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Chalcone based aryloxypropanolamines as potential antihyperglycemic agents.

Bioorganic & medicinal chemistry letters (2006-11-11)
Poonam Shukla, Amar Bahadur Singh, Arvind Kumar Srivastava, Ram Pratap
ABSTRACT

A series of chalcone based aryloxypropanolamines were synthesized and evaluated for their antihyperglycemic activity in SLM and STZ rat models. Most of the compounds exhibited moderate to good activity ranging from 6.5% to 31.1% in SLM and 8.3% to 22.6% in STZ models, respectively. The most potent compound 5 g exhibited glucose lowering of 26.7% in SLM and 22.6% in STZ models. A definite structure-activity relationship was observed while varying the nature as well as the position of the amine in ring B.

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Brand
Product Description

Sigma-Aldrich
Glyburide, meets USP testing specifications