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  • NH4OAc promoted cyclocondensation of 3-(o-allylphenyl)pentane-1,5-diones: synthesis of tetracyclic benzofused 1-azahomoisotwistanes.

NH4OAc promoted cyclocondensation of 3-(o-allylphenyl)pentane-1,5-diones: synthesis of tetracyclic benzofused 1-azahomoisotwistanes.

Organic letters (2012-07-24)
Meng-Yang Chang, Ming-Hao Wu, Hang-Yi Tai
ABSTRACT

A facile two-step synthetic route for preparing the novel tetracyclic skeleton of benzofused 2,6-diaryl-1-azahomoisotwistanes 2 had been developed. The route was carried out by a one-pot tandem cross-coupling reaction of o-allylbenzaldehydes 1 with aryl methyl ketones 3, and NH(4)OAc mediated the cascade cyclocondensation reaction of the resulting 1,5-diketones 4 with the 3-o-allylphenyl group in good yield in two steps.

MATERIALS
Product Number
Brand
Product Description

Supelco
Ammonium acetate, suitable for mass spectrometry (MS), LiChropur, eluent additive for LC-MS
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Ammonium acetate, for molecular biology, ≥98%
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Ammonium acetate, BioUltra, for molecular biology, ≥99.0%
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Ammonium acetate, BioXtra, ≥98%
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Ammonium acetate, 99.999% trace metals basis
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Pentane, ≥99% (GC)
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Pentane, analytical standard
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Pentane, spectrophotometric grade, ≥99%
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Pentane, puriss. p.a., ≥99.0% (GC)
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