
Journal of experimental & clinical cancer research : CR, 38(1), 472-472 (2019-11-23)
Alteration of signalling pathways regulating cell cycle progression is a common feature of cancer cells. Several drugs targeting distinct phases of the cell cycle have been developed but the inability of many of them to discriminate between normal and cancer
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