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Synthesis of all-trans arachidonic acid and its effect on rabbit platelet aggregation.

Bioorganic & medicinal chemistry letters (2005-05-07)
Dimitris Anagnostopoulos, Chryssostomos Chatgilialoglu, Carla Ferreri, Abdelouahid Samadi, Athanassia Siafaka-Kapadai
ABSTRACT

A simple and high-yielding method to convert natural all-cis PUFA derivatives to the corresponding all-trans geometrical isomers is described. The method is based on the thiyl radical-catalyzed cis-trans isomerization. The all-trans isomer of arachidonic acid was found to cause rabbit platelet aggregation at concentrations higher than 0.1 mM and inhibition of PAF-induced platelet aggregation in a concentration dependent manner with an IC(50) in the micromolar range.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Arachidonic acid, >95.0% (GC)
Sigma-Aldrich
Arachidonic acid, from non-animal source, ≥98.5% (GC)