Merck

Anti-HIV and antiplasmodial activity of original flavonoid derivatives.

Bioorganic & medicinal chemistry (2010-07-20)
Gilles Casano, Aurélien Dumètre, Christophe Pannecouque, Sébastien Hutter, Nadine Azas, Maxime Robin
ABSTRACT

In our search for potent anti-HIV and antiplasmodial agents, novel series of flavonoid derivatives and their chalcone intermediates were synthesized and evaluated for inhibition of HIV multiplication and antiproliferative activity on Plasmodium falciparum parasites. Chalcones exhibited a more selective antiplasmodial activity than flavonoids. Methoxyflavone 7e was the only one compound active in both P. falciparum and HIV-1 whereas aminomethoxyflavones showed activity against HIV-2. Para substitution on the B ring seemed to increase HIV-2 potency.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
2′,3′-Dideoxyinosine, ≥98% (HPLC)