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E C S Santos et al.
Zygote (Cambridge, England), 23(3), 352-359 (2013-12-21)
The aim of the present study was to examine the effects of brilliant cresyl blue (BCB) staining on mitochondrial functions in porcine oocytes. Cumulus-oocyte complexes (COCs) collected from slaughterhouse-derived porcine ovaries were cultured with (13 μM) or without (0 μM
Anna Paula Brandt et al.
Chemico-biological interactions, 218, 107-114 (2014-05-20)
Previously, we demonstrated that sydnone SYD-1 (3-[4-chloro-3-nitrophenyl]-1,2,3-oxadiazolium-5-olate) impairs the mitochondrial functions linked to energy provision and suggested that this effect could be associated with its antitumor activity. Herein, we evaluated the effects of SYD-1 (25 and 50 μM) on rat
M Staniszewska et al.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 34(7), 1429-1435 (2015-04-17)
The production of hydrolytic enzymes is considered a key virulence determinant of Candida albicans. Aminopeptidase 2 (Ape2) facilitates the penetration of C. albicans into the host tissue, by providing free amino acids to support fungal growth and proliferation. The objective
Michael S Dodd et al.
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 15, 19-19 (2013-02-19)
Alterations in cardiac metabolism accompany many diseases of the heart. The advent of cardiac hyperpolarized magnetic resonance spectroscopy (MRS), via dynamic nuclear polarization (DNP), has enabled a greater understanding of the in vivo metabolic changes that occur as a consequence
Valerio Leoni et al.
Clinical chemistry and laboratory medicine, 42(2), 186-191 (2004-04-06)
24S-Hydroxycholesterol (24OHC) and 27-hydroxycholesterol (27OHC) are two structurally similar oxysterols of different origins--the former almost exclusively formed in the brain and the latter formed to a lesser extent in the brain than in most other organs. HYPOTHESIS TO BE TESTED:
D R Khan et al.
Physiological genomics, 47(9), 432-442 (2015-06-18)
Acquisition of oocyte developmental competence needs to be understood to improve clinical outcomes of assisted reproduction. The stimulation of cumulus cell concentration of cyclic adenosine 3'5'-monophosphate (cAMP) by pharmacological agents during in vitro maturation (IVM) participates in improvement of oocyte
Carlos B Rueda et al.
Biochimica et biophysica acta, 1837(10), 1617-1624 (2014-05-14)
Calcium is thought to regulate respiration but it is unclear whether this is dependent on the increase in ATP demand caused by any Ca(2+) signal or to Ca(2+) itself. [Na(+)]i, [Ca(2+)]i and [ATP]i dynamics in intact neurons exposed to different
James M Pattarini et al.
Aviation, space, and environmental medicine, 84(9), 961-970 (2013-09-13)
Red Bull Stratos was a commercial program that brought a test parachutist protected by a full pressure suit to 127,852 ft (38,964 m), via a stratospheric balloon with a pressurized capsule, from which he free fell and subsequently parachuted to
S Kastenbauer et al.
Neurology, 58(2), 186-191 (2002-01-24)
To study reactive nitrogen species-mediated oxidative brain damage and antioxidant defenses in patients with acute bacterial meningitis. Nitrotyrosine (a widely used marker for the formation of reactive nitrogen species, such as peroxynitrite) and the lipid peroxidation product 4-hydroxynonenal were detected
R A Wevers et al.
Clinical chemistry, 41(5), 744-751 (1995-05-01)
This study describes a standardized method for recording single-pulse 1H-nuclear magnetic resonance (1H-NMR) spectra from cerebrospinal fluid (CSF). Quantitative data for alanine, valine, threonine, and lactic acid correlated well with data obtained with conventional techniques. The pH of the samples
P Fitzpatrick et al.
Carbohydrate polymers, 92(2), 1018-1025 (2013-02-13)
The interaction of native xanthan gum, deacetylated xanthan gum and depyruvated xanthan gum with konjac glucomannan has been studied using DSC and controlled stress rheometry. In the absence of electrolyte the DSC cooling curves for native xanthan and deacetylated xanthan
Imaging the cardiac diet.
B Daan Westenbrink et al.
European journal of heart failure, 15(2), 123-124 (2013-01-19)
Sarah C Atkinson et al.
Plant molecular biology, 81(4-5), 431-446 (2013-01-29)
Lysine is one of the most limiting amino acids in plants and its biosynthesis is carefully regulated through inhibition of the first committed step in the pathway catalyzed by dihydrodipicolinate synthase (DHDPS). This is mediated via a feedback mechanism involving
Yun-Liang Cui et al.
The American journal of Chinese medicine, 42(5), 1215-1227 (2014-09-02)
The intestine plays a vital role in the pathophysiology of sepsis development. The objective of the present study was to explore the effects of rhubarb on intestinal microcirculation in septic rats. We used moorFLPI laser speckle imaging to detect the
Tomoka Takatani-Nakase et al.
Biochemical and biophysical research communications, 463(1-2), 13-17 (2015-05-17)
Caspase-independent, non-apoptotic cell death is an important therapeutic target in myocardial ischemia. Leptin, an adipose-derived hormone, is known to exhibit cytoprotective effects on the ischemic heart, but the mechanisms are poorly understood. In this research, we found that pretreatment of
Hans F N Kvitvang et al.
Analytical chemistry, 83(7), 2705-2711 (2011-03-11)
Metabolite profiling methods are important tools for measurement of metabolite pools in biological systems. While most metabolite profiling methods report relative intensities or depend on a few internal standards representing all metabolites, the ultimate requirement for a quantitative description of
Keita Saito et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 21(22), 5073-5081 (2015-02-13)
X-ray irradiation of tumors causes diverse effects on the tumor microenvironment, including metabolism. Recent developments of hyperpolarized (13)C-MRI enabled detecting metabolic changes in tumors using a tracer [1-(13)C]pyruvate, which participates in important bioenergetic processes that are altered in cancers. Here
David G Cotter et al.
The Journal of biological chemistry, 288(27), 19739-19749 (2013-05-22)
Preservation of bioenergetic homeostasis during the transition from the carbohydrate-laden fetal diet to the high fat, low carbohydrate neonatal diet requires inductions of hepatic fatty acid oxidation, gluconeogenesis, and ketogenesis. Mice with loss-of-function mutation in the extrahepatic mitochondrial enzyme CoA
Federico A Zuljan et al.
International journal of food microbiology, 188, 99-107 (2014-08-08)
Lactic Acid Bacteria (LAB) are recognized as safe microorganisms with the capacity to improve the quality of dairy products. When the LAB Lactococcus lactis is employed as starter for the production of fermented foods, high quantities of important aroma compounds
M T P R Perera et al.
The British journal of surgery, 101(7), 775-783 (2014-04-29)
Donation after circulatory death (DCD) liver grafts have supplemented the donor organ pool, but certain adverse outcomes have prevented exploration of the full potential of such organs. The aim of this study was to determine key differences in basic energy
Jose L Izquierdo-Garcia et al.
Cancer research, 75(15), 2999-3009 (2015-06-06)
Mutant isocitrate dehydrogenase 1 (IDH1) catalyzes the production of 2-hydroxyglutarate but also elicits additional metabolic changes. Levels of both glutamate and pyruvate dehydrogenase (PDH) activity have been shown to be affected in U87 glioblastoma cells or normal human astrocyte (NHA)
Li Jing et al.
Food & function, 6(8), 2845-2853 (2015-07-21)
To elucidate the mechanism underlying the action of dietary vinegar on antithrombotic activity, acetic acid, the main acidic component of dietary vinegar, was used to determine antiplatelet and fibrinolytic activity. The results revealed that acetic acid significantly inhibits adenosine diphosphate
Wei Ge et al.
Scientific reports, 5, 13822-13822 (2015-09-09)
Infertility has long been a difficult issue for many couples. The successful differentiation of germ cells and live progeny from pluripotent stem cells brings new hope to the couples suffering with infertility. Here we successfully isolated human fetus skin-derived stem
Xiang Sheng et al.
Biochemistry, 53(27), 4455-4466 (2014-06-26)
Pyruvate carboxylase (PC) catalyzes the carboxylation of pyruvate to produce oxaloacetate. Its activity is directly related to insulin release and thus PC has recently attracted great interest as a potential target for diabetes treatment. In this article, the catalytic mechanism
Jianrong Lu et al.
Cancer letters, 356(2 Pt A), 156-164 (2014-04-16)
Compared to normal cells, cancer cells strongly upregulate glucose uptake and glycolysis to give rise to increased yield of intermediate glycolytic metabolites and the end product pyruvate. Moreover, glycolysis is uncoupled from the mitochondrial tricarboxylic acid (TCA) cycle and oxidative
Bertram L Koelsch et al.
Magnetic resonance in medicine, 74(3), 622-633 (2014-09-13)
Hyperpolarized (13) C magnetic resonance allows for the study of real-time metabolism in vivo, including significant hyperpolarized (13) C lactate production in many tumors. Other studies have shown that aggressive and highly metastatic tumors rapidly transport lactate out of cells.
H Tsuchiya et al.
Archives of oral biology, 28(11), 989-992 (1983-01-01)
alpha-Keto acids in human mixed saliva collected without stimulation were analysed by reversed-phase ion-pair high-performance liquid chromatography (HPLC). Several alpha-keto acids were found in saliva and their concentrations were: alpha-ketoglutaric acid (KGA), 221 +/- 142; pyruvic acid (PA), 7490 +/-
Rosa M Flores et al.
Journal of chromatography. A, 1418, 1-11 (2015-10-03)
Two, 3-step methods for derivatizing mono- and multi-functional species with carbonyl (CO), carboxylic acid (-COOH), and alcohol (-OH) moieties were compared and optimized. In Method 1, the CO, -COOH, and -OH moieties were converted (1) to methyloximes (R-CN-OCH3) with O-methylhydroxylamine
Yun-Jin Hong et al.
Biological & pharmaceutical bulletin, 38(2), 201-207 (2014-11-18)
2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is formed as a by-product of the Maillard reaction during cooking and frying of protein-rich foods at high temperatures. PhIP is metabolized in the liver by cytochrome P450 1A1/2 to carcinogenic metabolite N-hydroxy PhIP, which can form DNA
Y Li et al.
Applied microbiology and biotechnology, 57(4), 451-459 (2002-01-05)
Pyruvic acid is an important organic acid widely used in the chemical and drug, as well as agrochemical, industries. Compared with the chemical method, biotechnological production of pyruvic acid is an alternative approach because of the low cost. An overview
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