Inhibition of Porphyromonas gingivalis biofilm by oxantel.

Antimicrobial agents and chemotherapy (2009-12-30)
Stuart Dashper, Ching-Seng Ang, Sze Wei Liu, Rita Paolini, Paul Veith, Eric Reynolds
ABSTRACT

Porphyromonas gingivalis is a major pathogen of chronic periodontitis and exists in a biofilm on the surface of the tooth root. Oxantel, a cholinergic anthelmintic and fumarate reductase inhibitor, significantly inhibited biofilm formation by P. gingivalis and disrupted established biofilms at concentrations below its MIC against planktonic cells. Oxantel was more effective against P. gingivalis in biofilm than metronidazole, a commonly used antibiotic for periodontitis.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Thiabendazole, ≥99%, powder
Supelco
Thiabendazole, PESTANAL®, analytical standard
Sigma-Aldrich
Thiabendazole, BioReagent, suitable for plant cell culture, powder

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