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Anna Sheveleva et al.
Virus genes, 47(2), 385-388 (2013-07-03)
The near-complete (99.7 %) genome sequence of a novel Russian Plum pox virus (PPV) isolate Pk, belonging to the strain Winona (W), has been determined by 454 pyrosequencing with the exception of the thirty-one 5'-terminal nucleotides. This region was amplified using
M F Rai et al.
Osteoarthritis and cartilage, 27(6), 945-955 (2019-02-25)
To compare the transcriptome of articular cartilage from knees with meniscus tears to knees with end-stage osteoarthritis (OA). Articular cartilage was collected from the non-weight bearing medial intercondylar notch of knees undergoing arthroscopic partial meniscectomy (APM; N = 10, 49.7 ± 10.8 years, 50%
Kyra Campbell et al.
Nature communications, 10(1), 2311-2311 (2019-05-28)
Metastasis underlies the majority of cancer-related deaths yet remains poorly understood due, in part, to the lack of models in vivo. Here we show that expression of the EMT master inducer Snail in primary adult Drosophila intestinal tumors leads to
Sebastiaan Theuns et al.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases, 43, 135-145 (2016-05-18)
Next-generation sequencing (NGS) technologies are becoming increasingly accessible, leading to an expanded interest in the composition of the porcine enteric virome. In the present study, the fecal virome of a non-diarrheic Belgian piglet was determined. Although the virome of only
Zsolt B Nagy et al.
Analytical biochemistry, 337(1), 76-83 (2005-01-15)
Conventional approaches to target labeling for gene expression analysis using microarray technology typically require relatively large amounts of RNA, a serious limitation when the available sample is limited. Here we describe an alternative exponential sample amplification method by using quantitative
Kelsey L Tinkum et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(51), E7148-E7154 (2015-12-09)
Short-term fasting protects mice from lethal doses of chemotherapy through undetermined mechanisms. Herein, we demonstrate that fasting preserves small intestinal (SI) architecture by maintaining SI stem cell viability and SI barrier function following exposure to high-dose etoposide. Nearly all SI
Jorge Barbazán et al.
PloS one, 7(7), e40476-e40476 (2012-07-20)
Metastatic colorectal cancer (mCRC) relies on the detachment of aggressive malignant cells from the primary tumor into the bloodstream and, concordantly, the presence of these Circulating Tumor Cells (CTC) is associated with a poor prognosis. In this work, the molecular
Alka A Potdar et al.
Journal of Crohn's & colitis, 13(8), 1055-1066 (2019-03-17)
Heterogeneity in Crohn's disease [CD] provides a challenge for the development of effective therapies. Our goal was to define a unique molecular signature for severe, refractory CD to enable precision therapy approaches to disease treatment and to facilitate earlier intervention
Shogo Sato et al.
Cell, 170(4), 664-677 (2017-08-13)
The process of aging and circadian rhythms are intimately intertwined, but how peripheral clocks involved in metabolic homeostasis contribute to aging remains unknown. Importantly, caloric restriction (CR) extends lifespan in several organisms and rewires circadian metabolism. Using young versus old
Fubo Wang et al.
Oncotarget, 5(22), 11091-11102 (2014-12-20)
The current strategy for diagnosing prostate cancer (PCa) is mainly based on the serum prostate-specific antigen (PSA) test. However, PSA has low specificity and has led to numerous unnecessary biopsies. We evaluated the effectiveness of urinary metastasis-associated lung adenocarcinoma transcript
Bridget S Banach et al.
Journal of virological methods, 156(1-2), 19-26 (2008-11-26)
Propagation of new human respiratory virus pathogens in established cell lines is hampered by a lack of predictability regarding cell line permissivity and by availability of suitable antibody reagents to detect infection in cell lines that do not exhibit significant
F S Salah et al.
Cell death & disease, 7, e2205-e2205 (2016-04-29)
GABARAP belongs to an evolutionary highly conserved gene family that has a fundamental role in autophagy. There is ample evidence for a crosstalk between autophagy and apoptosis as well as the immune response. However, the molecular details for these interactions
Alberto Parras et al.
Nature, 560(7719), 441-446 (2018-08-17)
Common genetic contributions to autism spectrum disorder (ASD) reside in risk gene variants that individually have minimal effect sizes. As environmental factors that perturb neurodevelopment also underlie idiopathic ASD, it is crucial to identify altered regulators that can orchestrate multiple
Sylvie Janssens et al.
mSystems, 3(1) (2018-02-13)
Zika virus (ZIKV) infection during early pregnancy can cause microcephaly and associated defects at birth, but whether it can induce neurologic sequelae that appear later in life remains unclear. Using a model of the developing brain based on embryonic stem
Csaba Vastagh et al.
Frontiers in molecular neuroscience, 12, 137-137 (2019-06-20)
In proestrus, the changing gonadal hormone milieu alters the physiological properties of GnRH neurons and contributes to the development of the GnRH surge. We hypothesized that proestrus also influences the expression of different ion channel genes in mouse GnRH neurons.
M Dietrich et al.
Journal of bacteriology, 196(5), 1102-1112 (2014-01-01)
The holE gene is an enterobacterial ORFan gene (open reading frame [ORF] with no detectable homology to other ORFs in a database). It encodes the θ subunit of the DNA polymerase III core complex. The precise function of the θ
Gloria Pascual et al.
Nature, 541(7635), 41-45 (2016-12-16)
The fact that the identity of the cells that initiate metastasis in most human cancers is unknown hampers the development of antimetastatic therapies. Here we describe a subpopulation of CD44
Francisco Freixo et al.
Nature communications, 9(1), 2330-2330 (2018-06-15)
Organization of microtubules into ordered arrays is best understood in mitotic systems, but remains poorly characterized in postmitotic cells such as neurons. By analyzing the cycling cell microtubule cytoskeleton proteome through expression profiling and targeted RNAi screening for candidates with
Meik Dilcher et al.
Virus genes, 45(3), 426-432 (2012-08-07)
Erve virus (ERVEV) is a European Nairovirus that is suspected to cause severe headache (thunderclap headache) and intracerebral hemorrhage. The mode of transmission to humans (ticks or mosquitoes) is still unknown. Currently, no standardized testing method for ERVEV exists and
Chenyan Shi et al.
Microbiome, 7(1), 121-121 (2019-08-30)
Mosquitoes are the most important invertebrate viral vectors in humans and harbor a high diversity of understudied viruses, which has been shown in many mosquito virome studies in recent years. These studies generally performed metagenomics sequencing on pools of mosquitoes
Genetic characterization of Tribevc virus and Kemerovo virus, two tick-transmitted human-pathogenic Orbiviruses
Dilcher M, et al.
Virology, 423, 68-76 (2012)
Mikus Abolins-Abols et al.
The Journal of experimental biology, 221(Pt 17) (2018-07-13)
Organisms are expected to invest less in reproduction in response to a stressor, but theory predicts that this effect should depend on the frequency and duration of stressors in the environment. Here, we investigated how an acute stressor affected testes
Scott A Tomlins et al.
Nature genetics, 39(1), 41-51 (2006-12-19)
Despite efforts to profile prostate cancer, the genetic alterations and biological processes that correlate with the observed histological progression are unclear. Using laser-capture microdissection to isolate 101 cell populations, we have profiled prostate cancer progression from benign epithelium to metastatic
Paula Climent-Cantó et al.
Nucleic acids research, 48(8), 4147-4160 (2020-02-28)
Linker histones H1 are principal chromatin components, whose contribution to the epigenetic regulation of chromatin structure and function is not fully understood. In metazoa, specific linker histones are expressed in the germline, with female-specific H1s being normally retained in the
Kate Van Brussel et al.
Viruses, 12(11) (2020-11-18)
Astroviruses, isolated from numerous avian and mammalian species including humans, are commonly associated with enteritis and encephalitis. Two astroviruses have previously been identified in cats, and while definitive evidence is lacking, an association with enteritis is suggested. Using metagenomic next-generation
James R Winton et al.
Microbiology resource announcements, 8(10) (2019-03-14)
We report here the genome sequences of two index strains of Pacific salmon paramyxovirus isolated in 1982 and 1983 from adult salmon in Oregon. The isolates are most closely related to Atlantic salmon paramyxovirus, the type species of the genus
Luca Urbani et al.
PloS one, 7(11), e49860-e49860 (2012-11-21)
Satellite cells (SCs) are essential for postnatal muscle growth and regeneration, however, their expansion potential in vitro is limited. Recently, hypoxia has been used to enhance proliferative abilities in vitro of various primary cultures. Here, by isolating SCs from single
Shota Nakamura et al.
PloS one, 4(1), e4219-e4219 (2009-01-22)
With the severe acute respiratory syndrome epidemic of 2003 and renewed attention on avian influenza viral pandemics, new surveillance systems are needed for the earlier detection of emerging infectious diseases. We applied a "next-generation" parallel sequencing platform for viral detection
Constanza Vásquez-Doorman et al.
PLoS genetics, 10(7), e1004452-e1004452 (2014-07-06)
Mechanisms that enable injury responses to prompt regenerative outgrowth are not well understood. Planarians can regenerate essentially any tissue removed by wounding, even after decapitation, due to robust regulation of adult pluripotent stem cells of the neoblast population. Formation of
Limited correlation of shotgun metagenomics following host depletion and routine diagnostics for viruses and bacteria in low concentrated surrogate and clinical samples
Oechslin CP, et al.
Frontiers in Cellular and Infection Microbiology, 2018, 375-375 null
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