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Highly enantioselective alkynylation of aldehydes using a new BINOL/Ti(OiPr)4/chiral sulfonamide catalyst system.

Chirality (2007-06-08)
Xingshu Li, Gui Lu, Xian Jia, Yinuo Wu, Albert S C Chan
ABSTRACT

A series of sulfonamides (2-4) were prepared from natural amino acids and used as additives in the BINOL-Ti(OiPr)(4) catalyzed enantioselective alkynylation of aldehydes. The reactions proceeded smoothly with good yields and very high ee's (up to 99%) in most cases.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Titanium(IV) isopropoxide, 97%
Sigma-Aldrich
Titanium(IV) isopropoxide, 99.999% trace metals basis
Sigma-Aldrich
Titanium(IV) isopropoxide, ≥97.0%
Sigma-Aldrich
Titanium(IV) isopropoxide, packaged for use in deposition systems