• Home
  • Search Results
  • Tributyrin attenuates obesity-associated inflammation and insulin resistance in high-fat-fed mice.

Tributyrin attenuates obesity-associated inflammation and insulin resistance in high-fat-fed mice.

American journal of physiology. Endocrinology and metabolism (2012-05-25)
Marco Aurélio Ramirez Vinolo, Hosana G Rodrigues, William T Festuccia, Amanda R Crisma, Vitor S Alves, Amanda R Martins, Catia L Amaral, Jarlei Fiamoncini, Sandro M Hirabara, Fabio T Sato, Ricardo A Fock, Gabriella Malheiros, Marinilce F dos Santos, Rui Curi

The aim of this study was to investigate whether treatment with tributyrin (Tb; a butyrate prodrug) results in protection against diet-induced obesity and associated insulin resistance. C57BL/6 male mice fed a standard chow or high-fat diet were treated with Tb (2 g/kg body wt, 10 wk) and evaluated for glucose homeostasis, plasma lipid profile, and inflammatory status. Tb protected mice against obesity and obesity-associated insulin resistance and dyslipidemia without food consumption being affected. Tb attenuated the production of TNFα and IL-1β by peritoneal macrophages and their expression in adipose tissue. Furthermore, in the adipose tissue, Tb reduced the expression of MCP-1 and infiltration by leukocytes and restored the production of adiponectin. These effects were associated with a partial reversion of hepatic steatosis, reduction in liver and skeletal muscle content of phosphorylated JNK, and an improvement in muscle insulin-stimulated glucose uptake and Akt signaling. Although part of the beneficial effects of Tb are likely to be secondary to the reduction in body weight, we also found direct protective actions of butyrate reducing TNFα production after LPS injection and in vitro by LPS- or palmitic acid-stimulated macrophages and attenuating lipolysis in vitro and in vivo. The results, reported herein, suggest that Tb may be useful for the treatment and prevention of obesity-related metabolic disorders.

Product Number
Product Description

Glyceryl tributyrate, ≥99%
Tributyrin, 97%, FG
Glyceryl tributyrate, puriss., ≥98.5% (GC)

Social Media

LinkedIn icon
Twitter icon
Facebook Icon
Instagram Icon


Research. Development. Production.

We are a leading supplier to the global Life Science industry with solutions and services for research, biotechnology development and production, and pharmaceutical drug therapy development and production.

© 2021 Merck KGaA, Darmstadt, Germany and/or its affiliates. All Rights Reserved.

Reproduction of any materials from the site is strictly forbidden without permission.