Merck

Decarboxylation mechanisms in biological system.

Bioorganic chemistry (2012-04-27)
Tingfeng Li, Lu Huo, Christopher Pulley, Aimin Liu
ABSTRACT

This review examines the mechanisms propelling cofactor-independent, organic cofactor-dependent and metal-dependent decarboxylase chemistry. Decarboxylation, the removal of carbon dioxide from organic acids, is a fundamentally important reaction in biology. Numerous decarboxylase enzymes serve as key components of aerobic and anaerobic carbohydrate metabolism and amino acid conversion. In the past decade, our knowledge of the mechanisms enabling these crucial decarboxylase reactions has continued to expand and inspire. This review focuses on the organic cofactors biotin, flavin, NAD, pyridoxal 5'-phosphate, pyruvoyl, and thiamin pyrophosphate as catalytic centers. Significant attention is also placed on the metal-dependent decarboxylase mechanisms.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Thiamine pyrophosphate, ≥95%