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Template synthesis, spectroscopic studies and biological activities of macrocyclic complexes derived from thiocarbohydrazide and glyoxal.

Journal of enzyme inhibition and medicinal chemistry (2007-05-24)
D P Singh, Ramesh Kumar, Vandna Malik, Parikshit Tyagi
ABSTRACT

A novel series of complexes of the type [M(TML)X2]; where TML is Tetradentate Macrocyclic Ligand; M = Co(II), Ni(II), Cu(II), Zn(II)or Cd(II); X = Cl-, CH3COO- or NO3- have been synthesized by template condensation of glyoxal and thiocarbohydrazide in the presence of divalent metal salts in methanolic medium. The complexes have been characterized by elemental analyses, conductance measurements, molecular weight determination, magnetic measurements, electronic, NMR, infrared and far infrared spectral studies. Electronic spectra along with magnetic moments suggest a six coordinate octahedral geometry for these complexes. The low molar conductance values indicates them to be non-electrolytes. The biological activities of the metal complexes have been tested in vitro against a number of pathogenic bacteria to assess their inhibitory potential.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Thiocarbohydrazide, 98%