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Y0000517

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Henriette Franz et al.
Oncotarget, 6(7), 4773-4789 (2015-03-10)
The histone code reader Spindlin1 (SPIN1) has been implicated in tumorigenesis and tumor growth, but the underlying molecular mechanisms remain poorly understood. Here, we show that reducing SPIN1 levels strongly impairs proliferation and increases apoptosis of liposarcoma cells in vitro...
Fariha Khan et al.
Nucleic acids research, 42(13), 8705-8718 (2014-06-25)
Glycine-rich RNA-binding proteins (GR-RBPs) are involved in cold shock response of plants as RNA chaperones facilitating mRNA transport, splicing and translation. GR-RBPs are bipartite proteins containing a RNA recognition motif (RRM) followed by a glycine-rich region. Here, we studied the...
Jiangbin Ye et al.
Cancer discovery, 4(12), 1406-1417 (2014-09-05)
The de novo synthesis of the nonessential amino acid serine is often upregulated in cancer. In this study, we demonstrate that the serine catabolic enzyme, mitochondrial serine hydroxymethyltransferase (SHMT2), is induced when MYC-transformed cells are subjected to hypoxia. In mitochondria...
Rieko Chiba et al.
Microbes and infection, 16(8), 702-706 (2014-06-18)
Visceral leishmaniasis is protozoonosis that occurs worldwide and still requires effective therapies with less toxicity. In this study, we examined the antileishmanial effect of nerve growth factor (NGF) using a murine infection model. NGF blocked the infection of macrophages by...
Yao-Tsung Yeh et al.
Free radical biology & medicine, 74, 1-13 (2014-06-22)
Phenethyl isothiocyanate (PEITC) is a naturally occurring cruciferous vegetable-derived compound that inhibits cell growth and induces apoptosis in oral cancer cells. However, the exact mechanism of PEITC action has not been fully elucidated. This study investigated the molecular mechanism and...
B Li et al.
Free radical research, 48(7), 758-768 (2014-04-12)
Stromal interaction molecule (STIM) proteins are parts of elaborate eukaryotic Ca(2+) signaling systems and are considered to be important players in regulating neuronal Ca(2+) homeostasis under normal ageing and pathological conditions. Here, we investigated the potential role of STIM1 in...
Fan Zheng et al.
Molecular biology of the cell, 25(18), 2750-2760 (2014-07-25)
Accurate chromosome segregation requires timely bipolar spindle formation during mitosis. The transforming acidic coiled-coil (TACC) family proteins and the ch-TOG family proteins are key players in bipolar spindle formation. They form a complex to stabilize spindle microtubules, mainly dependent on...
A Dadkhah et al.
Pharmaceutical biology, 53(2), 220-227 (2014-09-23)
Achillea wilhelmsii C. Koch (Asteraceae) is widely used in Iranian traditional medicine. This in vivo study evaluates the hepatoprotective role of Iranian A. wilhelmsii oils against acetaminophen-induced oxidative damages in rats. The animals were divided into five groups: in negative...
Hui Wang et al.
BioMed research international, 2014, 282657-282657 (2014-07-23)
Ionizing radiation (IR) is known not only to cause acute bone marrow (BM) suppression but also to lead to long-term residual hematopoietic injury. These effects have been attributed to IR inducing the generation of reactive oxygen species (ROS) in hematopoietic...
Chang-Soo Seong et al.
PloS one, 9(8), e103564-e103564 (2014-08-02)
Drosophila melanogaster flies mount an impressive immune response to a variety of pathogens with an efficient system comprised of both humoral and cellular responses. The fat body is the main producer of the anti-microbial peptides (AMPs) with anti-pathogen activity. During...
Ming-Wen Li et al.
Transgenic research, 24(1), 99-108 (2014-08-01)
Successful production of genetically modified mouse lines is dependent on germline transmission (GLT) of mutant alleles from chimeras. When natural mating fails to achieve GLT due to male infertility, sickness, or other problems, sperm can be harvested from chimeras and...
Caitlin E Presnell et al.
Current neurovascular research, 10(2), 185-194 (2013-03-09)
Excess reactive oxygen species (ROS) generation and oxidative stress in vascular tissue is associated with many diseases. Glutathione (GSH), one of the most abundant low molecular weight non-protein thiols, modulates physiological levels of ROS and is involved in the cell's...
Ye Han et al.
Nutrients, 7(1), 682-696 (2015-01-23)
The purpose of this study was to evaluate the hepatoprotective effect of maltol, a food-flavoring agent, on alcohol-induced acute oxidative damage in mice. Maltol used in this study was isolated from red ginseng (Panax ginseng C.A Meyer) and analyzed by...
Leyi Wang et al.
Biomaterials, 35(29), 8427-8438 (2014-07-06)
Many viral structural proteins and their truncated domains share a common feature of homotypic interaction forming dimers, trimers, and/or oligomers with various valences. We reported previously a simple strategy for construction of linear and network polymers through the dimerization feature...
Ning Chang et al.
Scientific reports, 5, 9612-9612 (2015-04-16)
CPD45 (chloroplast division45),which is also known as FHY3 (far-red elongated hypocotyl3), is a key factor in the far-red light signaling pathway in Arabidopsis. We previously showed that FHY3/CPD45 also regulates chloroplast division. Because light is also a regulator of chloroplast...
Miia J Rainio et al.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 167, 24-34 (2014-09-04)
Lead is a highly poisonous metal with a very long half-life, distributing throughout the body in blood and accumulating primarily in bones and kidney. We studied the short and long-term effects of early-life lead exposure on antioxidant defense and phagocytosis...
Ruei-Yue Liang et al.
Journal of molecular biology, 426(24), 4049-4060 (2014-10-15)
Rad23 was identified as a DNA repair protein, although a role in protein degradation has been described. The protein degradation function of Rad23 contributes to cell cycle progression, stress response, endoplasmic reticulum proteolysis, and DNA repair. Rad23 binds the proteasome...
Wen Dong et al.
Phytochemistry, 112, 151-159 (2014-12-03)
The regulation of plant cell growth and early defense response involves the insolubilization of hydroxyproline-rich glycoproteins (HRGPs), such as extensin, in the primary cell wall. In tomato (Lycopersicon esculentum), insolubilization occurs by the formation of tyrosyl-crosslinks catalyzed specifically by the...
Shu-Fang Xia et al.
Metabolism: clinical and experimental, 64(5), 566-579 (2015-02-12)
The exact mechanism for different propensities to obesity when consuming a high-fat diet (HFD) is largely unknown. Thyroid hormone (TH) is an important modulator of energy homeostasis and body weight. The present study aimed to find the potential mechanisms of...
Yilin Wang et al.
Journal of proteomics, 108, 484-493 (2014-06-24)
Plant receptor-like kinases (RLKs) constitute a large family of receptors coordinating developmental programs with adaptation to environmental stresses including immune defenses. BRI1-ASSOCIATED KINASE 1 (BAK1), a member of the plant RLK family, forms receptor complexes with multiple RLK proteins including...
Danzil Joseph et al.
Life sciences, 105(1-2), 31-42 (2014-04-22)
Although acute hyperglycemic (AHG) episodes are linked to lower glucose uptake, underlying mechanisms remain unclear. We hypothesized that AHG triggers reactive oxygen species (ROS) production and increases non-oxidative glucose pathway (NOGP) activation, i.e. stimulation of advanced glycation end products (AGE)...
Yanzhong Yang et al.
Nature communications, 6, 6428-6428 (2015-03-05)
The human genome encodes a family of nine protein arginine methyltransferases (PRMT1-9), whose members can catalyse three distinct types of methylation on arginine residues. Here we identify two spliceosome-associated proteins-SAP145 and SAP49-as PRMT9-binding partners, linking PRMT9 to U2 snRNP maturation....
Doriane Lorendeau et al.
Biochemical pharmacology, 90(3), 235-245 (2014-05-31)
The multidrug resistance protein 1 (MRP1) is involved in multidrug resistance of cancer cells by mediating drug efflux out of cells, often in co-transport with glutathione (GSH). GSH efflux mediated by MRP1 can be stimulated by verapamil. In cells overexpressing...
Jenna Oberstaller et al.
Nucleic acids research, 42(13), 8271-8284 (2014-06-25)
We provide the first comprehensive analysis of any transcription factor family in Cryptosporidium, a basal-branching apicomplexan that is the second leading cause of infant diarrhea globally. AP2 domain-containing proteins have evolved to be the major regulatory family in the phylum...
Jie Zhang et al.
PloS one, 9(9), e107478-e107478 (2014-09-13)
To interrogate why redox homeostasis and glutathione S-transferase P (GSTP) are important in regulating bone marrow cell proliferation and migration, we isolated crude bone marrow, lineage negative and bone marrow derived-dendritic cells (BMDDCs) from both wild type (WT) and knockout...
Shangcheng Xu et al.
Neuroscience letters, 590, 52-57 (2015-02-01)
Previous studies have indicated that oxidative stress and mitochondrial dysfunction are involved in the toxicity of nickel. Taurine is recognized as an efficient antioxidant and is essential for mitochondrial function. To investigate whether taurine could protect against the neurotoxicity of...
Suchera Loyprasert-Thananimit et al.
Biotechnology and applied biochemistry, 61(3), 357-362 (2013-10-18)
White spot syndrome virus (WSSV) is a major cause of infectious disease in cultured shrimp. A fast and reliable method for detecting and monitoring the amount of WSSV during farming would be extremely useful. This work describes a sandwich immunoassay...
Piia Kokkonen et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 63, 71-76 (2014-07-09)
SIRT6 is a modulator of chromatin structure having an important role in healthy ageing, and there is a crucial need to find specific modulators for it. Therefore, the activity of SIRT6 should be studied using a variety of methods. We...
Raquel González de Vega et al.
Analytical and bioanalytical chemistry, 407(9), 2405-2413 (2014-10-27)
A post-column isotope dilution analysis (IDA) methodology was applied to carry out quantitative speciation of selenium in human vitreous humor samples by size exclusion chromatography (SEC) coupled on-line to inductively coupled plasma mass spectrometry (ICP-MS). Two main selenium species detected...
Juliano Boufleur Farinha et al.
Life sciences, 121, 152-157 (2014-12-17)
The aim of this study was to investigate the effects of an active lifestyle on mitochondrial functioning, viability, bioenergetics, and redox status markers in peripheral blood mononuclear cells (PBMC) of overweight/ obese postmenopausal women. We performed a cross-sectional study with...
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