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Michael C Koetting et al.
International journal of pharmaceutics, 471(1-2), 83-91 (2014-05-24)
pH-Responsive hydrogels comprised of itaconic acid copolymerized with N-vinylpyrrolidone (P(IA-co-NVP)) were synthesized and tested as carriers for the oral delivery of high isoelectric point (pI) exhibiting therapeutic proteins. Swelling studies show that P(IA-co-NVP) hydrogels exhibit significantly greater and faster pH-responsive
Kateřina Punčochová et al.
International journal of pharmaceutics, 469(1), 159-167 (2014-04-23)
The objective of this study was to investigate the effect of different polymeric carriers in solid dispersions with an active pharmaceutical ingredient (API) on their water vapour sorption equilibria and the influence of the API-polymer interactions on the dissolution rate
A N Kuskov et al.
International journal of molecular medicine, 26(1), 85-94 (2010-06-02)
Novel amphiphilic poly-N-vinylpyrrolidone derivatives with different molecular weight of hydrophilic PVP fragment and one secondary di-n-alkyl terminal hydrophobic fragment of different length were synthesized to compare their inclination for formation of nano-scaled micelle-like aggregates in aqueous media with previously studied
James R Pinney et al.
Biomaterials, 35(31), 8820-8828 (2014-07-23)
Chronic fibrosis caused by acute myocardial infarction (MI) leads to increased morbidity and mortality due to cardiac dysfunction. We have developed a therapeutic materials strategy that aims to mitigate myocardial fibrosis by utilizing injectable polymeric microstructures to mechanically alter the
Yi Yang et al.
Toxicology letters, 208(1), 82-91 (2011-11-01)
N-vinylpyrrolidone dimer (VPD) is a novel experimental formulation excipient intended for preclinical toxicology studies. In a previous 4-week toxicity study, VPD induced dose-dependent hepatocellular and thyroid gland hypertrophy in Sprague-Dawley (SD) rats. The objectives of the current investigation were to
Guichang Jiang et al.
Biotechnology progress, 28(1), 215-222 (2011-09-22)
Water-soluble fullerene (C(60))-N-vinylpyrrolidone copolymers were prepared by the radical polymerization method. The structures of the copolymers were characterized by Fourier transform infrared, UV-Vis, (1)H NMR, (13)C NMR, gel permeation chromatography, thermogravimetric analyses, and scanning electron microscopy (SEM). The results presented
Sang-Jae Park et al.
Scientific reports, 5, 13866-13866 (2015-09-15)
A triboelectric nanogenerator composed of gold nanoflowers is demonstrated. The proposed triboelectric nanogenerator creates electricity by contact-separation-based electrification between an anodic metal and a cathodic polymer. For the improvement of output power via the enlargement of the effective surface area
Jeong Hun Park et al.
Biofabrication, 6(2), 025003-025003 (2014-03-25)
One of the major issues in tissue engineering has been the development of three-dimensional (3D) scaffolds, which serve as a structural template for cell growth and extracellular matrix formation. In scaffold-based tissue engineering, 3D printing (3DP) technology has been successfully
Dalapathi Gugulothu et al.
Journal of pharmaceutical sciences, 103(2), 687-696 (2014-01-01)
Inflammatory bowel diseases, which largely comprise ulcerative colitis (UC) and Crohn's disease, are increasingly posing as a global threat because of the incompetence of the current therapy in the entire patient population. This necessitates the identification of alternative therapeutic molecules
Saúl E Bustamante et al.
Journal of hazardous materials, 365, 725-732 (2018-11-26)
We have prepared polymeric films as easy-to-handle sensory materials for the colorimetric detection and quantification of phenol derivatives (phenols) in water. Phenols in water resources result from their presence in pesticides and fungicides, among other goods, and are harmful ecotoxins.
Fei Chang et al.
Journal of colloid and interface science, 459, 136-145 (2015-08-19)
A series of novel oxygen-rich bismuth oxychloride (Bi12O17Cl2) were synthesized through a facile poly(vinyl pyrrolidone) (PVP)-assisted hydrothermal route. These obtained Bi12O17Cl2 samples were characterized by various physicochemical techniques. It was found that a proper addition amount of PVP could promote
Munawar Hussain et al.
Talanta, 147, 1-7 (2015-11-26)
We present a fast, robust and straightforward spin force assisted surface imprinting approach for activated platelets and demonstrate that Heparin induced thrombocytopenia (HIT) platelet aggregation can be measured by this approach. A critical and challenging step in functional assays for
Chonlatid Sontimuang et al.
Analytical biochemistry, 410(2), 224-233 (2010-12-07)
Allergen protein detection was performed by a surface imprinted layer combined with an interdigitated capacitance (IDC) transducer that allowed label-free measurements. The immobilized imprinted polymers are the probes that bind to rubber allergen proteins extracted from products such as rubber
Robin Sachdeva et al.
Cell calcium, 78, 66-75 (2019-01-19)
Methylglyoxal (MG) is a by-product of glucose metabolism and its accumulation has been linked to the development of diabetic complications such as retinopathy and nephropathy by affecting multiple signalling pathways. However, its influence on the intracellular Ca2+ homeostasis and particularly
Trevor Gilbert et al.
ACS applied materials & interfaces, 9(48), 42179-42191 (2017-11-14)
Herein, we comprehensively investigate the internal morphology of fully injectable interpenetrating networks (IPNs) prepared via coextrusion of functionalized precursor polymer solutions based on thermoresponsive poly(N-isopropylacrylamide) (PNIPAM) and nonthermoresponsive poly(vinyl pyrrolidone) (PVP) by reactive mixing using kinetically orthogonal hydrazone and thiosuccinimide
Kamran Qadir et al.
Nano letters, 12(11), 5761-5768 (2012-10-17)
Recent progress in colloidal synthesis of nanoparticles with well-controlled size, shape, and composition, together with development of in situ surface science characterization tools, such as ambient pressure X-ray photoelectron spectroscopy (APXPS), has generated new opportunities to unravel the surface structure
Zhichen Zhu et al.
Journal of controlled release : official journal of the Controlled Release Society, 171(1), 73-80 (2013-07-09)
We report on hydrogen-bonded layer-by-layer (LbL) films as a robust, reusable platform for temperature-triggered "on-demand" release of drugs. Films with high drug loading capacity, temperature-controlled on-off drug release, and stability at physiological conditions were enabled by assembly of tannic acid
Alexander S Pozdnyakov et al.
International journal of nanomedicine, 11, 1295-1304 (2016-04-22)
New nontoxic hydrophilic nanocomposites containing metallic silver nanoparticles (AgNPs) in a polymer matrix were synthesized by the chemical reduction of silver ions in an aqueous medium. A new nontoxic water soluble copolymer of 1-vinyl-1,2,4-triazole and N-vinylpyrrolidone synthesized by free radical-initiated
Hang Li et al.
Annals of biomedical engineering, 42(7), 1456-1469 (2013-10-17)
Neural stem/progenitor cells (NSPCs) are able to differentiate into the primary cell types (neurons, oligodendrocytes and astrocytes) of the adult nervous system. This attractive property of NSPCs offers a potential solution for neural regeneration. 3D implantable scaffolds should mimic the
Tijs M Lammens et al.
Environmental science & technology, 45(19), 8521-8528 (2011-08-30)
Glutamic acid is an important constituent of waste streams from biofuels production. It is an interesting starting material for the synthesis of biobased chemicals, thereby decreasing the dependency on fossil fuels. The objective of this paper was to compare the
Janine Jansen et al.
Macromolecular bioscience, 12(5), 692-702 (2012-03-15)
Photo-crosslinkable, fumaric acid monoethyl ester-functionalized triblock oligomers are synthesized and copolymerized with N-vinyl-2-pyrrolidone to form biodegradable photo-crosslinked hydrogels. Poly(ethylene glycol) is used as the middle hydrophilic segment and the hydrophobic segments are based on D,L-lactide, trimethylene carbonate or a mixture
Ayesha Aijaz et al.
Tissue engineering. Part A, 21(21-22), 2723-2732 (2015-08-05)
Wound healing is a hierarchical process of intracellular and intercellular signaling. Insulin is a potent chemoattractant and mitogen for cells involved in wound healing. Insulin's potential to promote keratinocyte growth and stimulate collagen synthesis in fibroblasts is well described. However
D Zahn et al.
Water research, 150, 86-96 (2018-12-06)
Transformation of industrial chemicals might be a significant source of hitherto unknown persistent and mobile organic contaminants (PMOC, PM chemicals) present in the aquatic environment. Herein we depicted a three-step strategy consisting of (I) the prioritization of potential PMOC precursors
Jacob L Lilly et al.
PloS one, 9(12), e115630-e115630 (2014-12-24)
Determining the location of rare proteins in cells typically requires the use of on-sample amplification. Antibody based recognition and enzymatic amplification is used to produce large amounts of visible label at the site of protein expression, but these techniques suffer
Jinku Xu et al.
Journal of biomaterials science. Polymer edition, 21(3), 271-288 (2010-02-25)
The purpose of this study is to develop a soft contact lens vehicle for puerarin delivery to alleviate glaucoma. Poly(2-hydroxy-ethyl methacrylate-co-N-vinylpyrrolidone-co-methyl acrylate) (pHEMA-NVP-MA) contact lenses were prepared by UV irradiation of HEMA, NVP and MA, to which the cross-linker, a
Xinbo Sun et al.
Colloids and surfaces. B, Biointerfaces, 110, 96-104 (2013-05-28)
Colonization and biofilm-formation of Candida species on denture surfaces cause Candida-associated denture stomatitis (CADS), a common, recurring disease affecting up to 67% of denture wearers. We developed poly(N-vinyl-2-pyrrolidinone)-grafted denture materials that can be repeatedly recharged with various antifungal drugs to
Hong-Wei Di et al.
Journal of nanoscience and nanotechnology, 10(12), 8210-8216 (2010-12-03)
A novel route was proposed to design and construct a magnetic composite microsphere with a controllable and regular core-shell architecture, which consists of Fe3O4 nanoparticles chemical-covalently encapsulated with pH-smart poly(methacrylic acid-co-N-vinyl pyrrolidone) (P(MAA-co-NVP)) cross-linked copolymers by a surface-initiated radical dispersion
Leyuan Xu et al.
Pharmaceutical research, 32(1), 275-285 (2014-07-18)
This work was aimed at developing a semi-interpenetrating network (sIPN) co-electrospun gelatin/insulin fiber scaffold (GIF) formulation for transbuccal insulin delivery. Gelatin was electrospun into fibers and converted into an sIPN following eosin Y-initiated polymerization of polyethylene glycol diacrylate (PEG-DA). The
Yoko Yamakoshi et al.
Faraday discussions, 173, 287-296 (2014-12-04)
The photoinduced reactive oxygen species (ROS) generation from several water-soluble fullerenes was examined. Macromolecular or small molecular water-soluble fullerene complexes/derivatives were prepared and their (1)O(2) and O(2)˙(-) generation abilities were evaluated by ESR spin-trapping methods. As a result, efficient (1)O(2)
Yejing Liu et al.
Small (Weinheim an der Bergstrasse, Germany), 10(23), 4940-4950 (2014-07-23)
A major challenge in plasmonic hot spot fabrication is to efficiently increase the hot spot volumes on single metal nanoparticles to generate stronger signals in plasmon-enhanced applications. Here, the synthesis of designer nanoparticles, where plasmonic-active Au nanodots are selectively deposited
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