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Extraction, hemisynthesis, and synthesis of canthin-6-one analogues. Evaluation of their antifungal activities.

Journal of natural products (2005-11-29)
Flor Soriano-Agatón, Delphine Lagoutte, Erwan Poupon, François Roblot, Alain Fournet, Jean-Charles Gantier, Reynald Hocquemiller
ABSTRACT

Zanthoxylum chiloperone var. angustifolium was investigated. Alkaloids 1-3 from the canthin-6-one series were characterized. Derivatives 7-28 were prepared by hemisynthesis or total synthesis. All compounds were tested for in vitro antifungal activities against five pathogenic fungal strains. Analogues of canthin-6-one did not show better antifungal activities.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Ketoconazole, 99.0-101.0% (EP, titration)