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Mahshid Dehghan et al.
Circulation, 126(23), 2705-2712 (2012-12-06)
Diet quality is strongly related to cardiovascular disease (CVD) incidence, but little is known about its impact on CVD events in older people at high risk of CVD and receiving effective drugs for secondary prevention. This study assessed the association
Li Li et al.
Diabetes, 62(3), 762-774 (2012-12-15)
The mechanisms of the improvement of glucose homeostasis through angiotensin receptor blockers are not fully elucidated in hypertensive patients. We investigated the effects of telmisartan on insulin signaling and glucose uptake in cultured myotubes and skeletal muscle from wild-type and
Utpal Nandi et al.
Regulatory toxicology and pharmacology : RTP, 65(1), 68-78 (2012-12-04)
Metoprolol succinate (MET), a cardioselective β blocker and telmisartan (TEL), an angiotensin receptor blocker were administered orally, both individually and in combination to Wistar albino rats for evaluation of their pharmacokinetics, pharmacodynamics and repeated dose oral toxicity (28 days). Pharmacokinetic
Guangrong Zou et al.
Clinical and experimental hypertension (New York, N.Y. : 1993), 37(3), 223-234 (2014-10-02)
Spontaneously hypertensive rats (SHR) was used to study left ventricular hypertrophy (LVH) and its dynamic change after the interventions with Telmisartan and Amlodipine. The results showed that the expression of TRPC1, CaN and NFATC3 increased gradually with the pathogenesis and
Kiyoshi Kikuchi et al.
International journal of molecular sciences, 14(9), 18899-18924 (2013-09-26)
Stroke is a major cause of mortality and disability worldwide. The main cause of stroke is atherosclerosis, and the most common risk factor for atherosclerosis is hypertension. Therefore, antihypertensive treatments are recommended for the prevention of stroke. Three angiotensin receptor
Pitchai Balakumar et al.
Current diabetes reviews, 8(3), 183-190 (2012-03-21)
Diabetic nephropathy, a complex disorder with heterogeneous etiologies, remains one of the most threatening diseases worldwide. There were around 177 million people with diabetes mellitus worldwide, and it has been estimated to be increased to 360 million by 2030. Given
Tomoko Kurata et al.
Translational stroke research, 6(2), 107-115 (2014-01-18)
Telmisartan is expected to reduce not only the level of blood pressure but also neuroinflammation and neurotoxicity via pleiotrophic effects as a metabo-sartan. We examined the effects of telmisartan on Alzheimer's disease (AD) pathology in spontaneously hypertensive rat stroke resistant
A Soliman et al.
Transplantation proceedings, 44(10), 2936-2939 (2012-12-01)
This double-blind trial followed 16 patients with autosomal dominant polycystic kidney disease (ADPKD) who received telmisartan or sirolimus plus telmisartan for 24 months. The 6-month pilot study showed a promising effect of sirolimus. The primary metric of this 2-year study
Kota Sato et al.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 23(10), 2511-2519 (2014-09-24)
Telmisartan, an angiotensin receptor blocker with high lipid solubility, also called metabo-sartan, not only reduces blood pressure (BP), but also ameliorates inflammation in the cerebral cortex and in adipose tissue. We examined the effects of telmisartan on inflammatory responses of
Raimundo Fernandes de Araújo Júnior et al.
Experimental biology and medicine (Maywood, N.J.), 240(1), 34-44 (2014-08-16)
It has been well-characterized that the renin-angiotensin system (RAS) physiologically regulates systemic arterial pressure. However, RAS signaling has also been shown to increase cell proliferation during malignancy, and angiotensin receptor blockers (ARBs) are able to decrease pro-survival signaling by inhibiting
Ming Wang et al.
Chinese journal of integrative medicine, 20(10), 758-763 (2014-07-31)
To observe the time-effect relation of extracts from ginseng, notoginseng and chuanxiong on angiotensin II (Ang II)-induced senescence of vascular endothelial cells and explore the feature of Chinese medicine against vascular diseases. Human umbilical vein endothelial cells (HUVECs) cultured in
Yasunori Iida et al.
PloS one, 7(12), e49642-e49642 (2012-12-12)
Despite the importance of the renin-angiotensin (Ang) system in abdominal aortic aneurysm (AAA) pathogenesis, strategies targeting this system to prevent clinical aneurysm progression remain controversial and unproven. We compared the relative efficacy of two Ang II type 1 receptor blockers
Roland E Schmieder et al.
Journal of nephrology, 24(3), 263-273 (2011-03-05)
Renal dysfunction can be regarded as a continuum that extends from endothelial dysfunction to microalbuminuria, macroalbuminuria, end-stage renal disease and ultimately to death. All stages of this continuum are associated with progressively increasing cardiovascular risk. Preventing the development and progression
Anne Bayer et al.
Environmental science and pollution research international, 21(18), 10830-10839 (2014-06-06)
Pharmaceuticals and other anthropogenic trace contaminants reach wastewaters and are often not satisfactorily eliminated in sewage treatment plants. These contaminants and/or their degradation products may reach surface waters, thus influencing aquatic life. In this study, the behavior of five different
Yves Lacourcière
Clinical and experimental hypertension (New York, N.Y. : 1993), 35(1), 50-60 (2012-08-08)
The aim of this review was to compare telmisartan and valsartan in the treatment of hypertension. PubMed searches were conducted to identify randomized trials (n = 14) comparing the two agents, alone or combined with hydrochlorothiazide. With one exception, all
Ken-ichi Arita-Morioka et al.
Antimicrobial agents and chemotherapy, 59(1), 633-641 (2014-11-19)
Biofilms are complex communities of microorganisms that attach to surfaces and are embedded in a self-produced extracellular matrix. Since these cells acquire increased tolerance against antimicrobial agents and host immune systems, biofilm-associated infectious diseases tend to become chronic. We show
Eun-Sook Jeong et al.
Xenobiotica; the fate of foreign compounds in biological systems, 45(1), 10-18 (2014-07-19)
1. Fimasartan is an angiotensin receptor II antagonist used to treat patients with hypertension. This drug is mainly excreted into bile as either the parent compound or a glucuronide conjugate. In this study, we examined the glucuronidation of fimasartan and
Habib Eslami et al.
Neuroscience letters, 558, 31-36 (2013-11-12)
Telmisartan is an angiotensin II type 1 receptor blocker and partial agonist of peroxisome proliferator-activated receptor gamma (PPAR-γ). Here, we investigated the protective capacity of telmisartan against high glucose (HG)-elicited oxidative damage in PC12 cells. The activity of lactate dehydrogenase
A quest--halting the progression of autosomal dominant polycystic kidney disease.
David H Ellison et al.
The New England journal of medicine, 371(24), 2329-2331 (2014-11-18)
Luis M Ruilope
Current medical research and opinion, 27(8), 1673-1682 (2011-07-02)
Cardiovascular disease (CVD) places a significant burden on healthcare providers. High blood pressure (BP) is the single most prevalent risk factor for CVD worldwide and is responsible for more deaths than any other risk factor. 'Cardiovascular (CV) high-risk patients' make
Ambulatory central blood pressure: a new opportunity for mechanistic and clinical cardiovascular research.
Giuseppe Mancia
Hypertension (Dallas, Tex. : 1979), 61(6), 1148-1149 (2013-05-01)
Tomasz A Bonda et al.
Pharmacological reports : PR, 67(2), 204-208 (2015-02-26)
CCN family of proteins has been implicated in various processes in cardiovascular physiology and pathology, including angiogenesis, regeneration and fibrosis. In this study we assessed long term changes of CCN1 and CCN2 gene products abundance in the failing ventricular myocardium.
R Ceska et al.
Vnitrni lekarstvi, 56(8), 839-844 (2010-09-18)
Cardiovascular diseases (CVD) represent a significant health problem in all countries world-wide and in the developed world, including the Czech Republic, in particular. The underlying cause in the majority of CVD patients is atherosclerosis and its complications, respectively. The present
N Suksomboon et al.
Journal of clinical pharmacy and therapeutics, 37(3), 319-327 (2011-08-19)
Telmisartan is an angiotensin receptor blocker (ARB) originally developed for the treatment of hypertension. It can also partially activate peroxisome proliferator-activated receptor (PPAR)-γ, which may improve insulin sensitivity. This effect may prove useful in hypertensive patients with insulin resistance or
Jordan E Lake et al.
PloS one, 8(3), e58135-e58135 (2013-03-22)
Visceral adiposity in the setting of HIV infection and antiretroviral therapy (ART) is not fully understood, and treatment options remain limited. Telmisartan, an angiotensin receptor blocker and partial PPAR-γ agonist, has been shown to decrease visceral fat and improve metabolic
Holger Cynis et al.
International journal of experimental pathology, 94(3), 217-225 (2013-04-09)
Inflammation is an integral part of non-alcoholic fatty liver disease (NAFLD), the most prevalent form of hepatic pathology found in the general population. In this context, recently we have examined the potential role of Glutaminyl Cyclases (QC and isoQC), and
Keiji Ozeki et al.
PloS one, 8(2), e56770-e56770 (2013-03-02)
Current treatment target toward advanced colorectal cancers is mainly focused on the epidermal growth factor receptor (EGFR) signaling, but its additive effects with chemotherapy are still limited. A disintegrin and metalloproteinase (ADAM) cleaves the proheparin-binding epidermal growth factor like growth
Massimo Volpe
Expert review of cardiovascular therapy, 10(8), 1061-1072 (2012-10-04)
Angiotensin II receptor blockers (ARBs) inhibit the renin-angiotensin system. As a result, these agents provide beneficial effects in terms of cardiovascular (CV) and renal protection, independent of their blood pressure-lowering effects. Telmisartan and valsartan are the most intensively studied ARBs
Tomoko Kurata et al.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 23(10), 2580-2590 (2014-09-23)
In addition to reducing the level of blood pressure (BP), telmisartan was expected to show the long-term neuroprotective effects preventing accumulation of cellular amyloid beta peptide (Aβ) and phosphorylated tau (pτ) by ameliorating neuroinflammation. We examined effects of telmisartan on
Thomas Klein et al.
Medical molecular morphology, 47(3), 137-149 (2013-09-21)
Non-alcoholic steatohepatitis (NASH) is a primary cause of cirrhosis and hepatocellular carcinoma. Dipeptidyl peptidase (DPP)-4 inhibitors are established therapies for type 2 diabetes and although DPP-4 inhibitors can reduce hepatic steatosis, their impact on local inflammation and fibrosis in NASH
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